Induction of rapid IL-1β mRNA degradation in THP-1 cells mediated through the AU-rich region in the 3'UTR by a radicicol analogue

Cytokine

Volumn 8, Issue 10, 1996, Pages 751-761

  Kastelic, Tania ^a   Schnyder, Jörg ^a   Leutwiler, Albert ^a   Traber, René ^b   Streit, Bruno ^a   Niggli, Heinz ^a   MacKenzie, Andrew ^a   Cheneval, Dominique ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Sandoz Pharma Ltd   (Switzerland)

Author keywords

3'UTR; Auuua motif; mRNA degradation; Radicicol; THP 1

Indexed keywords

CYTOPLASM PROTEIN; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MYRISTIC ACID DERIVATIVE; RADICICOL DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA FLANKING REGION; DNA SEQUENCE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN RNA BINDING; PROTEIN SECRETION; RNA DEGRADATION; STRUCTURE ACTIVITY RELATION;

EID: 0030267257     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1996.0100     Document Type: Article

References (46)

1. 1. Dinarello CA (1991) Interleukin-1 and interleukin-1 antagonism. Blood 77: 1627-1652.
2. 2. Bevilacqua MP, Pober JS, Wheller ME, Cotran RS, Gimbrone MA (1985) Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes and related leukocyte cell lines. J Clin Invest 76: 2003-2011.
3. 3. Thornberry NA, Bull HG, Calayacay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJ-F, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin TT, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA, Tocci MJ (1992) A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356: 786-774.
4. 4. Wakabayashi G, Gelfando JA, Burke JF, Thompson RC, Dinarello CA (1991) A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits. FASEB J 5:338-343.
5. 5. Fanslow W, Sims JE, Sassenfeld H, Morrissey PJ, Gillis S, Dower SK, Widmer MB (1990) Regulation of alloreactivity in vivo by a soluble form of the interleukin-receptor. Science 248: 739-742.
6. 6. McIntyre KW, Stepan GJ, Kolinsky KD, Benjamin WR, Plocinski JM, Daffka KL, Campen CA, Chizzonite RA, Kilian PL (1991) Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody. J Exp Med 173: 931-939.
7. 7. Dinarello CA (1991) Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases. Curr Opin Immun 3: 941-948.
8. 8. Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A (1986) Control of cachectin (tumor necrosis factor) synthesis: mechanism of endotoxin resistance. Science 232: 977-980.
9. 9. Fenton MJ, Vermeulen MW, Clark BD, Webb AC, Auron PE (1988) Human pro-IL-1β_gene expression in monocytic cells is regulated by two distinct pathways. J Immunol 140: 2267-2273.
10. 10. Auwerx J (1991) The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation. Experientia 47: 22-30.
11. 11. Sachs AB (1993) Messenger RNA degradation in eukaryotes. Cell 74: 413-421.
12. 12. Peltz SW, Brewer G, Bernstein P, Hart PA, Ross J (1991) Regulation of mRNA turnover in eukaryotic cells. Crit Rev Euc Gene Expr 1: 99-126.
13. 13. Caput D, Beutler B, Hartog D, Thayer R, Brown-Shimer S, Cerami A (1986) Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci USA 83: 1670-1674.
14. 14. Shaw G, Kamen R (1986) A Conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659-667.
15. 15. Zubiaga AM, Belasco JG, Greenberg ME (1995) The nonamer UUAUUUAAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol Cell Biol 15: 2219-2230.
16. 16. Lindstein T, June CH, Ledbetter JA, Stella G, Thompson CB (1989) Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339-343.
17. 17. Savant-Bhonsale S, Cleveland DW (1992) Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a >20S degradation complex. Genes & Development 6: 1927-1939.
18. 18. Malter JS (1989) Identification of an AUUUA-specific messenger RNA binding protein. Science 244: 664-666.
19. 19. Malter JS, Hong Y (1991) A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore. J Biol Chem 266: 3167-3171.
20. 20. Bickel M, Iwai Y, Pluznik DH, Cohen R (1992) Binding of sequence-specific proteins to the adenosine-plus uridine-rich sequences of the murine granulocyte/macrophage colony-stimulating factor mRNA. Proc Natl Acad Sci USA 89: 10001-10005.
21. 21. Bohjanen PR, Petryniak B, June CH, Thompson CB, Lindsten T (1992) AU RNA-binding factors differ in their binding specificities and affinities. J Biol Chem 267: 6302-6309.
22. 22. Vakalopoulou E, Schaack J, Shenk T (1991) A 32-kilodalton protein binds to AU-rich domains in the 3′ untranslated region of rapidly degraded mRNAs. Mol Cell Biol 11: 3355-3364.
