메뉴 건너뛰기




Volumn 12, Issue 1, 1999, Pages 117-129

The hairpin ribozyme: Discovery, mechanism, and development for gene therapy

Author keywords

Catalytic RNA; Gene therapy; Hairpin ribozyme; Mechanism

Indexed keywords

RIBOZYME; RNA;

EID: 0032754961     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:12:1:117     Document Type: Review
Times cited : (29)

References (64)
  • 1
    • 0031961687 scopus 로고    scopus 로고
    • The hairpin ribozyme: Discovery, two-dimensional model and development for gene therapy
    • (Moldave, K., ed.), Academic Press, San Diego
    • Hampel, A. (1998) The hairpin ribozyme: Discovery, two-dimensional model and development for gene therapy, in Progress in Nucleic Acids Research and Molecular Biology, vol 58 (Moldave, K., ed.), Academic Press, San Diego, pp. 1-38.
    • (1998) Progress in Nucleic Acids Research and Molecular Biology , vol.58 , pp. 1-38
    • Hampel, A.1
  • 3
    • 0024448572 scopus 로고
    • Sequences required for self-catalyzed cleavage of the satellite RNA of tobacco ringspot virus
    • Haseloff, J. and Gerlach, W. (1989) Sequences required for self-catalyzed cleavage of the satellite RNA of tobacco ringspot virus. Gene 82, 43-52.
    • (1989) Gene , vol.82 , pp. 43-52
    • Haseloff, J.1    Gerlach, W.2
  • 4
    • 0028848490 scopus 로고
    • Catalytic properties derived from chicory yellow mottle virus and arabis mosaic virus satellite RNAs
    • DeYoung, M., Siwkowski, A., Lian, Y., and Hampel A. (1995) Catalytic properties derived from chicory yellow mottle virus and arabis mosaic virus satellite RNAs. Biochemistry 34, 15,785-15,791.
    • (1995) Biochemistry , vol.34 , pp. 15785-15791
    • DeYoung, M.1    Siwkowski, A.2    Lian, Y.3    Hampel, A.4
  • 5
    • 0022504077 scopus 로고
    • Satellite tobacco ringspot virus RNA: Biological activity of DNA clones and their in vitro transcripts
    • Gerlach, W. Buzayan, J., Schneider, I., and Bruening, G. (1986) Satellite tobacco ringspot virus RNA: Biological activity of DNA clones and their in vitro transcripts. Virology 151, 172-185.
    • (1986) Virology , vol.151 , pp. 172-185
    • Gerlach, W.1    Buzayan, J.2    Schneider, I.3    Bruening, G.4
  • 6
    • 0024340908 scopus 로고
    • RNA catalytic properties of the minimum (-)sTRSV sequence
    • Hampel, A. and Tritz, R. (1989) RNA catalytic properties of the minimum (-)sTRSV sequence. Biochemistry 28, 4929-4933.
    • (1989) Biochemistry , vol.28 , pp. 4929-4933
    • Hampel, A.1    Tritz, R.2
  • 7
    • 0025021952 scopus 로고
    • Hairpin catalytic RNA model: Evidence for helices and sequence requirement for substrate RNA
    • Hampel, A., Tritz, R., Hicks, M., and Cruz, P. (1990) Hairpin catalytic RNA model: Evidence for helices and sequence requirement for substrate RNA. Nucleic Acids Acids Res. 18, 299-304.
    • (1990) Nucleic Acids Acids Res. , vol.18 , pp. 299-304
    • Hampel, A.1    Tritz, R.2    Hicks, M.3    Cruz, P.4
  • 8
    • 0030938048 scopus 로고    scopus 로고
    • Analysis of hairpin ribozyme base mutations in loops 2 and 4 and their effects on cis-cleavage in vitro
    • Siwkowski, A., Shippy, R., and Hampel, A. (1997) Analysis of hairpin ribozyme base mutations in loops 2 and 4 and their effects on cis-cleavage in vitro. Biochemistry 36, 3930-3940.
