Cyclic AMP suppresses the inhibition of glycolysis by alternative oxidizable substrates in the heart

Journal of Clinical Investigation

Volumn 101, Issue 2, 1998, Pages 390-397

  Depre, Christophe ^a   Ponchaut, Sylvie ^a   Deprez, Johan ^a   Maisin, Liliane ^a   Hue, Louis ^a,b  

^a International Institute of Cellular and Molecular Pathology   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Cyclic AMP; Fructose 2,6 bisphosphate; Glucose; Lactate; Working heart

Indexed keywords

3 HYDROXYBUTYRIC ACID; 6 PHOSPHOFRUCTO 2 KINASE; 6 PHOSPHOFRUCTOKINASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; GLUCOSE; LACTIC ACID; PALMITIC ACID; PHOSPHORYLASE; PYRUVATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PHOSPHORYLATION; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOGENOLYSIS; GLYCOLYSIS; HEART MUSCLE METABOLISM; HEART PERFUSION; HEART WORK; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0032518294     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1168     Document Type: Article

References (41)

1. Shipp, J.C., L.H. Opie, and D.R. Challoner. 1961. Fatty acid and glucose metabolism in perfused rat heart. Nature. 189:1018-1019.
2. Randle, P.J., P.B. Garland, C.N. Hales, and E.A. Newsholme. 1963. The glucose/fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1:785-789.
3. Garland, P.B., P.J. Randle, and E.A. Newsholme. 1963. Citrate as an intermediary in the inhibition of phosphofructokinase in rat heart muscle by fatty acids, ketone bodies, pyruvate, diabetes and starvation. Nature. 200:169-170.
4. Pogson, C.I., and P.J. Randle. 1966. The control of rat heart phosphofructokinase by citrate and other regulators. Biochem. J. 100:683-693.
5. Hue, L., L. Maisin, and M.H. Rider. 1988. Palmitate inhibits liver glycolysis. Involvement of fructose 2,6-bisphosphate in the glucose/fatty acid cycle. Biochem. J. 251:541-545.
6. Wheeler, T.J., R.D. Fell, and M.A. Hauck. 1994. Translocation of two glucose transporters in heart: effects of rotenone, uncouplers, workload, palmitate, insulin and anoxia. Biochim. Biophys. Acta. 1196:191-200.
7. Williamson, J.R. 1962. Effects of insulin and diet on the metabolism of L(+)-lactate and glucose by the perfused rat heart. Biochem. J. 83:377-383.
8. Depre, C., K. Veitch, and L. Hue. 1993. Stimulation of glycogen synthesis by lactate in the isolated working rat heart. Acta Cardiol. 48:147-164.
9. Bristow, M.R., R. Cubbicciotti, and R. Ginsburg. 1982. Histamine-mediated adenylate cyclase activation in human myocardium. Mol. Pharmacol. 21: 671-679.
10. Neer, E.J., and D.E. Clapham. 1988. Roles of G-protein subunits in transmembrane signaling. Nature. 333:129-134.
11. Lopaschuk, G.D., M. Michalak, and E.L. Wandler. 1989. Prostaglandin E receptors in cardiac sarcolemma. Identification and coupling to adenylate cyclase. Circ. Res. 65:538-545.
12. Cramb, G., R. Banks, E.L. Rugg, and J.F. Aiton. 1987. Actions of atrial natriuretic peptide (ANP) on cyclic nucleotide concentrations and phosphatidylinositol turnover in ventricular myocytes. Biochem. Biophys. Res. Commun. 148:962-970.
13. Depre, C., and L. Hue. 1994. Cyclic GMP in the perfused rat heart. FEBS Lett. 345:241-245.
14. Williamson, J.R. 1964. Metabolic effects of epinephrine in the isolated, perfused rat heart. J. Biol. Chem. 239:2721-2729.
15. Collins-Nakai, R., D. Noseworthy, and G.D. Lopaschuk. 1994. Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism. Am. J. Physiol. 267:H1862-H1871.
16. Depre, C., M.H. Rider, K. Veitch, and L. Hue. 1993. Role of fructose 2,6-bisphosphate in the control of heart glycolysis. J. Biol. Chem. 268:13274-13279.
17. Taegtmeyer, H., R. Hems, and H.A. Krebs. 1980. Utilization of energy-providing substrates in the working rat heart. Biochem. J. 186:701-711.
18. Bontemps, F., L. Hue, and H.G. Hers. 1978. Phosphorylation in isolated rat hepatocytes. Biochem. J. 174:603-611.
19. 14C]glucose in the study of the so-called "futile cycles" in the liver and muscle. Biochem. Biophys. Res. Commun. 58:532-539.
