Autoantibodies associated with peripheral neuropathy

Muscle and Nerve

Volumn 22, Issue 7, 1999, Pages 800-822

  Quarles, Richard H ^a   Weiss, Michael D ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Antibody; Ganglioside; Glycolipid; Myelin associated glycoprotein; Neuropathy

Indexed keywords

AUTOANTIBODY; CELL PROTEIN; GANGLIOSIDE; GLYCOLIPID; MYELIN ASSOCIATED GLYCOPROTEIN;

ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; HUMAN; MONOCLONAL IMMUNOGLOBULINEMIA; NERVE BIOPSY; PARANEOPLASTIC SYNDROME; PATHOGENESIS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; REVIEW; SENSORY NEUROPATHY; SUBCLAVIAN STEAL SYNDROME;

ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; AUTOANTIBODIES; CARBOHYDRATE SEQUENCE; HUMANS; MOLECULAR SEQUENCE DATA; PARAPROTEINEMIAS; PERIPHERAL NERVOUS SYSTEM DISEASES; POLYNEUROPATHIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032778964     PISSN: 0148639X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4598(199907)22:7<800::AID-MUS2>3.0.CO;2-F     Document Type: Review

References (197)

1. Antoine JC, Mosnier JF, Lapras J, Convers P, Absi L, Laurent B, Michel D. Chronic inflammatory demyelinating polyneuropathy associated with carcinoma. J Neurol Neurosurg Psychiatry 1996;60:188-190.
2. Arasaki K, Kusunoki S, Kudo N, Kanazawa I. Acute conduction block in vitro following exposure to antiganglioside sera. Muscle Nerve 1993;16:587-593.
3. Ariga T, Kohriyama T, Freddo L, Latov N, Saito M, Kon K, Ando S, Suzuki M, Hemling ME, Rinehart KL Jr, et al. Characterization of sulfated glucuronic acid containing glycolipids reacting with IgM M-proteins in patients with neuropathy. J Biol Chem 1987;262:848-853.
4. Aspinall GO, McDonald AG, Pang H, Kurjanczyk LA, Penner JL. Lipopolysaccharides of Campylobacter jejuni serotype O:19: structures of core oligosaccharide regions from the serostrain and two bacterial isolates from patients with the Guillain-Barre syndrome. Biochemistry 1994;33:241-249.
5. Ayadi H, Mihaesco E, Congy N, Roy JP, Gendron MC, Laperriere J, Prelli F, Frangione B, Brouet JC. H chain V region sequences of three human monoclonal IgM with anti-myelin-associated glycoprotein activity. J Immunol 1992;148: 2812-2816.
6. Baba H, Daune GC, Ilyas AA, Pestronk A, Cornblath DR, Chaudhry V, Griffin JW, Quarles RH. Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy. J Neuroimmunol 1989;25: 143-150.
7. Bird SJ, Brown MJ, Shy ME, Scherer SS. Chronic inflammatory demyelinating polyneuropathy associated with malignant melanoma. Neurology 1996;46:822-824.
8. Bollensen E, Schachner M. The peripheral myelin glycoprotein P0 expresses the L2/HNK-1 and L3 carbohydrate structures shared by neural adhesion molecules. Neurosci Lett 1987;82:77-82.
9. Briani C, Berger JS, Latov N. Antibodies to chondroitin sulfate C: a new detection assay and correlations with neurological diseases. J Neuroimmunol 1998;84:117-121.
10. Brouet JC, Mariette X, Gendron MC, Dubreuil ML. Monoclonal IgM from patients with peripheral demyelinating neuropathies cross-react with bacterial polypeptides. Clin Exp Immunol 1994;96:466-469.
11. Buchwald B, Toyka KV, Zielasek J, Weishaupt A, Schweiger S, Dudel J. Neuromuscular blockade by immunoglobulin G from patients with Guillain-Barré syndrome: a macro-patch-clamp study. Ann Neurol 1998;44:913-920.
12. Burger D, Perruisseau G, Simon M, Steck AJ. Comparison of the N-linked oligosaccharide structures of the two major human myelin glycoproteins MAG and P0: assessment of the structures bearing the epitope for HNK-1 and human monoclonal immunoglobulin M found in demyelinating neuropathy. J Neurochem 1992;58:854-861.
13. Cavanna B, Carpo M, R. P, Scarpini E, Meucci N, Allaria S, Scarlato G, Nobile-Orazio E. Anti-GM2 antibodies: clinical correlates and reactivity with a human neuroblastoma cell line. J Neuroimmunol 1999;94:157-154.
14. Chassande B, LegerJM, Younes-Chennoufi AB, Bengoufa D, Maisonobe T, Bouche P, Baumann N. Peripheral neuropathy associated with IgM monoclonal gammopathy: correlations between M-protein antibody activity and clinical/ electrophysiological features in 40 cases. Muscle Nerve 1998; 21:55-62.
15. Chiba A, Kusunoki S, Obata H, Machinami R, Kanazawa I. Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain-Barre syndrome: clinical and immunohistochemical studies. Neurology 1993;43:1911-1917.
16. Chiba A, Kusunoki S, Obata H, Machinami R, Kanazawa I. Ganglioside composition of the human cranial nerves, with special reference to pathophysiology of Miller Fisher syndrome. Brain Res 1997;745:32-36.
17. Chou DK, Ilyas AA, Evans JE, Costello C, Quarles RH, Jungalwala FB. Structure of sulfated glucuronyl glycolipids in the nervous system reacting with HNK-1 antibody and some IgM paraproteins in neuropathy. J Biol Chem 1986;261: 11717-1125.
18. Connolly AM, Pestronk A. Anti-tubulin autoantibodies in acquired demyelinating polyneuropathies. J Infect Dis 1997;176(suppl 2):S157-S159.
