Treatment with interferon-α preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors (CFU-GM) from patients with chronic myeloid leukemia but spares normal CFU-GM

Journal of Clinical Investigation

Volumn 102, Issue 4, 1998, Pages 710-715

  Gordon, M Y ^a,c   Marley, S B ^a   Lewis, J L ^a   Davidson, R J ^a   Nguyen, D X ^a   Grand, F H ^a   Amos, T A S ^a,b   Goldman, J M ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b ROYAL UNITED HOSPITAL   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

BCR ABL; Expansion; Fluorescence in situ hybridization; Prognosis; Therapy

Indexed keywords

ALPHA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MECHANISM; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0032529110     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3094     Document Type: Article

References (32)

1. Gordon, M.Y., and J.M. Goldman. 1996. Cellular and molecular mechanisms in chronic myeloid leukaemia: biology and treatment. Br. J. Haematol. 95:10-20.
2. Amos, T.A.S., J.L. Lewis, F.H. Grand, R.P. Gooding, J.M. Goldman, and M.Y. Gordon. 1995. Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids. Br. J. Haematol. 91:387-393.
3. Selleri, C., T. Sato, L. Del Vecchi, L. Luciano, A.J. Barrett, B. Rotoli, N.S. Young, and J.P. Maciejewski. 1997. Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia. Blood. 89:957-964.
4. Albrecht, T., R. Schwab, M. Henkes, C. Peschel, C. Huber, and W.E. Aulitzky. 1996. Primary proliferating immature myeloid cells from CML patients are not resistant to induction of apoptosis by DNA damage and growth factor withdrawal. Br. J. Haematol. 95:501-507.
5. Carlo-Stella, C., G. Dotti, L. Mangoni, E. Regazzi, D. Garau, A. Bonati, C. Almici, G. Sammarelli, B. Savoldo, M.T. Rizzo, et al. 1996. Selection of myeloid progenitors lacking BCR/ABL mRNA in chronic myelogenous leukemia patients after in vitro treatment with the tyrosine kinase inhibitor genistein. Blood 88:3091-3100.
6. Roger, R., C. Issaad, M. Pallardy, M.C. Leglise, A.G. Turhan, J. Bertoglio, and J. Breard. 1996. BCR-ABL does not prevent apoptotic cell death induced by human natural killer cells or lymphokine-activated killer cells. Blood. 87:1113-1122.
7. Bedi, A., B.A. Zehnbauer, J.P. Baeber, S.J. Sharkis, and R.J. Jones. 1994. Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood. 83: 2038-2044.
8. Fernandez, R.S., A.M. Gorman, A. McGahon, M. Lawlor, S. McCann, and T.G. Cotter. 1996. The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia. Leukemia. 10(Suppl 2):17-21.
9. Talpaz, M., K. McCredie, H. Kantajian, J. Trujillo, M. Keating, and J. Gutterman. 1986. Chronic myelogenous leukaemia: haematological remissions with alpha interferon. Br. J. Haematol. 64:87-95.
10. Dowding, C., A.-P. Guo, D. Maisin, M.Y. Gordon, and J.M. Goldman. 1991. The effects of interferon-α on the proliferation of CML progenitor cells in vitro are not related to the precise position of the M-BCR breakpoint. Br. J. Haematol. 77:165-171.
11. Galvani, D., and J.C. Cawley. 1989. Mechanism of action of α interferon in chronic granulocytic leukaemia: evidence for preferential inhibition of late progenitors. Br. J. Haematol. 73:475-479.
12. Olidapu-Williams, C., I. Svet-Moldavaskaya, J. Vilcek, T. Ohnuma, and J. Holland. 1981. Inhibitory effects of human leukocyte and fibroblast interferons on normal and chronic myelogenous leukemic granulocytic progenitor cells. Oncology. 338:356-360.
13. Gordon, M.Y., C.R. Dowding, G.P. Riley, J.M. Goldman, and M.F. Greaves. 1986. Altered adhesive interactions with marrow stroma of haematopoietic cells in chronic myeloid leukaemia. Nature. 328:342-344.