    • (1997) Biochemistry , vol.36 , pp. 3930-3940
    • Siwkowski, A.1    Shippy, R.2    Hampel, A.3
  • 9
    • 0032512431 scopus 로고    scopus 로고
    • Mutational analysis of loops 1 and 5 of the hairpin ribozyme
    • Shippy, R., Siwkowski, A., and Hampel, A. (1997) Mutational analysis of loops 1 and 5 of the hairpin ribozyme. Biochemistry 37, 564-570.
    • (1997) Biochemistry , vol.37 , pp. 564-570
    • Shippy, R.1    Siwkowski, A.2    Hampel, A.3
  • 10
    • 0029762740 scopus 로고    scopus 로고
    • Enhanced folding of hairpin ribozymes with replaced domains
    • Komatsu, Y., Kanzaki, I., and Ohtsuka, E. (1996) Enhanced folding of hairpin ribozymes with replaced domains. Biochemistry 35, 9815-9820.
    • (1996) Biochemistry , vol.35 , pp. 9815-9820
    • Komatsu, Y.1    Kanzaki, I.2    Ohtsuka, E.3
  • 11
    • 0027310473 scopus 로고
    • Catalytically active geometry in the reversible circularization of mini-monomer RNAs derived from the complementary strand of tobacco ringspot virus satellite RNA
    • Feldstein, P. and Bruening, G. (1993) Catalytically active geometry in the reversible circularization of mini-monomer RNAs derived from the complementary strand of tobacco ringspot virus satellite RNA. Nucleic Acids Res. 21, 1991-1998.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 1991-1998
    • Feldstein, P.1    Bruening, G.2
  • 12
    • 0028137344 scopus 로고
    • Loop-size variation to probe a bent structure of a hairpin ribozyme
    • Komatsu, Y., Koizumi, M. Nakamura, H., and Ohtsuka, E. (1994) Loop-size variation to probe a bent structure of a hairpin ribozyme. J. Am. Chem. Soc. 116, 3692-3696.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 3692-3696
    • Komatsu, Y.1    Koizumi, M.2    Nakamura, H.3    Ohtsuka, E.4
  • 14
    • 0032061318 scopus 로고    scopus 로고
    • Folding of the hairpin ribozyme in its natural conformation achieves close physical proximity of the loops
    • Murchie, A., Thompson, J., Walter, F., and Lilley, D. (1998) Folding of the hairpin ribozyme in its natural conformation achieves close physical proximity of the loops. Molecular Cell 1, 873-881.
    • (1998) Molecular Cell , vol.1 , pp. 873-881
    • Murchie, A.1    Thompson, J.2    Walter, F.3    Lilley, D.4
  • 15
    • 0023055382 scopus 로고
    • Nucleotide sequence and newly formed phosphodiester bond of spontaneously ligated satellite tobacco ringspot virus RNA
    • Buzayan, J., Hampel, A., and Bruening, G. (1986) Nucleotide sequence and newly formed phosphodiester bond of spontaneously ligated satellite tobacco ringspot virus RNA. Nucleic Acids Res. 14, 9729-9743.
    • (1986) Nucleic Acids Res. , vol.14 , pp. 9729-9743
    • Buzayan, J.1    Hampel, A.2    Bruening, G.3
  • 16
    • 0025335881 scopus 로고
    • Two autolytic processing reactions of a satellite RNA proceed with inversion or configuration
    • van Tol, H., Buzayan, J., Feldstein, P. Eckstein, F., and Bruening, G. (1990) Two autolytic processing reactions of a satellite RNA proceed with inversion or configuration. Nucleic Acids. Res. 18, 1971-1975.
    • (1990) Nucleic Acids. Res. , vol.18 , pp. 1971-1975
    • Van Tol, H.1    Buzayan, J.2    Feldstein, P.3    Eckstein, F.4    Bruening, G.5
  • 17
    • 0022504693 scopus 로고
    • Non-enzymatic cleavage and ligation of RNAs complementary to a plant virus satellite RNA
    • Buzayan, J., Gerlach, W., and Bruening, G. (1986) Non-enzymatic cleavage and ligation of RNAs complementary to a plant virus satellite RNA. Nature 323, 349-353.
    • (1986) Nature , vol.323 , pp. 349-353
    • Buzayan, J.1    Gerlach, W.2    Bruening, G.3
  • 18
    • 0024464361 scopus 로고
    • Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA
    • Feldstein, P., Buzayan, J., and Bruening, G. (1989) Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA. Gene 82, 53-61.
