Low levels of tissue factor are compatible with development and hemostasis in mice

Journal of Clinical Investigation

Volumn 101, Issue 3, 1998, Pages 560-569

  Parry, Graham C N ^a   Erlich, Jonathan H ^a   Carmeliet, Peter ^b   Luther, Thomas ^c   Mackman, Nigel ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Interuniversity Institute for Biostatistics   (Belgium)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Blood coagulation factors; Gene expression; Regulation; Transgenic animals

Indexed keywords

BLOOD CLOTTING FACTOR; THROMBOPLASTIN;

AMINO ACID SUBSTITUTION; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE TARGETING; HEMOSTASIS; HYPERCOAGULABILITY; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; THROMBOSIS; TISSUE GROWTH; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

EID: 0032006548     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI814     Document Type: Article

References (48)

1. Bach, R.R. 1988. Initiation of coagulation by tissue factor. Crit Rev. Biochem. 23:339-368.
2. Edgington, T.S., N. Mackman, K. Brand, and W. Ruf. 1991. The structural biology of expression and function of tissue factor. Thromb. Haemost. 66: 67-79.
3. Contrino, J., G. Hair, D.L. Kreutzer, and F.R. Rickles. 1996. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat. Med. 2:209-215.
4. Zhang Y., Y. Deng. T. Luther. M. Müller. R. Ziegler, R. Waldherr, D.M. Stern, and P.P. Nawroth. 1994. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J. Clin. Invest. 94:1320-1327.
5. Mueller, B.M., R.A. Reisfeld. T.S. Edgington. and W. Ruf. 1992. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. Proc. Natl. Acad. Sci. USA. 89:1-6.
6. Bromberg, M.E., W.H. Konigsberg, J.F. Madison, A. Pawashe, and A. Garen. 1995. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc. Natl. Acad. Sci. USA. 92:8205-8209.
7. Soifer, S.J., K.G. Peters. J. O'Keefe, and S.R. Coughlin. 1994. Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am. J. Pathol. 144:60-69.
8. Luther, T., C. Flösscl. N. Mackman, A. Bicrhaus, M. Kasper, S. Albrecht. E.H. Sage, L. Iruela-Arispe. H. Grossmann, A. Ströhlein, et al. 1996. Tissue factor expression during human and mouse development. Am. J. Pathol 149:101-113.
9. Toomey, J.R., K.E. Kratzer, N.M. Lasky, J.J. Stanton. and G.J. Broze, Jr. 1996. Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood. 88:1583-1587.
10. Bugge, T.H., Q. Xiao. K.W. Kombrinck, M.J. Flick, K. Holmback, M.J.S. Danton, M.C. Colbert, D.P. Witte, K. Fujikawa, E.W. Davie, and J.L. Degen. 1996. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc. Natl. Acad. Sci. USA. 93: 6258-6263.
11. Carmeliet, P., N. Mackman, L. Moons, T. Luther. P. Gressens, I. Van Vlaenderen, H. Demunck, M. Kasper, G. Breier, P. Evrard, et al. 1996. Role of tissue factor in embryonic blood vessel development. Nature. 383:73-75.
12. Fleck, R.A., L.V.M. Rao, S.I. Rapaport, and N. Varki. 1990. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. Thromb. Res. 57:765-781.
13. Drake, T.A., J.H. Morrissey, and T.S. Edgington. 1989. Selective cellular expression of tissue factor in human tissues. Am. J. Pathol. 134:1087-1097.
14. Osterud, B., and T. Flæstad. 1983. Increased tissue thromboplastin activity in monocytes of patients with meningococcal infection: related to an unfavorable prognosis. Thromb. Haemost. 49:5-7.