19. Connolly AM, Pestronk A, Mehta S, Yee WC, Green BJ, Fellin C, Olney RK, Miller RG, Devor WN. Serum IgM monoclonal autoantibody binding to the 301 to 314 amino acid epitope of beta-tubulin: clinical association with slowly progressive demyelinating polyneuropathy. Neurology 1997;48:243-248.
20. Connolly AM, Pestronk A, Trotter JL, Feldman EL, Cornblath DR, Olney RK. High-titer selective serum anti-beta-tubulin antibodies in chronic inflammatory demyelinating polyneuropathy. Neurology 1993;43:557-562.
21. Corbo M, Quattrini A, Latov N, Hays AP. Localization of GM1 and Gal(beta 1-3)GalNAc antigenic determinants in peripheral nerve. Neurology 1993;43:809-814.
22. Corbo M, Quattrini A, Lugaresi A, Santoro M, Latov N, Hays AP. Patterns of reactivity of human anti-GM1 antibodies with spinal cord and motor neurons. Ann Neurol 1992;32: 487-493.
23. Dalakas M. Basic aspects of neuroimmunology as they relate to immunotherapeutic targets: present and future prospects. Ann Neurol 1995;37(suppl 1):S2-S13.
24. Dalakas M. Mechanism of action of intravenous immunoglobulin and therapeutic considerations in the treatment of autimmune neruologic diseases. Neurology 1998;51(suppl 5):S2-S8.
25. Dalakas M, Quarles R, Farrer R, Dambrosia J, Soueidan S, Stein D, Cupler E, Sekul E, Otero C. A controlled study of intravenous immunoglobulin in demyelinating neuropathy. Ann Neurol 1996;40:792-795.
26. Dalakas MC, Quarles RH. Autoimmune ataxic neuropathies (sensory ganglionopathies): are glycolipids the responsible autoantigens? [editorial]. Ann Neurol 1996;39:419-422.
27. Dalmau J, Furneaux HM, Gralla RJ, Kris MG, Posner JB. Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer - a quantitative western blot analysis. Ann Neurol 1990;27:544-552.
28. Dalmau J, Graus F, Rosenblum MK, Posner JB. Anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients. Medicine (Baltimore) 1992;71:59-72.
29. Darnell RB, DeAngelis LM. Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies. Lancet 1993;341:21-22.
30. Daune GC, Farrer RG, Dalakas MC, Quarles RH. Sensory neuropathy associated with monoclonal immunoglobulin M to GD1b ganglioside. Ann Neurol 1992;31:683-685.
31. Dellagi K, Brouet JC, Perreau J, Paulin D. Human monoclonal IgM with autoantibody activity against intermediate filaments. Proc Natl Acad Sci USA 1982;79:446-450.
32. Denny-Brown D. Primary sensory neuropathy with muscular changes associated with carcinoma. J Neurol Neurosurg Psychiatry 1948;11:73-81.
33. Dick DJ, Harris JB, Falkous G, Foster JB, Xuereb JH. Neuronal anti-nuclear antibody in paraneoplastic sensory neuronopathy. J Neurol Sci 1988;85:1-8.
34. Dyck PJ, Low PA, Windebank AJ, Jaradeh SS, Gosselin S, Bourque P, Smith BE, Kratz KM, Karnes JL, Evans BA, et al. Plasma exchange in polyneuropathy associated with monoclonal gammopathy of undetermined significance. N Engl J Med 1991;325:1482-1486.
35. Fabian RH. Uptake of plasma IgG by CNS motoneurons: comparison of antineuronal and normal IgG. Neurology 1988;38:1775-1780.
36. Fabian RH. Uptake of antineuronal IgM by CNS neurons: comparison with antineuronal IgG. Neurology 1990;40: 419-422.
37. Ferrari S, Morbin M, Nobile-Orazio E, Musso A, Tomelleri G, Bertolasi L, Rizzuto N, Monaco S. Antisulfatide polyneuropathy: antibody-mediated complement attack on peripheral myelin. Acta Neuropathol (Berl) 1998;96:569-574.
38. Field MC, Wing DR, Dwek RA, Rademacher TW, Schmitz B, Bollensen E, Schachner M. Detection of multisulphated N-linked glycans in the L2/HNK-1 carbohydrate epitope expressing neural adhesion molecule P0. J Neurochem 1992; 58:993-1000.
39. Filbin MT. The muddle with MAG. Mol Cell Neurosci 1996; 8:84-92.
40. Fruttiger M, Montag D, Schachner M, Martini R. Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur J Neurosci 1995;7:511-515.
41. Fuller G, Spies J, Pollard J, McLeod J. Demyelinating neuropathy triggered by melanoma immunotherapy. Neurology 1994;44:2404-2405.
42. Furneaux HF, Reich L, Posner JB. Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes. Neurology 1990;40:1085-1091.
43. Gabriel CM, Hughes RA, Moore SE, Smith KJ, Walsh FS. Induction of experimental autoimmune neuritis with peripheral myelin protein-22. Brain 1998;121:1895-1902.
44. Gabriel JM, Erne B, Bernasconi L, Tosi C, Probst A, Landmann L, Steck AJ. Confocal microscopic localization of anti-myelin-associated glycoprotein autoantibodies in a patient with peripheral neuropathy initially lacking a detectable IgM gammopathy. Acta Neuropathol (Berl) 1998;95:540-546.
45. Gabriel JM, Erne B, Miescher GC, Miller SL, Vital A, Vital C, Steck AJ. Selective loss of myelin-associated glycoprotein from myelin correlates with anti-MAG antibody titre in demyelinating paraproteinaemic polyneuropathy. Brain 1996; 119:775-787.