    • (1989) Gene , vol.82 , pp. 53-61
    • Feldstein, P.1    Buzayan, J.2    Bruening, G.3
  • 19
    • 0009545065 scopus 로고    scopus 로고
    • Biochemistry of the hairpin ribozyme
    • R. G., (Scanlon, K. and Kashani-Sabet, M., ed.) Landes, Austin
    • Hampel, A. and Siwkowski, A. (1998) Biochemistry of the hairpin ribozyme, in Ribozymes in the Gene Therapy of Cancer, R. G., (Scanlon, K. and Kashani-Sabet, M., ed.) Landes, Austin, pp. 15-22.
    • (1998) Ribozymes in the Gene Therapy of Cancer , pp. 15-22
    • Hampel, A.1    Siwkowski, A.2
  • 20
    • 0028837570 scopus 로고
    • Kinetics and thermodynamics of intermolecular catalysis by hairpin ribozymes
    • Hegg, L. and Fedor, M. (1995) Kinetics and thermodynamics of intermolecular catalysis by hairpin ribozymes. Biochemistry 34, 15,813-15,828.
    • (1995) Biochemistry , vol.34 , pp. 15813-15828
    • Hegg, L.1    Fedor, M.2
  • 21
    • 0029866783 scopus 로고    scopus 로고
    • Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: Implications for secondary structure
    • Schmidt, S., Beigelman, L. Karpeisky, A., Usman, N. Sorensen, U., and Gait, M. (1996) Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: Implications for secondary structure. Nucleic Acids Res. 24, 573-581.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 573-581
    • Schmidt, S.1    Beigelman, L.2    Karpeisky, A.3    Usman, N.4    Sorensen, U.5    Gait, M.6
  • 22
    • 0029121067 scopus 로고
    • Modification of primary structures of hairpin ribozymes for probing active conformations
    • Komatsu, Y., Kanzaki, I., Koizumi, M., and Ohtsuka, E. (1995) Modification of primary structures of hairpin ribozymes for probing active conformations. J. Mol. Biol. 252, 296-304.
    • (1995) J. Mol. Biol. , vol.252 , pp. 296-304
    • Komatsu, Y.1    Kanzaki, I.2    Koizumi, M.3    Ohtsuka, E.4
  • 23
    • 0031995580 scopus 로고    scopus 로고
    • The hairpin ribozyme: Structure, assembly and catalysis
    • Walter, N. and Burke, J. (1998) The hairpin ribozyme: Structure, assembly and catalysis. Current Opinion in Chemical Biology 2, 24-30.
    • (1998) Current Opinion in Chemical Biology , vol.2 , pp. 24-30
    • Walter, N.1    Burke, J.2
  • 24
    • 0026506026 scopus 로고
    • In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions
    • Berzal-Herranz, A., Joseph, B., and Burke, J. (1992) In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions. Genes and Development 6, 129-134.
    • (1992) Genes and Development , vol.6 , pp. 129-134
    • Berzal-Herranz, A.1    Joseph, B.2    Burke, J.3
  • 26
    • 0026047343 scopus 로고
    • Binding and cleavage of nucleic acids by the hairpin ribozyme
    • Chowrira, B. and Burke, J. (1991) Binding and cleavage of nucleic acids by the hairpin ribozyme. Biochemistry 30, 8518-8522.
    • (1991) Biochemistry , vol.30 , pp. 8518-8522
    • Chowrira, B.1    Burke, J.2
  • 27
    • 0031194873 scopus 로고    scopus 로고
    • A unique mechanism for RNA ctalysis: The role of metal cofactors in hairpin ribozyme cleavage
    • Hampel, A. and Cowen, J. (1997) A unique mechanism for RNA ctalysis: The role of metal cofactors in hairpin ribozyme cleavage. Chemistry and Biology 4, 513-517.
    • (1997) Chemistry and Biology , vol.4 , pp. 513-517
    • Hampel, A.1    Cowen, J.2
  • 28
    • 0031215134 scopus 로고    scopus 로고
    • An unusual pH-independent and metal ion independent mechanism for hairpin ribozyme catalysis
    • Nesbitt, S., Hegg, L., and Fedor, M. (1997) An unusual pH-independent and metal ion independent mechanism for hairpin ribozyme catalysis. Chemistry and Biology 4, 619-630.
