T-T Cellular Interaction between CD4-CD8- Regulatory T Cells and T Cell Clones Presenting TCR Peptide: Its Implication for TCR Vaccination Against Experimental Autoimmune Encephalomyelitis

Journal of Immunology

Volumn 157, Issue 4, 1996, Pages 1781-1790

  Kozovska, Milena F ^a   Yamamura, Takashi ^a   Tabira, Takeshi ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GEL PROTEIN, GELONIUM MULTIFLORUM; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE ANTIGEN RECEPTOR; VEGETABLE PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; AMINO ACID SEQUENCE; ARTICLE; AUTOIMMUNE DISEASE; CELL CLONE; FEMALE; GERMFREE ANIMAL; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION; VACCINATION;

AMINO ACID SEQUENCE; ANTIGENS, CD4; ANTIGENS, CD8; ANTIGENS, CD80; AUTOIMMUNE DISEASES; CLONE CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTE SUBSETS; VACCINATION;

EID: 0030586659     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Alvord, E. C., Jr., M. W. Kies, and A. J. Suckling, eds. 1984. Experimental Allergic Encephalomyelitis: A Useful Model for Multiple Sclerosis. Alan R. Liss, New York.
2. Tabira, T., and J. Kira. 1992. Strain and species differences of encephalitogenic determinants of myelin basic protein and proteolipid apoprotein. In Myelin: Biology and Chemistry. R. E. Martenson, ed. CRC Press, Boca Raton, p. 783.
3. Ben-Nun, A., H. Wekerle, and I. R. Cohen. 1981. Vaccination against autoimmune encephalomyelitis using attenuated cells of a T lymphocyte line reactive against myelin basic protein. Nature 292:60.
4. Acha-Orbea, H., D. J. Mitchell, L. Timmermann, D. C. Wraith, G. S. Tausch, M. K. Waldor, S. S. Zamvil, H. O. McDevitt, and L. Steinman. 1988. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263.
5. Urban, J. L., V. Kumar, D. H. Kono, C. Gomez, S. J. Horvath, J. Clayton, D. G. Ando, E. E. Sercarz, and L. Hood. 1988. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54:577.
6. Burns, F. R., X. Li, N. Shen, H. Offner, Y. K. Chou, A. A. Vandenbark, and E. Heber-Katz. 1989. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med. 16:27.
7. Vandenbark, A. A., G. Hashim, and H. Offner. 1989. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341:541.
8. Howell, M. D., S. T. Winters, T. Olee, H. C. Powell, D. J. Carlo, and S. W. Brostoff. 1989. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246:668.
9. Stevens, D. B., W. J. Karpus, K. E. Gould, and R. H. Swanborg. 1992. Studies of Vβ8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 37:123.
10. Offner, H., G. A. Hashim, and A. A. Vandenbark. 1991. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 251: 430.
11. + cells recognizing epitopes of the T cell receptor β chain from a myelin basic protein-specific T cell clone. Eur. J. Immunol. 23:530.
12. Chou, Y. K., W. J. Morrison, A. D. Weinberg, R. Dedrick, R. Whitham, D. N. Bourdette, G. Hashim, H. Offner, and A. A. Vandenbark. 1994. Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of Vβ5.2 and Vβ6.1 CDR2 peptides. J. Immunol. 152:2520.
13. Vainiene, M., D. P. Gold, B. Celnik, G. A. Hashim, A. A. Vandenbark, and H. Offner. 1992. Common sequence on distinct Vβ genes defines a protective idiotope in experimental encephalomyelitis. J. Neurosci. Res. 31:413.
14. + T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178:909.
15. Kuhröber, A., R. Schirmbeck, and J. Reimann. 1994. Vaccination with T cell receptor peptides primes anti-receptor cytotoxic T lymphocytes (CTL) and anergizes T cells specifically recognized by these CTL. Eur. J. Immunol. 24:1172.
16. + T cells expressing Vβ8 TCR: a role of the Qa-1 molecule. Immunity 2:185.
17. + T cells. Immunity 2:177.
18. Broeren, C. P. M., M. A. Lucassen, M. J. B. van Stipdonk, R. van der Zee, C. J. P. Boog, J. G. Kusters, and W. van Eden. 1994. CDR1 T-cell receptor β-chain peptide induces major histocompatibility complex class II-restricted T-T cell interactions. Proc. Natl. Acad. Sci. USA 91:5997.
