Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission

Journal of Infectious Diseases

Volumn 180, Issue 3, 1999, Pages 614-620

  Lockett, Sarah F ^a   Alonso, Alicia ^a   Wyld, Rona ^b   Martin, Maureen P ^e   Robertson, J Roy ^b   Gore, Sheila M ^d   Leen, Clifford L S ^c   Brettle, Ray P ^c   Yirrell, David L ^a   Carrington, Mary ^e   Brown, Andrew J Leigh ^a,f  

^a Animal Department   (United Kingdom)

^b Edinburgh Drug Addiction Study   (United Kingdom)

^c CITY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e SAIC FREDERICK INC   (United States)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HETEROSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIRUS TRANSMISSION;

COHORT STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HETEROSEXUALITY; HETEROZYGOTE; HIV INFECTIONS; HIV SEROPOSITIVITY; HOMOZYGOTE; HUMANS; MALE; MUTATION; POLYMERASE CHAIN REACTION; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; RISK FACTORS;

EID: 0032828483     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314918     Document Type: Article

References (39)

1. 1. McNeil AJ, Yap PL, Gore SM, et al. Association of HLA types A1-B8-DR3 and B27 with rapid and slow progression of HIV disease. QJM 1996;89: 177-85.
2. 2. Steel CM, Ludlam CA, Beatson D, et al. HLA haplotype A1 B8 DR3 us a risk factor for HIV-related disease. Lancet 1988;1:1185-8.
3. 3. Kaslow RA, Carrington M, Apple R, et al. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection, Nat Med 1996;2:405-11.
4. 4. Just JJ, Abrams E, Louie L, et al. Influence of host genotype on progression to acquired immunodeficiency syndrome among children infected with human immunodeficiency virus type 1. J Pediatr 1995;127:544-9.
5. 5. Alkhatib G, Combadiere C, Broder CC, et al. CC-CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion co-factor for macrophage-tropic HIV-1. Science 1996;272:1955-8.
6. 6. Choe II, Farzan M, Sun Y, et al. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996;86: 1135-48.
7. 7. Deng H, Liu R, Ellmeier W, et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996;381:661-6.
8. - cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996;381:667-73.
9. 9. Liu R, Paxton W, Choe S, et al. Homozygous defect in HIV-1 co-receptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996;86:367-77.
10. 10. Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996;273:1856-62.
11. 11. Samson M, Libert F, Doranz B, et al. Resistance to HIV-1 infection in caucasian individuals hearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996;382:722-5.
12. 12. Biti R, French R, Young J, Bennetts B, Stewart G, Liang T. HIV-1 infection in an individual homozygous for the CCR-5 deletion allele. Nat Med 1997;3:252-3.
13. 13. O'Brien TR, Winkler C, Dean M, et al. HIV-1 infection in man homozygous for CCRΔ32. Lancet 1997;349:1219.
14. 14. Theodorou I, Meyer L, Magierowska M, Katlama C, Rouzioux C, Seroco Study Group. HIV-1 infection in an individual homozygous for CCR5Δ32. Lancet 1997;349:1219-20.
15. 15. Balotta C, Bagnarelli P, Violin M, et al. Homozygous Δ32 deletion of the CCR-5 chemokine receptor gene in an HIV-1 infected patient. AIDS 1997;11:F67-71.
16. 16. Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCK-2 and CCR-5 variants on HIV-1 infection and disease progression. Science 1997;277:959-65.
17. 17. Kostrikis LG, Huang Y, Moore JP, et al. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med 1998;4:350-3.
18. 18. Rizzardi GP, Morawetz RA, Vicenzi E, et al. CCR2 polymorphism and HIV disease, Nat Med 1998;4:252-3.
19. 19. Martin MP, Dean M, Smith MW, et al. Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science 1998;282:1907-11.
20. 20. Giesecke J, Ramstedt K, Granath F, Ripa T, Rado G, Westrell M. Partner notification as a tool for research in HIV epidemiology: behavior change, transmission risk and incidence trends. AIDS 1992;6:101-7.
21. 21. Leigh Brown AJ, Lohidel D, Wade CM, et al. The molecular epidemiology of human immunodeficiency virus type 1 in six cities in Britain and Ireland. Virology 1997;235:166-77.
22. 22. Robertson JR, Wyld R, Elton R, Brettle R. Heterosexual transmission of HIV in men and women in a Scottish cohort. AIDS 1998;12:823-4.
23. 23. Fielding KL, Brettle RP, Gore SM, et al. Heterosexual transmission of HIV analyzed by generalized estimating equations. Stat Med 1995;14:1365-78.
24. 24. Simmonds P, Balfe P, Ludlam CA, Bishop JO, Leigh Brown AJ. Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1. J Virol 1990;64:5840-50.
25. 25. Boom R, Sol CJA, Salimans MMM, Jansen CL, Wertheim-van Dillen PME, Van Der Noordaa J. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 1990;28:495-503.
26. 26. Huang Y, Paxton WA, Wolinsky SM, et al. The role ofa mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 1996;2:1240-3.
27. 27. Rohlf FJ, Sokal RR. Statistical tables. San Francisco: WH Freeman, 1969.
28. 28. European Study Group. Comparison of female to male and male to female transmission of HIV in 563 stable couples. BMJ 1992;304:809-13.
29. 29. Eugen-Olsen J, Iversen AKN, Garred P, et al. Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS 1997;11: 305-10.
30. 30. Meyer L, Magierowska M, Hubert JB, et al. Early protective effect of CCR-5 Δ32 heterozygosity on HIV-1 disease progression: relationship with viral load. AIDS 1997;11:F73-8.
31. 31. Stewart GJ, Ashton LJ, Biti RA, et al. Increased frequency of CCR-5 Δ32 heterozygotes among long-term non-progressors with HIV-1 infection. AIDS 1997;11:1833-8.
32. 32. O'Brien TR, Padian NS, Hodge T, Goedert JJ, O'Brien SJ, Carrington M. CCR-5 genotype and sexual transmission of HIV-1, AIDS 1998;12:444-5.
33. 33. Hoffman TL, MacGregor RR, Burger H, Mick R, Doms RW, Collman RG. CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status. J Infect Dis 1997;176:1093-6.
34. 34. Michael NL, Louie LG, Rohrbaugh AL, et al. The role of CCR-5 and CCR-2 polymorphisms in HIV-1 transmission and disease progression. Nat Med 1997;3:1160-2.
35. 35. Lee B, Doranz BJ, Rana S, et al. Influence of the CCR2-V641 polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR5 and CXCR-4, J Virol 1998;72: 7450-8.
36. 36. Wu L, Paxton WA, Kassam N, et al. CCR5 levels and expression pattern correlate with infectibility by macrophage-tropic HIV-1, in vitro. J Exp Med 1997;185:1681-91.
37. 37. Winkler C, Modi W, Smith MW, et al. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. Science 1998;279:389-93.
38. 38. Laga M, Taelman H, Van der Stuyft P, Bonneux L, Vercauteren G, Piot P. Advanced immunodefifiency as a risk factor for heterosexual transmission of HIV. AIDS 1989;3:361-6.
39. 39. Fiore JM, Zhang YJ, Björndal A, et al. Biological correlates of HIV-1 heterosexual transmission. AIDS 1997;11:1089-94.