Comparing transcriptional activation and autostimulation by ZEBRA and ZEBRA/c-Fos chimeras

Journal of Virology

Volumn 70, Issue 3, 1996, Pages 1493-1504

  Kolman, John L ^a,b   Taylor, Naomi ^a,c   Gradoville, Lyn ^a   Countryman, Jill ^a   Miller, George ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; COMPLEMENTARY DNA; MESSENGER RNA; ONCOPROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; EPSTEIN BARR VIRUS; ESCHERICHIA COLI; GENE EXPRESSION; IMMEDIATE EARLY GENE; NONHUMAN; ONCOGENE C FOS; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION INITIATION; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS REPLICATION;

EID: 0030025841     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.3.1493-1504.1996     Document Type: Article

References (66)

1. Agre, P., P. F. Johnson, and S. L. McKnight. 1989 Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP Science 246:922-925.
2. Angel, P., K. Hattori, T. Smeal, and M. Karin. 1988. The jun proto-oncogene is positively autoregulated hy its product, Jun/Ap-1. Cell 55:875-885.
3. Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739.
4. Baer, R., A. T. Bankier, M. D. Biggin, P. L. Deininger, P. J. Farrell, T. J. Gibson, G. Hatful, G. S. Hudson, S. C. Satchwell, C. Seguin, P. S. Tuffenell, and B. Barrell. 1984. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature (London) 310:207-211.
5. Baichwal, V. R., A. Park, and R. Tjian. 1992. The cell-type-specific activator region of c-Jun juxtaposes constitutive and negatively regulated domains. Genes Dev. 6:1493-1502.
6. Baumann, R., E. Grogan, M. Ptashne, and G. Miller. 1993 Changing Epstein-Barr viral ZEBRA protein into a more powerful activator enhances its capacity to disrupt latency. Proc. Natl Acad. Sci. USA 90:4436-4440.
7. Biggin, M., M. Bodescot, M. Perricaudet, and P. J. Farrell. 1987. Epstein-Barr virus gene expression in P3HR-1-superinfected Raji cells. J. Virol. 61:3120-3132.
8. Carey, M., J. L. Kolman, D. A. Katz, L. Gradoville, L. Barberis, and G. Miller. 1992. Transcriptional synergy by the Epstein-Barr virus transactivator ZEBRA. J. Virol. 66:4803-4813.
9. Chang, Y.-N., D. L.-Y. Dong, G. S. Hayward, and S. D. Hayward. 1990. The Epstein-Barr virus Zta transactivator: a member of the bZip family with unique DNA-binding specificity and a dimerization domain that lacks the characteristic heptad leucine zipper motif J Virol. 64:3358-3369.
10. Chi, T., and M. Carey. 1993. The ZEBRA activation domain: modular organization and mechanism of action. Mol. Cell. Biol. 13:7045-7055.
11. Countryman, J., H. Jenson, R. Seibl, H. Wolf, and G. Miller. 1987. Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency. J. Virol. 61:3672-3679.
12. Countryman, J., and G. Miller. 1985. Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogenous viral DNA Proc. Natl. Acad. Sci. USA 82:4085-4089.
13. Countryman, J. K., L. Heston, L. Gradoville, H. Himmelfarb, S. Serdy, and G. Miller. 1994. Activation of the Epstein-Barr virus BMRF1 and BZLF1 promoters by ZEBRA in Saccharomyces cerevisiae. J Virol. 68:7628-7633.
14. Daibata, M., S. H. Speck, C. Mulder, and T. Sairenji. 1994. Regulation of the BZLF1 promoter of Epstein-Barr virus by second messengers in anti-immunoglobulin-treated B cells. Virology 198:446-454
15. Davis, M. G., and E. S. Huang. 1988. Transfer and expression of plasmids containing human cytomegalovirus immediate-early gene 1 promoter-enhancer sequences in eukaryotic and prokaryotic cells. Biotechnol. Appl. Biochem. 10:6-12
16. Faggioni, A., C. Zompetta, S. Grimaldi, G. Barile, L. Frati, and J. Lazdins. 1986. Calcium modulation activates Epstein-Barr virus genome in latently infected cells Science 232:1554-1556
17. Farrell, P. J., D. T. Rowe, C. M. Rooney, and T. Kouzarides. 1989. Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos. EMBO J. 8:127-132.
18. Fixman, E. D., G. S. Hayward, and S. D. Hayward. 1992. trans-Acting requirements for replication of Epstein-Barr virus ori-Lyt. J. Virol. 66:5030-5039.
19. Flemington, E., and S. H. Speck. 1990. Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1 J Virol 64:1227-1232
20. Flemington, E., and S. H. Speck. 1990 Evidence for coiled-coil dimer formation by an Epstein-Barr virus transactivator that lacks a heptad repeat of leucine residues. Proc. Natl. Acad. Sci. USA 87:9459-9463
