CaM kinase augments cardiac L-type Ca2+ current: A cellular mechanism for long Q-T arrhythmias

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 276, Issue 6 45-6, 1999, Pages

  Wu, Yuejin ^a   MacMillan, Leigh B ^b   McNeill, R Blair ^b   Colbran, Roger J ^b   Anderson, Mark E ^a,b,c  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Action potential; Arrhythmia; Calcium channels; Long Q T syndrome; Sarcoplasmic reticulum

Indexed keywords

BARIUM; CALCIUM; CALCIUM CHANNEL; INHIBITOR PROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN); RYANODINE RECEPTOR;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CELL MEMBRANE DEPOLARIZATION; DIALYSIS; HEART ARRHYTHMIA; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; RABBIT; SARCOPLASMIC RETICULUM; ULTRASTRUCTURE;

EID: 0033038508     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.276.6.h2168     Document Type: Article

References (36)

1. 2+ current in rabbit ventricular myocytes. Circ. Res. 75: 854-861, 1994.
2. 2+/ calmodulin dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J. Pharmacol. Exp. Ther. 287: 996-1006, 1998.
3. Bouchard, R. A., R. B. Clark, and W. R. Giles. Effects of action potential duration on excitation-contraction coupling in rat ventricular myocytes. Action potential voltage-clamp measurements. Circ. Res. 76: 790-801, 1995.
4. Bourinet, E., F. Fournier, P. Lory, P. Charnet, and J. Nargeot. Protein kinase C regulation of cardiac calcium channels expressed in Xenopus oocytes. Pflügers Arch. 421: 247-255, 1992.
5. 2+-calmodulin-dependent protein kinase in human epithelial cells. J. Physiol. (Lond.) 488: 37-55, 1995.
6. Braun, A. P., and H. Schulman. The multifunctional calcium/ calmodulin-dependent protein kinase: from form to function. Annu. Rev. Physiol. 57: 417-445, 1995.
7. 2+/calmodulin-dependent protein kinase II using the baculovirus expression system. Biochem. Biophys. Res. Commun. 173: 578-584, 1990.
8. Carl, S. L., K. Felix, A, H. Caswell, N. R. Brandt, W. J. Ball, Jr., P. L. Vaghy, Meissner, G, and D. G. Ferguson. Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium. J. Cell Biol. 129: 672-682, 1995.
9. Chao, S. H., Y. Suzuki, J. R. Zysk, and W. Y. Cheung. Activation of calmodulin by various metal cations as a function of ionic radius. Mol. Pharmacol. 26: 75-82, 1984.
10. 2+ channels. Science 270: 1502-1506, 1995.
11. Fabiato, A. Effects of ryanodine in skinned cardiac cells. Federation Proc. 44: 2970-2976, 1985.
12. Ferreira, G., J. Yi, E. Rios, and R. Shirokov. Ion-dependent inactivation of barium current through L-type calcium channels. J. Gen. Physiol. 109: 449-461, 1997.
13. Fraser, I. D., S. J. Tavalin, L. B. Lester, L. K. Langeberg, A. M. Westphal, R. A. Dean, N. V. Marrion, and J. D. Scott. A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events. EMBO J. 17: 2261-2272, 1998.
14. Gao, T., T. S. Puri, B. L. Gerhardstein, A. J. Chien, R. D. Green, and M. M. Hosey. Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes. J. Biol. Chem. 272: 19401-19407, 1997.
15. Gupta, R. C., and E. G. Kranias. Purification and characterization of a calcium-calmodulin-dependent phospholamban kinase from canine myocardium. Biochemistry 28: 5909-5916, 1989.
16. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391: 85-100, 1981.
17. 2+ window current in heart cells. Circ. Res. 70: 445-455, 1992.
18. Hryshko, L. V., and D. M. Bers. Ca current facilitation during postrest recovery depends on Ca entry. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H951-H961, 1990.
19. Iwasa, T., N. Inoue, K. Fukunaga, T. Isobe, T. Okuyama, and E. Miyamoto. Purification and characterization of a multi-functional calmodulin-dependent protein kinase from canine myocardial cytosol. Arch. Biochem. Biophys. 248: 21-29, 1986.
20. Jahn, H., W. Nastainczyk, A. Rohrkasten, T. Schneider, and F. Hofmann. Site-specific phosphorylation of the purified receptor for calcium-channel blockers by cAMP-and cGMP-dependent protein kinases, protein kinase C, calmodulin-dependent protein kinase II and casein kinase II. Eur. J. Biochem. 178: 535-542, 1988.
21. January, C. T., and J. M. Riddle. Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2-current. Circ. Res. 64: 977-990, 1989.
22. Marban, E., S. W. Robinson, and W. G. Wier. Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J. Clin. Invest. 78: 1185-1192, 1987.
23. 2+/calmodulin-dependent protein kinase II with neuronal cytoskeletal proteins. Characterization of binding to a 190-kDa postsynaptic density protein. J. Biol. Chem. 270: 10043-10049, 1995.
24. Mochly-Rosen, D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science 268: 247-251, 1995.
25. 2+/ calmodulin-dependent protein kinase. J. Biol. Chem. 271: 14964-14970, 1996.
26. Roden, D. M., R. Lazzara, M. Rosen, P. J. Schwartz, J. Towbin, and G. M. Vincent. Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS. Circulation 94: 1996-2012, 1996.
27. 2+ channels due to phosphorylation by cAMP-dependent protein kinase. Nature 364: 240-243, 1993.
28. Smith, M. K., R. J. Colbran, and T. R. Soderling. Specificities of autoinhibitory domain peptides for four protein kinases. Implications for intact cell studies of protein kinase function. J. Biol. Chem. 265: 1837-1840, 1990.
29. Strack, S., and R. J. Colbran. Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor. J. Biol. Chem. 273: 20689-20692, 1998.
30. Sunahara, R. K., C. W. Dessauer, and A. G. Gilman. Complexity and diversity of mammalian adenylyl cyclases. Annu. Rev. Pharmacol. Toxicol. 36: 461-480, 1996.
31. 2+ content during the cardiac cycle in guinea pig and rat ventricular myocytes. Biophys. J. 72: 1319-1326, 1997.
32. Wrzosek, A., H. Schneider, S. Grueninger, and M. Chiesi. Effect of thapsigargin on cardiac muscle cells. Cell Calcium 13: 281-292, 1992.
33. 2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx. Proc. Natl. Acad. Sci. USA 91: 9659-9663, 1994.
34. 2+ buffering in guinea pig ventricular cardiomyocytes. Biophys. J. 72: 175-187, 1997.
35. Yuan, W., and D. M. Bers. Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H982-H93, 1994.
36. Zygmunt, A. C., and W. R. Gibbons. Properties of the calcium-activated chloride current in heart. J. Gen. Physiol. 99: 391-414, 1992.