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Volumn 58, Issue 10, 1999, Pages 1099-1110

Extra neurofilament NF-L subunits rescue motor neuron disease caused by overexpression of the human NF-H gene in mice

Author keywords

Adenovirus; Amyotrophic lateral sclerosis; Motor neuron disease; Neurofilament; Transgenic mice

Indexed keywords

NEUROFILAMENT PROTEIN;

EID: 0032835532     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199910000-00009     Document Type: Article
Times cited : (73)

References (42)
  • 1
    • 0027293898 scopus 로고
    • Neurofilaments are obligate heteropolymers in vivo
    • Lee MK, Xu Z, Wong PC, Cleveland DW. Neurofilaments are obligate heteropolymers in vivo. J Cell Biol 1993;122:1337-50
    • (1993) J Cell Biol , vol.122 , pp. 1337-1350
    • Lee, M.K.1    Xu, Z.2    Wong, P.C.3    Cleveland, D.W.4
  • 2
    • 0027763184 scopus 로고
    • The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation
    • Heins S, Wong PC, Muller S, Goldie K, Cleveland DW, Aebi U. The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation. J Cell Biol 1993;123:1517-33
    • (1993) J Cell Biol , vol.123 , pp. 1517-1533
    • Heins, S.1    Wong, P.C.2    Muller, S.3    Goldie, K.4    Cleveland, D.W.5    Aebi, U.6
  • 4
    • 0027220073 scopus 로고
    • Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments
    • Ching GY, Liem RK. Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments. J Cell Biol 1993;122:1323-35
    • (1993) J Cell Biol , vol.122 , pp. 1323-1335
    • Ching, G.Y.1    Liem, R.K.2
  • 5
    • 0031263931 scopus 로고    scopus 로고
    • Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments
    • Zhu Q, Couillard-Després S, Julien JP. Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments. Exp Neurol 1997;148:299-316
    • (1997) Exp Neurol , vol.148 , pp. 299-316
    • Zhu, Q.1    Couillard-Després, S.2    Julien, J.P.3
  • 6
    • 0032482231 scopus 로고    scopus 로고
    • Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content
    • Elder GA, Friedrich VL, Bosco P, et al. Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content. J Cell Biol 1998;141: 727-39
    • (1998) J Cell Biol , vol.141 , pp. 727-739
    • Elder, G.A.1    Friedrich, V.L.2    Bosco, P.3
  • 7
    • 0032487502 scopus 로고    scopus 로고
    • Requirement of heavy neurofilament subunit in the development of axons with large calibers
    • Elder GA, Friedrich VL, Kang CH, et al. Requirement of heavy neurofilament subunit in the development of axons with large calibers. J Cell Biol 1998;143:195-205
    • (1998) J Cell Biol , vol.143 , pp. 195-205
    • Elder, G.A.1    Friedrich, V.L.2    Kang, C.H.3
  • 8
    • 0032487499 scopus 로고    scopus 로고
    • Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation
    • Rao MV, Houseweart MK, Williamson TL, Crawford TO, Folmer J, Cleveland DW. Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation. J Cell Biol 1998;143:171-81
    • (1998) J Cell Biol , vol.143 , pp. 171-181
    • Rao, M.V.1    Houseweart, M.K.2    Williamson, T.L.3    Crawford, T.O.4    Folmer, J.5    Cleveland, D.W.6
  • 9
    • 0032487532 scopus 로고    scopus 로고
    • Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport. Relief of axonopathy resulting from the toxin b,b'-iminodipropionitrile
    • Zhu Q, Lindenbaum M, Levavasseur F, Jacomy H, Julien JP. Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport. Relief of axonopathy resulting from the toxin b,b'-iminodipropionitrile. J Cell Biol 1998;143: 183-93
    • (1998) J Cell Biol , vol.143 , pp. 183-193