20. Neely, J.R., R.M. Demon, P.J. England, and P.J. Randle. 1972. The effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart. Biochem. J. 128:147-152.
21. Bergmeyer, H.U. 1984. Methods of Enzymatic Analysis. 3rd ed. VCH, Weinheim.
22. Hue, L., F. Bontemps, and H.G. Hers. 1975. The effect of glucose and potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations. Biochem. J. 152:105-114.
23. Dopere, F., F. Vanstapel, and W. Stalmans. 1980. Glycogen-synthase phosphatase in rat liver. Two protein components and their requirement for the activation of different types of substrate. Eur. J. Biochem. 104:137-146.
24. McCormack, J.G., and R.M. Denton. 1980. Role of calcium ions in the regulation of intramitochondrial metabolism. Biochem. J. 190:95-105.
25. 2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity. Biochem. J. 202:419-427.
26. Deprez, J., D. Vertommen, D.R. Alessi, L. Hue, and M.H. Rider. 1997. Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J. Biol. Chem. 272:17269-17275.
27. Dobson, J.G., J. Ross, and S.E. Mayer. 1976. The role of cyclic adenosine 3′,5′-monophosphate and calcium in the regulation of contractility and glycogen phosphorylase activity in guinea pig papillary muscle. Circ. Res. 39:388-395.
28. Depre, C., and L. Hue. 1997. Inhibition of glycogenolysis by a glucose analogue in the working rat heart. J. Mol. Cell. Cardiol. 29:2253-2259.
29. 2+ to stimulate glucose transport and GLUT4 translocation in perfused rat heart. Biochim. Biophys. Acta. 1094:217-223.
30. Fischer, Y., J. Thomas, G.D. Holman, H. Rose, and H. Kammermeier. 1996. Contraction-independent effects of catecholamines on glucose transport in isolated rat cardiomyocytes. Am. J. Physiol. 39:C1204-C1210.
31. Morgan, H.E., and A. Parmeggiani. 1964. Regulation of glycogenolysis in muscle. II. Control of glycogen phosphorylase reaction in isolated perfused heart. J. Biol. Chem. 239:2435-2439.
32. Hue, L., and M.H. Rider. 1987. Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues. Biochem. J. 245:313-324.
33. Wiesner, R.J., U. Kreutzer, P. Rosen, and M.K. Grieshaber. 1988. Subcellular distribution of malate-aspartate cycle intermediates during normoxia and anoxia in the heart. Biochim. Biophys. Acta. 36:114-123.
34. Clark, M.G., and G.S. Patten. 1981. Epinephrine activation of phosphofructokinase in perfused rat heart independent of changes in effector concentrations. J. Biol. Chem. 256:27-30.
35. Söling, H.D., and I.A. Brand. 1981. Covalent modification of phosphofructokinase by phosphorylation-dephosphorylation. Curr. Top. Cell. Regul. 20: 107-138.
36. Kitajima, S., R. Sakakibara, and K. Uyeda. 1983. Significance of phosphorylation of phosphofructokinase. J. Biol. Chem. 258:13292-13298.
37. Hofer, H.W. 1985. Phosphorylation of phosphofructokinase. The possible role of covalent modification in the regulation of glycolysis. In Regulation of Carbohydrate Metabolism. Vol. I. R. Beitner, editor. CRC Press, Boca Raton. 105-141.
38. Kitamura, K., K. Kangawa, H. Matsuo, and K. Uyeda. 1988. Phosphorylation of myocardial fructose 6-phosphate, 2-kinase:fructose-2,6-bisphosphatase by cyclic AMP-dependent protein kinase and protein C. Activation by phosphorylation and amino acid sequences of the phosphorylation sites. J. Biol. Chem. 263:16796-16801.
39. Rider, M.H., J. Van Damme, D. Vertommen, A. Michel, J. Vandekerckhove, and L. Hue. 1992. Evidence for new phosphorylation sites for protein kinase C and cyclic AMP-dependent protein kinase in bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. FEBS Lett. 310:139-142.
40. Hiraoka, T., M. DeBuysere, and M.E. Olson. 1980. Studies on the effects of β-adrenergic agonists on the regulation of pyruvate dehydrogenase in the perfused rat heart. J. Biol. Chem. 255:7604-7609.
41. Kerbey, A.L., P.J. Randle, R.H. Cooper, S. Whitehouse, H.T. Pask, and R.M. Denton. 1976. Regulation of pyruvate dehydrogenase in rat heart. Biochem. J. 154:327-348.