Rhythm anomalies related to delayed repolarization in vivo: Influence of sarcolemmal Ca++ entry and intracellular Ca++ overload

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 1, 1996, Pages 231-239

  Carlsson, Leif ^a   Drews, Lissen ^a   Duker, Göran ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ALMOKALANT; CALCIUM CHANNEL BLOCKING AGENT; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FLUNARIZINE; METHOXAMINE; NISOLDIPINE; RYANODINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; HEART REPOLARIZATION; INTRAVENOUS DRUG ADMINISTRATION; LONG QT SYNDROME; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SARCOLEMMA; TORSADE DES POINTES;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ACTION POTENTIALS; ANIMALS; CALCIUM; ELECTROCARDIOGRAPHY; FLUNARIZINE; MALE; NISOLDIPINE; PROPANOLAMINES; RABBITS; RYANODINE; SARCOLEMMA; TORSADES DE POINTES;

EID: 0030433179     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. ALIOT, E., SZABO, B., SWEIDAN, R. AND LAZZARA, R.: Prevention of torsades de pointes with calcium channel blockade in an animal model. J. Am. Coll. Cardiol. 5: 492, 1985.
2. ANTZELEVITCH, C., SICOURI, S., LITOVSKY, S. H., LUKAS, A., KRISHNAN, S. C., DI DIEGO, J. M., GINTANT, G. A. AND LIU, D. W.: Heterogeneity within the ventricular wall: Electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ. Res. 69: 1427-1449, 1991.
3. AXENBORG, J. E. AND HIRSCH, I.: A PC-based on-line system for physiological in vivo and in vitro experiments. Comput. Methods Programs Biomed. 41: 55-67, 1993.
4. BEN-DAVID, J., ZIPES, D. P., AYERS, G. M. AND PRIDE, H. P.: Canine left ventricular hypertrophy predisposes to ventricular tachycardia induction by phase 2 early afterdepolarizations after administration of BAY K 8644. J. Am. Coll. Cardiol. 20: 1576-1584, 1992.
5. BILLMAN, G. E., MCILROY, B. AND JOHNSON, J. D.: Elevated myocardial calcium and its role in sudden cardiac death. FASEB J. 5: 2586-2592, 1991.
6. BRIL, A., FAIVRE, J. F., FOREST, M. C., CHEVAL, B., GOUT, B., LINÉE, P., RUFFOLO, R. R. JR. AND POYSER, R. H.: Electrophysiological effect of BRL-32872, a novel antiarrhythmic agent with potassium and calcium channel blocking properties, in guinea pig cardiac isolated preparations. J. Pharmacol. Exp. Ther. 273: 1264-1272, 1995.
7. BRIL, A., FAIVRE, J. F., LANDAIS, L., FOREST, M. C., GOUT, B., LINNÉ, P., RUFFOLO, R. R. JR. AND POYSER, R. H.: Effect of BRL-32872, a new class III antiarrhythmic agent, on the susceptibility to experimentally-induced triggered arrhythmias. FASEB J. 8: A79, 1994.
8. BRIL, A., GOUT, B., BONHOMME, M., LANDAIS, L., FAIVRE, J. F., LINEE, P., POYSER, R. H. AND RUFFOLO, R. R. JR.: Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: Experimental profile of BRL-32872. J. Pharmacol. Exp. Ther. 276: 637-646, 1996.
9. BUCHANAN, L. V., KABELL, G., BRUNDEM, M. N. AND GIBSON, J. K.: Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia. J. Cardiovasc. Pharmacol. 22: 540-549, 1993.
10. CAMPBELL, R. M., WOOSLEY, R. L., IANSMITH, D. H. S. AND RODEN, D. M.: Lack of triggered automaticity despite repolarization abnormalities due to bepridil and lidoflazine. PACE. 13: 30-36, 1990.
11. CARDIAC ARRHYTHMIA SUPPRESSION TRIAL (CAST) INVESTIGATORS: Increased mortality due to encainide or flecainide in a randomized trial of arrhythmia suppression after myocardial infarction. New Engl. J. Med. 321: 406-412, 1989.
12. CARLSSON, L., ABRAHAMSSON, C., ANDERSSON, B., DUKER, G., AND SCHILLER-LINHARDT, G.: Proarrhythmic effects of the class III antiarrhythmic agent almokalant: Importance of rate of infusion, QT interval dispersion and early afterdepolarizations. Cardiovasc. Res. 27: 2186-2193, 1993a.
13. CARLSSON, L., ABRAHAMSSON, C., DREWS, L. AND SCHILLER-LINHARDT, G.: Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization. Circulation 85: 1491-1500, 1992.
