The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia

Neurobiology of Disease

Volumn 6, Issue 5, 1999, Pages 433-439

  Bondy, Brigitta ^a   Spaeth, Michael ^b   Offenbaecher, Martin ^a   Glatzeder, Karin ^a   Stratz, Thomas ^c   Schwarz, Markus ^a   De Jonge, Sylvia ^a   Krüger, Marc ^a   Engel, Rolf R ^a   Färber, Lothar ^d   Pongratz, Dieter E ^b   Ackenheil, Manfred ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Hochrhein Institut   (Germany)

^d Novartis Pharma GmbH   (Germany)

Author keywords

5 HT2A receptors; Fibromyalgia; Polymorphism; Serotonin

Indexed keywords

SEROTONIN 2A RECEPTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; FIBROMYALGIA; GENE FREQUENCY; GENE SILENCING; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NOCICEPTION; ONSET AGE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SYMPTOMATOLOGY;

EID: 0032726813     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.1999.0262     Document Type: Article

References (36)

1. Almay B. G., Haggendal J., Von K. L., Oreland L. 5-HIAA and HVA in CSF in patients with idiopathic pain disorders. Biol. Psychiatry. 22:1987;403-412.
2. Almay B. G., Johansson F., Von K. L., Le G. P., Terenius L. Substance P in CSF of patients with chronic pain syndromes. Pain. 33:1988;3-9.
3. Arranz M., Collier D., Sodhi M., Ball D., Roberts G., Price J., Sham P., Kerwin R. Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet. 346:1995;281-282.
4. Arranz M. J., Erdmann J., Kirov G., Rietschel M., Sodhi M., Albus M., Ball D., Maier W., Davies N., Franzek E., Abusaad I., Weigelt B., Murray R., Shimron A. D., Kerwin R., Propping P., Sham P., Nothen M. M., Collier D. A. 5-HT2A receptor and bipolar affective disorder: Association studies in affected patients. Neurosci. Lett. 224:1997;95-98.
5. Buskila D., Neumann L., Hazanov I., Carmi R. Familial aggregation in the fibromyalgia syndrome. Semin. Arthritis Rheum. 26:1996;605-611.
6. Butcher J. N., Dahlstrom W. G., Graham J. R., Tellegen A., Kaemmer B. Minnesota Multiphasic Personality Inventory (MMPI-2) Manual for Administering and Scoring. 1989;Univ. Minnesota Press, Minneapolis.
7. Cloninger C. R. A systematic method for clinical description and classification of personality variants. A proposal. Arch. Gen. Psychiatry. 44:1987;573-588.
8. Costa, P. T, &, McCrae, R. R. 1992, Revised NEO Personality Inventory (NEO PI-R) and NEO Five Factor Inventory. Professional Manual. In, Anonymous Psychological Assessment Resources, Odessa.
9. Crofford L. J., Engleberg N. C., Demitrack M. A. Neurohormonal perturbations in fibromyalgia. Baillieres. Clin. Rheumatol. 10:1996;365-378.
10. Demitrack M. A. Neuroendocrine correlates of chronic fatigue syndrome: A brief review. J. Psychiatr. Res. 31:1997;69-82.
11. Demitrack M. A. Chronic fatigue syndrome and fibromyalgia. Dilemmas in diagnosis and clinical management. Psychiatr. Clin. North Am. 21:1998;671-692.
12. Erdmann J., Shimron Abarbanell D., Rietschel M., Albus M., Maier W., Korner J., Bondy B., Chen K., Shih J. C., Knapp M., Propping P., Nothen M. M. Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: Identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum. Genet. 97:1996;614-619.
13. Farmer A., Scourfield J., Martin N., Cardno A., McGuffin P. Is disabling fatigue in childhood influenced by genes. Psychol. Med. 29:1999;282.
14. Fassbender K., Samborsky W., Kellner M., Muller W., Lautenbacher S. Tender points, depressive and functional symptoms: Comparison between fibromyalgia and major depression. Clin. Rheumatol. 16:1997;76-79.
15. Goldenberg D. L., Simms R. W., Geiger A., Komaroff A. L. High frequency of fibromyalgia in patients with chronic fatigue seen in a primary care practice. Arthritis Rheum. 33:1990;381-387.
