Structure-activity relationship of HIV-1 protease inhibitors containing α-hydroxy-β-amino acids. Detailed study of P1 site

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 9, 1999, Pages 2063-2072

  Takashiro, Eiji ^a   Hayakawa, Ichiro ^a   Nitta, Tamayo ^a   Kasuya, Atsushi ^a   Miyamoto, Shuichi ^a   Ozawa, Yuji ^a   Yagi, Ryuichi ^a   Yamamoto, Ikue ^a   Shibayama, Takahiro ^a   Nakagawa, Akihiko ^a   Yabe, Yuichiro ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

(3 HYDROXY 2,5 DIMETHYLBENZOYL)[HYDROXYAMINO 4 (BETA NAPHTHYL)BUTANOYL]CHLOROPROLINE TERT BUTYLAMIDE; BETA AMINO ACID; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; HALF-LIFE; HIV PROTEASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PHENYLALANINE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032835609     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00127-3     Document Type: Article

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