    • (1997) Chemistry and Biology , vol.4 , pp. 619-630
    • Nesbitt, S.1    Hegg, L.2    Fedor, M.3
  • 29
    • 0030967825 scopus 로고    scopus 로고
    • Metal ions play a passive role in the hairpin ribozyme catalysed reaction
    • Young, K., Gill, F., and Grasby, J. (1997) Metal ions play a passive role in the hairpin ribozyme catalysed reaction. Nucleic Acids Res. 25, 3760-3766.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 3760-3766
    • Young, K.1    Gill, F.2    Grasby, J.3
  • 30
    • 0032491204 scopus 로고    scopus 로고
    • Structure and activity of hairpin ribozyme in its natural junction conformation: Effect of metal ions
    • Walter, F., Alastair, I., Murchie, H., Thomson, J., and Lilley, D. (1998) Structure and activity of hairpin ribozyme in its natural junction conformation: Effect of metal ions. Biochemistry 37, 14,195-14,203.
    • (1998) Biochemistry , vol.37 , pp. 14195-14203
    • Walter, F.1    Alastair, I.2    Murchie, H.3    Thomson, J.4    Lilley, D.5
  • 31
    • 0032534533 scopus 로고    scopus 로고
    • Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions
    • Earnshaw, D. and Gait, M. (1998) Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions. Nucleic Acids Res. 26, 5551-5561.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 5551-5561
    • Earnshaw, D.1    Gait, M.2
  • 32
    • 0027400338 scopus 로고
    • Metallobiochemistry of RNA: Cobalt hexaammine as a probe for magnesium binding sites
    • Cowan, J. (1993) Metallobiochemistry of RNA: Cobalt hexaammine as a probe for magnesium binding sites. Journal of Inorganic Biochemistry 49, 171-175.
    • (1993) Journal of Inorganic Biochemistry , vol.49 , pp. 171-175
    • Cowan, J.1
  • 33
    • 0004289454 scopus 로고
    • Biological chemistry of magnesium ion with physiological metabolites, nucleic acids, and drug molecules
    • (Cowen, J. ed.) VCH publishers, Inc., New York
    • Cowan, J. (1995) Biological chemistry of magnesium ion with physiological metabolites, nucleic acids, and drug molecules, in The Biological Chemistry of Magnesium, (Cowen, J. ed.) VCH publishers, Inc., New York. pp. 185-209.
    • (1995) The Biological Chemistry of Magnesium , pp. 185-209
    • Cowan, J.1
  • 34
    • 0028237035 scopus 로고
    • Stabilization of RNA structure by Mg ions: Specific and non-specific effects
    • Laing, L., Gluick, T., and Draper, D. (1994) Stabilization of RNA structure by Mg ions: Specific and non-specific effects. J. Mol. Biol. 237, 577-587.
    • (1994) J. Mol. Biol. , vol.237 , pp. 577-587
    • Laing, L.1    Gluick, T.2    Draper, D.3
  • 35
    • 0031915892 scopus 로고    scopus 로고
    • Screening for important base identities in the hairpin ribozyme by in vitro selection for cleavage
    • Siwkowski, A., Humphrey, M., DeYoung, M., and Hampel, A. (1998) Screening for important base identities in the hairpin ribozyme by in vitro selection for cleavage. Biotechniques 24, 278-284.
    • (1998) Biotechniques , vol.24 , pp. 278-284
    • Siwkowski, A.1    Humphrey, M.2    DeYoung, M.3    Hampel, A.4
  • 37
    • 0025932338 scopus 로고
    • Novel guanosine requirement for catalysis by the hairpin ribozyme
    • Chowrira, B. M., Berzal-Herranz, A., and Burke, J. (1991) Novel guanosine requirement for catalysis by the hairpin ribozyme. Nature 354, 320-322.
