Synthesis and pharmacological evaluation of carboxamide derivatives as selective serotoninergic 5-HT4 receptor agonists

European Journal of Medicinal Chemistry

Volumn 34, Issue 4, 1999, Pages 329-341

  Itoh, Katsuhiko ^a   Kanzaki, Koji ^a   Ikebe, Tsuguo ^a   Kuroita, Takanobu ^a   Tomozane, Hideo ^a   Sonda, Shuji ^a   Sato, Noriko ^a   Haga, Keiichiro ^a   Kawakita, Takeshi ^a  

^a Yoshitomi Pharmaceutical Industries Ltd   (Japan)

Author keywords

5 HT4 receptor; 5 HT4 receptor agonist; Carboxamide; Receptor model construction; Structure activity relationship

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 4 AMINO 5 CHLORO 2 METHOXY N [1 [2 [(METHYLSULFONYL)AMINO]ETHYL] 4 PIPERIDINYLMETHYL]BENZAMIDE; AMIDE; CLEBOPRIDE; GRANISETRON; SEROTONIN; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COLON MOTILITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; MALE; NONHUMAN; RECEPTOR AFFINITY; SEROTONINERGIC SYSTEM; SMOOTH MUSCLE CONTRACTILITY; STRUCTURE ACTIVITY RELATION;

EID: 0032751003     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80083-X     Document Type: Review

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