14. CARLSSON, L., ALMGREN, O. AND DUKER, G.: QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: Etiology and interventions. J. Cardiovasc. Pharmacol. 16: 276-285, 1990.
15. CARLSSON, L., DREWS, L., DUKER, G. AND SCHILLER-LINHARDT, G.: Attenuation of proarrhythmias related to delayed repolarization by low-dose lidocaine in the anesthetized rabbit. J. Pharmacol. Exp. Ther. 267: 1076-1080, 1993b.
16. COLATSKY, T. J. AND ARGENTIERI, T. M.: Potassium channel blockers as antiarrhythmic drugs. Drug Develop. Res. 33: 235-249, 1994.
17. COSIO, F. G., GOICOLEA, A., LÓPEZ GIL, M., KALLMEYER, C. AND BARROSO, J. L.: Suppression of torsades de pointes with verapamil in patients with atrioventricular block. Eur. Heart J. 12: 635-638 1991.
18. DE FERRARI, G. M., NADOR, F., BERIA, G., SALA, S., LOTTO, A. AND SCHWARTZ, P. J.: Effect of calcium channel block on the wall motion abnormality of the idiopathic long QT syndrome. Circulation 89: 2126-2132, 1994.
19. DE FERRARI, G. M., VIOLA, M., D'AMATO, E., ANTOLINI, R. AND FORTI, S.: Distinct patterns of calcium transients during early and delayed afterdepolarizations induced by isoproterenol in ventricular myocytes. Circulation 91: 2510-2515, 1995.
20. DESSERTENNE, F.: La tachycardie ventriculaire à deux foyers opposés variables. Arch. Mal. Coeur. 59: 263-272, 1966.
21. FLORES, N. A. AND SHERIDAN, D. J.: Electrophysiological effects of alpha-adrenoceptor stimulation in perfused and superfused myocardium. J. Mol. Cell. Cardiol. 23: 973-985, 1991.
22. HOLM, S.: A simple sequentially rejective multiple test procedure. Scand. J. Stat. 6: 65-70, 1979.
23. HOLMES, B., BROGDEN, R. N., HEEL, R. C., SPEIGHT, T. M. AND AVERY, G. S.: Flunarizine: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use. Drugs 27: 6-44, 1984.
24. JACKMAN, W. M., FRIDAY, K. J., ANDERSON, J. L., ALIOT, E. M., CLARK, M. AND LAZZARA, R.: The long QT syndromes: A critical review, new clinical observations and a unifying hypothesis. Progr. Cardiovasc. Dis. 31: 115-172, 1988.
25. JACKMAN, W. M., SZABO, B., FRIDAY, K. J., MARGOLIS, P. D., MOULTON, K., WANG, X., PATTERSON, E. AND LAZZARA, R.: Ventricular tachyarrhythmias related to early afterdepolarizations and triggered firing: Relationship to QT interval prolongation and potential therapeutic role for calcium channel blocking agents. J. Cardiovasc. Electrophysiol. 1: 170-195, 1990.
26. 2+ current. Circ. Res. 64: 977-990, 1989.
27. 2+ channel agonist Bay K 8644. Circ. Res. 62: 563-571, 1988.
28. KENNELLY, B.: Comparison of lidoflazine and quinidine in prophylactic treatment of arrhythmias. Br. Heart J. 39: 540-546, 1977.
29. KOWEY, P. R., VERRIER, R. L. AND LOWN, B.: Effect of alpha-adrenergic receptor stimulation on ventricular electrical properties in the normal canine heart. Am. Heart J. 105: 366-371, 1983.
30. LEMAY, R. J. AND GIBSON, K.: Ibutilide fumarate retains antiarrhythmic properties when combined with diltiazem in a canine model of cardiac electrophysiology. FASEB J. 9: A604, 1995.
31. MARBAN, E., ROBINSON, S. W. AND WIER, W. G.: Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J. Clin. Invest. 78: 1185-1192, 1986.
32. MING, Z., ARONSON, R. AND NORDIN, C.: Mechanism of current-induced early afterdepolarizations in guinea pig ventricular myocytes. Am. J. Physiol. 267: H1419-H1428, 1994a.
33. MING, Z., NORDIN, C. AND ARONSON, R. S.: Role of L-type calcium channel window current in generating current-induced early afterdepolarizations. J. Cardiovasc. Electrophysiol. 5: 323-334, 1994b.
34. +-induced ventricular tachyarrhythmias in anesthetized dogs. J. Cardiovasc. Pharmacol. 15: 552-561, 1990.
