메뉴 건너뛰기




Volumn 10, Issue 9, 1999, Pages 1880-1890

Short-term pravastatin mediates growth inhibition and apoptosis, independently of Ras, via the signaling proteins p27(Kip1) and PI3 kinase

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BB; PRAVASTATIN; PROTEIN P27; RAF PROTEIN; RAS PROTEIN; RHO FACTOR;

EID: 0032803586     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/asn.v1091880     Document Type: Article
Times cited : (62)

References (57)
  • 1
    • 0028935780 scopus 로고
    • Protein lipidation in cell signaling
    • Casey PJ: Protein lipidation in cell signaling. Science 268: 221-226, 1995
    • (1995) Science , vol.268 , pp. 221-226
    • Casey, P.J.1
  • 4
    • 0031799044 scopus 로고    scopus 로고
    • MEK inhibition augments raf activity, but has variable effects on mitogenesis, in vascular smooth muscle cells
    • Weiss RH, Maga EA, Ramirez A: MEK inhibition augments Raf activity, but has variable effects on mitogenesis, in vascular smooth muscle cells. Am J Physiol 274: C1521-C1529, 1998
    • (1998) Am J Physiol , vol.274
    • Weiss, R.H.1    Maga, E.A.2    Ramirez, A.3
  • 5
    • 0026669450 scopus 로고
    • Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells
    • Weiss RH, Nuccitelli R: Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells. J Biol Chem 267: 5608-5613, 1992
    • (1992) J Biol Chem , vol.267 , pp. 5608-5613
    • Weiss, R.H.1    Nuccitelli, R.2
  • 6
    • 0027263326 scopus 로고
    • Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types
    • Satoh T, Fantl WJ, Escobedo JA, Williams LT, Kaziro Y: Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types. Mol Cell Biol 13: 3706-3713, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 3706-3713
    • Satoh, T.1    Fantl, W.J.2    Escobedo, J.A.3    Williams, L.T.4    Kaziro, Y.5
  • 7
    • 0029940760 scopus 로고    scopus 로고
    • The mitogenic inhibitory effect of phorbol esters is associated with decreased activation of phosphatidylinositol-3 kinase
    • Weiss RH, Yabes AP: The mitogenic inhibitory effect of phorbol esters is associated with decreased activation of phosphatidylinositol-3 kinase. Am J Physiol 270: C619-C627, 1996
    • (1996) Am J Physiol , vol.270
    • Weiss, R.H.1    Yabes, A.P.2
  • 8
    • 0024406286 scopus 로고
    • All ras proteins are polyisoprenylated but only some are palmitoylated
    • Hancock JF, Magee AI, Childs JE, Marshall CJ: All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57: 1167-1177, 1989
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Childs, J.E.3    Marshall, C.J.4
  • 9
    • 0028196986 scopus 로고
    • Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers
    • Silvius JR, l'Heureux F: Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers. Biochemistry 33: 3014-3022, 1994
    • (1994) Biochemistry , vol.33 , pp. 3014-3022
    • Silvius, J.R.1    L'Heureux, F.2
  • 10
    • 0021711754 scopus 로고
    • Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs
    • Ulsh LS, Shih TY: Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs. Mol Cell Biol 4: 1647-1652, 1984
    • (1984) Mol Cell Biol , vol.4 , pp. 1647-1652
    • Ulsh, L.S.1    Shih, T.Y.2
  • 11
    • 0029609856 scopus 로고
    • Effect of lovastatin and fluoromevalonate on phosphatidylinositol 3-kinase activity stimulated with PDGF
    • Iwama A, Sawamura M, Nara Y, Yamori Y: Effect of lovastatin and fluoromevalonate on phosphatidylinositol 3-kinase activity stimulated with PDGF. Clin Exp Pharmacol Physiol 22[Suppl 1]: S318-S320, 1995
    • (1995) Clin Exp Pharmacol Physiol , vol.22 , Issue.1 SUPPL.