19. Sakai, K., A. A. Sinha, D. J. Mitchell, S. S. Zamvil, J. B. Rothbard, H. O. McDevitt, and L. Steinman. 1988. Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein. Proc. Natl. Acad. Sci. USA 85:8608.
20. Yamamura, T., T. Kondo, S. Sakanaka, M. Kozovska, T.-C. Geng, K. Takahashi, and T. Tabira. 1994. Analysis of T cell antigen receptors of myelin basic protein specific T cells in SJL/J mice demonstrates an α-chain CDR3 motif associated with encephalitogenic T cells. Int. Immunol. 6:947.
21. Falcioni, F., D. Vidovic, E. S. Ward, D. Bolin, G. Singh, H. Shah, B. Ober, and Z. A. Nagy. 1995. Self tolerance to T cell receptor Vβ sequences. J. Exp. Med. 182:249.
22. Tokuchi, F., M. Nishizawa, J. Nihei, K. Motoyama, K. Nagashima, and T. Tabira. 1990. Lymphokine production by encephalitogenic and non-encephalitogenic T-cell clones reactive to the same antigenic determinant. J. Neuroimmunol. 30:71.
23. Sakai, K., T. Namikawa, T. Kunishita, K. Yamanouchi, and T. Tabira. 1986. Studies of experimental allergic encephalomyelitis by using encephalitogenic T cell lines and clones in euthymic and athymic mice. J. Immunol. 137:1527.
24. Rock, K. L., L. Rothstein, S. Gamble, and C. Fleischacker. 1993. Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J. Immunol. 150:438.
25. Inobe, J.-i., T. Yamamura, T. Kunishita, and T. Tabira. 1993. T lymphocyte lines and clones selected against synthetic myelin basic protein 82-102 peptide from Japanese multiple sclerosis patients. J. Neuroimmunol. 46:83.
26. Townsend, A., and H. Bodmer. 1989. Antigen recognition by class I-restricted T lymphocytes. Anna. Rev. Immunol. 7:601.
27. Rock, K. L., S. Gamble, and L. Rothstein. 1990. Presentation of exogenous antigen with class I major histocompatibility complex molecules. Science 249:918.
28. Lorber, M. I., M. R. Loken, A. M. Stall, and F. W. Pitch. 1982. 1-A antigens on cloned alloreactive murine T lymphocytes are acquired passively. J Immunol. 128:2798.
29. Reizis, B., C. Schramm, I. R. Cohen, and F. Mor. 1994. Expression of major histocompatibility complex class II molecules in rat T cells. Eur. J. Immunol. 24:2796.
30. Mosmann, T. R., and R. L. Coffmann. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
31. Lanzavecchia, A., E. Roosnek, T. Gregory, P. Berman, and S. Abrignani. 1988. T cells can present antigen such as HIV gp 120 targeted to their own surface molecules. Nature 334:530.
32. LaSalle, J. M., K. Ota, and D. A. Harter. 1991. Presentation of autoantigen by human T cells. J. Immunol. 147:774.
33. Barnaba, V., C. Watts, M. de Boer, P. Lane, and A. Lanzavecchia. 1994. Professional presentation of antigen by activated human T cells. Eur. J. Immunol. 24:71.
34. Ulmer, J. B., J. J. Donnelly, and M. A. Liu. 1994. Presentation of an exogenous antigen by major histocompatibility complex class I molecules. Eur. J. Immunol. 24:1590.
35. - splenic T cells from Lewis rats recovered from experimental autoimmune encephalomyelitis respond to encephalitogenic T cells that mediate this disorder. Cell. Immunol. 137: 292.
36. -) T cells responding to syngeneic encephalitogenic T cell clones. J. Neuroimmunol. (Suppl. 1):57.
37. -TCRαβ thymocytes: a model based on T-cell receptor avidity. Immunol. Today 16:428.
38. Sun, D., Y. Qin, J. Chluba, J. T. Epplen, and H. Wekerle. 1988. Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T-T interactions. Nature 332:843.
39. Miller, A., O. Lider, and H. Weiner. 1991. Antigen-driven bystander suppression after oral administration of antigens. J. Exp. Med. 174:791.
40. Offner, H., M. Vainiene, B. Celnik, A. D. Weinberg, A. Buenafe, and A. A. Vandenbark. 1994. Coculture of TCR peptide-specific T cells with basic protein-specific T cells inhibits proliferation, IL-3 mRNA, and transfer of experimental autoimmune encephalomyelitis. J. Immunol. 153:4988.
41. + cells in T cell receptor peptide-induced clonal unresponsiveness. Science 259:91.
42. Schönrich, G., U. Kalinke, F. Momburg, M. Malissen, A.-M. Schmitt-Verhulst, B. Malissen, G. I. Hammerling, and B. Arnold. 1991. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65:293.