46. Giese KP, Martini R, Lemke G, Soriano P, Schachner M. Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell 1992;71:565-576.
47. Graus F, Cordon-Cardo C, Posner JB. Neuronal antinuclear antibody in sensory neuronopathy from lung cancer. Neurology 1985;35:538-543.
48. Graus F, Dalmou J, Rene R, Tora M, Malats N, Verschuuren JJ, Cardenal F, Vinolas N, Garcia del Muro J, Vadell C, Mason WP, Rosell R, Posner JB, Real FX. Anti-Hu antibodies in patients with small-cell lung cancer: association with complete response to therapy and improved survival. J Clin Oncol 1997;15:2866-2872.
49. Graus F, Elkon KB, Cordon-Cardo C, Posner JB. Sensory neuronopathy and small cell lung cancer. Antineuronal antibody that also reacts with the tumor. Am J Med 1986;80: 45-52.
50. Graus F, Ribalta T, Campo E, Monforte R, Urbano A, Rozman C. Immunohistochemical analysis of the immune reaction in the nervous system in paraneoplastic encephalomyelitis. Neurology 1990;40:219-222.
51. Greenlee JE, Parks TN, Jaeckle KA. Type IIa ('anti-Hu') antineuronal antibodies produce destruction of rat cerebellar granule neurons in vitro. Neurology 1993;43:2049-2054.
52. Griffin JW, Cornblath DR, Alexander E, CampbellJ, Low PA, Bird S, Feldman EL. Ataxic sensory neuropathy and dorsal root ganglionitis associated with Sjogren's syndrome. Ann Neurol 1990;27:304-315.
53. Griffin JW, Li CY, Ho TW, Xue P, Macko C, Gao CY, Yang C, Tian M, Mishu B, Cornblath DR, et al. Guillain-Barre syndrome in northern China. The spectrum of neuropathological changes in clinically defined cases. Brain 1995;118: 577-595.
54. Hahn A. Treatment of chronic inflammatory demyelinating polyneuropathy with intravenous immunoglobulin. Neurology 1998;51(suppl 5):S16-S21.
55. Hakomori S, Yamamura S, Handa AK. Signal transduction through glycosphingolipids. Introduction and recent studies on glycosphingolipid-enriched microdomains. Ann NY Acad Sci 1998;845:1-10.
56. Hammer JA, O'Shannessy DJ, De LM, Gould R, Zand D, Daune G, Quarles RH. Immunoreactivity of PMP-22, P0, and other 19 to 28 kDa glycoproteins in peripheral nerve myelin of mammals and fish with HNK1 and related antibodies. J Neurosci Res 1993;35:546-558.
57. Harvey GK, Toyka KV, Zielasek J, Kiefer R, Simonis C, Hartung HP. Failure of anti-GM1 IgG or IgM to induce conduction block following intraneural transfer. Muscle Nerve 1995;18:388-394.
58. Hays AP, Latov N, Takatsu M, Sherman WH. Experimental demyelination of nerve induced by serum of patients with neuropathy and an anti-MAG IgM M-protein. Neurology 1987;37:242-256.
59. Hays AP, Lee SS, Latov N. Immune reactive C3d on the surface of myelin sheaths in neuropathy. J Neuroimmunol 1988;18:231-244.
60. Heiman-Patterson T, Krupa T, Thompson P, Nobile-Orazio E, Tahmoush AJ, Shy ME. Anti-GM1/GD1b M-proteins damage human spinal cord neurons co-cultured with muscle. J Neurol Sci 1993;120:38-45.
61. Hirota N, Kaji R, Bostock H, Shindo K, Kawasaki T, Mizutani K, Oka N, Kohara N, Saida T, Kimura J. The physiological effect of anti-GM1 antibodies on saltatory conduction and transmembrane currents in single motor axons. Brain 1997; 120:2159-2169.
62. Ho TW, McKhann GM, Griffin JW. Human autoimmune neuropathies. Annu Rev Neurosci 1998;21:187-226.
63. Ho TW, Mishu B, Li CV, Gao CY, Cornblath DR, Griffin JW, Asbury AK, Blaser MJ, McKhann GM. Guillain-Barre syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies. Brain 1995;118: 597-605.
64. Hormigo A, Lieberman F. Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity. J Neuroimmunol 1994;55:205-212.
65. Ichimura M, Yamamoto M, Kobayashi Y, Kawakami O, Niimi Y, Hattori N, Nagamatsu M, Hashizume Y, Sobue G. Tissue distribution of pathological lesions and Hu antigen expression in paraneoplastic sensory neuronopathy. Acta Neuropathol (Berl) 1998;95:641-648.
66. Ilyas AA, Chou DK, Jungalwala FB, Costello C, Quarles RH. Variability in the structural requirements for binding of human monoclonal anti-myelin-associated glycoprotein immunoglobulin M antibodies and HNK-1 to sphingoglycolipid antigens. J Neurochem 1990;55:594-601.
67. Ilyas AA, Cook SD, Dalakas MC, Mithen FA. Anti-MAG IgM paraproteins from some patients with polyneuropathy associated with IgM paraproteinemia also react with sulfatide. J Neuroimmunol 1992;37:85-92.
68. Ilyas AA, Li SC, Chou DK, Li YT, Jungalwala FB, Dalakas MC, Quarles RH. Gangliosides GM2, IV4GalNAcGM1b, and IV4GalNAcGC1a as antigens for monoclonal immunoglobulin M in neuropathy associated with gammopathy. J Biol Chem 1988;263:4369-4373.
69. Ilyas AA, Mithen FA, Dalakas MC, Chen ZW, Cook SD. Antibodies to acidic glycolipids in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy. J Neurol Sci 1992;107:111-121.
