메뉴 건너뛰기




Volumn 24, Issue 2, 1996, Pages 116-122

Flow cytometric analysis of apoptosis and BCL-2 in primary breast carcinomas: Clinical and biological implications

Author keywords

Apoptosis; bcl 2; Flow cytometry; Mammary carcinoma

Indexed keywords

PROTEIN BCL 2;

EID: 0029955620     PISSN: 01964763     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0320(19960601)24:2<116::AID-CYTO3>3.0.CO;2-H     Document Type: Article
Times cited : (30)

References (53)
  • 2
    • 0025937489 scopus 로고
    • Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
    • Askew DS, Ashmun RA, Simmons BC, Cleveland JL: Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6:1915-1922, 1991.
    • (1991) Oncogene , vol.6 , pp. 1915-1922
    • Askew, D.S.1    Ashmun, R.A.2    Simmons, B.C.3    Cleveland, J.L.4
  • 3
    • 0027993895 scopus 로고
    • Bcl-2 imimmoreactivity in breast carcinoma correlates with hormone receptor positivity
    • Bhargava V, Kell DL, van de Rijn M, Warnke RA: Bcl-2 imimmoreactivity in breast carcinoma correlates with hormone receptor positivity. Am J Pathol 145:535-540, 1994.
    • (1994) Am J Pathol , vol.145 , pp. 535-540
    • Bhargava, V.1    Kell, D.L.2    Van de Rijn, M.3    Warnke, R.A.4
  • 4
    • 0000558672 scopus 로고
    • Nuclear structure in cancer tissues
    • Black MM, Speer FD: Nuclear structure in cancer tissues. Am J Clin Pathol 26:250-256, 1956.
    • (1956) Am J Clin Pathol , vol.26 , pp. 250-256
    • Black, M.M.1    Speer, F.D.2
  • 7
    • 0028071583 scopus 로고
    • Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and adult human kidney
    • Chandler D, EI-Naggar AK, Brisbay S, Redline RW, McDonnell TJ: Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and adult human kidney. Hum Pathol 25:789-796, 1994.
    • (1994) Hum Pathol , vol.25 , pp. 789-796
    • Chandler, D.1    Ei-Naggar, A.K.2    Brisbay, S.3    Redline, R.W.4    McDonnell, T.J.5
  • 9
    • 0028325283 scopus 로고
    • The prevalence of bcl-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status
    • Doglioni C, Dei Tos AP, Laurino L, Chiarelli C, Barbareschi M, Viale G: The prevalence of bcl-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status. Virchows Archiv 424:47-51, 1994.
    • (1994) Virchows Archiv , vol.424 , pp. 47-51
    • Doglioni, C.1    Dei Tos, A.P.2    Laurino, L.3    Chiarelli, C.4    Barbareschi, M.5    Viale, G.6
  • 10
    • 0028025563 scopus 로고
    • Apoptosis in cancer therapy: Crossing the threshold
    • Fisher DE: Apoptosis in cancer therapy: Crossing the threshold. Cell 78:539-542, 1994.
    • (1994) Cell , vol.78 , pp. 539-542
    • Fisher, D.E.1
  • 11
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501, 1992.
    • (1992) J Cell Biol , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 13
    • 0027269557 scopus 로고
    • Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays
    • Gorczyca W, Gong J, Darzynkiewicz Z: Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53:1945-1951, 1993.
    • (1993) Cancer Res , vol.53 , pp. 1945-1951
    • Gorczyca, W.1    Gong, J.2    Darzynkiewicz, Z.3
  • 14
    • 0027947764 scopus 로고
    • Detection of apoptosis-associated DNA strand breaks in fine-needle aspiration biopsies by in situ end labeling of fragmented DNA
    • Gorczyca W, Tuziak T, Kram A, Melamed MR, Darzynkiewicz Z: Detection of apoptosis-associated DNA strand breaks in fine-needle aspiration biopsies by in situ end labeling of fragmented DNA. Cytometry 15:169-175, 1994.
    • (1994) Cytometry , vol.15 , pp. 169-175
    • Gorczyca, W.1    Tuziak, T.2    Kram, A.3    Melamed, M.R.4    Darzynkiewicz, Z.5
  • 16
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336, 1990.
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 17
    • 0025835716 scopus 로고
    • Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death
    • Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ: Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci 88:6961-6965, 1991.
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 6961-6965
    • Hockenbery, D.M.1    Zutter, M.2    Hickey, W.3    Nahm, M.4    Korsmeyer, S.J.5
  • 18
    • 0029328602 scopus 로고
    • Bcl-2, a novel regulator of cell death
    • Hockenbery DM. Bcl-2, a novel regulator of cell death. BioEssays 17:631-638, 1995.
    • (1995) BioEssays , vol.17 , pp. 631-638
    • Hockenbery, D.M.1
  • 20
    • 0027944957 scopus 로고
    • Bcl-2 protein expression and long-term survival in breast cancer