    • (1991) Nature , vol.354 , pp. 320-322
    • Chowrira, B.M.1    Berzal-Herranz, A.2    Burke, J.3
  • 38
    • 0028903816 scopus 로고
    • Purine functional groups in essential residues of the hairpin ribozyme required for catalytic cleavage of RNA
    • Grasby, J., Mersmann, K., Singh, M., and Gait, M. (1995) Purine functional groups in essential residues of the hairpin ribozyme required for catalytic cleavage of RNA. Biochemistry 34, 4068-4076.
    • (1995) Biochemistry , vol.34 , pp. 4068-4076
    • Grasby, J.1    Mersmann, K.2    Singh, M.3    Gait, M.4
  • 39
    • 0033065715 scopus 로고    scopus 로고
    • The influence of junction conformation on RNA cleavage by the hairpin ribozyme in its natural junction form
    • Thomson, J. and Lilley, D. (1999) The influence of junction conformation on RNA cleavage by the hairpin ribozyme in its natural junction form. RNA 5, 180-187.
    • (1999) RNA , vol.5 , pp. 180-187
    • Thomson, J.1    Lilley, D.2
  • 40
    • 0032192170 scopus 로고    scopus 로고
    • Expression of ribozymes in gene transfer systems to modulate target RNA levels
    • Welch, P., Barber, J., and Wong-Staal, F. (1998) Expression of ribozymes in gene transfer systems to modulate target RNA levels. Current Opinion in Biotechnology. 9, 486-496.
    • (1998) Current Opinion in Biotechnology , vol.9 , pp. 486-496
    • Welch, P.1    Barber, J.2    Wong-Staal, F.3
  • 42
    • 0000415254 scopus 로고    scopus 로고
    • Inhibition of HIV replication by the hairpin ribozyme
    • (Eckslein, F. and Lilley, D, ed.) Springer-Verlag, Berlin
    • Welch, P., Hampel, A., Barber, J., Wong-Staal, F., and Yu, M. (1996) Inhibition of HIV replication by the hairpin ribozyme, in Catalytic RNA, vol. 10, (Eckslein, F. and Lilley, D, ed.) Springer-Verlag, Berlin, pp. 315-327.
    • (1996) Catalytic RNA , vol.10 , pp. 315-327
    • Welch, P.1    Hampel, A.2    Barber, J.3    Wong-Staal, F.4    Yu, M.5
  • 43
    • 0030933218 scopus 로고    scopus 로고
    • Multigene antiviral vectors inhibit diverse human immunodeficiency virus type 1 clades
    • Gervaix, A., Li, X., Kraus, G., and Wong-Staal, F. (1997) Multigene antiviral vectors inhibit diverse human immunodeficiency virus type 1 clades. Journal of Virology 71, 3048-3053.
    • (1997) Journal of Virology , vol.71 , pp. 3048-3053
    • Gervaix, A.1    Li, X.2    Kraus, G.3    Wong-Staal, F.4
  • 44
    • 0031564333 scopus 로고    scopus 로고
    • Gene therapy targeting peripheral blood CD34+ hematopoietic stem cells of HIV-infected individuals
    • Gervaix, A., Schwarz, L., Law, P. Ho, A., Looney, D., Lane, T., and Wong-Staal, F. (1997) Gene therapy targeting peripheral blood CD34+ hematopoietic stem cells of HIV-infected individuals. Human Gene Therapy 8, 2229-2238.
    • (1997) Human Gene Therapy , vol.8 , pp. 2229-2238
    • Gervaix, A.1    Schwarz, L.2    Law, P.3    Ho, A.4    Looney, D.5    Lane, T.6    Wong-Staal, F.7
  • 46
    • 0031934753 scopus 로고    scopus 로고
    • Gene therapy targeting cord blood-derived CD34+ cells from HIV-exposed infants: Preclinical studies
    • Li, X., Gervaix, A., Kang, D., Law, P., Spector, S., Ho, A., and Wong-Staal, F. (1998) Gene therapy targeting cord blood-derived CD34+ cells from HIV-exposed infants: Preclinical studies. Gene therapy 5, 233-239.
    • (1998) Gene therapy , vol.5 , pp. 233-239
    • Li, X.1    Gervaix, A.2    Kang, D.3    Law, P.4    Spector, S.5    Ho, A.6    Wong-Staal, F.7
  • 47
    • 0026496702 scopus 로고
    • Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme
    • Ojwang, J., Hampel, A., Looney, D., and Wong-Staal, F. (1992) Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme. Proc. Nat. Acad. Sci. USA 89, 10,802-10,806.
