Lymphoproliferative disease in human peripheral blood mononuclear cell- injected SCID mice. IV. Differential activation of human Th1 and Th2 lymphocytes and influence of the atopic status on lymphoma development

Journal of Immunology

Volumn 160, Issue 5, 1998, Pages 2514-2522

  Coppola, Vincenzo ^a   Veronesi, Arianna ^a   Indraccolo, Stefano ^a,b   Calderazzo, Francesca ^a   Mion, Marta ^a   Minuzzo, Sonia ^a   Esposito, Giovanni ^a   Mauro, Daniele ^a   Silvestri, Barbara ^a   Gallo, Paolo ^a   Falagiani, Paolo ^c   Amadori, Alberto ^a   Chieco Bianchi, Luigi ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Ist Sci Tumori Biotech Section ^*

^c Lofarma SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 4; MONOCLONAL ANTIBODY CD3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPY; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE TRANSFER; LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; TUMOR GROWTH;

EID: 0032030584     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.160.5.2514     Document Type: Article

References (64)

1. Dick, J. E., T. Lapidot, and F. Pflumio. 1991. Transplantation of normal and leukemic human bone marrow into immune-deficient mice: development of animal models for human hematopoiesis. Immunol. Rev. 124:25.
2. Simpson, E., J. Farrant, and P. Chandler. 1991. Phenotypic and functional studies of human peripheral blood lymphocytes engrafted in scid mice. Immunol. Rev. 124:97.
3. Mosier, D. E., R. J. Gulizia, S. M. Baird, and D. B. Wilson. 1988. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335:256.
4. Rowe, M., L. S. Young, J. Crocker, H. Stokes, S. Henderson, and A. B. Rickinson. 1991. Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man. J. Exp. Med. 173:147.
5. Cannon, M. J., P. Pisa, R. I. Fox, and N. R. Cooper. 1990. Epstein-Barr virus induces aggresive lymphoproliferative disorders of human B cell origin in SCID/hu chimeric mice. J. Clin. Invest. 85:1333.
6. Ioachim, H. L. 1990. The opportunistic tumors of immune deficiency. Adv. Cancer Res. 54:301.
7. Levine, A. M. 1993. AIDS-related malignancies: the emerging epidemics. J. Natl. Cancer Inst. 85:1382.
8. Amadori, A., A. Veronesi, V. Coppola, S. Indraccolo, M. Mion, and L. Chieco-Bianchi. 1996. The hu-PBL-SCID mouse in human lymphocyte function and lymphomagenesis studies: achievements and caveats. Semin. Immunol. 8:249.
9. Veronese, M. L., A. Veronesi, E. D'Andrea, A. Del Mistro, S. Indraccolo, M. R. Mazza, M. Mion, R. Zamarchi, C. Menin, M. Panozzo, A. Amadori, and L. Chieco-Bianchi. 1992. Lymphoproliferative disease in human peripheral blood mononuclear cell-injected SCID mice. I. T lymphocyte requirement for B cell tumor generation. J. Exp. Med. 176:1763.
10. Tary-Lehmann, M., A. Saxon, and P. V. Lehmann. 1995. The human immune system in hu-PBL-SCID mice. Immunol. Today 16:529.
11. + T cell repertoire in hu-PBL-SCID chimeras. J. Exp. Med. 180:1817.
12. Saxon, A., E. Macy, K. Denis, M. Tary-Lehmann, O. Witte, and J. Braun. 1991. Limited repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans. J. Clin. Invest. 87:658.
13. Tary-Lehmann, M., and A. Saxon. 1992. Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J. Exp. Med. 175:503.
14. Nonoyama, S., F. O. Smith, and H. D. Ochs. 1993. Specific antibody production to a recall or a neoantigen by SCID mice reconstituted with human peripheral blood lymphocytes. J. Immunol. 151:3894.
15. Williams, S. S., T. Umemoto, H. Kida, E. A. Repasky, and R. B. Bankert. 1992. Engraftment of human peripheral blood leukocytes into severe combined immunodeficient mice results in the long term and dynamic production of human xenoreactive antibodies. J. Immunol. 149:2830.
16. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
17. Romagnani, S. 1991. Human Th1 and Th2 subsets: doubt no more. Immunol. Today 12:256.
18. Kelso, A. 1995. Th1 and Th2 subsets: paradigms lost? Immunol. Today 16:374.