14. Gordon, M.Y., J. Atkinson, D. Clarke, C.R. Dowding, J.M. Goldman, P.G. Grimsley, M. Siczkowski, and M.F. Greaves. 1991. Deficiency of a phosphatidylinositol-anchored cell adhesion molecule influences haemopoietic progenitor binding to marrow stroma in chronic myeloid leukaemia. Leukemia. 5:693-698.
15. Verfaillie, C.M., J.B. McCarthy, and P.B. McGlave. 1992. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV. J. Clin. Invest. 90:1232-1241.
16. Dowding, C., A.-P. Guo, J. Osterholz, M. Sicskowski, J. Goldman, and M. Gordon. 1991. Interferon-α overrides the deficient adhesion of chronic myeloid leukemia primitive progenitor cells to bone marrow stromal cells. Blood. 78:499-505.
17. Bhatia, R., E.A. Wayner, P.B. McGlave, and C.M. Verfaillie. 1994. Interferon-alpha restores normal adhesion of chronic myelogenous hematopoietic progenitors to bone marrow stroma by correcting impaired beta-1 integrin receptor function. J. Clin. Invest. 94:384-391.
18. Gordon, M.Y. 1994. Plastic-adherent cells in human bone marrow generate long-term hematopoiesis in vitro. Leukemia. 8:865-870.
19. Gordon, M.Y., J.L. Lewis, F.H. Grand, S.B. Marley, and J.M. Goldman. 1996. Phenotype and progeny of primitive adherent human hematopoietic progenitors. Leukemia. 10:1347-1351.
20. Grand, F.H., S.B. Marley, A. Chase, I. Titley, L. Healy, A. Spencer, A. Reiter, J.M. Goldman, and M.Y. Gordon. 1997. BCR/ABL-negative progenitors are enriched in the adherent fraction of CD34+ cells circulating in the blood of chronic phase chronic myeloid leukemia patients. Leukemia. 11:1486-1492.
21. Gordon, M.Y., J.L. Lewis, S.B. Marley, F.H. Grand, and J.M. Goldman. 1997. Stromal cells negatively regulate primitive haemopoietic cell activation via a phosphatidylinositol-anchored cell adhesion/signalling mechanism. Br. J. Hematol. 96:647-653.
22. Wooldridge, M.J.A. 1995. A study of the incubation period, or age of onset, of the transmissible spongiform encephalopathies/prion diseases. Ph.D. thesis. University of London. 259 pp.
23. Altman, D. 1990. Practical Statistics for Medical Research. Blackwell Scientific Publications, Oxford, UK. 433 pp.
24. BMDP Statistical Software Manual. Vol 1. University of California Press, Berkeley, CA. 135 pp.
25. Udomsakdi, C., C.J. Eaves, B. Swolin, D.S. Reid, M.J. Barnett, and A.C. Eaves. 1992. Rapid decline of chronic myeloid leukemic cells in long-term culture due to defect at the leukemic stem cell level. Proc. Natl. Acad. Sci. USA. 89:6192-6196.
26. Marley, S.B., J.L. Lewis, M.A. Scott, J.M. Goldman, and M.Y. Gordon. 1996. Evaluation of "discordant maturation" in chronic myeloid leukaemia using cultures of primitive progenitor cells and their production of clonogenic progeny. Br. J. Haematol. 95:299-305.
27. Talpaz, M., H. Kantarjian, K. McCredie, J. Trujillo, M. Keating, and J. Gutterman. 1986. Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia. N. Engl. J. Med. 314:1065-1069.
28. Grunfeld, C., D.P. Kotler, J.K. Shigenaga, W. Dorrier, A. Tiernay, J. Wang, R.N. Pierson, and K.R. Feingold. 1991. Circulating interferon-α levels and hypertriglyceridemia in the acquired immunodeficiency syndrome. Am. J. Med. 90:154-162.
29. Bernier, J., A. Reuter, Y. Vrindts-Gevaert, and P. Franchimont. 1984. Radioimmunoassay of leukocyte (alpha) interferon and its application to some clinical conditions. J. Nucl. Med. 25:765-772.
30. Sherwin, S.A., J.A. Knost, S. Fein, P.G. Abrams, K.A. Foon, J.J. Ochs, C. Schoenberger, A.E. Maluish, and R.K. Oldham. 1982. A multiple-dose phase I trial of recombinant leukocyte A interferon in cancer patients. JAMA. 248: 2461-2466.
31. Corssmit, E.P.M., R. Heijligenberg, C.E. Hack, E. Endert, H.P. Sauerwein, and J.A. Romijn. 1997. Effects of interferon-alpha (IFN-α) administration in healthy humans. Clin. Exp. Immunol. 107:359-363.
32. Eaves, C.J., and A.C. Eaves. 1997. Stem cell kinetics. Baillieres Clin. Haematol. 10:233-257.