    • (1992) Proc. Nat. Acad. Sci. USA , vol.89 , pp. 10802-10806
    • Ojwang, J.1    Hampel, A.2    Looney, D.3    Wong-Staal, F.4
  • 48
    • 0031440054 scopus 로고    scopus 로고
    • Intracellular immunization of rhesus CD34+ hematopoietic progenitor cells with a hairpin ribozyme protects T cells and macrophages from simian immunodeficiency virus infection
    • Rosenzweig, M., Marks, D., Hempel, D., Heusch, M., Kraus, G., Wong-Staal, F., and Johnson, R. (1997) Intracellular immunization of rhesus CD34+ hematopoietic progenitor cells with a hairpin ribozyme protects T cells and macrophages from simian immunodeficiency virus infection. Blood. 90, 4822-4831.
    • (1997) Blood , vol.90 , pp. 4822-4831
    • Rosenzweig, M.1    Marks, D.2    Hempel, D.3    Heusch, M.4    Kraus, G.5    Wong-Staal, F.6    Johnson, R.7
  • 49
    • 0028051280 scopus 로고
    • Intracellular immunization of human T-cells with a hairpin ribozyme against human immunodeficiecy virus type 1
    • Yamada, O., Yu, M., Yee, J., Kraus, G., Looney, D., and F. Wong-Staal (1994) Intracellular immunization of human T-cells with a hairpin ribozyme against human immunodeficiecy virus type 1. Gene Therapy, 1, 38-45.
    • (1994) Gene Therapy , vol.1 , pp. 38-45
    • Yamada, O.1    Yu, M.2    Yee, J.3    Kraus, G.4    Looney, D.5    Wong-Staal, F.6
  • 52
  • 53
    • 0029972264 scopus 로고    scopus 로고
    • A potential therapeutic application of hairpin ribozymes: In vitro and in vivo studies of gene therapy for hepatitis C virus infection
    • Welch, P., Tritz, R., Yei, S., Leavitt, M., Yu, M., and Barber, J. (1996) A potential therapeutic application of hairpin ribozymes: In vitro and in vivo studies of gene therapy for hepatitis C virus infection. Gene Therapy 3, 994-1001.
    • (1996) Gene Therapy , vol.3 , pp. 994-1001
    • Welch, P.1    Tritz, R.2    Yei, S.3    Leavitt, M.4    Yu, M.5    Barber, J.6
  • 54
    • 0030743739 scopus 로고    scopus 로고
    • Intracellular application of hairpin ribozyme genes against hepatitis B virus
    • Welch, P., Tritz, R., Yei, S., Barber, J., and Yu, M. (1997) Intracellular application of hairpin ribozyme genes against hepatitis B virus. Gene Therapy 4, 736-743.
    • (1997) Gene Therapy , vol.4 , pp. 736-743
    • Welch, P.1    Tritz, R.2    Yei, S.3    Barber, J.4    Yu, M.5
  • 55
    • 0031965901 scopus 로고    scopus 로고
    • Ribozyme-targeted destruction of RNA associated with autosomal-dominant retinitis pigmentosa
    • Drenser, K., Timmers, A., Hauswirth, W. and Lewin, A. (1998) Ribozyme-targeted destruction of RNA associated with autosomal-dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 39, 681-689.
    • (1998) Invest. Ophthalmol. Vis. Sci. , vol.39 , pp. 681-689
    • Drenser, K.1    Timmers, A.2    Hauswirth, W.3    Lewin, A.4
  • 56
    • 0031880563 scopus 로고    scopus 로고
    • Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa
    • Lewin, A., Drenser, K., Hauswirth, W., Nishikawa, S., Yasumura, D., Flannery, J., and La Vail, M. (1998) Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa. Nature Medicine 4, 967-971.