19. + T cells producing Th2-type cytokines. FASEB J. 9:81.
20. Hamann, D., C. M. U. Hilkens, J. L. Grogan, S. M. A. Lens, M. L. Kapsenberg, M. Yazdanbakhsh, and R. A. W. van Lier. 1996. CD30 expression does not discriminate between human Th1-and Th2-type T cells. J. Immunol. 156:1387.
21. Amadori, A., R. Zamarchi, V. Ciminale, A. Del Mistro, S. Siervo, A. Alberti, M. Colombatti, and L. Chieco-Bianchi. 1989. HIV-1-specific B cell activation: a major constituent of spontaneous B cell activation during HIV-1 infection. J. Immunol. 146:2146.
22. + cell function down-regulation in AIDS patients. J. Immunol. 148:2709.
23. Jung, T., U. Schauer, C. Heusser, C. Neumann, and C. Rieger. 1993. Detection of intracellular cytokines by flow cytometry. J. Immunol. Methods 159:197.
24. Indraccolo, S., M. Mion, R. Biagiotti, S. Romagnani, M. Morfini, G. Longo, R. Zamarchi, L. Chieco-Bianchi, and A. Amadori. 1996. Genetic variability of the human CD4 V2 domain. Immunogenetics 44:70.
25. Emilie, D., M. Peuchmaur, M. C. Maillot, M. C. Crevon, N. Brousse, J. F. Delfraissy, J. Dormont, and P. Galanaud. 1990. Production of interleukins in human immunodeficiency virus-1 replicating lymph nodes. J. Clin. Invest. 86: 148.
26. Amadori, A., R. Zamarchi, M. L. Veronese, M. Panozzo, A. Barelli, A. Borri, M. Sironi, F. Colotta, A. Mantovani, and L. Chieco-Bianchi. 1991. B cell activation during HIV-1 infection. II. Cell-to-cell interactions and cytokine requirement. J. Immunol. 146:57.
27. Amadori, A., P. Gallo, R. Zamarchi, M. L. Veronese, A. De Rossi, D. Wolf, and L. Chieco-Bianchi. 1990. IgG oligoclonal bands in sera of HIV-1 infected patients are mainly directed against HIV-1 determinants. AIDS Res. Hum. Retroviruses 6:581.
28. Romagnani, S. 1994. Regulation of the development of type 2 T-helper cells in allergy. Curr. Opin. Immunol. 6:838.
29. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar T lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
30. Picker, L. J., M. H. Singh, J. R. Treer, S. L. Waldrop, P. R. Bergstresser, and V. C. Maino. 1995. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 86:1408.
31. Picchio, G. R., R. Kobayashi, M. Kirven, S. M. Baird, T. J. Kipps, and D. E. Mosier. 1992. Heterogeneity among Epstein-Barr virus seropositive donors in the generation of immunoblastic B-cell lymphomas in SCID mice receiving human peripheral blood leukocyte grafts. Cancer Res. 52:2468.
32. Smith, C. I. E., M. R. Abedi, K. B. Islam, M. E. B. Johansson, B. Christensson, and L. Hammarstrom. 1991. Humoral immunity in SCID mice reconstituted with cells from immunoglobulin-deficient or normal humans. Immunol. Rev. 124:114.
33. Veronese, M. L., A. Veronesi, L. Bruni, V. Coppola, E. D'Andrea, A. Del Mistro, S. Mezzalira, M. Montagna, G. Ruffatto, A. Amadori, and L. Chieco-Bianchi. 1994. Properties of tumor arising in SCID mice injected with PBMC from EBV-positive donors. Leukemia 8:214s.
34. Rocken, M., M. Racke, and E. M. Shevach. 1996. IL-4 induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 17:225.
35. Swain, S. 1995. Who does the polarizing? Curr. Biol. 5:849.
36. Kumar, V., V. Bhardwaj, L. Soares, J. Alexander, A. Sette, and E. Sercarz. 1995. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon γ by T cells. Proc. Natl. Acad. Sci. USA 92:9510.
37. Gajewski, T. F., M. Pinnas, T. Wong, and F. W. Fitch. 1991. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen presenting cell populations. J. Immunol. 146:1750.
38. McArthur, J. G., and D. H. Raulet. 1993. CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4. J. Exp. Med. 178:1645.
39. + T cells. J. Immunol. 154:1684.
40. + T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J. Exp. Med. 181:1081.
41. + T cells toward a Th1 or Th2 functional phenotype. J. Immunol. 148:47.
42. + T cells. J. Immunol. 146:577.