    • Zhu, Q.1    Lindenbaum, M.2    Levavasseur, F.3    Jacomy, H.4    Julien, J.P.5
  • 10
    • 0030915589 scopus 로고    scopus 로고
    • Neurofilaments and motor neuron disease
    • Julien JP. Neurofilaments and motor neuron disease. Trends Cell Biol. 1997;7:243-49
    • (1997) Trends Cell Biol. , vol.7 , pp. 243-249
    • Julien, J.P.1
  • 13
    • 0027468295 scopus 로고
    • Neurofilament mRNA is reduced in Parkinson's disease substantia nigra pars compacta neurons
    • Hill WD, Arai M, Cohen JA, Trojanowski JQ. Neurofilament mRNA is reduced in Parkinson's disease substantia nigra pars compacta neurons. J Comp Neurol 1993;329:328-36
    • (1993) J Comp Neurol , vol.329 , pp. 328-336
    • Hill, W.D.1    Arai, M.2    Cohen, J.A.3    Trojanowski, J.Q.4
  • 14
    • 0027465098 scopus 로고
    • Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis
    • Côté F, Collard JF, Julien JP. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis. Cell 1993;73:35-46
    • (1993) Cell , vol.73 , pp. 35-46
    • Côté, F.1    Collard, J.F.2    Julien, J.P.3
  • 15
    • 0027410516 scopus 로고
    • Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
    • Xu Z, Cork LC, Griffin JW, Cleveland DW. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell 1993;73:23-33
    • (1993) Cell , vol.73 , pp. 23-33
    • Xu, Z.1    Cork, L.C.2    Griffin, J.W.3    Cleveland, D.W.4
  • 16
    • 0028116467 scopus 로고
    • A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease
    • Lee MK, Marszalek JR, Cleveland DW. A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron. 1994;13:975-88
    • (1994) Neuron. , vol.13 , pp. 975-988
    • Lee, M.K.1    Marszalek, J.R.2    Cleveland, D.W.3
  • 17
    • 0029124072 scopus 로고
    • Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons
    • Wong PC, Marszalek J, Crawford TO, et al. Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons. J Cell Biol 1995;130:1413-22
    • (1995) J Cell Biol , vol.130 , pp. 1413-1422
    • Wong, P.C.1    Marszalek, J.2    Crawford, T.O.3
  • 18
    • 0029052277 scopus 로고
    • Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits
    • Tu PH, Elder G, Lazzarini RA, Nelson D, Trojanowski JQ, Lee VMY. Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits. J Cell Biol. 1995;129:1629-40
    • (1995) J Cell Biol. , vol.129 , pp. 1629-1640
    • Tu, P.H.1    Elder, G.2    Lazzarini, R.A.3    Nelson, D.4    Trojanowski, J.Q.5    Lee, V.M.Y.6
  • 19
    • 0029807823 scopus 로고    scopus 로고
    • Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport
    • Marszalek JR, Williamson TL, Lee MK, et al. Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport. J Cell Biol 1996;135:711-24
    • (1996) J Cell Biol , vol.135 , pp. 711-724
    • Marszalek, J.R.1    Williamson, T.L.2    Lee, M.K.3
  • 20
    • 0031890760 scopus 로고    scopus 로고
    • Neuropathological abnormalities in transgenic mice harbouring a phosphorylation mutant neurofilament transgene
    • Gibb BJM, Brion JP, Brownlees J, Anderton BH, Miller CCJ. Neuropathological abnormalities in transgenic mice harbouring a phosphorylation mutant neurofilament transgene. J Neurochem 1998;70: 492-500.
    • (1998) J Neurochem , vol.70 , pp. 492-500
    • Gibb, B.J.M.1    Brion, J.P.2    Brownlees, J.3    Anderton, B.H.4    Miller, C.C.J.5
  • 21
    • 0028001606 scopus 로고
    • Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis
    • Figlewicz DA, Krizus A, Martinoli MG, et al. Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum Mol Genet 1994;3:1757-61
