Influence of host and parasite factors on the innate immune response and Th2 stability following infection with Leishmania major

Microbes and Infection

Volumn 1, Issue 1, 1999, Pages 65-71

  Hondowicz, Brian ^a   Scott, Phillip ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

CELL MATURATION; CYTOKINE RELEASE; GENETIC ANALYSIS; GENETIC STABILITY; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL; REVIEW; STRAIN DIFFERENCE;

ANIMALIA; LEISHMANIA MAJOR;

EID: 0032839183     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(99)80016-1     Document Type: Note

References (30)

1. Afonso L.C.C., Scott P. Immune responses associated with the susceptibility of C57BL/10 mice to Leishmania amazonensis. Infect. Immun. 61:1993;2952-2959.
2. Chatelain R., Varkila K., Coffman R.L. IL-4 induces a Th2 response in Leishmaniamajor-infected mice. J. Immunol. 148:1992;1182-1187.
3. Guler M.L., Gorham J.D., Hsieh C.S., Mackey A.J., Steen R.G., Dietrich W.F., Murphy K.M. Genetic susceptibility to LeishmaniaIL-12 responsiveness in Th1 cell development. Science. 271:1996;984-986.
4. Guler M.L., Jacobson N.G., Gubler U., Murphy K.M. T cell genetic background determines maintenance of IL-12 signalling. J. Immunol. 159:1997;1767-1774.
5. Heinzel F.P., Sadick M.D., Holaday B.J., Coffman R.L., Locksley R.M. Reciprocal expression of interferon gamma or IL4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. M. 169:1989;59-72.
6. Heinzel F.P., Schoenhaut D.S., Rerko R.M., Rosser L.E., Gately M.K. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. M. 177:1993;1505-1509.
7. Hondowicz B.D., Scharton-Kersten T.M., Jones D.E., Scott P. Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response. J. Immunol. 159:1997;5024-5031.
8. Howard J.G., Hale C., Liew F.Y. Immunologic regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to Leishmania tropica. J. Exp. M. 153:1981;557-568.
9. Hsieh C.S., Heimberger A.B., Gold J.S., O'Garra A., Murphy K.M. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an β T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA. 89:1992;6065-6069.
10. +T cells through IL-12 produced by Listeria-induced macrophages. Science. 260:1993;547-549.
11. Hsieh C.S., Macatonia S.E., O'Garra A., Murphy K.M. T cell genetic background determines default T helper phenotype development in vitro. J. Exp. M. 181:1995;713-721.
12. Julia V., Rassoulzadegan M., Glaichenhaus N. Resistance to Leishmania majorinduced by tolerance to a single antigen. Science. 274:1996;421-423.
13. Kopf M., Brombacher F., Kohler G., Kienzle G., Widmann K.H., Lefrang K., Humborg C., Ledermann B., Solbach W. IL-4 deficient BALB/c mice resist infection with Leishmania major. J. Exp. M. 184:1996;127-1136.
14. +T cells which are NK1.1-. Eur. J. Immunol. 25:1995;3298-3307.
15. +T cells instructs Th2 development and susceptibility to Leishmania majorin BALB/c mice. Immunity. 6:1995;541-549.
16. Mattner F., Magram J., Ferrante J., Launois P., Dipadova K., Behin R., Gately M.K., Louis J.A., Alber G. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania majorand mount a polarized Th2 cell response. Eur. J. Immunol. 26:1996;1553-1559.
17. Mattner F., Alber G., Magram J., Kopf M. The role of IL-12 and IL-4 in Leishmania majorinfection. Chem. Immunol. 68:1997;86-109.
18. Mougneau E., Altare F., Wakil A.E., Zheng S., Coppola T., Wang Z.E., Waldmann R., Locksley R.M., Glaichenhaus N. Expression cloning of a protective Leishmaniaantigen. Science. 268:1995;563-566.
19. Nabors G.S., Afonso L.C.C., Farrell J.P., Scott P. Switch from a type 2 to a type1 T helper cell response and cure of established Leishmania majorinfection in mice is induced by combined therapy with interleukin-12 and pentostam. Proc. Natl. Acad. Sci. USA. 92:1995;3142-3146.
20. Noben-Trauth N., Kropf P., Muller I. Susceptibility to Leishmania majorinfection in interleukin-4 deficient mice. Science. 271:1996;987-990.
21. +T cells during initiation of infection. J. Exp. M. 179:1994;447-456.
22. +T cell subsets and induces early resistance to Leishmania majorin mice. J. Exp. M. 178:1993;567-577.
23. Scharton-Kersten T., Afonso L.C.C., Wysocka M., Trinchieri G., Scott P. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154:1995;5320-5330.
24. Scott P., Caspar P., Sher A. Protection against Leishmania majorin BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes. J. Immunol. 144:1990;1075-1079.
25. Scott P. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147:1991;3149-3155.
26. Scott P., Eaton A., Gause W.C., Zhou X.D., Hondowicz B. Early IL-4 production does not predict susceptibility to Leishmania major. Exp. Parasitol. 84:1996;178-187.
27. Sypek J.P., Chung C.L., Mayor S.E.H., Subramanyam J.M., Goldman S.J., Sieburth D.S., Wolf S.F., Schaub R.G. Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective Th1 immune response. J. Exp. M. 177:1993;1797-1802.
28. Szabo S.J., Jacobson N.G., Dighe A.S., Gubler U., Murphy K.M. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 2:1995;665-675.
29. Szabo S.J., Dighe A.S., Gubler U., Murphy K.M. Regulation of the interleukin-12 B2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. M. 185:1997;817-824.
30. Titus R.G., Ceredig R., Cerottini J.C., Louis J.A. Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice. J. Immunol. 135:1985;2108-2114.