    • Joensuu H, Pylkkanen L, Toikkanen S: Bcl-2 protein expression and long-term survival in breast cancer. Am J Pathol 145:1191-1198, 1994.
    • (1994) Am J Pathol , vol.145 , pp. 1191-1198
    • Joensuu, H.1    Pylkkanen, L.2    Toikkanen, S.3
  • 21
  • 22
    • 0028021924 scopus 로고
    • Apoptotic cell death in human gastric carcinoma: Analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling
    • Kasagi N, Gomyo Y, Shirai H, Tsujitani S, Ito H: Apoptotic cell death in human gastric carcinoma: Analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. Jpn J Cancer Res 85:939-945, 1994.
    • (1994) Jpn J Cancer Res , vol.85 , pp. 939-945
    • Kasagi, N.1    Gomyo, Y.2    Shirai, H.3    Tsujitani, S.4    Ito, H.5
  • 23
    • 0026794967 scopus 로고
    • Detection of bcl-2 protein and bcl-2 messenger RNA in normal and neoplastic lymphoid tissues by immunohistochemistry and in situ hybridization
    • Kondo E, Nakamura S, Onoue H, Matsuo Y, Yoshino T, Aoki H, Hayashi K, Takahashi K, Minowada J, Nomura S, Akagi T: Detection of bcl-2 protein and bcl-2 messenger RNA in normal and neoplastic lymphoid tissues by immunohistochemistry and in situ hybridization. Blood 80:2044-2051, 1992.
    • (1992) Blood , vol.80 , pp. 2044-2051
    • Kondo, E.1    Nakamura, S.2    Onoue, H.3    Matsuo, Y.4    Yoshino, T.5    Aoki, H.6    Hayashi, K.7    Takahashi, K.8    Minowada, J.9    Nomura, S.10    Akagi, T.11
  • 24
    • 0026655474 scopus 로고
    • Bcl-2 initiates a new category of oncogenes: Regulators of cell death
    • Korsmeyer SJ: Bcl-2 initiates a new category of oncogenes: Regulators of cell death. Blood 80:879-886, 1992
    • (1992) Blood , vol.80 , pp. 879-886
    • Korsmeyer, S.J.1
  • 25
    • 0027362667 scopus 로고
    • Investigations of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
    • Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC: Investigations of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 53:4701-4714, 1993.
    • (1993) Cancer Res , vol.53 , pp. 4701-4714
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.J.4    Fenton, W.5    Reed, J.C.6
  • 27
    • 0028115802 scopus 로고
    • Bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumors and in situ cancer
    • Leek RD, Kaklamanis L, Pezzella F, Gatter KC, Harris AL: Bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumors and in situ cancer. Br J Cancer 69:135-139, 1994.
    • (1994) Br J Cancer , vol.69 , pp. 135-139
    • Leek, R.D.1    Kaklamanis, L.2    Pezzella, F.3    Gatter, K.C.4    Harris, A.L.5
  • 28
    • 0028559479 scopus 로고
    • Apoptosis in breast cancer as related to histopathological characteristics and prognosis
    • Lipponen P, Aaltomaa S, Kosma V-M, Syrjänen K: Apoptosis in breast cancer as related to histopathological characteristics and prognosis. Eur J Cancer 30A:2068-2073, 1994.
    • (1994) Eur J Cancer , vol.30 A , pp. 2068-2073
    • Lipponen, P.1    Aaltomaa, S.2    Kosma, V.-M.3    Syrjänen, K.4
  • 29
    • 0027956116 scopus 로고
    • Apoptosis in bladder cancer as related to standard prognostic factors and prognosis
    • Lipponen P, Aaltomaa S: Apoptosis in bladder cancer as related to standard prognostic factors and prognosis. J Pathol 173:333-339, 1994.
    • (1994) J Pathol , vol.173 , pp. 333-339
    • Lipponen, P.1    Aaltomaa, S.2
  • 30
    • 0029077154 scopus 로고
    • Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis
    • Lipponen P, Pietiläinen T, Kosma V-M, Aaltomaa S, Eskelinen M, Syrjänen K: Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis. J Pathol 177:49-55, 1995.
    • (1995) J Pathol , vol.177 , pp. 49-55
    • Lipponen, P.1    Pietiläinen, T.2    Kosma, V.-M.3    Aaltomaa, S.4    Eskelinen, M.5    Syrjänen, K.6
  • 31
    • 0027397760 scopus 로고
    • Bcl-2 proto-oncogene expression in Epstein-Barr-virus associated nasopharyngeal carcinoma
    • Lu Q-L, Elia G, Lucas S, Thomas JA: Bcl-2 proto-oncogene expression in Epstein-Barr-virus associated nasopharyngeal carcinoma. Int J Cancer 53:29-35, 1993.
    • (1993) Int J Cancer , vol.53 , pp. 29-35
    • Lu, Q.-L.1    Elia, G.2    Lucas, S.3    Thomas, J.A.4
  • 32
    • 0027286802 scopus 로고
    • Bcl-2 expression in adult and embryonic non-haematopoietic tissues
    • Lu Q-L, Poulsom R, Wong L et al: Bcl-2 expression in adult and embryonic non-haematopoietic tissues. J Pathol 169:431-437, 1993.
    • (1993) J Pathol , vol.169 , pp. 431-437
