Cardiotrophin-1 (CT-1): A novel hypertrophic and cardioprotective agent

International Journal of Experimental Pathology

Volumn 80, Issue 4, 1999, Pages 189-196

  Latchman, David S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cardioprotection; Cardiotrophin 1; Cytokines; Hypertrophy; IL 6

Indexed keywords

CARDIOTROPHIN 1; CYTOKINE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; STAT3 PROTEIN;

CELL SURVIVAL; ENZYME ACTIVATION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; CARDIOMEGALY; CYTOKINES; HEART; HUMANS; REPERFUSION INJURY;

EID: 0032852488     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.1999.00114.x     Document Type: Review

References (40)

1. Akira S., Nishio Y., Inoue M. et al. (1994) Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91 related transcription factor involved in the gp130 mediated signalling pathway. Cell 77, 63-71.
2. Benigni F., Fantuzzi G., Sacco S. et al. (1996a) Six different cytokines that share gp130 as a receptor subunit, induce serum amyloid A and potentiate the induction of the interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1. Blood 87, 1851-1854.
3. Benigni F., Sacco S., Pennica D. & Ghezzi P. (1996b) Cardiotrophin-1 inhibits tumor necrosis factor production in the heart and serum of lipoplysaccharide-treated mice and in vitro in mouse blood cells. Am. J. Pathol. 149, 1847-1850.
4. Chandrasekar B., Melby P.C., Pennica D. & Freeman G.L. (1998) Over expression of Cardiotrophin-1 and gp130 during experimental acute chagasic cardiomyopathy. Immunol. Lett. 61, 89-95.
5. Cheng W., Kajstura J., Nitahara J.A. et al. (1996) Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp. Cell Res. 226, 316-327.
6. Cumming D.V.E., Heads R.J., Watson A., Latchman D.S. & Yellon D.M. (1996) Differential protection of primary rat cardiocytes by transfection of specific heat stress proteins. J. Mol. Cell. Cardiol. 28, 2343-2349.
7. Gottlieb R.A., Burleson K.O., Kloner R.A., Babior B.M. & Engler R.L. (1994) Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J. Clin. Invest. 94, 1621-1628.
8. Habecker B.A., Pennica D. & Lando D. (1995) Cardiotrophin-1 is not the sweat gland-derived differentiation factor. Neuroreport 7, 41-44.
9. Heads R.J., Latchman D.S. & Yellon D.M. (1994) Stable high level expression of a transfected human HSP70 gene protects a heart-derived muscle cell line against thermal stress. J. Mol. Cell. Cardiol. 26, 695-699.
10. Heads R.J., Yellon D.M. & Latchman D.S. (1995) Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein goes in myogenic cells. J. Mol. Cell. Cardiol. 27, 1669-1678.
11. Hirano T., Nakajima K. & Hibi M. (1997) Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev. 8, 241-252.
12. Hirota H., Yoshida K., Kishimoto T. & Taga T. (1995) Continuous activation of gp130, a signal transducing receptor component for interleukin 6 related cytokines causes myocardial hypertrophy in mice. Proc. Natl. Acad. Sci. USA 92, 4862-4866.
13. Horvath C.M. & Darnell J.E. (1997) The state of the STATs: recent developments in the study of signal transduction to the nucleus. Current Opinion Cell Biol. 9, 233-239.
14. Ishikawa M., Saito Y., Miyamoto Y. et al. (1996) cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats. Biochem. Biophys. Res. Comm. 219, 377-381.
15. Jin H., Yang R., Keller G.A. et al. (1996) In vivo effects of cardiotrophin-1. Cytokine 8, 920-926.
16. Jin H., Yang R., Ko A., Pennica D., Wood W.I. & Paoni N.F. (1998) Effects of cardiotrophin-1 on haemodynamics cardiac function in conscious rats. Cytokine 10, 19-25.
17. Kajstura J., Cheng W., Reiss K. et al. (1996) Apoptotic and necrotic myocyte cell death are independent contributing variables of infarct size in rats. Lab. Invest. 74, 86-107.
