Design and synthesis of 6-chloro-3,4-dihydro-4-methyl-2H-1,4-benzoxazine-8-carboxamide derivatives as potent serotonin-3 (5-HT3) receptor antagonists

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 4, 1996, Pages 756-764

  Kuroita, Takanobu ^a   Sakamori, Masamitsu ^a   Kawakita, Takeshi ^a  

^a Research Laboratories   (Japan)

Author keywords

1,4 benzoxazine 8 carboxamide; 5 HT3 receptor antagonist; 5 HT3 receptor binding; Structure activity relationship; Von Bezold Jarisch reflex

Indexed keywords

AZASETRON; N (1 AZABICYCLO[2.2.2]OCT 3 YL) 6 CHLORO 3,4 DIHYDRO 4 METHYL 2H 1,4 BENZOXAZINE 8 CARBOXAMIDE; SEROTONIN 3 ANTAGONIST; UNCLASSIFIED DRUG; ZACOPRIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYCARDIA; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; BLOOD PRESSURE; CEREBRAL CORTEX; GRANISETRON; HEART RATE; MALE; OXAZINES; RATS; RECEPTORS, SEROTONIN; REFLEX; SEROTONIN ANTAGONISTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029887563     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.756     Document Type: Article

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