23. 23. Levine TD, Gao F, King PH, Andrews LG, Keene JD (1993) Hel-N1: an autoimmune RNA-binding protein with specificity for 3′ uridylate-rich untranslated regions of growth factor mRNAs. Mol Cell Biol 13: 34940-3504.
24. 24. You Y, Chen CA, Shyu A (1992) U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3′ untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation. Mol Cell Biol 12: 2931-2940.
25. 25. Schuler GA, Cole MD (1988) GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor. Cell 55: 1115-1122.
26. 26. Bohjanen PR, Petryniak B, June CH, Thompson CB, Lindsten T (1991) An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′ untranslated region of lymphokine mRNA. Mol Cell Biol 11: 3288-3295.
27. 27. Schnyder J, Payne T, Dinarello CA (1987) Human monocyte or recombinant interleukin 1's are specific for the secretion of a metalloproteinase from chondrocytes. J Immunol 138: 496-503.
28. 28. Ramage P, Cheneval D, Chvei M, Graff P, Hemmig R, Heng R, Kocher H.-P, MacKenzie A, Memmert K, Revesz L, Wishart W (1995) Expression, refolding and autocatalytic proteolytic processing of the interleukin-1β converting enzyme precursor. J Biol Chem 270: 9378-9383.
29. 29. Siljander P, Hurme M (1993) Continuous presence of phorbol ester is required for its IL-1β mRNA stabilizing effect. FEBS Lett 315: 81-84.
30. 30. Müller G, Ruppert S, Schmid E, Schütz G (1988) Functional analysis of alternatively spliced tyrosinase gene transcripts. EMBO J 7: 2723-2730.
31. 31. Cleveland DW, Yen TJ (1989) Multiple determinants of eukaryotic mRNA stability. New Biol 1: 121-126.
32. 32. Lee SW, Tsou A-P, Chan H, Thomas J, Petrie K, Eugut EM, Allison AC (1988) Glucocorticoids selectively inhibit the transcription of the interleukin 1β gene and decrease the stability of interleukin 1β mRNA. Proc Natl Acad Sci USA 85: 1204-1208.
33. 33. Gorospe M, Kumar S, Baglioni C (1993) Tumor necrosis factor increase stability of interleukin-1 mRNA by activating protein kinase C. J Biol Chem 268: 6214-6220.
34. 34. Akeson AL, Woods CW, Mosher LB, Thomas CE, Jackson RL (1991) Inhibition of IL-1β expression in THP-1 cells by probucol and tocopherol. Atherosclerosis 86: 261-270.
35. 35. Mahoney CW, Azzi A (1988) Vitamin E inhibits protein kinase C activity. Biochem Biophys Res Commun 154: 694-697.
36. 36. Antrast J, Lasnier F, Pairault J (1991) Adipsin gene expression in 3T3-F442A adipocytes is posttranscriptionally down-regulated by retinoid acid. J Biol Chem 266: 1157-1161.
37. 37. Moreira AL, Sampaio EP, Zmuidzinas A, Frindt P, Smith KA, Kaplan G (1993) Thalidomide exerts its inhibitory action on tumor necrosis factor α by enhancing mRNA degradation. J Exp Med 177: 1675-1680.
38. 38. Distel R, Robinson GS, Spiegelman BM (1992) Fatty acid regulation of gene expression. J Biol Chem 267: 5937-5941.
39. 39. Nair APK, Hahn S, Banholzer R, Hirsch HH, Moroni Ch (1994) Cyclosporin A inhibits growth of autocrine tumor cell lines by destabilizing interleukin-3 mRNA. Nature 369: 239-242.
40. 40. Delmotte P, Delmotte-Plaquee J (1953) A new antifungal substance of fungal origin. Nature 171: 344.
41. 41. Kwon HJ, Yoshida M, Fukui Y, Horinouchoi S, Beppu T (1992) Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol. Cancer Res 52: 6926-6930.
42. 42. Kwon HJ, Yoshida M, Abe K, Horinouchi S, Beppu T (1992) Radicicol, an agent inducing the reversal of transformed phenotypes of src-transformed fibroblasts. Biosci Biotech Biochem 56: 538-539.
43. 43. Chanmugam P, Feng L, Liou S, Jang BC, Boudreau M, Yu G, Lee JH, Kwon HJ, Beppu T, Yoshida M, Xia Y, Wilson CB, Hwang D (1995) Radicicol, a protein tyrosine kinase inhibitor, supresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis. J Biol Chem 270: 5418-5426.
44. 44. Chirgwin JM, Przbybyla AE, MacDonald RJ, Rutter WJ (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonucleases. Biochemistry 18: 5294-5299.
45. 45. Cheneval D, Christy RJ, Geiman D, Cornelius P, Lane MD (1991) Cell-free transcription directed by the 422 adipose P2 gene promoter: Activation by the CCAAT/enhancer binding protein. Proc Natl Acad Sci 88: 8465-8469.
46. 46. Melton DA, Krieg PA, Rebagliati MR, Maniatis T, Zinn K, Green MR (1984) Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmid containing a bacteriophage SP6 promoter. Nucleic Acids Res 12: 7035-7056.