18. Kishimoto T., Taga T. & Akira, S. (1994) Cytokine signal transduction. Cell 76, 253-262.
19. Kishimoto T., Akira S., Narazaki M. & Taga T. (1995) Interleukin-6 family of cytokines and gp130. Blood 86, 1243-1254.
20. Kuwahara K., Saito Y., Ogawa Y. et al. (1998) Endothelin-1 and Cardiotrophin-1 induce brain natriuretic peptide gene expression by distinct transcriptional mechanisms. J. Clin. Pharmacol. 31, S354-S356.
21. Latini R., Bianchi M., Correale E. et al. (1994) Cytokines in acute myocardial infarction: selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist. J. Cardiovasc. Pharmacol. 23, 1-6.
22. Martin J.L., Mestril R., Hilal-Dandan R., Brunton L.L. & Dilmann W. H. (1997) Small heat-shock proteins and protection against ischaemic injury in cardiac myocytes. Circulation 96, 4343-4348.
23. Nakajima T., Kinoshita S., Sasagawa T. et al. (1993) Phosphorylation at threonine-235 by a ras-dependent mitogen activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90, 2207-2211.
24. Olivetti G., Quani F., Sala R. et al. (1994) Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J. Mol Cellular Cardiol. 28, 2005-2016.
25. Olivetti G., Abbi R., Quani F. et al. (1997)Apoptosis in the failing human heart. New Engl. J. Med. 336, 1131-1141.
26. Pennica D., King K.L., Shaw K.J. et al. (1995a) Expression cloning of cardiotrophin 1 a cytokine that induces cardiac myocyte hypertrophy. Proc. Natl. Acad. Sci. USA 92, 1142-1146.
27. Pennica D., Shaw K.J., Swanson T.A. et al. (1995b) Cardiotrophin-1: Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J. Biol. Chem. 270, 10915-10922.
28. Pennica D., Arce V., Swanson A. et al. (1996a) Cardiotrophin-1 a cytokine present in embryonic muscle, supports long term survival of spinal motoneurons. Neuron 17, 63-74.
29. Pennica D., Swanson T.A., Shaw K.J. et al. (1996b) Human cardiotrophin-1: protein and gene structure, biological and binding activities and chromosomal localizations. Cytokine 183-189.
30. Pennica D., Wood W.I. & Chien K.R. (1996C) Cardiotrophin-1: a multifunctional cytokine that signals via LiF receptor gp130 Dependent pathways. Cytokine Growth Factor Rev. 7, 81-91.
31. Peters M., Roeb E., Pennica D., Meyer zum Buschenfelde K.-H. & Rose-John S. (1995) A new hepatocyte stimulating factor: cardiotrophin-1 (CT-1). FEBS Lett. 372, 177-180.
32. Robledo O., Fourcin M., Chevalier S. et al. (1997) Signaling of the Cardiotrophin-1 Receptor. J. Biol. Chem. 272, 4855-4863.
33. Sheng Z., Pennica D., Wood W.I. & Chien K.R. (1996) Cardio-trophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. Development 122, 419-428.
34. Sheng Z., Knowlton K., Chen J., Hoshijima M., Brown H. & Chein K.R. (1997) Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen activated protein kinase dependent pathway. J. Biol. Chem. 272, 5783-5791.
35. Stephanou A., Amin V., Isenberg D.A., Akira S., Kishimoto T. & Latchman D.S. (1997) Interleukin-6 activates heat shock protein 90 B gene expression. Biochem. J. 321, 103-106.
36. Stephanou A., Brar B., Heads R. et al. (1998) Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli. J. Mol. Cell. Cardiol. 30, 849-855.
37. Umansky S.R., Cuenco G.M., Khutzian S.S., Barr P.J. & Tomei L.D. (1995) Post-ischemic apoptotic death of rat neonatal cardiomyocytes. Cell Death Differentiation 2, 235-241.
38. Wegenka U.M., Buschmann J., Lutticken C., Heinrich P.C. & Horn F. (1993) Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly acivated by interleukin-6 at the posttranslational level. Mol. Cell. Biol. 13, 276-288.
39. Wollert K.C., Taga T., Saito M. et al. (1996) Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. J. Biol. Chem. 271, 9535-9545.
40. Yoshida K., Taga T., Saito M. et al. (1996) Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. USA 93, 407-411.