21. Flemington, E., and S. H. Speck. 1990. Identification of phorbol ester response elements in the promoter of Epstein-Barr virus putative lytic switch gene BZLF1. J. Virol. 64:1217-1226.
22. Flemington, E. K., A. M. Borras, J. P. Lytle, and S. H. Speck. 1992. Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain J. Virol. 66:922-929.
23. Flemington, E. K., A. E. Goldfeld, and S. H. Speck. 1991 Efficient transcription of the Epstein-Barr virus immediate-early BZLF1 and BRLF1 genes requires protein synthesis. J. Virol. 65:7073-7077.
24. Flemington, E. K., J. P. Lytle, C. Cayrol, A. M. Borras, and S. H. Speck. 1994. DNA-binding-defective mutants of the Epstein-Barr virus lytic switch activator Zta transactivate with altered specificities. Mol. Cell. Biol. 14:3041-3052.
25. Furnari, F. B., V. Zacny, E. B. Quinlivan, S. Kenney, and J. S. Pagano. 1994. RAZ, an Epstein-Barr virus transdominant repressor that modulates the viral reactivation mechanism J. Virol. 68:1827-1836
26. Giot, J.-F., I. Mikaelian, M. Buisson, E. Manet, I. Joab, J.-C. Nicolas, and A. Sergeant. 1991. Transcriptional interference between the EBV transcription factors EB1 and R: both DNA-binding and activation domains are required. Nucleic Acids Res 19:1251-1258.
27. Glover, J. N., and S. C. Harrison. 1995 Crystal structure of the heterodimeric bZip transcription factor c-Fos-c-Jun bound to DNA. Nature (London) 373:257-261.
28. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051
29. Gradoville, L., E. Grogan, N. Taylor, and G. Miller. 1990. Differences in the extent of activation of Epstein-Barr virus replicative gene expression among four non-producer cell lines stably transformed by oriP/BZLF1 plasmids. Virology 178:345-354.
30. Holley-Guthrie, E., E. B. Quinlivan, E.-C. Mar, and S. Kenney. 1990. The Epstein-Barr virus (EBV) BMRF1 promoter for early antigen (EA-D) is regulated by the EBV transactivators BRLF1 and BZLF1 in a cell-specific manner. J. Virol. 64:3753-3759
31. Johnson, P. F., and S. L. McKnight. 1989. Eukaryotic transcriptional regulatory proteins. Annu. Rev. Biochem. 58:799-938.
32. Kenney, S., E. Holley-Guthrie, E.-C. Mar, and M. Smith. 1989. The Epstein-Barr virus RMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators. J. Virol. 63:3878-3883.
33. Kenney, S. C., G. E. Holley, E. B. Quinlivan, D. Gutsch, Q. Zhang, T. Bender, J. F. Giot, and A. Sergeant. 1992. The cellular oncogene c-myb can interact synergistically with the Epstein-Barr virus BZLF1 transactivator in lymphoid cells Mol Cell Biol 12:136-146.
34. Koerner, T. J., J. E. Hill, A. M. Myers, and A. Tzagoloff. 1991. High-expression vectors with multiple cloning sites for construction of trpE fusion genes pATH vectors. Methods Enzymol 194:477-490.
35. Kolman, J. L., N. Taylor, D. R. Marshak, and G. Miller. 1993. Serine-173 of the Epstein-Barr virus ZEBRA protein is required for DNA binding and is a target for casein kinase 11 phosphorylation. Proc Natl Acad Sci. USA 90:10115-10119.
36. Kouzarides, T., G. Packham, A. Cook, and P. J. Farrell. 1991. The BZLF1 protein of EBV has a coiled coil dimerization domain without a heptad leucine repeat but with homology to the C/EBP leucine zipper. Oncogene 6:195-204.
37. Kouzarides, T., and E. Ziff. 1989. Leucine zippers of Fos, Jun and GCN4 dictate dimerization specificity and thereby control DNA binding Nature (London) 340:568-571.
38. Kouzarides, T., and E. Ziff. 1988. The role of the leucine zipper in the Fos-Jun interaction. Nature (London) 336:646-651.
39. Lieberman, P. M., and A. J. Berk. 1990. In vitro transcriptional activation, dimerization, and DNA-binding specificity of the Epstein-Barr virus Zta protein. J. Virol. 64:2560-2568.
40. Lieberman, P. M., J. M. Hardwick, and S. D. Hayward. 1989 Responsiveness of the Epstein-Barr virus NotI repeat promoter to the Z transactivator is mediated in a cell-type-specific manner by two independent signal regions J. Virol. 63:3040-3050
41. Lieberman, P. M., J. M. Hardwick, J. Sample, G. S. Hayward, and S. D. Hayward. 1990. The Zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions J Virol. 64:1143-1155.
42. Luka, J., B. Kallin, and G. Klein. 1979. Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrate. Virology 94:228-231
