Genetic dissection of cell growth arrest functions mediated by the Epstein-Barr virus lytic gene product, Zta

Journal of Virology

Volumn 73, Issue 11, 1999, Pages 9029-9038

  Rodriguez, Antonio ^a   Armstrong, Monica ^a   Dwyer, Daniel ^a   Flemington, Erik ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; VIRUS DNA;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL GROWTH; DISSECTION; EPSTEIN BARR VIRUS; GENETIC TRANSCRIPTION; MITOSIS INHIBITION; NONHUMAN; ONCOGENE C FOS; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIMIAN VIRUS 40; TRANSACTIVATION; VIRUS REPLICATION;

EID: 0032876837     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.11.9029-9038.1999     Document Type: Article

References (68)

1. Ait-Si-Ali, S., S. Ramirez, F.-X. Barre, F. Dkhissi, L. Magnaghi-Jaulin, F. A. Girault, P. Robin, M. Knibiehler, L. L. Pritchard, B. Ducommun, D. Trouche, and A. Harel-Bellan. 1998. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Nature 396:184-186.
2. Alday, M. J., A. Sinclair, G. Parker, D. H. Crawford, and P. J. Farrell. 1995. Epstein-Barr virus efficiently immortalizes human B cells without neutralizing the function of p53. EMBO J. 14:1382-1391.
3. Baumann, M., H. Mischak, S. Dammeier, W. Kolch, O. Gires, D. Pich, R. Zeidler, H.-J. Delecluse, and W. Hammerschmidt. 1998. Activation of the Epstein-Barr virus transcription factor BZLF1 by 12-O-tetradecanolyphorbol-13-acetate-induced phosphorylation. J. Virol. 72:8105-8114.
4. Becker, J., U. Leser, M. Marschall, A. Langford, W. Jilg, H. Gelderblom, P. Reichart, and H. Wolf. 1991. Expression of proteins encoded by Epstein-Barr virus transactivator genes depends on differentiation of epithelial cells in oral hairy leukoplakia. Proc. Natl. Acad. Sci. USA 88:8332-8336.
5. Bresnahan, W., P. Boldogh, E. Thompson, and T. Albrecht. 1997. Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1. Virology 224:150-160.
6. 1 cell cycle arrest through induction of cyclindependent kinase inhibitors. EMBO J. 15:2748-2759.
7. 1 growth arrest mediated by a region encompassing the bZIP domain of the Epstein-Barr virus transactivator Zta. J. Biol. Chem. 271:31799-31802.
8. Cayrol, C., and E. K. Flemington. 1995. Identification of cellular target genes of the Epstein-Barr virus transactivator Zta: activation of transforming growth factor βigh3 (TGF-βigh3) and TGF-β1. J. Virol. 69:4206-4212.
9. Chang, Y.-N., D. L.-Y. Dong, G. S. Hayward, and S. D. Hayward. 1990. The Epstein-Barr virus Zta transactivator: a member of the bZIP family with unique DNA binding specificity and dimerization domain that lacks the characteristic heptad leucine zipper motif. J. Virol. 64:3358-3369.
10. Chi, T., and M. Carey. 1993. The ZEBRA activation domain: modular organization and mechanism of action. Mol. Cell. Biol. 13:7045-7055.
11. Cohen, J. I., F. Wang, J. Mannick, and E. Kieff. 1989. Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation. Proc. Natl. Acad. Sci. USA 86:9558-9562.
12. Countryman, J., H. Jensen, R. Seibel, H. Wolf, and G. Miller. 1987. Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency. J. Virol. 61:3672-3679.
13. 1/S transition. J. Virol. 71:1629-1634.
14. Farrell, P. J., D. T. Rowe, C. M. Rooney, and T. Kouzarides. 1989. Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos. EMBO J. 8:127-132.
15. Fixman, E. D., G. S. Hayward, and S. D. Hayward. 1995. Replication of Epstein-Barr virus oriLyt: lack of a dedicated virally encoded origin-binding protein and a dependence on Zta in cotransfection assays. J. Virol. 69:2998-3006.
16. Flemington, E., A. M. Borras, J. P. Lytle, and S. Speck. 1992. Characterization of the Epstein-Barr virus BZLF1 protein trans-activation domain. J. Virol. 66:922-929.
17. Flemington, E., and S. Speck. 1990. Autoregulation of the Epstein-Barr virus putative lytic switch gene BZLF1. J. Virol. 64:1227-1232.
18. Flemington, E., and S. H. Speck. 1990. Evidence for coiled-coil dimer formation by an Epstein-Barr virus transactivator that lacks a heptad repeat of leucine residues. Proc. Natl. Acad. Sci. USA 87:9459-9463.
