Tissue distribution of pathological lesions and Hu antigen expression in paraneoplastic sensory neuronopathy

Acta Neuropathologica

Volumn 95, Issue 6, 1998, Pages 641-648

  Ichimura, Miyuki ^a   Yamamoto, Masahiko ^a   Kobayashi, Yasushi ^a   Kawakami, Osamu ^a   Niimi, Yuki ^a   Hattori, Naoki ^a   Nagamatsu, Masaaki ^a   Hashizume, Yoshio ^b   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Hu antigen; Multifocal lesion; Paraneoplastic sensory neuronopathy; Tissue distribution

Indexed keywords

ANTIBODY; ANTIGEN; MESSENGER RNA;

AGED; ANTIGEN EXPRESSION; ARTICLE; AUTOPSY; CANCER CELL; CASE REPORT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DORSAL ROOT; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; NEUROPATHOLOGY; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; SENSORY NERVE CELL; SENSORY NEUROPATHY; SYMPATHETIC GANGLION; TISSUE; TISSUE DISTRIBUTION;

EID: 0031746333     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050851     Document Type: Article

References (39)

1. Anderson NE, Rosenblum MK, Graus F, Wiley RG, Posner JB (1988) Autoantibodies in paraneoplastic syndromes associated with small-cell lung cancer. Neurology 38:1391-1398
2. Chalk CH, Lennon VA, Stevens JC, Windebank AJ (1993) Seronegatibity for type 1 antineuronal nuclear antibodies ('Hu') in subacute sensory neuropathy patients without cancer. Neurology 43:2209-2211
3. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann Biochem 162:156-159
4. Croft PB, Henson RA, Urich H, Wilkinson PC (1965) Sensory neuropathy with bronchial carcinoma: a study of four cases showing serological abnormalities. Brain 88:501-514
5. Dalmau J, Furneaux HM, Rosenblum MK, Graus F, Posner JB (1991) Detection of the anti-Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/sensory neuropathy. Neurology 41:1757-1764
6. Denny-Brown D (1948) Primary sensory neuropathy with muscular changes associated with carcinoma. J Neurol Neurosurg Psychiatry 11:73-87
7. Dyck PJ, Bailey AA, Olszewski J (1958) Carcinomatous neuropathy: a case of sensory neuropathy and myopathy with onset three and one half years before clinical recognition of the bronchogenic carcinoma. Can Med Assoc J 79:913-916
8. Graus F, Cordon-Cardo C, Posner JB (1985) Neuronal antinuclear antibody in sensory neuropathy from lung cancer. Neurology 35:538-543
9. Graus F, Elkon KB, Cordon-Cardo C, Posner JB (1986) Sensory neuronopathy and small cell lung cancer: antineuronal antibody that also reacts with the tumor. Am J Med 80:45-52
10. Greenlee JE, Parks TN, Jaeckle KA (1993) Type I-a ('anti-Hu') antineuronal antibodies produce destruction of rat cerebellar granule neurons in vitro. Neurology 43:2049-2054
11. Griffin JW, Cornblath DR, Alexander E, Campbell J, Low PA, Bird S, Feldman EE (1990) Ataxic sensory neuropathy and dorsal root ganglionitis associated with Sjögren's syndrome. Ann Neurol 27:304-315
12. Hainfellner JA, Kristoferitsch W, Lassmann H, Bernheimer H, Neisser A, Drlicek M, Beer F, Budka H (1996) T cell-mediated ganglionitis associated with acute sensory neuropathy. Ann Neurol 39:543-547
13. Hormigo A, Lieberman F (1994) Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity. J Neuroimmunol 55:205-212
14. Horwich MS, Cho L, Porro RS, Posner JB (1977) Subacute sensory neuropathy: a remote effect of carcinoma. Ann Neurol 2:7-19
15. King PH (1994) Hel-N2: a novel isoform of Hel-N1 which is conserved in rat neural tissue and produced in early embryogenesis. Gene 151:261-265
16. King PH, Dropcho EJ (1996) Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma. Ann Neurol 39:679-681
17. Kumazawa K, Sobue G, Yamamoto K, Mitsuma T (1993) Segmental anhidrosis in the spinal dermatomes in Sjögren's syndrome-associated neuropathy. Neurology 43:1820-1823
18. Levine TD, Gao F, King PH, Andrews LG, Keene JD (1993) Hel-N1: an autoimmune RNA-binding protein with specificity for 3′ uridylate-rich untranslated regions of growth factor mR-NAs. Mol Cell Biol 13:3494-3504
19. Manley GT, Smitt PS, Dalmau J, Posner JB (1995) Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites. Ann Neurol 45:102-110