35. PRYSTOWSKY, E. N.: Effects of bepridil on cardiac electrophysiologic properties. Am. J. Cardiol. 69: 63D-67D, 1992.
36. RODEN, D. M.: Torsade de pointes. Clin. Cardiol. 16: 683-686, 1993a.
37. RODEN, D. M.: Current status of class III antiarrhythmic drug therapy. Am. J. Cardiol. 72: 44B-49B, 1993b.
38. ROSEN, M. R., JECK, C. D. AND STEINBERG, S. F.: Autonomic modulation of cellular repolarization and of the electrocardiographic QT interval. J. Cardiovasc. Electrophysiol. 3: 487-499, 1992.
39. SHIMIZU, W., OHE, T., KURITA, T., KAWADE, M., ARAKAKI, Y., AIHARA, N., KAMAKURA, S., KAMIYA, T. AND SHIMOMURA, K.: Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome. J. Am. Coll. Cardiol. 26: 1299-309, 1995.
40. SINGH, B. N. AND VAUGHAN WILLIAMS, E. M.: The effect of amiodarone, a new antianginal drug, on cardiac muscle. Br. J. Pharmacol. 39: 657-667, 1970.
41. SOMBERG, J. C.: Calcium channel blockers that prolong the QT interval. Am. Heart J. 109: 416-421, 1985.
42. STACY, G. P. JR., JOBE, R. L., TAYLOR, L. K. AND HANSEN, D. E.: Stretch-induced depolarizations as a trigger of arrhythmias in isolated canine left ventricles. Am. J. Physiol. 263: H613-H621, 1992.
43. STARMER, C. F., ROMASHKO, D. N., REDDY, R. S., ZILBERTER, Y. I., STAROBIN, J., GRANT, A. O. AND KRINSKY, V. I.: Proarrhythmic response to potassium channel blockade: Numerical studies of polymorphic tachyarrhythmias. Circulation 92: 595-605, 1995.
44. STRAUSS, H. C., BIGGER, J. T. AND HOFFMAN, B. F.: Electrophysiological and beta-receptor blocking effects of MJ 1999 on dog and rabbit cardiac tissue. Circ. Res. 26: 661-678, 1970.
45. +-induced early afterdepolarizations in Purkinje fibers. J. Cardiovasc. Electrophysiol. 5: 933-944, 1994.
46. TAKAHASHI, N., ITO, M., INOUE, T., KOUMATSU, K., TAKESHITA, Y., TSUMABUKI, S., TAMURA, M., INOUE, K., MAEDA, T. AND SAIKAWA, T.: Torsades de pointes associated with acquired long QT syndrome: Observation of 7 cases. J. Cardiol. 23: 99-106, 1993.
47. TAN, H. L., HOU, C. J. Y., LAUER, M. R. AND SUNG, R. J.: Electrophysiologic mechanisms of the long QT interval syndromes and torsades de pointes. Ann. Intern. Med. 122: 701-714, 1995.
48. TYTGAT, J., VEREECKE, J. AND CARMELIET, E.: Differential effects of verapamil and flunarizine on cardiac L-type and T-type Ca channels. Naunyn-Schmiedeberg's Arch. Pharmacol. 337: 690-692, 1988.
49. VAN ZWIETEN, P. A.: Differentiation of calcium entry blockers into calcium channel blockers and calcium overload blockers. Eur. Neurol. 25: suppl. 1, 57-67, 1986.
50. VERDUYN, S. C., VOS, M. A., GORGELS, A. P., VAN DER ZANDE, J., LEUNISSEN, J. D. M. AND WELLENS, H. J.: The effect of flunarizine and ryanodine on acquired torsades de pointes arrhythmias in the intact canine heart. J. Cardiovasc. Electrophysiol. 6: 189-200, 1995b.
51. VERDUYN, S. C., VOS, M. A., VAN DER ZANDE, J., DE GROOT, M., ALLESSIE, M. AND WELLENS, H. J.: Biventricular hypertrophy facilitates occurrence of acquired torsade de pointes arrhythmias in dogs. Circulation 92: I-504, 1995a.
52. VOS, M. A., VERDUYN, S. C., GORGELS, A. P. M., LIPCSEI, G. C. AND WELLENS, H. J. J: Reproducible induction of early afterdepolarizations and torsades de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation 91: 864-872, 1995.
53. ZHOU, J. T., ZHENG, L. R. AND LIU, W. Y.: Role of early afterdepolarization in familial long QT syndrome and torsade de pointes. PACE. 15: 2164-2168, 1992.