    • (1998) Nature Medicine , vol.4 , pp. 967-971
    • Lewin, A.1    Drenser, K.2    Hauswirth, W.3    Nishikawa, S.4    Yasumura, D.5    Flannery, J.6    La Vail, M.7
  • 57
    • 0028286313 scopus 로고
    • Ribozyme mediated degradation of b-amyloid peptide precursor mRNA in COS-7 cells
    • Denman, R., Smedman, M., Ju, W., Rubenstein, R., Potempska, A., and Miller, D. (1994) Ribozyme mediated degradation of b-amyloid peptide precursor mRNA in COS-7 cells. Nucleic Acids Res. 22, 2375-2382.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 2375-2382
    • Denman, R.1    Smedman, M.2    Ju, W.3    Rubenstein, R.4    Potempska, A.5    Miller, D.6
  • 58
    • 0031241407 scopus 로고    scopus 로고
    • Ribozyme-mediated inhibition of Philadelphia chromosome-positive acute lymphoblastic leukemia cell line expressing the p190 ber-abl oncogene
    • Snyder, D., Wu, Y., McMahon, R., Yu, L., Rossi, J., and Forman, S. (1997) Ribozyme-mediated inhibition of Philadelphia chromosome-positive acute lymphoblastic leukemia cell line expressing the p190 ber-abl oncogene. Biol. Blood Marrow Transplant 3, 179-186.
    • (1997) Biol. Blood Marrow Transplant , vol.3 , pp. 179-186
    • Snyder, D.1    Wu, Y.2    McMahon, R.3    Yu, L.4    Rossi, J.5    Forman, S.6
  • 60
    • 0027417088 scopus 로고
    • Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates
    • Joseph, S., Berzal-Herranz, A., Chowrira, B., and Burke, J. (1993) Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates. Genes and Development 7, 130-138.
    • (1993) Genes and Development , vol.7 , pp. 130-138
    • Joseph, S.1    Berzal-Herranz, A.2    Chowrira, B.3    Burke, J.4
  • 61
    • 0030630461 scopus 로고    scopus 로고
    • Computer Analysis of the conservation and uniqueness of ribozyme-targeted HIV sequences
    • (Turner, P. ed.), Humana Press, Totawa. NJ
    • DeYoung, M.B., Siwkowski, A., and Hampel, A. (1997) Computer Analysis of the conservation and uniqueness of ribozyme-targeted HIV sequences, in_Methods in Molecular Biology: Ribozyme Protocols, (Turner, P. ed.), Humana Press, Totawa. NJ. pp. 27-36.
    • (1997) Methods in Molecular Biology: Ribozyme Protocols , pp. 27-36
    • DeYoung, M.B.1    Siwkowski, A.2    Hampel, A.3
  • 62
    • 0030634287 scopus 로고    scopus 로고
    • Design of the hairpin ribozyme for targeting specific RNA sequences
    • (Turner, P. ed.), Humana Press, Totawa, NJ
    • Hampel, A., DeYoung, M., Galasinski, S., and Siwkowski, A. (1997) Design of the hairpin ribozyme for targeting specific RNA sequences, in_Methods in Molecular Biology: Ribozyme Protocols, (Turner, P. ed.), Humana Press, Totawa, NJ, pp. 171-177.
    • (1997) Methods in Molecular Biology: Ribozyme Protocols , pp. 171-177
    • Hampel, A.1    DeYoung, M.2    Galasinski, S.3    Siwkowski, A.4
  • 63
    • 0025071240 scopus 로고
    • Solution structure of an unusually stable RNA hairpin, 5′ GGAC(UUCG)GUCC
    • Cheong, C., Varani, G., and Tinoco, I. (1990) Solution structure of an unusually stable RNA hairpin, 5′ GGAC(UUCG)GUCC. Nature, 346, 680-682.
    • (1990) Nature , vol.346 , pp. 680-682
    • Cheong, C.1    Varani, G.2    Tinoco, I.3
  • 64
    • 0033058951 scopus 로고    scopus 로고
    • The sCYMVI ribozyme: Targeting rules and cleavage of heterologous RNA
    • Lian, Ying, DeYoung, M., Siwkowski, A., Hampel, A., and Rappaport, J. (1999) The sCYMVI ribozyme: Targeting rules and cleavage of heterologous RNA. Gene Therapy, 6, 1114-1119.
    • (1999) Gene Therapy , vol.6 , pp. 1114-1119
    • Lian1    Ying2    DeYoung, M.3    Siwkowski, A.4    Hampel, A.5    Rappaport, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.