Suppression of developmental retinal cell death but not of photoreceptor degeneration in bax -deficient mice

Investigative Ophthalmology and Visual Science

Volumn 39, Issue 9, 1998, Pages 1713-1720

  Ogilvie, Judith Mosinger ^a,b   Deckwerth, Thomas L ^a   Michael Knudson, C ^a   Korsmeyer, Stanley J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTRAL INSTITUTE FOR THE DEAF   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA DEGENERATION; RETINA GANGLION CELL;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; CELL SURVIVAL; DNA DAMAGE; DNA FRAGMENTATION; FEMALE; GENE DELETION; MALE; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; NEURONS; OPTIC NERVE; PHOTORECEPTORS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RETINA; RETINAL DEGENERATION; RETINAL GANGLION CELLS;

EID: 0031828871     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Oppenheim RW. Cell death during development of the nervous system. Annit Rev Neurosci. 1991;14:453-501.
2. Hume DA, Perry VH, Gordon S. Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. J Cell Biol. 1983;97:253-257.
3. Young RW. Cell death during differentiation of the retina in the mouse, y Comp Neural. 1984;229:362-373.
4. Chang G-Q, Hao Y, Wong F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Nenron. 1993;11:595-605.
5. Lolley RN, Rong II, Craft CM. Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction. Invest Ophthalmol Vis Sci. 1994;35:358-362.
6. Portera-Cailliau C, Sung CH, Nathans J, Adler R. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci USA. 1994;91:974-978.
7. Korsmeyer SJ. Regulators of cell death. Treuils Genet. 1995;11:101-105.
8. Reed JC. Double identity for proteins of the Bcl-2 family. Nature. 1997;387:773-776.
9. Garcia I, Martinou I, Tsujimoto Y, Martinou JC. Prevention of programmed cell death of sympathetic neurons by the bcl-2 protooncogene. Science. 1992;258:302-304.
10. Martinou JC, Dubois-Dauphin M, Staple JK, et al. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron. 1994;13:1017-1030.
11. Greenlund LJ, Korsmeyer SJ, Johnson EM Jr. Role of BCL-2 in the survival and function of developing and mature sympathetic neurons. Neuron. 1995;15:649-661.
12. Deckwerth TL, Elliott JL, Knudson CM, et'al. BAX is required for neuronal death after trophic factor deprivation and during development. Neuron. 1996;17:401-411.
13. Michaelidis TM, Sendtner M, Cooper JD, et al. Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron. 1996;17:75-89.
14. Miller TM, Moulder KL, Knudson CM, et al. BAX deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol. 1997;139:205-217.
15. Tanabe H, Eguchi Y, Kamada S, Martinou JC, Tsujimoto Y. Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death. Eur J Neurosci. 1997;9:848856.
16. Vekrellis K, McCarthy MJ, Watson A, et al. Bax promotes neuronal cell death and is downregulated during the development of the nervous system. Development. 1997;124:1239-1249.
17. Bonfanti L, Strettoi E, Chierzi S, et al. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J Neurosci. 1996; 16:4186-4194.
18. Cenni MC, Bonfanti L, Martinou JC, et al. Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice. Enr J Neurosci. 1996;8:1735-1745.
19. Porciatti V, Pizzorusso T, Cenni MC, Maffei L. The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2. Proc Natl Acad Sci USA. 1996;93:14955-14959.
20. Chen J, Plannery JG, LaVail MM, et al. Bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proc Natl Acad Sci USA. 1996;93:7042-7047.
21. tml mice by an apoptosis suppressor gene. Invest Opbtbahnol Vis Sci. 1997;38:943-950.
22. L transgenes and photoreceptor degeneration. Invest Ophthalmol Vis Sci. 1996;37: 2434-2446.
23. Gavrieli Y, Sherman Y, Ben-Sasson S. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
24. Williams RW, Strom RC, Rice DS, Goldowitz D. Genetic and environmental control of variation in retinal ganglion cell number in mice. J Neurosci. 1996;16:7193-7205.
25. Farber DB, Plannery JG, Bowes-Rickman C. The rd mouse story: seventy years of research on an animal model of inherited retinal degeneration. Pros Retinal Eye Res. 1994;13:31-64.
26. Potts RA, Dreher B, Bennett MR. The loss of ganglion cells in the developing retina of the rat. Brain Res. 1982;255:481-486.
27. Johnson JE, Barde YA, Schwab M, Thoenen H. Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells. J Neurosci. 1986;6:3031-3038.
28. Cui Q, Harvey AR. NT-4/5 reduces naturally occurring retinal ganglion cell death in neonatal rats. Netiroreport. 1994;5:1882-1884.
29. Meycr-Franke A, Kaplan MR, Pfrieger FW, Barres BA. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron. 1995;15:805-819.
30. O'Leary DDM, Crespo D, Fawcett JW, Cowan WM. The effect of intraocular tetrodotoxin on the postnatal reduction in the numbers of optic nerve axons in the rat. Brain Res. 1986:395:96-103.
31. Bunch ST, Fawcett JW. NMDA receptor blockade alters the topography of naturally occurring ganglion cell death in the rat retina. Dev Biol. 1993;160:434-442.
32. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993;74:609-619.
33. Knudson CM, Korsmeyer SJ. Bcl-2 and Bax function independently to regulate cell death. Nat Genet. 1997;16:358-363.
34. Jensen RJ. Receptive-field properties of displaced starburst amacrine cells change following axotomy-induced degeneration of ganglion cells. Vis Neurosci. 1995;12:177-184.
35. Hollander H, Bisti S, Maffei L, Hebel R. Electroretinographic responses and retrograde changes of retinal morphology after intracranial optic nerve section. A quantitative analysis in the cat. Exp Brain Res. 1984;55:483-493.
36. Jelsma TN, Friedman HH, Berkelaar M, Bray GM, Aguayo AJ. Different forms of the neurotrophin receptor trkB mRNA predominate in rat retina and optic nerve. J Neurobiol. 1993:24:1207-1214.
37. Perez M-TR, Caminos E. Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina. Neurosci Lett. 1995;183:96-99.
38. Rickman DW, Bredia NC. Expression of the protooncogene, trk, receptors in the developing rat retina. Vis Neurosci. 1995;12:215-222.
39. Ugolini G, Cremisi F, Maffei L. TrkA, TrkB, and p75 mRNA expression is developmentally regulated in the rat retina. Brain Res. 1995;704:121-124.
40. B expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina. Proc Natl Acad Sci USA. 1996;93:12564-12569.
41. McLaughlin ME, Ehrhart TL, Berson EL, Dryja TP. Mutation spectrum of the gene encoding the β-subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa. Proc Natl Acad Sci USA. 1995;92:3249-3253.
42. Bowes C, Li T, Danciger M, et al. Retinal degeneration in the rd mouse is caused by a defect in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase. Nature. 1990;347:677-680.
43. Pittler SJ, Baehr W. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase rd mouse. Proc Natl Acad Sci USA. 1991;88:8322-8326.
44. Lern J, Plannery JG, Li T, et al. Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase β subunit. Proc Natl Acad Sci USA. 1992;89:4422-4426.
45. Carter-Dawson LD, LaVail MM, Sidman RL. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophtbalmol Vis Sci. 1978;17:489-498.
46. Cayouette M, Gravel C. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther. 1997;8:423-430.