43. Manet, E., H. Gruffat, M. C. Trescol-Biemont, N. Moreno, P. Chambard, J. F. Giot, and A. Sergeant. 1989. Epstein-Barr virus bicistronic mRNAs generated by facultative splicing code for two transcriptional transactivators. EMBO J. 8:1819-1826.
44. Mikaelian, I., E. Drouet, V. Marechal, G. Denoyel, J. C. Nicolas, and A. Sergeant. 1993. The DNA-binding domain of two bZip transcription factors, the Epstein-Barr virus switch gene product EB1 and Jun, is a bipartite nuclear targeting sequence. J. Virol. 67:734-742.
45. Miller, G., H. Himmelfarb, L. Heston, J. Countryman, L. Gradoville, R. Baumann, T. Chi, and M. Carey. 1993. Comparing regions of the Epstein-Barr virus ZEBRA protein which function as transcriptional activating sequences in Saccharomyces cerevisiae and in B cells. J Virol. 67:7472-7481.
46. Miller, G., M. Rabson, and L. Heston. 1984. Epstein-Barr virus with heterogeneous DNA disrupts latency. J. Virol. 50:174-182.
47. Montalvo, E. A., M. Cottam, S. Hill, and Y. J. Wang. 1995. YY1 binds to and regulates cis-acting negative elements in the Epstein-Barr virus BZLF1 promoter. J. Virol 69:4158-4165.
48. Nakabeppu, Y., and D. Nathans. 1989. The basic region of Fos mediates specific DNA binding EMBO J. 8:3833-3841.
49. Packham, G., M. Brimmell, D. Cook, A. J. Sinclair, and P. J. Farrell. 1993 Strain variation in Epstein-Barr virus immediate early genes. Virology 192: 541-550.
50. Packham, G., A. Economou, C. M. Rooney, D. T. Rowe, and P. J. Farrell. 1990. Structure and function of the Epstein-Barr virus BZLF1 protein. J. Virol 64:2110-2116.
51. Pearson, G. R., B. Vroman, B. Chase, T. Sculley, M. Hummel, and E. Kieff. 1983. Identification of polypeptide components of the Epstein-Barr virus early antigen complex with monoclonal antibodies J Virol. 47:193-201.
52. Ptashne, M. 1988. How eukaryotic transcriptional activators work. Nature (London) 335:683-689.
53. Quinlivan, E. B., G. E. Holley, M. Norris, D. Gutsch, S. L. Bachenheimer, and S. C. Kenney. 1993. Direct BRLF1 binding is required for cooperative BZLF1/BRLF1 activation of the Epstein-Barr virus early promoter, BMRF1. Nucleic Acids Res. 21:1999-2007.
54. Rabson, M., L. Heston, and G. Miller. 1983. Identification of a rare Epstein-Barr virus mutant that enhances early antigen expression in Raji cells. Proc. Natl. Acad. Sci. USA 80:2762-2766.
55. Rooney, C., D. T. Rowe, T. Ragot, and P. J. Farrell. 1989. The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle. J. Virol. 63:3109-3116.
56. Schepers, A., D. Pich, and W. Hammerschmidt. 1993. A transcription factor with homology to the AP-1 family links RNA transcription and DNA replication in the lytic cycle of Epstein-Barr virus. EMBO J. 12:3921-3919
57. Sellers, J. W., and K. Strahl. 1989. Changing Fos oncoprotcin to a Junindependent DNA-binding protein with GCN4 dimerization specificity by swapping 'leucine zippers'. Nature (London) 341:74-76
58. Sinclair, A. J., M. Brimmell, F. Shanahan, and P. J. Farrell. 1991. Pathways of activation of the Epstein-Barr virus productive cycle. J. Virol. 65:2237-2244.
59. Takada, K., and Y. Ono. 1989. Synchronous and sequential activation of latently infected Epstein-Barr virus genomes J Virol. 63:445-449.
60. 59a Taylor, N. Unpublished data.
61. Taylor, N., J. Countryman, C. Rooney, D. Katz, and G. Miller. 1989. Expression of the BZLF1 latency-disrupting gene differs in standard and defective Epstein-Barr viruses. J. Virol 63:1721-1728.
62. Taylor, N., E. Flemington, J. L. Kolman, R. P. Baumann, S. H. Speck, and G. Miller. 1991. ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding specificities for sites in the Epstein-Barr virus BZLF1 promoter. J. Virol. 65:4033-4041.
63. Tovey, M. G., G. Lenoir, and L. J. Begon. 1978. Activation of latent Epstein-Barr virus by antibody to human IgM. Nature (London) 276:270-272
64. Urier, G., M. Buisson, P. Chambard, and A. Sergeant. 1989. The Epstein-Barr virus early protein EB1 activates transcription from different responsive elements including AP-1 binding sites. EMBO J. 8:1447-1453.
65. Vinson, C. R., P. B. Sigler, and S. L. McKnight. 1989. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science 246:911-916.
66. zur Hausen, H., F. J. O'Neill, U. K. Freese, and E. Hecher. 1978. Persisting oncogenic herpesvirus induced by tumor promoter TPA. Nature (London) 272:373-375.