70. Ilyas AA, Quarles RH, Dalakas MC, Brady RO. Polyneuropathy with monoclonal gammopathy: glycolipids are frequently antigens for IgM paraproteins. Proc Natl Acad Sci USA 1985;82:6697-6700.
71. Ilyas AA, Quarles RH, Dalakas MC, Fishman PH, Brady RO. Monoclonal IgM in a patient with paraproteinemic polyneuropathy binds to gangliosides containing disialosyl groups. Ann Neurol 1985;18:655-659.
72. Ilyas AA, Willison HJ, Dalakas MC, Whitaker JN, Quarles RH. Identification and characterization of gangliosides reacting with IgM paraproteins in three patients with neuropathy associated with biclonal gammopathy. J Neurochem 1988;51: 851-858.
73. Irie S, Saito T, Nakamura K, Kanazawa N, Ogino M, Nukazawa T, Ito H, Tamai Y, Kowa H. Association of anti-GM2 antibodies in Guillain-Barre syndrome with acute cytomegalovirus infection. J Neuroimmunol 1996;68:19-26.
74. Jacobs BC, van Doom PA, Groeneveld JH, Tio-Gillen AP, van der Meche FG. Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barre syndrome. J Neurol Neurosurg Psychiatry 1997;62:641-643.
75. Jacobs D, van Doom P, Schmitz P, Tio-Gillen A, Herbrink P, LH Visse L, van der Meche F. Campylobacter jejuni infections and anti-GM1 antibodies in Guillain-Barre syndrome. Ann Neurol 1996;40:181-187.
76. Jungalwala FB. Expression and biological functions of sulfoglucuronyl glycolipids (SGGLs) in the nervous system - a review. Neurochem Res 1994;19:945-957.
77. Kahn SN, Stanton NL, Sumner AJ, Brown MJ, Spitalnik SL, Morein B. Analysis of the feline immune response to human myelin-associated glycoprotein. J Neurol Sci 1989;89: 141-148.
78. Kanda T, Yoshino H, Ariga T, Yamawaki M, Yu RK. Glycosphingolipid antigens in cultured bovine brain microvascular endothelial cells: sulfoglucuronosyl paragloboside as a target of monoclonal IgM in demyelinative neuropathy. J Cell Biol 1994;126:235-246.
79. Keilhauer G, Faissner A, Schachner M. Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies. Nature 1985;316:728-730.
80. Kelm S, Pelz A, Schauer R, Filbin MT, Tang S, de Bellard ME, Schnaar RL, Mahoney JA, Hartnell A, Bradfield P, et al. Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily. Curr Biol 1994; 4:965-972.
81. Kirkpatrick LL, Brady ST. Cytoskeleton of neurons and glia. In: Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD, editors. Basic neurochemistry: molecular cellular and medical aspects, 6th ed. Philadelphia: Lippincott-Raven; 1999.
82. Koehler NK, Martin R, Wietholter H. The antibody repertoire in experimental allergic neuritis: evidence for PMP-22 as a novel neuritogen. J Neuroimmunol 1996;71:179-189.
83. Kohriyama T, Kusunoki S, Ariga T, Yoshino JE, DeVries GH, Latov N, Yu RK. Subcellular localization of sulfated glucuronic acid-containing glycolipids reacting with anti-myelin-associated glycoprotein antibody. J Neurochem 1987;48: 1516-1522.
84. Kornberg A, Pestronk A. Chronic motor neuropathies: diagnosis, therapy and pathogenesis. Ann Neurol 1995; 37(suppl):S43-S50.
85. Kruse J, Mailhammer R, Wernecke H, Faissner A, Sommer I, Goridis C, Schachner M. Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1. Nature 1984;311:153-155.
86. Kusunoki S, Chiba A, Kon K, Ando S, Arisawa K, Tate A, Kanazawa I. N-acetylgalactosaminyl GD1a is a target molecule for serum antibody in Guillain-Barre syndrome. Ann Neurol 1994;35:570-576.
87. Kusunoki S, Chiba A, Tai T, Kanazawa I. Localization of GM1 and GD1b antigens in the human peripheral nervous system. Muscle Nerve 1993;16:752-756.
88. Kusunoki S, Mashiko H, Mochizuki N, Chiba A, Arita M, Hitoshi S, Kanazawa I. Binding of antibodies against GM1 and GD1b in human peripheral nerve. Muscle Nerve 1997; 20:840-845.
89. Kusunoki S, Shimizu J, Chiba A, Ugawa Y, Hitoshi S, Kanazawa I. Experimental sensory neuropathy induced by sensitization with ganglioside GD1b. Ann Neurol 1996;39: 424-431.
90. Kuwabara S, Yuki N, Koga M, Hattori T, Matsuura D, Miyake M, Noda M. IgG anti-GM1 antibody is associated with reversible conduction failure and axonal degeneration in Guillain-Barre syndrome. Ann Neurol 1998;44:202-208.
91. Latov N. Antibodies to glycoconjugates in neuropathy and motor neuron disease. Prog Brain Res 1994;101:295-303.
92. Latov N. Pathogenesis and therapy of neuropathies associated with monclonal gammopathies. Ann Neurol 1995;37: S32-S42.
93. Ledeen RW, Wu G, Lu ZH, Kozireski-Chuback D, Fang Y. The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding. Ann NY Acad Sci 1998; 845:161-175.
94. Lee G, Ware RR, Latov N. Somatically mutated member of the human V lambda VIII gene family encodes anti-myelin-associated glycoprotein (MAG) activity. J Neuroimmunol 1994;51:45-52.
95. Li C, Tropak MB, Gerlai R, Clapoff S, Abramow NW, Trapp B, Peterson A, RoderJ. Myelination in the absence of myelin-associated glycoprotein. Nature 1994;369:747-750.