    • Lu, Q.-L.1    Poulsom, R.2    Wong, L.3
  • 34
    • 0024521441 scopus 로고
    • Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    • McDonnell TJ, Deane N, Platt FM, Nunez G, Jaeger U, McKearn JP, Korsmeyer SJ: Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57:79-88, 1989.
    • (1989) Cell , vol.57 , pp. 79-88
    • McDonnell, T.J.1    Deane, N.2    Platt, F.M.3    Nunez, G.4    Jaeger, U.5    McKearn, J.P.6    Korsmeyer, S.J.7
  • 36
    • 0027389763 scopus 로고
    • Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
    • Miyashita T, Reed JC: Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81:151-157, 1993.
    • (1993) Blood , vol.81 , pp. 151-157
    • Miyashita, T.1    Reed, J.C.2
  • 40
    • 0028203794 scopus 로고
    • Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells
    • Naumovski I, Cleary ML: Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood 83:2261-2267, 1994.
    • (1994) Blood , vol.83 , pp. 2261-2267
    • Naumovski, I.1    Cleary, M.L.2
  • 41
    • 0023691938 scopus 로고
    • Modified histogram subtraction technique for analysis of flow cytometry data
    • Overton WR: Modified histogram subtraction technique for analysis of flow cytometry data. Cytometry 9:619-626, 1988.
    • (1988) Cytometry , vol.9 , pp. 619-626
    • Overton, W.R.1
  • 43
    • 0027937033 scopus 로고
    • The effects of chemotherapy on morphology, cellular proliferation, apoptosis and oncoprotein expression in primary breast carcinoma
    • Rasbridge SA, Gillett CE, Seymour A-M, Patel K, Richards MA, Rubens RD, Millis RR: The effects of chemotherapy on morphology, cellular proliferation, apoptosis and oncoprotein expression in primary breast carcinoma. Br J Cancer 70:335-341, 1994.
    • (1994) Br J Cancer , vol.70 , pp. 335-341
    • Rasbridge, S.A.1    Gillett, C.E.2    Seymour, A.-M.3    Patel, K.4    Richards, M.A.5    Rubens, R.D.6    Millis, R.R.7
  • 44
    • 0029148958 scopus 로고
    • The expression and localization of bcl-2 protein in normal skin and in non-melanoma skin cancers
    • Rodriquez-Villanueva J, Colome MI, Brisbay S, McDonnell TJ: The expression and localization of bcl-2 protein in normal skin and in non-melanoma skin cancers. Path Res Pract 191:391-398, 1995.
    • (1995) Path Res Pract , vol.191 , pp. 391-398
    • Rodriquez-Villanueva, J.1    Colome, M.I.2    Brisbay, S.3    McDonnell, T.J.4
  • 45
    • 0029066597 scopus 로고
    • Bcl-2 expression and its association with cell kinetics in human gastric carcinomas and intestinal metaplasia
    • Saegusa M, Takano Y, Okayasu I: Bcl-2 expression and its association with cell kinetics in human gastric carcinomas and intestinal metaplasia. J Cancer Res & Clin Oncol 121:357-363, 1995.
    • (1995) J Cancer Res & Clin Oncol , vol.121 , pp. 357-363
    • Saegusa, M.1    Takano, Y.2    Okayasu, I.3
  • 49
    • 0029008234 scopus 로고
    • Flow cytometric analysis of apoptosis and bcl-2 in human solid neoplasms
    • Steck KD, McDonnell TJ, El-Naggar AK: Flow cytometric analysis of apoptosis and bcl-2 in human solid neoplasms. Cytometry 20:154-161, 1995.
    • (1995) Cytometry , vol.20 , pp. 154-161
    • Steck, K.D.1    McDonnell, T.J.2    El-Naggar, A.K.3
  • 50
    • 0029157380 scopus 로고
    • Estrogen promotes chemotherapeutic drug resistance by a mechanism involving bcl-2 proto-oncogene expression in human breast cancer cells
    • Teixeira C, Reed JC, Pratt MAC: Estrogen promotes chemotherapeutic drug resistance by a mechanism involving bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res 55:3902-3907, 1995.
    • (1995) Cancer Res , vol.55 , pp. 3902-3907
    • Teixeira, C.1    Reed, J.C.2    Pratt, M.A.C.3
  • 51
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux DL, Cory S, Adams JM: Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442, 1988.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 52
    • 0029007175 scopus 로고
    • Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7
    • Wang TTY, Phang JM: Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. Cancer Res 55:2487-2489, 1995.
    • (1995) Cancer Res , vol.55 , pp. 2487-2489
    • Wang, T.T.Y.1    Phang, J.M.2
  • 53
    • 0027479796 scopus 로고
    • Apoptosis (The 1992 Frank Rose Memorial Lecture)
    • Wyllie AH: Apoptosis (The 1992 Frank Rose Memorial Lecture). Br J Cancer 67:205-208, 1993.
    • (1993) Br J Cancer , vol.67 , pp. 205-208
    • Wyllie, A.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.