    • (1994) Hum Mol Genet , vol.3 , pp. 1757-1761
    • Figlewicz, D.A.1    Krizus, A.2    Martinoli, M.G.3
  • 22
    • 0032427646 scopus 로고    scopus 로고
    • Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS)
    • Tomkins J, Usher P, Slade JY, et al. Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS). NeuroReport 1998;9:3967-70
    • (1998) NeuroReport , vol.9 , pp. 3967-3970
    • Tomkins, J.1    Usher, P.2    Slade, J.Y.3
  • 23
    • 0032926368 scopus 로고    scopus 로고
    • Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis
    • Al-Chalabi A, Anderson PM, Nilsonn P, et al. Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis. Hum Mol Genet 1999;8:157-64
    • (1999) Hum Mol Genet , vol.8 , pp. 157-164
    • Al-Chalabi, A.1    Anderson, P.M.2    Nilsonn, P.3
  • 24
    • 0029004898 scopus 로고
    • Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis
    • Collard JF, Côté F, Julien JP. Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 1995;375:61-64
    • (1995) Nature , vol.375 , pp. 61-64
    • Collard, J.F.1    Côté, F.2    Julien, J.P.3
  • 25
    • 0023475704 scopus 로고
    • Expression and assembly of a human neurofilament protein in transgenic mice provide a novel neuronal marking system
    • Julien JP, Tretjakoff I, Beaudet L, Peterson A. Expression and assembly of a human neurofilament protein in transgenic mice provide a novel neuronal marking system. Genes Dev. 1987;1:1085-95
    • (1987) Genes Dev. , vol.1 , pp. 1085-1095
    • Julien, J.P.1    Tretjakoff, I.2    Beaudet, L.3    Peterson, A.4
  • 27
    • 0018581742 scopus 로고
    • Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells
    • Jones N, Shenk T. Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells. Cell 1979;17:683-89
    • (1979) Cell , vol.17 , pp. 683-689
    • Jones, N.1    Shenk, T.2
  • 28
    • 0028807696 scopus 로고
    • FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfert
    • Vilquin JT, Guerette B, Kinoshita I, et al. FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfert. HumGen Therapy 1995;6: 1391-401
    • (1995) HumGen Therapy , vol.6 , pp. 1391-1401
    • Vilquin, J.T.1    Guerette, B.2    Kinoshita, I.3
  • 29
    • 0029591404 scopus 로고
    • Multiple neuron-specific enhancers in the gene coding for the human neurofilament light chain
    • Charron G, Guy LG, Bazinet M, Julien JP. Multiple neuron-specific enhancers in the gene coding for the human neurofilament light chain. J Biol Chem 1995;270:30604-10
    • (1995) J Biol Chem , vol.270 , pp. 30604-30610
    • Charron, G.1    Guy, L.G.2    Bazinet, M.3    Julien, J.P.4
  • 30
    • 0030199247 scopus 로고    scopus 로고
    • Toxicity of replication-defective adenoviral recombinants in dissociated cultures of nervous tissue
    • Durham HD, Lochmüller H, Jani A, Ascadi G, Massie B, Karpati G. Toxicity of replication-defective adenoviral recombinants in dissociated cultures of nervous tissue. Exp Neurol 1996;140:14-29
    • (1996) Exp Neurol , vol.140 , pp. 14-29
    • Durham, H.D.1    Lochmüller, H.2    Jani, A.3    Ascadi, G.4    Massie, B.5    Karpati, G.6
  • 31
    • 0027506094 scopus 로고
    • Different posttranscriptional controls for the human neurofilament light and heavy genes in transgenic mice
    • Beaudet L, Côté F, Houle D, Julien JP. Different posttranscriptional controls for the human neurofilament light and heavy genes in transgenic mice. Mol Brain Res 1993;18:23-31
    • (1993) Mol Brain Res , vol.18 , pp. 23-31
    • Beaudet, L.1    Côté, F.2    Houle, D.3    Julien, J.P.4