96. Li F, Pestronk A, Griffin J, Feldman EL, Cornblath D, Trotter J, Zhu S, Yee WC, Phillips D, Peeples DM, et al. Polyneuropathy syndromes associated with serum antibodies to sulfatide and myelin-associated glycoprotein. Neurology 1991;41: 357-362.
97. Lieberman F, Marton LS, Stefansson K. Pattern of reactivity of IgM from the sera of eight patients with IgM monoclonal gammopathy and neuropathy with components of neural tissues: evidence for interaction with more than one epitope. Acta Neuropathol (Berl) 1985;68:196-200.
98. Liu J, Dalmau J, Szabo A, Rosenfeld M, Huber J, Furneaux H. Paraneoplastic encephalomyelitis antigens bind to the AU-rich elements of mRNA. Neurology 1995;45:544-550.
99. Lopate G, Parks BJ, Goldstein JM, Yee WC, Friesenhahn GM, Pestronk A. Polyneuropathies associated with high titre antisulphatide antibodies: characteristics of patients with and without serum monoclonal proteins. J Neurol Neurosurg Psychiatry 1997;62:581-585.
100. Lopate G, Pestronk A, Kornberg AJ, Yue J, Choksi R. IgM anti-sulfatide autoantibodies: patterns of binding to cerebellum, dorsal root ganglion and peripheral nerve. J Neurol Sci 1997;151:189-193.
101. Low K Orberger G, Schmitz B, Martini R, Schachner M. The L2/HNK-1 carbohydrate is carried by the myelin associated glycoprotein and sulphated glucuronyl glycolipids in muscle but not cutaneous nerves of adult mice. Eur J Neurosci 1994; 6:1773-1781.
102. Manfredini E, Nobile-Orazio E, Allaria S, Scarlato G. Anti-alpha-and beta-tubulin IgM antibodies in dysimmune neuropathies. J Neurol Sci 1995;133:79-84.
103. Manley G, Wong E, Dalmau J, Elkon K, Posner J, Furneaux H. Sera from some patients with antibody-associated paraneoplastic encephalomyelitis/sensory neuronopathy recognize the Ro-52K antigen. J Neurooncol 1994;19:105-112.
104. Manley GT, Smitt PS, Dalmau J, Posner JB. Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites. Ann Neurol 1995;38:102-110.
105. Marcus DM, Latov N, Hsi BP, Gillard BK. Measurement and significance of antibodies against GM1 ganglioside. Report of a workshop, 18 April 1989, Chicago, IL, USA. J Neuroimmunol 1989;25:255-259.
106. Marusich MF, Furneaux HM, Henion PD, Weston JA. Hu neuronal proteins are expressed in proliferating neurogenic cells. J Neurobiol 1994;25:143-155.
107. McGinnis S, Kohriyama T, Yu RK, Pesce MA, Latov N. Antibodies to sulfated glucuronic acid containing glycosphingolipids in neuropathy associated with anti-MAG antibodies and in normal individuals. J Neuroimmunol 1988;17: 119-126.
108. Melendez-Vasquez C, Redford J, Choudhary PP, Gray IA, Maitland P, Gregson NA, Smith KJ, Hughes RA. Immunological investigation of chronic inflammatory demyelinating polyradiculoneuropathy. J Neuroimmunol 1997;73:124-134.
109. Mendell JR, Sahenk Z, Whitaker JN, Trapp BD, Yates AJ, Griggs RC, Quarles RH. Polyneuropathy and IgM monoclonal gammopathy: studies on the pathogenetic role of anti-myelin-associated glycoprotein antibody. Ann Neurol 1985; 17:243-254.
110. Mohan PS, Chou DK, Jungalwala FB. Sulfoglucuronyl glycolipids bind laminin. J Neurochem 1990;54:2024-2031.
111. Molinuevo JL, Graus F, Serrano C, Rene R, Guerrero A, Illa I. Utility of anti-Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy. Ann Neurol 1998;44:976-980.
112. Moll JW, Markusse HM, Pijnenburg JJ, Vecht CJ, Henzen-Logmans SC. Antineuronal antibodies in patients with neurologic complications of primary Sjogren's syndrome. Neurology 1993;43:2574-2581.
113. Monaco S, Ferrari S, Bonetti B, Moretto G, Kirshfink M, Nardelli E, Nobileorazio E, Zanusso G, Rizzuto N, Tedesco F. Experimental induction of myelin changes by anti-MAG antibodies and terminal complement complex. J Neuropathol Exper Neurol 1995;54:96-104.
114. Montag D, Giese KP, Bartsch U, Martini R, Lang Y, Bluthmann H, Karthigasan J, Kirschner DA, Wintergerst ES, Nave KA, et al. Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron 1994;13: 229-246.
115. Morell P, Quarles RH. Myelin formation, structure and biochemistry. In: Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD, editors. Basic neurochemistry: molecular, cellular, and medical aspects, 6 ed. New York: Lippincott-Raven; 1999. p 117-144.
116. Nair SM, Zhao Z, Chou DK, Tobet SA, Jungalwala FB. Expression of HNK-1 carbohydrate and its binding protein, SBP-1, in apposing cell surfaces in cerebral cortex and cerebellum. Neuroscience 1998;85:759-771.
117. Needham LK, Schnaar RL. Carbohydrate recognition in the peripheral nervous system: a calcium-dependent membrane binding site for HNK-1 reactive glycolipids potentially involved in Schwann cell adhesion. J Cell Biol 1993;121: 397-408.
118. Needham LK, Schnaar RL. The HNK-1 reactive sulfoglucuronyl glycolipids are ligands for L-selectin and P-selectin but not E-selectin. Proc Natl Acad Sci USA 1993;90: 1359-1363.