    • Iwama, A.1    Sawamura, M.2    Nara, Y.3    Yamori, Y.4
  • 13
    • 0027185879 scopus 로고
    • Relationship between mevalonate pathway and arterial myocyte proliferation: In vitro studies with inhibitors of HMG-CoA reductase
    • Corsini A, Mazzotti M, Raiteri M, Soma MR, Gabbiani G, Fumagalli R, Paoletti R: Relationship between mevalonate pathway and arterial myocyte proliferation: In vitro studies with inhibitors of HMG-CoA reductase. Atherosclerosis 101: 117-125, 1993
    • (1993) Atherosclerosis , vol.101 , pp. 117-125
    • Corsini, A.1    Mazzotti, M.2    Raiteri, M.3    Soma, M.R.4    Gabbiani, G.5    Fumagalli, R.6    Paoletti, R.7
  • 14
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212, 1990
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 15
    • 0029926493 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation
    • McGuire TF, Qian Y, Vogt A, Hamilton AD, Sebti SM: Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. J Biol Chem 271: 27402-27407, 1996
    • (1996) J Biol Chem , vol.271 , pp. 27402-27407
    • McGuire, T.F.1    Qian, Y.2    Vogt, A.3    Hamilton, A.D.4    Sebti, S.M.5
  • 17
    • 0023615744 scopus 로고
    • Expression of ras proto-oncogene proteins in normal human tissues
    • Furth ME, Aldrich TH, Cordon-Cardo C: Expression of ras proto-oncogene proteins in normal human tissues. Oncogene 1: 47-58, 1987
    • (1987) Oncogene , vol.1 , pp. 47-58
    • Furth, M.E.1    Aldrich, T.H.2    Cordon-Cardo, C.3
  • 18
    • 0026652899 scopus 로고
    • Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
    • Fantl WJ, Escobedo JA, Martin GA, Turck CW, Del Rosario M, McCormick F, Williams LT: Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69: 413-423, 1992
    • (1992) Cell , vol.69 , pp. 413-423
    • Fantl, W.J.1    Escobedo, J.A.2    Martin, G.A.3    Turck, C.W.4    Del Rosario, M.5    McCormick, F.6    Williams, L.T.7
  • 19
    • 0027211693 scopus 로고
    • Phospholipase C-gamma-1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
    • Valius M, Kazlauskas A: Phospholipase C-gamma-1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 73: 321-334, 1993
    • (1993) Cell , vol.73 , pp. 321-334
    • Valius, M.1    Kazlauskas, A.2
  • 20
    • 0028351218 scopus 로고
    • Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites
    • Joly M, Kazlauskas A, Fay FS, Corvera S: Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science 263: 684-687, 1994
    • (1994) Science , vol.263 , pp. 684-687
    • Joly, M.1    Kazlauskas, A.2    Fay, F.S.3    Corvera, S.4
  • 22
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/akt cellular survival pathway
    • Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J: Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 16: 2783-2793, 1997
    • (1997) EMBO J , vol.16 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 23
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
    • Pap M, Cooper GM: Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 273: 19929-19932, 1998
    • (1998) J Biol Chem , vol.273 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 24
    • 0029039957 scopus 로고
    • Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway
    • Karnitz LM, Burns LA, Sutor SL, Blenis J, Abraham RT: Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol Cell Biol 15: 3049-3057, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 3049-3057
    • Karnitz, L.M.1    Burns, L.A.2    Sutor, S.L.3    Blenis, J.4    Abraham, R.T.5
  • 26
    • 0027425113 scopus 로고
    • Activation of ternary complex factor Elk-1 by MAP kinases
    • Janknecht R, Ernst WH, Pingoud V, Nordheim A: Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J 12: 5097-5104, 1993
    • (1993) EMBO J , vol.12 , pp. 5097-5104
    • Janknecht, R.1    Ernst, W.H.2    Pingoud, V.3    Nordheim, A.4
  • 27
    • 0031882123 scopus 로고    scopus 로고
    • The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif
    • Yang SH, Yates PR, Whitmarsh AJ, Davis RJ, Sharrocks AD: The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif. Mol Cell Biol 18: 710-720, 1998
    • (1998) Mol Cell Biol , vol.18 , pp. 710-720
    • Yang, S.H.1    Yates, P.R.2    Whitmarsh, A.J.3    Davis, R.J.4    Sharrocks, A.D.5
  • 28
    • 0029125757 scopus 로고
    • Integration of MAP kinase signal transduction pathways at the serum response element
    • Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ: Integration of MAP kinase signal transduction pathways at the serum response element. Science 269: 403-407, 1995
    • (1995) Science , vol.269 , pp. 403-407
    • Whitmarsh, A.J.1    Shore, P.2    Sharrocks, A.D.3    Davis, R.J.4
  • 29
    • 0030835430 scopus 로고    scopus 로고
    • Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
    • Woods D, Parry D, Cherwinski H, Bosch E, Lees E, McMahon M: Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 17: 5598-5611, 1997
    • (1997) Mol Cell Biol , vol.17 , pp. 5598-5611
    • Woods, D.1    Parry, D.2    Cherwinski, H.3    Bosch, E.4    Lees, E.5    McMahon, M.6
  • 30
    • 0032575705 scopus 로고    scopus 로고
    • A matter of life and cell death
    • Evan G, Littlewood T: A matter of life and cell death. Science 281: 1317-1322, 1998
    • (1998) Science , vol.281 , pp. 1317-1322
    • Evan, G.1    Littlewood, T.2
  • 32
    • 0031020427 scopus 로고    scopus 로고
    • Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobility
    • Ferrier AF, Lee M, Anderson WB, Benvenuto G, Morrison DK, Lowy DR, DeClue JE: Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobility. J Biol Chem 272: 2136-2142, 1997
    • (1997) J Biol Chem , vol.272 , pp. 2136-2142
    • Ferrier, A.F.1    Lee, M.2    Anderson, W.B.3    Benvenuto, G.4    Morrison, D.K.5    Lowy, D.R.6    DeClue, J.E.7
  • 33
    • 0031054797 scopus 로고    scopus 로고
    • Negative modulation of membrane localization of the Raf-1 protein kinase by hyperphosphorylation
    • Wartmann M, Hofer P, Turowski P, Saltiel AR, Hynes NE: Negative modulation of membrane localization of the Raf-1 protein kinase by hyperphosphorylation. J Biol Chem 272: 3915-3923, 1997
    • (1997) J Biol Chem , vol.272 , pp. 3915-3923
    • Wartmann, M.1    Hofer, P.2    Turowski, P.3    Saltiel, A.R.4    Hynes, N.E.5
  • 34
    • 0030871667 scopus 로고    scopus 로고
    • High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
    • Sewing A, Wiseman B, Lloyd AC, Land H: High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol Cell Biol 17: 5588-5597, 1997
    • (1997) Mol Cell Biol , vol.17 , pp. 5588-5597
    • Sewing, A.1    Wiseman, B.2    Lloyd, A.C.3    Land, H.4
  • 35
    • 0027496730 scopus 로고
    • ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells
    • Kumagai N, Morii N, Fujisawa K, Nemoto Y, Narumiya S: ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J Biol Chem 268: 24535-24538, 1993
    • (1993) J Biol Chem , vol.268 , pp. 24535-24538
    • Kumagai, N.1    Morii, N.2    Fujisawa, K.3    Nemoto, Y.4    Narumiya, S.5
  • 36
    • 0027374497 scopus 로고
    • Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho
    • Zhang J, King WG, Dillon S, Hall A, Feig L, Rittenhouse SE: Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho. J Biol Chem 268: 22251-22254, 1993
    • (1993) J Biol Chem , vol.268 , pp. 22251-22254
    • Zhang, J.1    King, W.G.2    Dillon, S.3    Hall, A.4    Feig, L.5    Rittenhouse, S.E.6
  • 38
    • 0031453368 scopus 로고    scopus 로고
    • Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27
    • Weber JD, Hu W, Jefcoat SCJ, Raben DM, Baldassare JJ: Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27. J Biol Chem 272: 32966-32971, 1997
    • (1997) J Biol Chem , vol.272 , pp. 32966-32971
    • Weber, J.D.1    Hu, W.2    Jefcoat, S.C.J.3    Raben, D.M.4    Baldassare, J.J.5
  • 39
    • 0028892646 scopus 로고
    • Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity
    • Lebowitz PF, Davide JP, Prendergast GC: Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity. Mol Cell Biol 15: 6613-6622, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 6613-6622
    • Lebowitz, P.F.1    Davide, J.P.2    Prendergast, G.C.3
  • 40
    • 0027995468 scopus 로고
    • Role of bound GDP in the stability of the rho A-rho GDI complex purified from neutrophil cytosol
    • Bourmeyster N, Boquet P, Vignais PV: Role of bound GDP in the stability of the rho A-rho GDI complex purified from neutrophil cytosol. Biochem Biophys Res Commun 205: 174-179, 1994
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 174-179
    • Bourmeyster, N.1    Boquet, P.2    Vignais, P.V.3
  • 42
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley AJ, Hall A: The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70: 389-399, 1992
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 43
