Production of Nitric Oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- Mice

Journal of Immunology

Volumn 156, Issue 2, 1996, Pages 636-643

  Khan, Imtiaz A ^a   Matsuura, Tadashi ^a   Fonseka, Sujeewa ^a   Kasper, Lloyd H ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CONCANAVALIN A; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERFERON ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEPLETION; FEMALE; GENE DISRUPTION; INFECTION SENSITIVITY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; SURVIVAL; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; ARGININE; BIOLOGICAL RESPONSE MODIFIERS; CD4-POSITIVE T-LYMPHOCYTES; DNA-BINDING PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; INTERFERON REGULATORY FACTOR-1; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PHOSPHOPROTEINS; T-LYMPHOCYTE SUBSETS; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030060390     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Kasper, L. H., and J C. Boothroyd. 1993. In Immunology and Molecular Biology in Parasite Infection K. S. Warren, ed. Blackwell Scientific, Boston, p 269.
2. + immune T cells against toxoplasmosis in mice. J. Immunol. 144:1954.
3. + T cell clone protects against acute Toxoplasma gondii infection. J. Immunol. 152:1856.
4. Mcabe, R E., B. J. Luft, and J S Remington. 1984. Effect of murine Interferon gamma in murine toxoplasmosis. J. Infect. Dis. 150:961.
5. Suzuki, Y., F. K. Conley, and J S. Remington. 1989. Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice J. Immunol 143:2045.
6. Gazzinelli, R. T., M. Wysocka, S. Hayashi, E Y. Denkers, S. Hieny, P Caspar, G Trinchieri, and A. Sher. 1994 Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondrii J. Immunol 153:2533.
7. Khan, I A , T. Matsuura, and L H Kasper. 1994. Interleukin-12 enhances murine survival against acute toxoplasmosis. Infect. Immun 62:2639.
8. Gazzinelli, R T., S. Hieny, T. Wynn, and A. Sher 1993. Interleukin-12 is required for the T lymphocyte-independent function of IFN-γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci USA 90.6115.
9. Nathan, C F., H. W. Murray, M. E Weibe, and B Y. Rubin. 1983. Identification of interferon gamma. the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity J. Exp Med. 158:670.
10. Murray, H. W., G L. Spitalny, and C. F Nathan. 1985. Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-γ. J Immunol. 134. 1619.
11. Green, S. J., C. A Nacy, and M. S. Meltzer. 1991. Cytokine-induced synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens. J Leukocyte Biol. 50:93.
12. Mauel, J., A Ransjin, and Y. Buchmuller-Rouller. 1991. Killing of Leishmania parasites in activated murine macrophages is based on the L-arginine-dependent process that produces nitrogen derivatives. J. Leukocyte Biol. 49:73.
13. Roach, T. A., A. F. Kiderlen, and J. M. Blackwell. 1991. Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interferon-lipopolysaccharide-activated macrophages from lshs and lshr congenic mouse strains. Infect. Immun. 59.3935.
14. Steinberg, J., and F. McGuigan. 1992. Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection Eur. J. Immunol. 22 2741
15. Rockett, K. A., M. M. Auburn, E J. Rockett, W B. Cowden, and I. A Clark. 1994 Possible role of nitric oxide in malarial immunosuppression. Parasitol Immunol. 16.243
16. Gregory, S. H., E. J. Wing, R A. Hoffman, and R. L. Sher. 1993 Reactive nitrogen intermediates suppress the primary immunologic response to Listeria J. Immunol. 150:2901.
17. Khan, I A., T. Matsuura, and L H. Kasper. 1995. IL-10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice. Parasitol Immunol 17:185.
18. Candolfi, E., C. H. Hunter, and J. S. Remington. 1994. Mitogen and antigen specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates. Infect. Immun 62:1994