119. Noronha AB, Harper JR, Ilyas AA, Reisfeld RA, Quarles RH. Myelin-associated glycoprotein shares an antigenic determinant with a glycoprotein of human melanoma cells. J Neurochem 1986;47:1558-1565.
120. O'Hanlon GM, Paterson GJ, Veitch J, Wilson G, Willison HJ. Mapping immunoreactive epitopes in the human peripheral nervous system using human monoclonal anti-GM1 ganglioside antibodies. Acta Neuropathol (Berl) 1998;95:605-616.
121. O'Shannessy DJ, Willison HJ, Inuzuka T, Dobersen MJ, Quarles RH. The species distribution of nervous system antigens that react with anti-myelin-associated glycoprotein antibodies. J Neuroimmunol 1985;9:255-268.
122. Ogawa-Goto K, Abe T. Gangliosides and glycosphingolipids of peripheral nervous system myelins - a minireview. Neurochem Res 1998;23:305-310.
123. Ogawa-Goto K, Kubota K, Kurotani A, Abe T. Antibodies against sulfated glycosphingolipids of peripheral nerve myelins detected in patients with human cytomegalovirus infection. J Neuroimmunol 1994;55:55-60.
124. Ohsawa T, Miyatake T, Yuki N. Anti-B-series ganglioside-recognizing autoantibodies in an acute sensory neuropathy patient cause cell death of rat dorsal root ganglion neurons. Neurosci Lett 1993;157:167-170.
125. Ohtsuka K, Nakamura Y, Tagawa Y, Yuki N. Immunoadsorption therapy for Fisher syndrome associated with IgG anti-GQ1b antibody. AmJ Ophthalmol 1998;125:403-406.
126. Paparounas K, O'Hanlon GM, O'Leary CP, Rowan EG, Willison HJ. Anti-ganglioside antibodies can bind peripheral nerve nodes of Ranvier and activate the complement cascade without inducing acute conduction block in vitro. Brain. In press.
127. Paterson G, Wilson G, Kennedy PG, Willison HJ. Analysis of anti-GM1 ganglioside IgM antibodies cloned from motor neuropathy patients demonstrates diverse V region gene usage with extensive somatic mutation. J Immunol 1995;155: 3049-3059.
128. Pestronk A. Multifocal motor neuropathy: diagnosis and treatment. Neurology 1998;51 (suppl 5):S22-S24.
129. Pestronk A, Choksi R. Multifocal motor neuropathy. Serum IgM anti-GM1 ganglioside antibodies in most patients detected using covalent linkage of GM1 to ELISA plates. Neurology 1997;49:1289-1292.
130. Pestronk A, Choski R, Yee WC, Kornberg AJ, Lopate G, Trotter J. Serum antibodies to heparain sulfate glycosaminoglycans in Guillain-Barré syndrome and demyelinating polyneuropathies. J Neuroimmunol 1998;91:204-209.
131. Plomp JJ, Molenaar PC, Jacobs BC, Veitch J, Daha MR, van Doom PA, van der Meche FGA, Vincent MBPM, Willison HJ. Miller Fisher anti-GQ1b antibodies: α-latrotoxin -like effects on motor end plates. Ann Neurol 1999;45:189-199.
132. Posner JB. Anti-Hu autoantibody associated sensory neuropathy/encephalomyelitis: a model of paraneoplastic syndrome. Perspect Biol Med 1995;38:167-181.
133. Qin Z, Guan Y. Experimental polyneuropathy produced in guinea-pigs immunized against sulfatide. Neuroreport 1997; 8:2867-2870.
134. Quarles R. Glycoproteins of myelin sheaths. J Mol Neurosci 1997;8:1-12.
135. Quarles R, Colman D, Salzer J, Trapp B. Myelin-associated glycoprotein: Structure-function relationships and involvement in neurological diseases. In: Martenson R, editor. Myelin: biology and chemistry. Boca Raton, FL: CRC Press; 1992. p 4413-4448.
136. Quarles RH. Human monoclonal antibodies associated with neuropathy. Meth Enzymol 1989;179:291-299.
137. Quarles RH. The spectrum and pathogenesis of antibody mediated neuropathies. The Neuroscientist 1997;3:195-204.
138. Quarles RH, Dalakas MC. Do anti-ganglioside antibodies cause human peripheral neuropathies? J Clin Invest 1996; 97:1136-1137.
139. Quarles RH, Ilyas AA, Willison HJ. Antibodies to gangliosides and myelin proteins in Guillain-Barré syndrome. Ann Neurol 1990; 27(suppl):S48-S52.
140. Quarles RH, Morell P, McFarland HF. Diseases involving myelin. In: Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD, editors. Basic neurochemistry: molecular, cellular and medical aspects, 5th ed. New York: Lippincott-Raven; 1998. p 783-804.
141. Ritchie TC, Fabian RH, Coulter JD. Axonal transport of antibodies to subcellular and protein fractions of rat brain. Brain Res 1985;343:252-261.
142. Roberts M, Willison H, Vincent A, Newsom-Davis J. Serum factor in Miller-Fisher variant of Guillain-Barre syndrome and neurotransmitter release Lancet 1994;343:454-455.
143. Roberts M, Willison HJ, Vincent A, Newsom-Davis J. Multifocal motor neuropathy human sera block distal motor nerve conduction in mice. Ann Neurol 1995;38:111-118.
144. Ropper AH, Gorson KC. Neuropathies associated with paraproteinemia. N Engl J Med 1998;338:1601-1607.
145. Rosenbluth J, Liang WL, Schiff R, Dou WK. Spinal cord dysmyelination induced in vivo by IgM antibodies to three different myelin glycolipids. Glia 1997;19:58-66.
