Phospholipase A2 and protein kinase C contribute to myofilament sensitization to 5-HT in the rabbit mesenteric artery

Journal of Physiology

Volumn 491, Issue 2, 1996, Pages 447-453

  Parsons, S J W ^a   Sumner, M J ^b   Garland, C J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; 5,8,11,14 ICOSATETRAYNOIC ACID; ALPHA 1 ADRENERGIC RECEPTOR; ARACHIDONIC ACID; CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; INDOMETACIN; MEPACRINE; MICONAZOLE; PHENYLEPHRINE; PHOSPHOLIPASE A2; PROTEIN KINASE C; SEROTONIN; SEROTONIN RECEPTOR; STAPHYLOCOCCUS ALPHA TOXIN; CALCIUM; PHOSPHOLIPASE A;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; FEMALE; MESENTERIC ARTERY; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; RABBIT; SENSITIZATION; VASCULAR SMOOTH MUSCLE; ANIMAL; DOSE RESPONSE; DRUG EFFECT;

ANIMALS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MESENTERIC ARTERIES; PHENYLEPHRINE; PHOSPHOLIPASES A; PROTEIN KINASE C; QUINACRINE; RABBITS; SEROTONIN;

EID: 0029670297     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021228     Document Type: Article

References (26)

1. BERRIDGE, M. J. (1990). Inositol trisphosphate and diacyglycerol as second messengers. Biochemical Journal 220, 345-360.
2. 2 activity of guinea-pig isolated perfused lungs: Stimulation and inhibition by anti-inflamatory steroids. British Journal of Pharmacology 62, 79-89.
3. 1-like receptors revealed by precontraction of rabbit isolated mesenteric artery. British Journal of Pharmacology 114, 309-314.
4. DAVIS, P. D., HILL, C. H., KEECH, E., LAWTON, G., NIXON, J. S., SEDWICK, A. D., WADSWORTH, J., WESTMACOTT, D. & WILKINSON, S. (1989). Potent selective inhibitors of protein kinase C. FEBS Letters 259, 61-63.
5. FABIATO, A. & FABIATO, F. (1979). Calculator programs for computing the composition of solutions containing multiple metals and ligands used for experiments on skinned muscle cells. Journal de Physiologie 75, 463-505.
6. FUSE, I., IWANAGA, T. & TAI, H. H. (1989). Phorbol ester, 1,2-diacylglycerol, and collagen induce inhibition of arachidonic acid incorporation into phospholipids in human platelets. Journal of Biological Chemistry 264, 3890-3895.
7. GONG, M. C., FUGLSANG, A., ALESSI, D., KOBAYASHI, S., COHEN, P., SOMLYO, A. V. & SOMLYO, A. P (1992). Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium. Journal of Biological Chemistry 267, 21492-21498.
8. GONG, M. C., SOMLYO, A. V. & SOMLYO, A. P. (1994). Free arachidonic acid (AA) and diacylglycerol (DAG) are increased by agonists in smooth muscle. Biophysical Journal 66, A409.
9. HORI, M., SATO, K., MIYAMOTO, S., OZAKI, H. & KARAKI, H. (1993). Different pathways of calcium sensitization activated by receptor agonists and phorbol esters in vascular smooth muscle. British Journal of Pharmacology 110, 1527-1531.
10. IRVINE, R. F. (1982). How is the level of arachidonic acid controlled in mammalian cells? Biochemical Journal 204, 3-16.
11. JIANG, M J. & MORGAN, K. G. (1989). Agonist specific myosin phosphorylation and intracellular calcium during isometric contractions of arterial smooth muscle. Pflügers Archiv 413, 637-643.
12. LANGE-CARTER, C. A., PLEIMAN, C. M., GARDNER, A. M., BLUMER, K. J. & JOHNSON, G. L. (1993). A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260, 315-319.
13. LEE, M. W. & SEVERSON, D. L. (1994). Signal transduction in vascular smooth muscle: diacylglycerol second messengers and PKC action. American Journal of Physiology 267, C659-678.
14. LESTER, D. S., COLLIN, C., ETCHEBERRIGARAY, R. & ALKON, D. L. (1991). Arachidonic acid and diacylglycerol act synergistically to activate protein kinase C in vitro and in vivo. Biochemical and Biophysical Research Communications 179, 1522-1529.
15. MURRAY, M. A., FARACI, F. M. & HEISTAD, D. D. (1992). Role of protein kinase C in constrictor responses of the rat basilar artery in vivo. Journal of Physiology 445, 169-179.
16. NAOR, N. (1991). Is arachidonic acid a second messenger in signal transduction? Molecular and Cellular Endocrinology 80, C181-186.
17. NISHIMURA, J., MORELAND, S., AHN, H. Y., KAWASE, T., MORELAND, R. S. & VAN BREEMEN, C. V. (1992). Endothelin increases myofilament calcium sensitivity in α-toxin permeabilized rabbit mesenteric artery. Circulation Research 71, 951-959.
18. 2+-force relationship in permeabilized arterial smooth muscle. In Regulation of Smooth Muscle Contraction, ed. MORELAND, R. S., pp. 111-127. Plenum Press, New York.
19. 2+ sensitivity. Canadian Journal of Physiology and Pharmacology 72, 1420-1426.
20. 2+-sensitization of coronary artery contraction in genetically hypertensive rats. Journal of Clinical Investigation 94, 1397-1403.
21. 1D receptor sub-type is negatively coupled to adenylate cyclase in calf substantia nigra. Naunyn-Schmiedeberg's Archives of Pharmacology 337, 602-608.
22. SEAGER, J. M., MURPHY, T. V. & GARLAND, C. J. (1994). Importance of inositol (1,4,5)-trisphosphate, intracellular calcium release and myofilament calcium sensitization in 5-hydroxytryptamine-evoked contraction of rabbit mesenteric artery. British Journal of Pharmacology 111, 525-532.
23. SHINOMURA, T., ASAOKA, Y., OKA, M., YOSHIDA, K. & NISHIZUKA, Y. (1991). Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications. Proceedings of the National Academy of Sciences of the USA 88, 5149-5153.
24. SMITH, G. L. & MILLER, D. J. (1985). Potentiometric measurements of stoichiometric and apparent affinity constants of EGTA for protons and divalent ions including calcium. Biochimica et Biophysica Acta 893, 287-299.
25. SOMLYO, A. P. & SOMLYO, A. V. (1994). Signal transduction and regulation in smooth muscle. Nature 372, 231-236.
26. SUMNER, M. J. & HUMPHREY, P. P. A. (1990). Sumatriptan (GR 43175) inhibits cyclic-AMP accumulation in dog isolated saphenous vein. British Journal of Pharmacology 99, 219-220.