19. Francis, A., L. Bradoville, and G. Miller. 1997. Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency. J. Virol. 71:3051-3061.
20. Giot, J.-F., I. Mikaelian, M. Buisson, E. Manet, I. Joab, J.-C. Nicolas, and A. Sergeant. 1991. Transcriptional interference between the EBV transcription factors EB1 and R: both DNA binding and activations of EB1 are required. Nucleic Acids Res. 19:1251-1258.
21. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547-5551.
22. Grogan, E. J., J. Jenson, J. Countryman, L. Heston, L. Gradoville, and G. Miller. 1987. Transfection of a rearranged viral DNA fragment, WZhet, stably converts latent Epstein-Barr virus infection to productive infection in lymphoid cells. Proc. Natl. Acad. Sci. USA 84:1332-1336.
23. Gutierrez, M. I., J.-G. Judde, I. T. MaGrath, and K. G. Bhatia. 1996. Switching viral latency to viral lysis: a novel therapeutic approach for Epstein-Barr virus-associated neoplasia. Cancer Res. 56:969-972.
24. Hammerschmidt, W., and B. Sugden. 1989. Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes. Nature (London) 340:393-397.
25. Henkel, T., P. D. Ling, S. D. Hayward, and M. G. Peterson. 1994. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein Jk. Science 265:92-95.
26. Hsieh, J. J.-D., and S. D. Hayward. 1995. Masking of the CBF/RBPJκ transcriptional repression domain by Epstein-Barr virus EBNA2. Science 268:560-563.
27. Kalejta, R., T. Shenk, and A. Beavis. 1997. Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry. Cytometry 29:286-291.
28. Kaye, K. M., K. M. Izumi, and E. Kieff. 1993. Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc. Natl. Acad. Sci. USA 90:9150-9154.
29. Kempkes, B., D. Spitkovsky, P. Jansen-Durr, J. W. Ellwart, E. Kremmer, H.-J. Delecluse, C. Rottenberger, G. W. Bornkamm, and W. Hammerschmidt. 1995. B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2. EMBO J. 14:88-96.
30. Kenney, S., E. Holley-Guthrie, E. C. Mar, and M. Smith. 1989. The Epstein-Barr virus BMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators. J. Virol. 63:3878-3883.
31. Kieff, E. (ed.). 1996. Epstein-Barr virus and its replication. Lippincott-Raven Press, New York, N.Y.
32. Klein, G. 1994. Epstein-Barr virus strategy in normal and Neoplastic B cells. Cell 77:791-793.
33. Kolman, J. L., N. Taylor, L. Gradoville, J. Countryman, and G. Miller. 1996. Comparing transcriptional activation and autostimulation by ZEBRA and ZEBRA/c-Fos chimeras. J. Virol. 70:1493-1504.
34. Kouzarides, T., G. Packham, A. Cook, and P. Farrell. 1991. The BLZF1 protein of EBV has a coiled coil dimerisation domain without a heptad leucine repeat but with homology to the C/EBP leucine zipper. Oncogene 6:195-204.
35. Lieberman, P., and A. Berk. 1990. In vitro transcriptional activation, dimerization, and DNA-binding specificity of the Epstein-Barr virus Zta protein. J. Virol. 64:2560-2568.
36. Lieberman, P. M., J. M. Hardwick, and S. D. Hayward. 1989. Responsiveness of the Epstein-Barr virus NotI repeat promoter to the Z transactivator is mediated in a cell-type-specific manner by two independent signal regions. J. Virol. 63:3040-3050.
37. 1 to S. J. Virol. 70:8850-8857.
38. 1 phase of the cell cycle. J. Virol. 73:676-683.
39. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
40. Mannick, J., J. I. Cohen, M. Birkenbach, A. Marchini, and E. Kieff. 1991. The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation. J. Virol. 65:6826-6837.
41. Mauser, A., and S. Kenny. 1998. The Epstein-Barr virus BZLF1 IE protein inhibits cellular differentiation and cell cycle progression. Epstein-Barr Virus Symposium.
42. Miller, G. 1990. Epstein-Barr virus, p. 1921-1958. In B. N. Fields and D. M. Knipe (ed.), Virology. Raven Press, New York, N.Y.
43. Mosialos, G., M. Birkenbach, R. Yalamanchili, T. VanArsdale, C. Ware, and E. Kieff. 1995. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80:389-399.
44. Muller, D., C. Bouchard, B. Rudolph, P. Steiner, I. Stuckmann, R. Saffrich, W. Ansorge, W. Huttner, and M. Eilers. 1997. Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes. Oncogene 15:2561-2576.
45. Nass, S., and R. Dickson. 1998. Epidermal growth factor-dependent cell cycle progression is altered in mammary epithelial cells that overexpress c-myc. Clin. Cancer Res. 4:1813-1822.