146. Salloway S, Mermel LA, Seamans M, Aspinall GO, Nam Shin JE, Kurjanczyk LA, Penner JL. Miller-Fisher syndrome associated with Campylobacter jejuni bearing lipopolysaccharide molecules that mimic human ganglioside GD3. Infect Immunol 1996;64:2945-2969.
147. Santoro M, Uncini A, Corbo M, Staugaitis SM, Thomas FP, Hays AP, Latov N. Experimental conduction block, induced by serum from a patient with anti-GM1 antibodies. Ann Neurol 1992;31:385-390.
148. Sater R, Rostami A. Treatment of Guillain-Barré syndrome with intravenous immunoglobulin. Neurology 1998; 51 (suppl 5):S9-S15.
149. Schnaar RL, Collins BE, Wright LP, Kiso M, Tropak MB, Roder JC, Crocker PR. Myelin-associated glycoprotein binding to gangliosides. Structural specificity and functional implications. Ann NY Acad Sci 1998;845:92-105.
150. Shapiro L, Doyle JP, Hensley P, Colman DR, Hendrickson WA. Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin. Neuron 1996;17:435-449.
151. Sheikh KA, Ho TW, Nachamkin I, Li CY, Cornblath DR, Asbury AK, Griffin JW, McKhann GM. Molecular mimicry in Guillain-Barre syndrome. Ann NY Acad Sci 1998;845: 307-321.
152. Sillevis Smitt PA, Manley GT, Posner JB. Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice. Neurology 1995;45: 1873-1878.
153. Snipes GJ, Suter U, Shooter EM. Human peripheral myelin protein-22 carries the L2/HNK-1 carbohydrate adhesion epitope. J Neurochem 1993;61:1961-1964.
154. Stubbs EB Jr, Fisher MA, Siegel GJ. Anti-tubulin antibodies in a sensorimotor neuropathy patient alter tubulin polymerization. Acta Neuropathol (Berl) 1998;95:302-305.
155. Stubbs EB Jr. , Fisher MA, Wilson JR, Siegel GJ. High-titer immunoglobulin M antibody to nerve-specific class III beta-tubulin in the serum of a patient with sensory demyelinating polyneuropathy [letter]. Muscle Nerve 1996;19:1638-1639.
156. Suter U, Snipes CJ. Peripheral myelin protein-22: Facts and hypotheses. J Neurosci Res 1995;40:145-151.
157. Szabo A, Dalmau J, Manley G, Rosenfeld M, Wong E, Henson J, Posner JB, Furneaux HM. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal. Cell 1991;67: 325-333.
158. Tagawa Y, Irie F, Hirabayashi Y, Yuki N. Cholinergic neuron-specific ganglioside GQ1b alpha a possible target molecule for serum IgM antibodies in some patients with sensory ataxia. J Neuroimmunol 1997;75:196-199.
159. Takatsu M, Hays AP, Latov N, Abrams GM, Nemni R, Sherman WH, Nobile-Orazio E, Saito T, Freddo L. Immunofluorescence study of patients with neuropathy and IgM M proteins. Ann Neurol 1985;18:173-181.
160. + currents in isolated rat myelinated nerve fibers. Ann Neurol 1995;37:436-442.
161. Tang S, Shen YJ, DeBellard ME, Mukhopadhyay G, Salzer JL, Crocker PR, Filbin MT. Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site. J Cell Biol 1997;138: 1355-1366.
162. Tatum AH. Experimental paraprotein neuropathy, demyelination by passive transfer of human IgM anti-myelin-associated glycoprotein. Ann Neurol 1993;33:502-506.
163. Thomas FP, Adapon PH, Goldberg GP, Latov N, Hays AP. Localization of neural epitopes that bind to IgM monoclonal autoantibodies (M-proteins) from two patients with motor neuron disease. J Neuroimmunol 1989;21:31-39.
164. Thomas FP, Trojaborg W, Nagy C, Santoro M, Sadiq SA, Latov N, Hays AP. Experimental autoimmune neuropathy with anti-GM1 antibodies and immunoglobulin deposits at the nodes of Ranvier. Acta Neuropathol (Berl) 1991;82: 378-383.
165. Thomas P, Willison H. Paraproteinaemic neuropathy. Baillere's Clin Neurol 1994;3:129-147.
166. Tora M, Graus F, de Bolos C, Real FX. Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas. Neurology 1997;48:735-741.
167. Trojaborg W, Hays AP, van den Berg L, Younger DS, Latov N. Motor conduction parameters in neuropathies associated with anti-MAG antibodies and other types of demyelinating and axonal neuropathies. Muscle Nerve 1995;18:730-735.
168. Tsuchida T, Saxton RE, Morton DL, Irie RF. Gangliosides of human melanoma. Cancer 1989;63:1166-1174.
169. Uncini A, Santoro M, Corbo M, Lugaresi A, Latov N. Conduction abnormalities induced by sera of patients with multifocal motor neuropathy and anti-GM1 antibodies. Muscle Nerve 1993;16:610-615.
170. Uyemura K, Kitamura K. Comparative studies on myelin proteins in mammalian peripheral nerve. Compreh Biochem Physiol [c] 1991;98:63-72.
171. Uyemura K, Kitamura K, Miura M. Structure and molecular biology of P0 glycoprotein. In: Martenson RE, ed. Myelin: chemistry and biology. Boca Raton, FL: CRC Press; 1992. p 481-508.
172. Van den Berg L, Hays AP, Nobile-Orazio E, Kinsella LJ, Manfredini E, Corbo M, Rosoklija G, Younger DS, Lovelace RE, Trojaborg W, Lange DE, Goldstein S, Delfiner JS, Sadiq SA, Sherman WH, Latov N. Anti-MAG and anti-SGPG antibodies in neuropathy. Muscle Nerve 1996;19:637-643.