    • 16844366239 scopus 로고    scopus 로고
    • Evidence for Rho-mediated agonist stimulation of phospholipase D in rat1 fibroblasts: Effects of Clostridium botulinum C3 exoenzyme
    • Malcolm KC, Elliott CM, Exton JH: Evidence for Rho-mediated agonist stimulation of phospholipase D in rat1 fibroblasts: Effects of Clostridium botulinum C3 exoenzyme. J Biol Chem 271: 13135-13139, 1996
    • (1996) J Biol Chem , vol.271 , pp. 13135-13139
    • Malcolm, K.C.1    Elliott, C.M.2    Exton, J.H.3
  • 45
    • 15644378138 scopus 로고    scopus 로고
    • Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells
    • Hirai A, Nakamura S, Noguchi Y, Yasuda T, Kitagawa M, Tatsuno I, Oeda T, Tahara K, Terano T, Narumiya S, Kohn LD, Saito Y: Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J Biol Chem 272: 13-16, 1997
    • (1997) J Biol Chem , vol.272 , pp. 13-16
    • Hirai, A.1    Nakamura, S.2    Noguchi, Y.3    Yasuda, T.4    Kitagawa, M.5    Tatsuno, I.6    Oeda, T.7    Tahara, K.8    Terano, T.9    Narumiya, S.10    Kohn, L.D.11    Saito, Y.12
  • 46
    • 0028062689 scopus 로고
    • Lovastatin disrupts early events in insulin signaling: A potential mechanism of lovastatin's anti-mitogenic activity
    • McGuire TF, Xu XQ, Corey SJ, Romero GG, Sebti SM: Lovastatin disrupts early events in insulin signaling: A potential mechanism of lovastatin's anti-mitogenic activity. Biochem Biophys Res Commun 204: 399-406, 1994
    • (1994) Biochem Biophys Res Commun , vol.204 , pp. 399-406
    • McGuire, T.F.1    Xu, X.Q.2    Corey, S.J.3    Romero, G.G.4    Sebti, S.M.5
  • 47
    • 0028892253 scopus 로고
    • Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins
    • Rameh LE, Chen CS, Cantley LC: Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell 83: 821-830, 1995
    • (1995) Cell , vol.83 , pp. 821-830
    • Rameh, L.E.1    Chen, C.S.2    Cantley, L.C.3
  • 49
    • 0032488912 scopus 로고    scopus 로고
    • Newly synthesized Rho A, not Ras, is isoprenylated and translocated to membranes coincident with progression of the G1 to S phase of growth-stimulated rat FRTL-5 cells
    • Noguchi Y, Nakamura S, Yasuda T, Kitagawa M, Kohn LD, Saito Y, Hirai A: Newly synthesized Rho A, not Ras, is isoprenylated and translocated to membranes coincident with progression of the G1 to S phase of growth-stimulated rat FRTL-5 cells. J Biol Chem 273: 3649-3653, 1998
    • (1998) J Biol Chem , vol.273 , pp. 3649-3653
    • Noguchi, Y.1    Nakamura, S.2    Yasuda, T.3    Kitagawa, M.4    Kohn, L.D.5    Saito, Y.6    Hirai, A.7
  • 50
    • 0032494101 scopus 로고    scopus 로고
    • 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
    • Guijarro C, Blanco-Colio LM, Ortego M, Alonso C, Ortiz A, Plaza JJ, Diaz C, Hernandez G, Edigo J: 3-Hydroxy-3-methyl-glutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circ Res 83: 490-500, 1998
    • (1998) Circ Res , vol.83 , pp. 490-500
    • Guijarro, C.1    Blanco-Colio, L.M.2    Ortego, M.3    Alonso, C.4    Ortiz, A.5    Plaza, J.J.6    Diaz, C.7    Hernandez, G.8    Edigo, J.9
  • 51
    • 0029670477 scopus 로고    scopus 로고
    • Translational control of p27Kip1 accumulation during the cell cycle
    • Hengst L, Reed SI: Translational control of p27Kip1 accumulation during the cell cycle. Science 271: 1861-1864, 1996
    • (1996) Science , vol.271 , pp. 1861-1864
    • Hengst, L.1    Reed, S.I.2
  • 53
    • 0031050738 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied sub-stratum attachment
    • Lebowitz PF, Sakamuro D, Prendergast GC: Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied sub-stratum attachment. Cancer Res 57: 708-713, 1997
    • (1997) Cancer Res , vol.57 , pp. 708-713
    • Lebowitz, P.F.1    Sakamuro, D.2    Prendergast, G.C.3
  • 55
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
    • Cox AD, Der CJ: Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras? Biochim Biophys Acta 1333: F51-F71, 1997
    • (1997) Biochim Biophys Acta , vol.1333
    • Cox, A.D.1    Der, C.J.2
  • 56
    • 0026895892 scopus 로고
    • Protein prenylation: Key to ras function and cancer intervention?
    • Khosravi-Far R, Cox AD, Kato K, Der CJ: Protein prenylation: Key to ras function and cancer intervention? Cell Growth Differ 3: 461-469, 1992
    • (1992) Cell Growth Differ , vol.3 , pp. 461-469
    • Khosravi-Far, R.1    Cox, A.D.2    Kato, K.3    Der, C.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.