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Volumn 70, Issue 2, 1998, Pages 492-500

Neuropathological abnormalities in transgenic mice harbouring a phosphorylation mutant neurofilament transgene

Author keywords

Neurofilament light chain; Neurofilaments; Neuropathology; Phosphorylation; Protein kinase A; Transgenic mice

Indexed keywords

MUTANT PROTEIN; NEUROFILAMENT PROTEIN;

EID: 0031890760     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70020492.x     Document Type: Article
Times cited : (35)

References (37)
  • 2
    • 0027506094 scopus 로고
    • Different posttranscriptional controls for the human neurofilament light and heavy genes in transgenic mice
    • Beaudet L., Côté F., Houle D., and Julien L-P. (1993) Different posttranscriptional controls for the human neurofilament light and heavy genes in transgenic mice. Mol. Brain Res. 18, 23-31.
    • (1993) Mol. Brain Res. , vol.18 , pp. 23-31
    • Beaudet, L.1    Côté, F.2    Houle, D.3    Julien, L.-P.4
  • 3
    • 0023929799 scopus 로고
    • Both adult and juvenile tau microtubule-associated proteins are axon specific in the developing and adult rat cerebellum
    • Brion J.-P., Guilleminot J., Couchie D., Flament-Durand J., and Nunez J. (1988) Both adult and juvenile tau microtubule-associated proteins are axon specific in the developing and adult rat cerebellum. Neuroscience 25, 139-146.
    • (1988) Neuroscience , vol.25 , pp. 139-146
    • Brion, J.-P.1    Guilleminot, J.2    Couchie, D.3    Flament-Durand, J.4    Nunez, J.5
  • 4
    • 0026097837 scopus 로고
    • The N- and C-termini of tau proteins are differentially associated with neurofibrillary tangles in Alzheimer's disease
    • Brion J.-P., Hanger D. P., Bruce M. T., Couck A. M., Flament-Durand J., and Anderton B. H. (1991) The N-and C-termini of tau proteins are differentially associated with neurofibrillary tangles in Alzheimer's disease. Biochem. J. 273, 127-133.
    • (1991) Biochem. J. , vol.273 , pp. 127-133
    • Brion, J.-P.1    Hanger, D.P.2    Bruce, M.T.3    Couck, A.M.4    Flament-Durand, J.5    Anderton, B.H.6
  • 5
    • 0028143773 scopus 로고
    • Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurones
    • Brion J.-P., Octave J. N., and Couck A. M. (1994) Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurones. Neuroscience 63, 895-909.
    • (1994) Neuroscience , vol.63 , pp. 895-909
    • Brion, J.-P.1    Octave, J.N.2    Couck, A.M.3
  • 6
    • 0027372314 scopus 로고
    • Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo
    • Egelhoff T. T., Lee R. J., and Spudich J. A. (1993) Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo. Cell 75, 363-371.
    • (1993) Cell , vol.75 , pp. 363-371
    • Egelhoff, T.T.1    Lee, R.J.2    Spudich, J.A.3
  • 7
    • 0028283501 scopus 로고
    • Intermediate filaments: Structure, dynamics, function, and disease
    • Fuchs E. and Weber K. (1994) Intermediate filaments: structure, dynamics, function, and disease. Annu. Rev. Biochem. 63, 345-382.
    • (1994) Annu. Rev. Biochem. , vol.63 , pp. 345-382
    • Fuchs, E.1    Weber, K.2
  • 10
    • 0025107358 scopus 로고
    • Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit
    • Gill S. R., Wong P. C., Monteiro M. J., and Cleveland D. C. (1990) Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit. J. Cell Biol. 111, 2005-2019.
    • (1990) J. Cell Biol. , vol.111 , pp. 2005-2019
    • Gill, S.R.1    Wong, P.C.2    Monteiro, M.J.3    Cleveland, D.C.4
  • 11
    • 0027763184 scopus 로고
    • The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation
    • Heins S., Wong P. C., Müller S., Goldie K., Cleveland D. W., and Aebi U. (1993) The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation. J. Cell Biol. 123, 1517-1533.
    • (1993) J. Cell Biol. , vol.123 , pp. 1517-1533
    • Heins, S.1    Wong, P.C.2    Müller, S.3    Goldie, K.4    Cleveland, D.W.5    Aebi, U.6
  • 12
    • 0028226737 scopus 로고
    • Phosphorylation of native and reassembled neurofilaments composed of NF-L. NF-M, and NF-H by the catalytic subunit of cAMP-dependent protein kinase
    • Hisanaga S., Matsuoka Y., Nishizawa K., Saito T., Inagaki M., and Hirokawa N. (1994) Phosphorylation of native and reassembled neurofilaments composed of NF-L. NF-M, and NF-H by the catalytic subunit of cAMP-dependent protein kinase. Mol. Biol. Cell 5, 161-172.
    • (1994) Mol. Biol. Cell , vol.5 , pp. 161-172
    • Hisanaga, S.1    Matsuoka, Y.2    Nishizawa, K.3    Saito, T.4    Inagaki, M.5    Hirokawa, N.6
  • 13
    • 0025220189 scopus 로고
    • Effects of phosphorylation of the neurofilament L protein on filamentous structures
    • Hisanaga S.-I., Gonda Y., Inagaki M., Ikai A., and Hirokawa N. (1990) Effects of phosphorylation of the neurofilament L protein on filamentous structures. Cell Regul. 1, 237-248.
    • (1990) Cell Regul. , vol.1 , pp. 237-248
    • Hisanaga, S.-I.1    Gonda, Y.2    Inagaki, M.3    Ikai, A.4    Hirokawa, N.5
  • 14
    • 0028567874 scopus 로고
    • Constitutive activation of Mekl by mutation of serine phosphorylation sites
    • Huang W. and Erikson R. L. (1994) Constitutive activation of Mekl by mutation of serine phosphorylation sites. Proc. Natl. Acad. Sci. USA 91, 8960-8963.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8960-8963
    • Huang, W.1    Erikson, R.L.2
  • 15
    • 0023475704 scopus 로고
    • Expression and assembly of a human neurofilament protein in transgenic mice provide a novel neuronal marking system
    • Julien J.-P., Tretjakoff I., Beaudet L., and Peterson A. (1987) Expression and assembly of a human neurofilament protein in transgenic mice provide a novel neuronal marking system. Genes Dev. 1, 1085-1095.
    • (1987) Genes Dev. , vol.1 , pp. 1085-1095
    • Julien, J.-P.1    Tretjakoff, I.2    Beaudet, L.3    Peterson, A.4
  • 16
  • 17
    • 0027293898 scopus 로고
    • Neurofilaments are obligate heteropolymers in vivo
    • Lee M. K., Xu Z., Wong P. C., and Cleveland D. W. (1993) Neurofilaments are obligate heteropolymers in vivo. J. Cell Biol. 122, 1337-1350.
    • (1993) J. Cell Biol. , vol.122 , pp. 1337-1350
    • Lee, M.K.1    Xu, Z.2    Wong, P.C.3    Cleveland, D.W.4
  • 18
    • 0028116467 scopus 로고
    • A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease
    • Lee M. K., Marszalek J. R., and Cleveland D. W. (1994) A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 13, 975-988.
    • (1994) Neuron , vol.13 , pp. 975-988
    • Lee, M.K.1    Marszalek, J.R.2    Cleveland, D.W.3
  • 19
    • 0029024481 scopus 로고
    • Abnormal perikaryal accumulation of neurofilament light protein in the brain of mice transgenic for the human protein: Sequence of postnatal development
    • Ma D., Descarries L., Julien J.-P., and Doucet G. (1995) Abnormal perikaryal accumulation of neurofilament light protein in the brain of mice transgenic for the human protein: sequence of postnatal development. Neuroscience 68, 135-149.
    • (1995) Neuroscience , vol.68 , pp. 135-149
    • Ma, D.1    Descarries, L.2    Julien, J.-P.3    Doucet, G.4
  • 20
    • 0018178434 scopus 로고