19. Drapier, J. C., J. Wietzerbin, and J B Hibbs 1988. Interferon-γ and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur. J. Immunol. 18:1587.
20. Ding, A. H., C. F. Nathan, and D J Steuhr. 1988. Release of nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J. Immunol. 141:2407.
21. Xie, Q. W., R. Whisant, and C. Nathan. 1993. Promoter of mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J. Exp Med 177:1779
22. Lowenstein, C. J., E W. Alley, P. Raval, A. M. Snowman, S. H. Snyder, S. W Russel, and W. J. Murphy 1993 Macrophage nitric oxide synthase gene: two upstream regions mediate induction by Interferon gamma and lipopolysaccharide. Proc. Natl Acad. Sci. USA 90.9730.
23. Kamijo, R , H., Harada, T. Matasuyama, M. Bosland, J. Gerecitano, D. Shapiro, J. Le, T. Kimura, S. J. Green, T. W. Mak, T. Taniguchi, and J. Vilcek. 1994. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263:1612.
24. Green, L C. D , D. D. A Wagner, J. Glogowski, P. L. Skepper, J. S Sishnok, and S. R. Tannenbaum. 1982 Analysis of nitrate, nitrite and (15 N) in biological fluids. Anal Biochem. 126:131
25. Reiner, S. L., S. Zheng, D. B. Corry, and R. M. Locksley. 1993. Constructing polycompetitor CDNAs for quantitative PCR J. Immunol. Methods 165 37.
26. Gazzinelli, R T., N. A. Giese, and H. C. Morse. 1994. In vivo treatment with interleukin-12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS). J. Exp Med. 180:2199.
27. Woods, M. L , J. Mayer, T. G. Evans, and J B Hibbs 1994. Antiparasitic effects of nitric oxide in an in vitro murine model of Chylamidia trachomatis infection and in vivo murine model of Leishmania major infection In Macrophage-Pathogen Interactions, 1st Ed., Ch. 10. B S Zwilling and T. K. Eisenstein, eds., Marcel Dekker, Inc., pp 179-196
28. Sibley, L. D., L. Adams, Y. Fukutomi, and J L. Krahenbuhl 1992 Tumor necrosis factor-α triggers antitoxoplasmal activity of IFN-γ-primed macrophages. J Immunol. 147:2340
29. Langermans, J. A. M , M E. B. Van der Hulst, P. H. Nibereing, P. S. Hiemstra, L Fransen, and R. Van Furth. 1992. IFN-γ induced L-arginine dependent toxoplasmastic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-α. J. Immunol. 148:568.
30. Chao, C. C , W R. Anderson, S Hu, G. Gekker, A. Martella, and P K. Peterson. 1993. Activated microglia inhibit multiplication of Toxoplasma gondii via nitric oxide mechanism. Clin. Immunol Immunopathol. 67:178.
31. Tsuji, M., Y Miyahira, R. S. Nussenzweig, M. Aguet, M. Reichel, and F. Zavala. 1995. Development of antimalaria immunity in mice lacking IFN-γ receptor. J. Immunol. 154.5338.
32. + T lymphocytes in IFN-γ production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol 149:3003
33. + cytotoxic T lymphocytes specific for Toxoplasma gondii lyse tachyzoite-infected target cells. J. Immunol. 151:2034
34. Mills, C D 1991. Molecular basis of "suppressor macrophages": arginine metabolism via nitric oxide synthetase pathway. J. Immunol. 146:2719.
35. Rowland, R. R R., E. A. Butz, and G W. Plagemann. 1994. Nitric oxide production by splenic macrophages is not responsible for T cell suppression during acute infection with lactate dehydrogenase-elevating virus. J. Immunol 152:5785.
36. Haque, S., I. A. Khan, A. Haque, and L. H. Kasper. 1994. Impairment of the cellular immune response in acute murine toxoplasmosis regulation of IL-2 production and macrophage-mediated inhibitory effects. Infect. Immun. 62:2908
37. Wynn, T A , D. Jankovic, S Hieny, K Zioncheck, P. Jardieu, A. W. Cheever, and A. Sher. 1995. IL-12 exacerbates rather than suppress T helper 2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol 154 3999.
38. + T lymphocytes. J. Immunol 155:111
39. Wang, Z. E., S Zheng, D. B. Corry, D. K Dalton, R. A. Seeder, S L. Reiner, and R. M. Locksley. 1994. Interferon gamma-independent effects of interleukin-12 administered during acute or established infection due to Leishmania major. Proc. Natl. Acad. Sci. USA 91:12932.