Analogues of WAY 100635 as radiotracers for in vivo imaging of 5-HT(1A) receptors

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 42, Issue 7, 1999, Pages 611-620

  Wilson, Alan A ^a   Garcia, Armando ^a   Li, Jin ^a   DaSilva, Jean N ^a,b   Houle, Sylvain ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

5 HT(1A); Carbon 11; Positron emission tomography; WAY 100635

Indexed keywords

CARBON;

5-HT(1A); ALKOXIDE PRECURSOR; BRAIN UPTAKE; C-ALKYLATION; CARBON-11; HIGH SPECIFIC ACTIVITIES; IN-VIVO IMAGING; IODOMETHANE; SYNTHESISED; WAY 100635;

POSITRON EMISSION TOMOGRAPHY;

CARBON 11; DRUG ANALOG; METHYL IODIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR; TRACER;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; DIASTEREOISOMER; DRUG DISTRIBUTION; DRUG SYNTHESIS; HIPPOCAMPUS; NONHUMAN; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALIA;

EID: 0032793091     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199907)42:7<611::AID-JLCR221>3.0.CO;2-L     Document Type: Article

References (31)

1. Fletcher A., Cliffe I.A., and Dourish C.T. -Trends Pharmacol. Sci. 14: 441 (1993).
2. Hashimoto T., Nishino N., Nakai H., and Tanaka C. -Life Sci. 48: 355 (1991).
3. 1A receptors in depression and anxiety; S. M. Stahl, M. Gasper, J. M. Keppel Hesselink and J. Traber, Ed.; Raven Press: New York, 1992; pp 35.
4. Forster E.A., Cliffe I.A., Bill D.J., Dover G.M., Jones D., Reilly Y., and Fletcher A. -Eur. J. Pharmacol. 281: 81 (1995).
5. Gozlan H., Thibault S., Laporte A.-M., Lima L., and Hamon M. -Eur. J. Pharmacol. 288: 173 (1995).
6. Mathis C.A., Simpson N.R., Mahmood K., Kinahan P.E., and Mintun M.A. -Life Sci. 55: 403 (1994).
7. Pike V.W., McCarron J.A., Lammerstma A.A., Hume S.P., Poole K., Grasby P.M., Malizia A., Cliffe I.A., Fletcher A., and Bench C. -Eur J Pharmacol 283: R1 (1995).
8. Houle S., DaSilva J.N., and Wilson A.A. -Canadian Assoc. Nucl. Med. Scientific Meeting, Quebec City P37 (1996).
9. Osman S., Lundkvist C., Pike V.W., Halldin C., McCarron J.A., Swahn C.G., Ginovart N., Luthra S.K., Bench C.J., Grasby P.M., Wikstrom H., Barf T., Cliffe I.A., Fletcher A., and Farde L. -Nucl. Med. Biol. 23: 627 (1996).
10. Pike V.W., McCarron J.A., Lammertsma A.A., Osman S., Hume S.P., Sargent P.A., Bench C.J., Cliffe I.A., Fletcher A., and Grasby P.M. -Eur J Pharmacol 301: R5 (1996).
11. McCarron J.A., Turton D.R., Pike V.W., and Poole K.G. -J Labelled Compds. Radiopharm. 38: 941 (1996).
12. Zhuang Z.P., Kung M.-P., and Kung H.F. -J. Med. Chem. 37: 1406 (1994).
13. Wilson A.A., Inaba T., Fischer N., Dixon L., Nobrega J., DaSilva J.N., and Houle S. -Nucl. Med. Biol 25: 769 (1998).
14. Kung H.F., Stevenson A., Zhuang Z.P., Kung M.P., Frederick D., and Hurt S.D. -Synapse 23: 344 (1996).
15. Shiue C.Y., Shiue G.G., Mozley P.D., Kung M.P., Zhuang Z.P., Kim H.J., and Kung H.F. -Synapse 25: 147 (1997).
16. Zhuang Z.P., Kung M.P., Mu M., and Kung H.F. -J Med Chem 41: 157 (1998).
17. Le Bars D., Lemaire C., Ginovart N., Plenevaux A., Aerts J., Brihaye C., Hassoun W., Leviel V., Mekhsian P., Weissmann D., Pujol J.F., Luxen A., and Comar D. -Nucl Med Biol 25: 343 (1998).
18. Groutas W.C., and Felker D. -Synthesis 861 (1980).
19. 1A Receptors - Behavioural and Neurochemical Pharmacology; C. T. Dourish, S. Ahlenius and P. H. Hutson, Ed.; Ellis Horwood: Chichester, 1987; pp 67.
20. th International Symposium on Radiopharmaceutical Chemistry, Vancouver, B.C. Canada, August 13-17, 292 (1995).
21. Mokrosz J.L., Paluchowska M.H., Klodzinska A., Charakchievaminol S., and Chojnackawojcik E. -Arch Pharm 328: 770 (1995).
22. Zhuang Z.-P., Kung M.-P., Chumpradit S., Mu M., and Kung H.F. -J. Med. Chem. 37: 4572 (1994).
23. Details of the multiplet pattern analysis of the 1HNMR spectra of 3/4 and 5/6 are available from the authors.
24. Winstein S., and Holness N.J. -J. Amer. Chem. Soc. 77: 5562 (1955).
25. Pretch E., Seibel J., Simon W., and Clerc T. (1989).
26. Hume S.P., Ashworth S., Opacka-Juffry J., Ahier R.G., Lammertsma A.A., Pike V.W., Cliffe I.A., Fletcher A., and White A.C. -Eur. J. Pharmacol. 271: 515 (1994).
27. Mathis C.A., Huang Y., and Simpson N.R. -J. Label. Compound Radiopharm. 40: 563 (1997).
28. Parsey R.V., Hwang D., Simpson N., Kegeles L., Anjilvel Y., Zea-Ponce Y., Lombardo I., Popilskis S., Van Heertum R., Mann J.J., and Laruelle M. -Neuroimage Z: A10 (1998).
29. Dewey S.L., Smith G.S., Logan J., Brodie J.D., Simkowitz P., Macgregor R.R., Fowler J.S., Volkow N.D., and Wolf A.P. -Proc Natl Acad Sci Usa 90: 11816 (1993).
30. Wilson A.A., DaSilva J.N., and Houle S. -J. Labelled Compd. Radiopharm. 34: 759 (1994).
31. Wilson A.A., DaSilva J.N., and Houle S. -Nucl. Med. Biol. 23: 141 (1996).