15. Edwards, R.L., F.R. Rickles, and M. Cronlund. 1981. Abnormalities of blood coagulation in patients with cancer. J. Lab. Clin. Med. 98:917-928.
16. Leatham, E., P. Bath. J. Tooze, and A. Camm. 1995. Increased monocyte tissue factor expression in coronary disease. Br. Heurt J. 73:10-13.
17. Drake, T.A., J. Cheng, A. Chang, and F.B. Taylor, Jr. 1993. Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis. Am. J. Pathol. 142:1-13.
18. Morrissey, J.H., and T.A. Drake. 1993. Proeoagulant response of the endothelium and monocytes. In Pathophysiology of Shock, Sepsis and Organ Failure. G. Schlag and H. Redl. editors. Springer-Verlag, Berlin. 564-574.
19. Levi, M., H. ten Cate, K.A. Bauer. T. van der Poll, T.S. Edgington, H.R. Büller, S.J.H. van Deventer, C.E. Hack. J. Wouter ten Cate, and R.D. Rosenberg. 1994. Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J. Clin. Invest. 93:114-120.
20. Taylor, F.B., Jr., A. Chang, W. Ruf. J.H. Morrissey, L. Hinshaw, R. Catlett, K. Blick, and T.S. Edgington. 1991. Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. Circ. Shock. 33: 127-134.
21. Wilcox, J.N., K.M. Smith, S.M. Schwanz, and D. Gordon. 1989. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc. Natl. Acad. Sci. USA 86:2839-2843.
22. Moreno, P.R., V.H. Bernardi, J. López-Cuéllar, A.M. Murcia, I.F. Palacios, H.K. Gold, R. Mehran, S.K. Sharma, Y. Nemerson, V. Fuster, and J.T. Fallon. 1996. Macrophages, smooth muscle cells, and tissue factor in unstable angina. Implications for cell-mediated thrombogenicity in acute coronary syndromes. Circulation. 94:3090-3097.
23. Marmur, J.D., M. Rossikhina, A. Guha, B. Fyfe, V. Friedrich, M. Mendlowitz, Y. Nemerson, and M.B. Taubman. 1993. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury. J. Clin. Invest. 91:2253-2259.
24. Golino, P., M. Ragni, P. Cirillo, V.E. Avvedimento, A. Feliciello, N. Esposito, A. Scognamiglio, B. Trimarco, G. Iaccarino M. Condorelli, et al. 1996. Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion. Nat. Med. 2:35-10.
25. Ragni, M., P Cirillo, I. Pascucci, A. Scognamiglio, D. D'Andrea, N. Eramo, M.D. Ezekowitz, A.B. Pawashe, M. Chiariello, and P. Golino. 1996. Monoclonal antibody against tissue factor shortens tissue plasminogen activator lysis time and prevents reocclusion in a rabbit model of carotid artery thrombosis. Circulation. 93:1913-1918.
26. Jang, I.-K., H.K. Gold, R.C. Leinbach, J.T. Fallon, D. Collen, and J.N. Wilcox. 1992. Antithrombotic effect of a monoclonal antibody against tissue factor in a rabbit model of platelet-mediated arterial thrombosis. Arterioscler. Thromb. 12:948-954.
27. Mackman, N. 1995. Regulation of the tissue factor gene. FASEB . (Fed Am. Soc. Exp. Biol.) J. 9:883-889.
28. Mackman, N., K. Brand, and T.S. Edgington. 1991. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-I monocytic cells requires both activator protein 1 and nuclear factor κB binding sites. J. Exp. Med. 174:1517-1526.
29. Oeth, P.A., G.C.N. Parry, C. Kunsch, P. Nantermet, C.A. Rosen, and N. Mackman. 1994. Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a κB-like site. Mol. Cell. Biol. 14:3772-3781.
30. Parry, G.C., and N. Mackman. 1995. Transcriptional regulation of tissue factor expression in human endothelial cells. Arterioscler. Thromb. 15:612-621.
31. Bierhaus, A., Y, Zhang, Y. Deng, N. Mackman, P. Quehenberger, M. Haase, T. Luther, M. Müller. H. Böhrer. J. Greten. et al. 1995. Mechanism of the tumor necrosis factor α-mediated induction of endothelial tissue factor. J. Biol. Chem. 270:26419-26432.
