Ex vivo effects associated with the expression of a bcr-abl-specific ribozyme in a CML cell line

Antisense and Nucleic Acid Drug Development

Volumn 8, Issue 1, 1998, Pages 15-23

  Wright, Louise A ^a   Milliken, Sam ^a   Biggs, James C ^a   Kearney, Phillip ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; MESSENGER RNA; RIBOZYME;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN K 562; CHIMERA; CHRONIC MYELOID LEUKEMIA; COLONY FORMING UNIT; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0031909906     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1998.8.15     Document Type: Article

References (5)

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2. BEDI, A., ZEHNBAUER, B.A., BARBER, J.P., SHARKIS, S.J., and JONES, R.J. (1994). Inhibition of apoptosis by bcr-abl in chronic myeloid leukemia. Blood 83, 2038-2044.
3. BERTRAND, E.L., CASTANOTTO, D., ZHOU, C., CARBONNELLE, C., LEE, N.S., GOOD, P., CHATTERJEE, S., GRANGE, T., PICTET, R., KOHN, D., ENGELKE, D., and ROSSI, J.J. (1997). The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization. RNA 3, 75-88.
4. CAI, D.W., MUKHOPADHYAY, T., and ROTH, J.A. (1995). Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA. Cancer Gene Ther. 2, 199-205.
5. WU, S-Q., VOELKERDING, K.V., SABATINI, L., CHEN, X-R., HUANG, J., and MEISNER, L.F. (1995). Extensive amplification of bcr/abl fusion genes clustered on three marker chromosomes in human leukemic cell line K-562. Leukemia 9, 858-862.