Alterations in receptor activation and divalent cation activation of agonist binding by deletion of intracellular domains of the glucagon receptor

Journal of Biological Chemistry

Volumn 272, Issue 12, 1997, Pages 7765-7769

  Chicchi, Gary G ^a   Graziano, Michael P ^a   Koch, Greg ^a   Hey, Patricia ^a   Sullivan, Kathleen ^a   Vicario, Pasquale P ^a   Cascieri, Margaret A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; GLUCAGON; GLUCAGON RECEPTOR; GUANYLYLIMIDODIPHOSPHATE;

ANIMAL CELL; ARTICLE; DELETION MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CATIONS, DIVALENT; CELL MEMBRANE; COS CELLS; GLUCAGON; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; RADIOLIGAND ASSAY; RECEPTORS, GLUCAGON; RECOMBINANT PROTEINS; SEQUENCE DELETION;

EID: 0030909710     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.12.7765     Document Type: Article

References (11)

1. Jelinek, L. J., Lok, S., Rosenberg, G. B., Smith, R. A., Grant, F. J., Biggs, S., Bensch, P. A., Kuijper, J. L., Sheppard, P. O., Sprecher, C. A., O'Hara, P. J., Foster, D., Walker, K M., Chen, L. H. J., McKernan, P. A., and Kindsvogel, W. (1993) Science 259, 1614-1616
2. Strader, C. D., Fong, T. M., Tota, M. R., Underwood, D., and Dixon, R. A. F. (1994) Annu. Rev. Biochem. 63, 101-132
3. Cascieri, M. A., Fong, T. M., and Strader, C. D. (1995) J. Pharmacol. Toxicol. Methods 33, 179-185
4. Strader, C. D., Dixon, R. A. F., Cheung, A. H., Candelore, M. R., Blake, A. D., and Sigal, I. S. (1987) J. Biol. Chem. 262, 16439-16443
5. Takhar, S., Gyomorey, S., Su, R.-C., Mathi, S. K., Li, X., and Wheeler, M. B. (1996) Endocrinology 137, 2175-2178
6. MacNeil, D. J., Occi, J. L., Hey, P. J., Strader, C. D., and Graziano, M. P. (1994) Biochem. Biophys. Res. Commun. 198, 328-334
7. Tota, M. R., Xu, L., Sirotani, A., Strader, C. D., and Graziano, M. P. (1995) J. Biol. Chem. 270, 26466-26472
8. Probst, W. C., Snyder, L. A., Schuster, D. I., Brosius, J., and Sealfon, S. C. (1992) DNA Cell Biol. 11, 1-20
9. Padrell, E., Herberg, J. T., Monsatirsky, B., Floyd, G., Premont, R. T., and Iyengar, R. (1987) Endocrinology 120, 2316-2325
10. Rojas, F. J., and Birnbaumer, L. (1985) J. Biol. Chem. 260, 7829-7835
11. Post, S. R., Miyazaki, H., and Tager, H. S. (1992) J. Biol. Chem. 267, 25776-25785