20. Moll JWB, Markusse HM, Pijnenburg JJJM, Vechit CH, Henzen-Sogmans SC (1993) Antineuronal antibodies in patients with neurologic complications of primary Sjögren's syndrome. Neurology 43:2574-2581
21. Moll JWB, Antoine JC, Brashear HR, Delattre J, Drlicek M, Dropcho EJ, Giomerro B, Graus F, Greenlee J, Honnorat J, Jaeckle KA, Tanaka K, Vecht CJ (1995) Guidelines on the detection of paraneoplastic anti-neuronal-specific antibodies: report from the workshop to the forth meeting of the International society of Neuro-Immunology on paraneoplastic neurological disease, 22-23 October 1994, Rotterdam, The Netherlands. Neurology 45:1937-1941
22. Ogawa M, Ohnishi A, Toyama I, Fujiyoshi K, Morita T (1985) An autopsy case of carcinomatous sensory neuropathy: the correlation between the morphometric findings of the primary sensory neuron and clinical findings. Clin Neurol 25:307-313
23. Ohnishi A, Kuroiwa Y, Inoshita S, Ohmori T (1985) Morphometric analysis of primary sensory neuron in an autopsy case of asymmetric carcinomatous neuropathy. Comparative study of right and left sides. Neurol Med 22:547-554
24. Saito T, Hosoda M, Kowa H, Tazaki Y, Ohbu M (1987) An autopsy case of carcinomatous sensory neuropathy with mediastinal malignant tumor. Clin Neurol 27:877-885
25. Sakai K, Gofuku M, Kitagawa Y, Ogasawara T, Hirose G, Yamazaki M, Koh CS, Yanagisawa N, Steinman L (1994) A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma. Biochem Biophys Res Commun 199:1200-1208
26. Sillevis-Smitt PAE, Manley GT, Posner JB (1995) Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurological disease in mice. Neurology 45: 1873-1878
27. Sillevis-Smitt PAE, Manley GT, Moll JWB, Dalmau J, Posner JB (1996) Pitfall in the diagnosis of autoantibodies associated with paraneoplastic neurologic disease. Neurology 46:1739-1741
28. Sobue G, Hashizume Y, Mukai E, Hirayama M, Mitsuma T, Takahashi A (1989) X-linked recessive bulbospinal neuropathy: a clinicopathological study. Brain 112:209-232
29. Sobue G, Yanagi T, Hashizume Y (1988) Chronic progressive sensory ataxic neuropathy with polyclonal gammopathy and disseminated focal perivascular cellular infiltrations. Neurology 38:463-467
30. Steller U, Kohls S, Muller B, Soller R, Schlender J, Blohm DH (1996) The RNA binding protein HuD: rat cDNA and analysis of the alternative spliced mRNA in neuronal differentiating cell lines P19 and PC12. Brain Res Mol Brain Res 35:285-296
31. Szabo A, Daknau J, Manley G, Rosenfeld M, Wong E, Henson J, Posner JB, Furneaux HM (1991) HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domain of the 70K U1 sn RNP protein. Cell 67:325-333
32. Tora M, Graus F, Bolos C de, Real FX (1997) Cell surface expression of paraneoplastic encephalomyelitis/sensory neuropathy-associated Hu antigens in small-cell lung cancers and neuroblastomas. Neurology 48:735-741
33. Verma A, Berger JR, Snodgrass S, Periro C (1996) Motor neuron disease: a paraneoplastic process associated with anti-Hu antibody and small-cell lung carcinoma. Ann Neurol 40: 112-116
34. Wondrusch E, Zifko U, Grisold W (1996) Neuromuscular disorders in systemic malignancy and its treatment [Letter]. Muscle Nerve 10:1362-1364
35. Yamada A, Takeuchi H, Miki H, Touge T, Deguchi K (1990) Subacute sensory neuropathy associated with carcinoma: an autopsy case report and an analysis of Japanese cases. Clin Neurol 30:860-863
36. Yamada M, Inaba A, Yamawaki M, Ishida K, Yokota T, Uchihara T, Eishi Y, Okeda R (1994) Paraneoplastic encephalomyeloganglionitis: cellular binding sites of the antineuronal antibody. Acta Neuropathol 88:85-92
37. Yamamoto K, Ohnishi A, Noda S, Umezaki H, Yamamoto T (1989) An autopsy case of carcinomatous sensory neuropathy associated with gastric adenosquamous carcinoma. Clin Neurol 29:493-496
38. Yamamoto M, Sobue G, Yamamoto K, Terao S, Mitsuma T (1996) Expression of glial cell line-derived neurotrophic factor mRNA in the spinal cord and muscle in amyotrophic lateral sclerosis. Neurosci Lett 204:117-120
39. NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissue. Neurochem Res 21:929-938