32. Moll, T., M. Czyz, H. Holzmuller, R. Hofer-Warbinek, E. Wagner, H. Winkler, F.D. Bach, and E. Hofer. 1995. Regulation of the tissue factor promoter in endothelial cells. J. Biol. Chem. 270:3849-3857.
33. Taby, O., C.-L. Rosenfield. V. Bogdanov. Y. Nemerson, and M.B. Taubman. 1996. Cloning of the rat tissue factor cDNA and promoter: identification of a serum-response region. Thromb. Haemost. 76:697-702.
34. Mackman, N., J.H. Morrissey, B. Fowler, and T.S. Edgington. 1989. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry. 28:1755-1762.
35. Mackman, N., S. Imes. W.H. Maske, B. Taylor. A.J. Lusis, and T.A. Drake. 1992. Structure of the murine tissue factor gene: chromosome location and conservation of regulatory elements in the promoter. Arterioscler. Thromb. 12:474-483.
36. Morrissey, J.H., H. Fakhrai, and T.S. Edgington. 1987. Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade. Cell. 50:129-135.
37. Morrissey, J.H., S.A. Gregory. N. Mackman, and T.S. Edgington. 1989. Tissue factor regulation and gene organization. Oxf. Surv. Eukaryotic Genes. 6: 67-84.
38. Stuhlmeier, K.M., V. Csizmadia, Q. Cheng. H. Winkler, and F.H. Bach. 1994. Selective inhibition of E-selectin, ICAM-I. and VCAM in endothelial cells. Eur: J. Immimol. 24:2186-2190.
39. Prud'Homme. G.J., D.H. Kono, and A.N. Theofilopoulos. 1995. Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1β. interleukin-10 and interferon-gamma mRNA in the lymph nodes of lupus-prone mice. Mol. lmnuinol. 32:495-503.
40. Morrissey, J.H., D.S. Fair, and T.S. Edginglon. 1988. Monoclonal antibody analysis of purified and cell-associated tissue factor. Thromb. Res. 52:247-261.
41. Fang, C.H., T.C. Lin, A. Guha, Y. Nemerson, and W.H. Konigsberg. 1996. Activation of factor X by factor Vila complexed with human-mouse tissue factor chimeras requires human exon 3. Thromb. Huemost. 76:361-368.
42. Mackman, N. 1994. Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers. J. Biol. Chem. 269:26363-26367.
43. Drake, T.A., J.H. Morrissey, and T.S. Edgington. 1989. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am. J. Pathol. 134:1087-1097.
44. o4. Schlaeger, T.M., S. Bartunkova, J.A. Lawitts, G. Teichmann, W. Risau. U. Deutsch, and T.N. Sato. 1997. Uniform vascular-endothelial-cell-specific gcne expression in both embryonic and adult transsenic mice. Proc: Natl. Acad. Sci. USA. 94:3058-3063.
45. Franklin, G.C., M. Donovan, G.I.R. Adam, L. Holmgren, S. PteiferOhlsson, and R. Ohlsson. 1991. Expression of the human PDGF-B gene is regulated by both positively and negatively acting cell type-specific regulatory elements located in the first intron. EMBO (Eur. Mot. Biol. Organ.) J. 10:1365-1373.
46. Eddleston, M., J.C. de la Torre. M.B.A. Oldstone. D.J. Loskutoff, T.S. Edgington, and N. Mackman. 1993. Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis. J. Clin. Invest. 92:349-358.
47. Mackman, N., M.S. Sawdey, M.R. Keeton, and D.J. Loskutoff. 1993. Murine tissue factor gene expression in vivo: tissue and cell specificity and regulation by lipopolysaccharide. Am. J. Pathol. 143:76-84.
48. Toomey, J.R., K.E. Kratzer. N.M. Lasky, and G.J. Broze, Jr. 1997. Effect of tissue factor deficiency on mouse and tumor development. Proc. Natl. Acad. Sci. USA. 94:6922-6926.