Alleles of the Plasmodium falciparum Pfmdr1 gene appear not to be associated with chloroquine resistance in India

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 91, Issue 4, 1997, Pages 454-455

  Bhattacharya, Pramatha R ^a   Biswas, Sukla ^a   Kabilan, Lalitha ^a  

^a NATIONAL INSTITUTE OF MALARIA RESEARCH   (India)

Author keywords

Chloroquine resistance; India; Malaria; Pfmdr1 gene; Plasmodium falciparum

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE;

ALLELE; ARTICLE; DRUG RESISTANCE; INDIA; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 0030818265     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(97)90283-2     Document Type: Article

References (13)

1. Awad-El-Kariem, F. M., Miles, M. A. & Warhurst, D. C. (1992). Chloroquine resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the Pfmdr1 gene thought to be associated with chloroquine resistance. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 587-589.
2. Basco, K. L., DePeoulas, E. P., LeBras, J. & Wilson, C. M. (1996). Plasmodium falciparum: molecular characterization of multidrug-resistant Cambodian isolates. Experimental Parasitology, 82, 97-103.
3. Biswas, S., Saxena, Q. B., Roy, A. & Sharma, V. P. (1988). Isolation of different erythrocytic stages of Plasmodium falciparum and synchronization in culture. Indian Journal of Malariology, 25, 7-10.
4. Cox-Singh, J., Singh, B., Alias, A. & Abdullah, M. S. (1995). Assessment of the association between three pfmdr1 point mutations and chloroquine resistance in vitro of Malaysian Plasmodium falciparum isolates. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 436-437.
5. Foote, S. J., Thompson, J. K., Cowman, A. F. & Kemp, D. J. (1989). Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of Plasmodium falciparum. Cell, 57, 921-930.
6. Foote, S. J., Kyle, D. E., Martin, R. K., Oduola, A. M. J., Forsyth, K., Kemp, D. J. & Cowman, A. F. (1990). Several alleles of the multidrug-resistant gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature, 345, 255-258.
7. Frean, J. A., Awad El Kariem, F. M., Warhurst, D. C. & Miles, M. A. (1992). Rapid detection of pfmdrl mutations in chloroquine-resistant Plasmodium falciparum malaria by polymerase chain reaction analysis of blood spots. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 29-30.
8. Krogstad, D. J., Gluzman, I. Y., Kyle, D. E., Oduola, A. J., Martin, S. J., Millhouse, W. K. & Schlesinger, P. H. (1987). Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science, 238, 1283-1285.
9. Martin, S. K., Oduola, A. M. J. & Millhouse,W. K. (1987). Reversal of chloroquine resistance in Plasmodium falciparum by verapamil. Science, 235, 899-901.
10. Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B. & Erlich, H. A. (1988). Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science, 239, 487-491.
11. Trager, W. & Jensen, J. B. (1976). Human malaria parasites in continuous culture. Science, 193, 673-765.
12. Wilson, C. M., Serrano, A. E.,Walsey, A., Bogenschutz, M. P., Shankar, A. H. & Wirth, D. (1989). Amplification of a gene related to mammalian mdr genes in drug resistant Plasmodium falciparum. Science, 244, 1184-1186.
13. Zalis, M. G., Craig, M. W., Zhang, Y. & Wirth, D. F. (1993). Characterization of the pfmdr2 gene for Plasmodium falciparum. Molecular and Biochemical Parasitology, 62, 83-92.