46. Perez-Roger, I., D. Solomon, A. Sewing, and H. Land. 1997. Myc activation of cyclinE/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes. Oncogene 14: 2373-2381.
47. Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275:523-527.
48. Rodriguez, A., and E. Flemington. 1999. Transfection-mediated cell-cycle signaling: considerations for transient transfection-based cell-cycle studies. Anal. Biochem. 272:171-181.
49. Rodriguez, A., and E. Flemington. Unpublished data.
50. Salvant, B. S., E. A. Fortunato, and D. H. Spector. 1998. Cell cycle dysregulation by human cytomegalovirus: influence of the cell cycle phase at the time of infection and effects on cyclin transcription. J. Virol. 72:3729-3741.
51. Sarisky, R. T., Z. Gao, P. M. Lieberman, E. D. Fixman, G. S. Hayward, and S. D. Hayward. 1996. A replication function associated with the activation domain of the Epstein-Barr virus Zta transactivator. J. Virol. 70:8340-8347.
52. Schepers, A., D. Pich, J. Mankertz, and W. Hammerschmidt 1993. cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus. J. Virol. 67:4237-4245.
53. Shadan, F. F., L. M. Cowsert, and L. P. Billarreal. 1994. n-Butyrate, a cell cycle blocker, inhibits the replication of polyomaviruses and papillomaviruses but not that of adenoviruses and herpesviruses. J. Virol. 68:4785-4796.
54. Sheikh, M., X.-S. Li, J.-C. Chen, Z.-M. Shao, J. Ordonez, and J. Fontana. 1994. Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways. Oncogene 9:3407-3415.
55. Sinclair, A. J., I. Palmero, G. Peters, and P. J. Farrell. 1994. EBNA-2 and EBNA-LP cooperate to cause G0 to G1 transition during immortalization of resting human B lymphocytes by Epstein-Barr virus. EMBO J. 13:3321-3328.
56. Sixbey, J. W., S. M. Lemon, and J. S. Pagano. 1986. A second site for Epstein-Barr virus shedding: the uterine cervix. Lancet ii:1122-1124.
57. Sixbey, J. W., J. G. Nedrud, N. Raab-Traub, R. A. Hanes, and J. S. Pagano. 1984. Epstein-Barr virus replication in oropharyngeal epithelial cells. N. Engl. J. Med. 310:1225-1230.
58. Speck, S. H., T. Chatila, and E. K. Flemington. 1997. Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene. Trends Microbiol. 5:399-405.
59. Takase, K., C. A. Kelleher, N. Terada, J. F. Jones, J. J. Lucas, and E. W. Gelfand. 1996. Dissociation of EBV genome replication and host cell proliferation in anti-IgG-stimulated Akata cells. Clin. Immunol. Immunopathol. 8:168-174.
60. Tomkinson, B., E. Robertson, and E. Kieff. 1993. Epstein-Barr virus nuclear proteins EBNA-3A and EBNA-3C are essential for B-lymphocyte growth transformation. J. Virol. 67:2014-2025.
61. Urier, G., M. Buisson, P. Chambard, and A. Sergeant. 1989. The Epstein-Barr virus early protein EB1 activates transcription from different responsive elements including AP-1 binding sites. EMBO J. 8:1447-1453.
62. Vlach, J., S. Hennecke, K. Alevizopoulos, D. Conti, and B. Amati. 1996. Growth arrest by the cyclin dependent kinase inhibitor p27kip1 is abrogated by c-Myc. EMBO J. 15:6595-6604.
63. Wolf, H., M. Haus, and E. Wilmes. 1984. Persistence of Epstein-Barr virus in the parotid gland. J. Virol. 51:795-798.
64. Yates, J. L., N. Warren, and B. Sugden. 1985. Stable replication of plasmids derived from Epstein-Barr virus in a variety of mammalian cells. Nature 313:812-815.
65. Young, L. S., R. Lau, M. Rowe, G. Niedobotek, G. Packham, F. Shanahan, D. T. Rowe, D. Greenspan, J. S. Greenspan, A. B. Rickinson, and P. J. Farrell. 1991. Differentiation associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia. J. Virol. 65:2868-2874.
66. Young, L. S., and M. Rowe. 1992. Epstein-Barr virus, lymphomas and Hodgkin's disease. Semin. Cancer Biol. 3:273-284.
67. Zerby, D., C.-J. Chen, E. Poon, D. Lee, R. Shiekhattar, and P. Lieberman. 1999. The amino-terminal C/H1 domain of CREB binding protein mediates Zta transcriptional activation of latent Epstein-Barr virus. Mol. Cell. Biol. 19:1617-1626.
68. Zhang, Z., D. Gutsch, and S. Kenney. 1994. Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency. J. Virol. 14:1929-1938.