    • A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples
    • Markwell M. A. K., Haas S. M., Bieber L. L., and Tolbert N. E. (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87, 206-210.
    • (1978) Anal. Biochem. , vol.87 , pp. 206-210
    • Markwell, M.A.K.1    Haas, S.M.2    Bieber, L.L.3    Tolbert, N.E.4
  • 21
    • 0028956596 scopus 로고
    • CNS distribution and overexpression of neurofilament light proteins (NF-L) in mice transgenic for the human NF-L: Aberrant accumulation in thalamic perikarya
    • Mathieu J.-F., Ma D., Descarries L., Vallée A., Parent A., Julien J.-P., and Doucet G. (1995) CNS distribution and overexpression of neurofilament light proteins (NF-L) in mice transgenic for the human NF-L: aberrant accumulation in thalamic perikarya. Exp. Neurol. 132, 134-146.
    • (1995) Exp. Neurol. , vol.132 , pp. 134-146
    • Mathieu, J.-F.1    Ma, D.2    Descarries, L.3    Vallée, A.4    Parent, A.5    Julien, J.-P.6    Doucet, G.7
  • 22
    • 0025153538 scopus 로고
    • Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: Increased neurofilament density in axons without affecting caliber
    • Monteiro M. J., Hoffman P. N., Gearhart J. D., and Cleveland D. W. (1990) Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J. Cell Biol. 111, 1543-1557.
    • (1990) J. Cell Biol. , vol.111 , pp. 1543-1557
    • Monteiro, M.J.1    Hoffman, P.N.2    Gearhart, J.D.3    Cleveland, D.W.4
  • 23
    • 0025196189 scopus 로고
    • Effect of phosphorylation on 68 KDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in vitro
    • Nakamura Y., Takeda M., Angelides K. J., Tanaka T., Tada K., and Nishimura T. (1990) Effect of phosphorylation on 68 KDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in vitro. Biochem. Biophys. Res. Commun. 169, 744-750.
    • (1990) Biochem. Biophys. Res. Commun. , vol.169 , pp. 744-750
    • Nakamura, Y.1    Takeda, M.2    Angelides, K.J.3    Tanaka, T.4    Tada, K.5    Nishimura, T.6
  • 24
    • 0027531842 scopus 로고
    • The regulation of neurofilament protein dynamics by phosphorylation: Clues to neurofibrillary pathobiology
    • Nixon R. A. (1993) The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathobiology. Brain Pathol. 3, 29-38.
    • (1993) Brain Pathol. , vol.3 , pp. 29-38
    • Nixon, R.A.1
  • 25
    • 0025943790 scopus 로고
    • Neurofilament phosphorylation: A new look at regulation and function
    • Nixon R. A. and Sihag R. K. (1991) Neurofilament phosphorylation: a new look at regulation and function. Trends Neurosci. 11, 501-506.
    • (1991) Trends Neurosci. , vol.11 , pp. 501-506
    • Nixon, R.A.1    Sihag, R.K.2
  • 26
    • 0028877020 scopus 로고
    • Deletion of the 3′-untranslated region alters the level of mRNA expression of a neurofilament light subunit transgene
    • Schwartz M. L., Bruce J., Schneidman P. S., and Schlaepfer W. W. (1995) Deletion of the 3′-untranslated region alters the level of mRNA expression of a neurofilament light subunit transgene. J. Biol. Chem. 270, 26364-26369.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26364-26369
    • Schwartz, M.L.1    Bruce, J.2    Schneidman, P.S.3    Schlaepfer, W.W.4
  • 27
    • 0000994037 scopus 로고
    • Neurofilament proteins
    • Burgoyne R. D.,ed, Wiley-Liss, New York
    • Shaw G. (1991) Neurofilament proteins, in The Neuronal Cytoskeleton (Burgoyne R. D.,ed), pp. 185-214. Wiley-Liss, New York.
    • (1991) The Neuronal Cytoskeleton , pp. 185-214
    • Shaw, G.1
  • 28
    • 0025950711 scopus 로고
    • Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments
    • Sihag R. K. and Nixon R. A. (1991) Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. J. Biol. Chem. 266, 18861-18867.
    • (1991) J. Biol. Chem. , vol.266 , pp. 18861-18867
    • Sihag, R.K.1    Nixon, R.A.2
  • 29
    • 0026737240 scopus 로고
    • Intermediate filaments: Not so tough after all
    • Skalli O., Chou Y.-H., and Goldman R. D. (1992) Intermediate filaments: not so tough after all. Trends Cell Biol. 2, 308-312.
    • (1992) Trends Cell Biol. , vol.2 , pp. 308-312
    • Skalli, O.1    Chou, Y.-H.2    Goldman, R.D.3
  • 30
    • 0030585377 scopus 로고    scopus 로고
    • cAMP-dependent phosphorylation of neurofilament proteins NF-L and NF-M inhibits their coassembly into filaments in vitro
    • Streifel T. D., Avalos R. T., and Cohlberg J. A. (1996) cAMP-dependent phosphorylation of neurofilament proteins NF-L and NF-M inhibits their coassembly into filaments in vitro. Biochem. Biophys. Res. Commun. 222, 646-651.
    • (1996) Biochem. Biophys. Res. Commun. , vol.222 , pp. 646-651
    • Streifel, T.D.1    Avalos, R.T.2    Cohlberg, J.A.3
  • 31
    • 0029052277 scopus 로고
    • Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits
    • Tu P.-H., Elder G., Lazzarini R. A., Nelson D., Trojanowski J. Q., and Lee V. M.-Y. (1995) Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits. J. Cell Biol. 129, 1629-1640.
    • (1995) J. Cell Biol. , vol.129 , pp. 1629-1640
    • Tu, P.-H.1    Elder, G.2    Lazzarini, R.A.3    Nelson, D.4    Trojanowski, J.Q.5    Lee, V.M.-Y.6
  • 32
    • 0027308768 scopus 로고
    • Intermediate filaments: Regulation of gene expression and assembly
    • Van de Klundert F. A. J. M., Raats J. M. H., and Bloemendal H. (1993) Intermediate filaments: regulation of gene expression and assembly. Eur. J. Biochem. 214, 351-366.
    • (1993) Eur. J. Biochem. , vol.214 , pp. 351-366
    • Van De Klundert, F.A.J.M.1    Raats, J.M.H.2    Bloemendal, H.3
  • 33
    • 0028111812 scopus 로고
    • Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit
    • Vickers J. C., Morrison J. H., Friedrich V. L. Jr., Elder G. A., Perl D. P., Katz R. N., and Lazzarini R. A. (1994) Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit. J. Neurosci. 14, 5603-5612.
    • (1994) J. Neurosci. , vol.14 , pp. 5603-5612
    • Vickers, J.C.1    Morrison, J.H.2    Friedrich Jr., V.L.3    Elder, G.A.4    Perl, D.P.5    Katz, R.N.6    Lazzarini, R.A.7
  • 34
    • 0019448317 scopus 로고
    • Monoclonal antibodies to mammalian neurofilaments
    • Wood J. N. and Anderton B. H. (1981) Monoclonal antibodies to mammalian neurofilaments. Biosci. Rep. 1, 263-268.
    • (1981) Biosci. Rep. , vol.1 , pp. 263-268
    • Wood, J.N.1    Anderton, B.H.2
  • 35
    • 0027410516 scopus 로고
    • Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
    • Xu Z., Cork L. C., Griffin J. W., and Cleveland D. W. (1993) Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell 73, 23-33.
    • (1993) Cell , vol.73 , pp. 23-33
    • Xu, Z.1    Cork, L.C.2    Griffin, J.W.3    Cleveland, D.W.4
  • 37
    • 0025964033 scopus 로고
    • The regulatory role of known tyrosine autophosphorylation sites of the insulin receptor kinase domain
    • Zhang B., Tavare J. M., Ellis L., and Roth R. A. (1991) The regulatory role of known tyrosine autophosphorylation sites of the insulin receptor kinase domain. J. Biol. Chem. 266, 990-996.
    • (1991) J. Biol. Chem. , vol.266 , pp. 990-996
    • Zhang, B.1    Tavare, J.M.2    Ellis, L.3    Roth, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.