173. van den Berg L, Sadiq SA, Thomas FP, Latov N. Characterization of HNK-1 bearing glycoproteins in human peripheral nerve myelin. J Neurosci Res 1990;25:295-299.
174. van der Meche F, van Doorn P. Guillain-Barre syndrome and chronic inflammatory deymelinating polyneuropathy: immune mechanisms and update on current therapies. Ann Neurol 1995;37(suppl):S14-S31.
175. van der Meche FG, van Doom PA. Future developments in the treatment of immune-mediated polyneuropathies. Eur Neurol 1997;38:230-237.
176. van Schaik IN, Vermeulen M, van Doorn PA, Brand A. Anti-beta-tubulin antibodies have no diagnostic value in patients with chronic inflammatory demyelinating polyneuropathy. J Neurol 1995;242:599-603.
177. Visser LH, van der Meche FG, Meulstee J, Rothbarth PP, Jacobs BC, Schmitz PI, van Doorn PA. Cytomegalovirus infection and Guillain-Barre syndrome: the clinical, electrophysiologic, and prognostic features. Dutch Guillain-Barre study group. Neurology 1996;47:668-673.
178. Vital C, Vital A, Deminiere C, Julien J, Lagueny A, Steck AJ. Myelin modifications in 8 cases of peripheral neuropathy with Waldenstrom's macroglobulinemia and anti-MAG activity. Ultrastruct Pathol 1997;21:509-516.
179. Voshol H, van Zuylen CW, Orberger G, Vliegenthart JF, Schachner M. Structure of the HNK-1 carbohydrate epitope on bovine peripheral myelin glycoprotein P0. J Biol Chem 1996;271:22957-229660.
180. Weiss MD, Luciano CA, Semino-Mora C, Dalakas MC, Quarles RH. Molecular mimicry in chronic inflammatory demyelinating polyneuropathy and melanoma. Neurology 1998;51: 1738-1741.
181. Weiss MD, Dalakas MC, Lauter CJ, Willison HJ, Quarles RH. Variability in the binding of anti-MAG and anti-SGPG antibodies to target antigens in demyelinating neuropathy and IgM paraproteinemia. J Neuroimmunol 1999;95:174-184.
182. Weng NP, Ritter E, Yucel E, Zhang D, Ritter G, Marcus DM. Specificity and structure of murine monoclonal antibodies against GM1 ganglioside. J Neuroimmunol 1994;55:61-68.
183. Weng NP, Yu-Lee LY, Sanz I, Patten BM, Marcus DM. Structure and specificities of anti-ganglioside autoantibodies associated with motor neuropathies. J Immunol 1992;149: 2518-2529.
184. Willison HJ, Minna JD, Brady RO, Quarles RH. Glycoconjugates in nervous tissue and small cell lung cancer share immunologically cross-reactive carbohydrate determinants. J Neuroimmunol 1986;10:353-365.
185. Willison HJ, O'Hanlon GM, Paterson G, Veitch J, Wilson G, Roberts M, Tang T, Vincent A, A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18. J Clin Invest 1996;97:1155-1164.
186. Willison HJ, Trapp BD, Bacher JD, Dalakas MC, Griffin JW, Quarles RH. Demyelination induced by intraneural injection of human antimyelin-associated glycoprotein antibodies. Muscle Nerve 1988;11:1169-1176.
187. Wirguin I, Briani C, Suturkova-Milosevic L, Fisher T, Della-Latta P, Chalif P, Latov N. Induction of anti-GM1 ganglioside antibodies by Campylobacter jejuni lipopolysaccharides. J Neuroimmunol 1997;78:138-142.
188. Yates AJ, Rampersaud A. Sphingolipids as receptor modulators. An overview. Ann NY Acad Sci 1998;845:57-71.
189. Yin X, Crawford TO, Griffin JW, Tu P, Lee VM, Li C, Roder J, Trapp BD. Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J Neurosci 1998;18:1953-1962.
190. Yoshino H, Ariga T, Latov N, Miyatake T, Kushi Y, Kasama T, Handa S, Yu RK. Fucosyl-GM1 in human sensory nervous tissue is a target antigen in patients with autoimmune neuropathies. J Neurochem 1993;61:658-663.
191. Yu RK, Ariga T. The role of glycosphingolipids in neurological disorders. Mechanisms of immune action. Ann NY Acad Sci 1998;845:285-306.
192. Yuki N, Ariga T. Antibodies to fucogangliosides in neurological diseases. J Neurol Sci 1997;150:81-84.
193. Yuki N, Tagawa Y, Handa S. Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol 1996;70:1-6.
194. Yuki N, Taki T, Handa S. Antibody to GalNAc-GD1a and GalNAc-GM1b in Guillain-Barre syndrome subsequent to Campylobacter jejuni enteritis. J Neuroimmunol 1996;71: 155-161.
195. Yuki N, Taki T, Inagaki F, Kasama T, Takahashi M, Saito K, Handa S, Miyatake T. A bacterium lipopolysaccharide that elicits Guillain-Barre syndrome has a GM1 ganglioside-like structure. J Exp Med 1993;178:1771-1775.
196. Yuki N, Taki T, Takahashi M, Saito K, Yoshino H, Tai T, Handa S, Miyatake T. Molecular mimicry between GQ1b ganglioside and lipopolysaccharides of Campylobacter jejuni isolated from patients with Fisher's syndrome. Ann Neurol 1994;36:791-793.
197. Yuki N, Yamamoto T, Hirata K. Correlation between cytomegalovirus infection and IgM anti-MAG/SGPG antibody-associated neuropathy. Ann Neurol 1998;44:408-410.