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Volumn 44, Issue 4, 1996, Pages 756-764
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Design and synthesis of 6-chloro-3,4-dihydro-4-methyl-2H-1,4-benzoxazine-8-carboxamide derivatives as potent serotonin-3 (5-HT3) receptor antagonists
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Author keywords
1,4 benzoxazine 8 carboxamide; 5 HT3 receptor antagonist; 5 HT3 receptor binding; Structure activity relationship; Von Bezold Jarisch reflex
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Indexed keywords
AZASETRON;
N (1 AZABICYCLO[2.2.2]OCT 3 YL) 6 CHLORO 3,4 DIHYDRO 4 METHYL 2H 1,4 BENZOXAZINE 8 CARBOXAMIDE;
SEROTONIN 3 ANTAGONIST;
UNCLASSIFIED DRUG;
ZACOPRIDE;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ARTICLE;
BRADYCARDIA;
CONFORMATIONAL TRANSITION;
DRUG CONFORMATION;
DRUG DESIGN;
DRUG POTENCY;
DRUG RECEPTOR BINDING;
DRUG SYNTHESIS;
INTRAVENOUS DRUG ADMINISTRATION;
MALE;
MOUSE;
NONHUMAN;
RECEPTOR AFFINITY;
STRUCTURE ACTIVITY RELATION;
ANIMALS;
BENZAMIDES;
BICYCLO COMPOUNDS, HETEROCYCLIC;
BINDING, COMPETITIVE;
BLOOD PRESSURE;
CEREBRAL CORTEX;
GRANISETRON;
HEART RATE;
MALE;
OXAZINES;
RATS;
RECEPTORS, SEROTONIN;
REFLEX;
SEROTONIN ANTAGONISTS;
STEREOISOMERISM;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 0029887563
PISSN: 00092363
EISSN: None
Source Type: Journal
DOI: 10.1248/cpb.44.756 Document Type: Article |
Times cited : (34)
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References (24)
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