  • 32
    • 0031958195 scopus 로고    scopus 로고
    • Intermediate filament disassembly in cultured dorsal root ganglion neurons is associated with amino-terminal head domain phosphorylation of specific subunits
    • Giasson BI, Mushynski. WE. Intermediate filament disassembly in cultured dorsal root ganglion neurons is associated with amino-terminal head domain phosphorylation of specific subunits. J Neurochem 1998;70:1869-75
    • (1998) J Neurochem , vol.70 , pp. 1869-1875
    • Giasson, B.I.1    Mushynski, W.E.2
  • 33
    • 1842329729 scopus 로고    scopus 로고
    • Adenoviral gene transfert of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to longterm survival of axotomized motoneurons
    • Gravel C, Götz R, Lorrain A, Sendtner M. Adenoviral gene transfert of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to longterm survival of axotomized motoneurons. Nature Medicine 1998;3:765-70
    • (1998) Nature Medicine , vol.3 , pp. 765-770
    • Gravel, C.1    Götz, R.2    Lorrain, A.3    Sendtner, M.4
  • 34
    • 0030953519 scopus 로고    scopus 로고
    • Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors
    • Haase G, Kennel P, Pettmann B, et al. Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors. Nature Medicine 1997;3:429-36
    • (1997) Nature Medicine , vol.3 , pp. 429-436
    • Haase, G.1    Kennel, P.2    Pettmann, B.3
  • 36
    • 0024313983 scopus 로고
    • Axotomy-induced changes in the expression of a type III neuronal intermediate filament gene
    • Oblinger MM, Wong J, Parysek LM. Axotomy-induced changes in the expression of a type III neuronal intermediate filament gene. J Neurosci 1989;9:3766-75
    • (1989) J Neurosci , vol.9 , pp. 3766-3775
    • Oblinger, M.M.1    Wong, J.2    Parysek, L.M.3
  • 38
    • 0027480379 scopus 로고
    • Dynamics of the neuronal intermediate filaments
    • Okabe S, Miyasaka H, Hirokawa N. Dynamics of the neuronal intermediate filaments. J Cell Biol 1993;121:375-86
    • (1993) J Cell Biol , vol.121 , pp. 375-386
    • Okabe, S.1    Miyasaka, H.2    Hirokawa, N.3
  • 39
    • 0028000952 scopus 로고
    • Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons
    • Takeda S, Okabe S, Funakoshi T, Hirokawa N. Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons. J Cell Biol 1994;127:173-85
    • (1994) J Cell Biol , vol.127 , pp. 173-185
    • Takeda, S.1    Okabe, S.2    Funakoshi, T.3    Hirokawa, N.4
  • 40
    • 0032817551 scopus 로고    scopus 로고
    • Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits
    • in press
    • Jacomy H, Zhu Q, Couillard-Després S, Beaulieu JM, Julien JP. Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. J Neurochem 1999(in press)
    • (1999) J Neurochem
    • Jacomy, H.1    Zhu, Q.2    Couillard-Després, S.3    Beaulieu, J.M.4    Julien, J.P.5
  • 41
    • 0029894157 scopus 로고    scopus 로고
    • Subunit composition of neurofilaments specifies axonal diameter
    • Xu Z, Marszalek JR, Lee MK, et al. Subunit composition of neurofilaments specifies axonal diameter. J Cell Biol 1996;133:1061-69
    • (1996) J Cell Biol , vol.133 , pp. 1061-1069
    • Xu, Z.1    Marszalek, J.R.2    Lee, M.K.3
  • 42
    • 0030745364 scopus 로고    scopus 로고
    • Neuropathology of amyotrophic lateral sclerosis: New perspectives on an old disease
    • Chou, SM. Neuropathology of amyotrophic lateral sclerosis: New perspectives on an old disease. J Form Med Ass 1997;96:488-98
    • (1997) J Form Med Ass , vol.96 , pp. 488-498
    • Chou, S.M.1


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