43. Bohjanen, P. R., M. Okajima, and R. J. Hodes. 1990. Differential regulation of interleukin 4 and interleukin 5 gene expression: a comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines. Proc. Natl. Acad. Sci. USA 87:5283.
44. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom B. R. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279.
45. Schall, T. J., R. E. O'Hehir, D. V. Goeddel, and J. R. Lamb. 1992. Uncoupling of cytokine mRNA expression and protein secretion during the induction phase of T cell anergy. J. Immunol. 148:38.
46. Rao, A. 1994. NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol. Today 15:274.
47. Smyth, M. J., C. O. C. Zachariae, Y. Norihisa, J. R. Ortaldo, A. Hishinuma, and K. Matsushima. 1992. IL-8 gene expression and production in human peripheral blood lymphocyte subsets. J. Immunol. 146:3815.
48. Jenkins, M. K., D. M. Pardoll, J. Mizuguchi, T. M. Chused, and R. H. Schwartz. 1987. Molecular events in the induction of a nonresponsive state in interleukin-2-producing T-lymphocyte clones. Proc. Natl. Acad. Sci. USA 84:5409.
49. Lamb, J. R., E. D. Zanders, W. Sewell, M. J. Crumpton, M. Feldmann, and M. J. Owen. 1987. Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways. Eur. J. Immunol. 17: 1641.
50. Jenkins, M. K., D. M. Pardoll, J. Mizuguchi, H. Quill, and R. H. Schwartz. 1987. T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state. Immunol. Rev. 95:113.
51. Mosier, D. E., G. R. Picchio, S. M. Baird, R. Kobayashi, and T. J. Kipps. 1992. Epstein-Barr virus-induced human B cell lymphomas in SCID mice reconstituted with human peripheral blood leukocytes. Cancer Res. 52:5552s.
52. + helper T cells from atopic subjects. Eur. J. Immunol. 22:1615.
53. Alderson, M. 1974. Mortality from malignant disease in patients with asthma. Lancet 2:1475.
54. McWhorter, W. P. 1988. Allergy and risk of cancer: a prospective study using NHANESI follow-up data. Cancer 62:451.
55. Bernstein, L., and R. K. Ross. 1992. Prior medication use and health history as risk factors for non-Hodgkin's lymphoma: preliminary results from a case-control study in Los Angeles County. Cancer Res. 52:5510s.
56. Veronesi, A., V. Coppola, M. L. Veronese, C. Menin, L. Bruni, E. D'Andrea, M. Mion, A. Amadori, and L. Chieco-Bianchi. 1994. Lymphoproliferative disease in human peripheral-blood-mononuclear-cell-injected SCID mice. II. Role of host and donor factors in tumor generation. Int. J. Cancer 59:676.
57. Lenoir, G. M., and G. W. Bornkamm. 1987. Burkitt's lymphoma, a human cancer model for the study of multistep development of cancer: proposal for a new scenario. Adv. Viral Oncol. 7:173.
58. Swinnen, L. J., M. R. Costanzo-Nordin, S. G. Fisher, E. J. O'Sullivan, M. R. Johnson, A. L. Heroux, R. Pifarre, and R. I. Fisher. 1990. Increased incidence of lymphoproliferative disorders after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients. N. Engl. J. Med. 323: 1723.
59. Hussell, T., P. G. Isaacson, J. E. Crabtree, and J. Spencer. 1993. The response of cells from low-grade B-cell lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 342:571.
60. Carlsson, R., C. Martensson, S. Kalliomaki, H. Ohlin, and C. A. Borrebaeck. 1992. Human peripheral blood lymphocytes transplanted into SCID mice constitute an in vivo culture system exhibiting several parameters found in a normal humoral immune response and are a source of immunocytes for the production of human monoclonal antibodies. J. Immunol. 148:1065.
61. Torbett, B. E., G. Picchio, and D. E. Mosier. 1991. hu-PBL-SCID mice: a model for human immune function, AIDS, and lymphomagenesis. Immunol. Rev. 124: 139.
62. Mosier, D. E., R. J. Gulizia, S. M. Baird, D. B. Wilson, D. H. Spector, and S. A. Spector. 1991. Human immune-deficiency virus infection of human-PBL-SCID mice. Science 251:791.
63. h2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107.
64. Del Prete, G. F., E. Maggi, G. Pizzolo, and S. Romagnani. 1995. CD30, Th2 cytokines and HIV infection: a complex and fascinating link. Immunol. Today 16:76.