16. Gutierrez B., Bertranpetit J., Collier D., Arranz M. J., Valles V., Guillamat R., van O. J., Fananas L. Genetic variation of the 5-HT2A receptor gene and bipolar affective disorder. Hum. Genet. 100:1997;582-584.
17. Hawi Z., Myakishev M. V., Straub R. E., O'Neill A., Kendler K. S., Walsh D., Gill M. No association or linkage between the 5-HT2a/T102C polymorphism and schizophrenia in Irish families. Am. J. Med. Genet. 74:1997;370-373.
18. Hickie I., Bennett B., Lloyd A., Heath A., Martin N. Complex genetic and environmental relationships between psychological distress, fatigue and immune functioning: A twin study. Psychol. Med. 29:1999;277.
19. Hudson J. I., Pope H. G. The concept of affective spectrum disorder: relationship to fibromyalgia and other syndromes of chronic fatigue and chronic muscle pain. Baillieres. Clin. Rheumatol. 8:1994;839-856.
20. Inayama Y., Yoneda H., Sakai T., Ishida T., Nonomura Y., Kono Y., Takahata R., Koh J., Sakai J., Takai A., Inada Y., Asaba H. Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am. J. Med. Genet. 67:1996;103-105.
21. Johnson S. P. Fluoxetine and amitriptyline in the treatment of fibromyalgia. J. Fam. Pract. 44:1997;128-130.
22. Juhl J. H. Fibromyalgia and the serotonin pathway. Altern. Med. Rev. 3:1998;367-375.
23. Jung A. C., Staiger T., Sullivan M. The efficacy of selective serotonin reuptake inhibitors for the management of chronic pain. J. Gen. Intern. Med. 12:1997;384-389.
24. Lautenschlager J., Bruckle W., Schnorrenberger C. C., Muller W. Measuring pressure pain of tendons and muscles in healthy probands and patients with generalized tendomyopathy (fibromyalgia syndrome). Z. Rheumatol. 47:1988;397-404.
25. Nyholt D. R., Curtain R. P., Gaffney P. T., Brimage P., Goadsby P. J., Griffiths L. R. Migraine association and linkage analyses of the human 5-hydroxytryptamine (5HT2A) receptor gene. Cephalalgia. 16:1996;463-467.
26. Schwarz M. J., Spaeth M., Müller-Bardorff H., Pongratz D. E., Bondy B., Ackenheil M. Relationship of substance P, 5-hydroxyindolic acetic acid and tryptophan in serum of fibromyalgia patients. Neuroscience Letters. 259:1999;196-198.
27. Tokunaga A., Saika M., Senba E. 5-HT2A receptor subtype is involved in the thermal hyperalgesic mechanism of serotonin in the periphery. Pain. 76:1998;349-355.
28. van Praag H. M., Asnis G. M., Kahn R. S., Brown S. L., Korn M., Friedman J. M., Wetzler S. Monoamines and abnormal behaviour. A multi-aminergic perspective. Br. J. Psychiatry. 157:1990;723-734.
29. Von K. L., Almay B. G., Johansson F. Personality traits in patients with idiopathic pain disorder. Acta Psychiatr. Scand. 76:1987;490-498.
30. Ward N. G., Bloom V. L., Dworkin S., Fawcett J., Narasimhachari N., Friedel R. O. Psychobiological markers in coexisting pain and depression: Toward a unified theory. J. Clin. Psychiatry. 43:1982;32-41.
31. Ward R. P., Dorsa D. M. Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum. J. Comp. Neurol. 370:1996;405-414.
32. Warren-JT J., Peacock M. L., Rodriguez L. C., Fink J. K. An MspI polymorphism in the hyman serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis. Hum. Mol. Genet. 2:1993;338.
33. Williams J., Spurlock G., McGuffin P., Mallet J., Nothen M. M., Gill M., Aschauer H., Nylander P. O., Macciardi F., Owen M. J. Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group [see comments]. Lancet. 347:1996;1294-1296.
34. Wolfe F., Russell I. J., Vipraio G., Ross K., Anderson J. Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population. J. Rheumatol. 24:1997;555-559.
35. Wolfe F., Smythe H. A., Yunus M. B., Bennett R. M., Bombardier C., Goldenberg D. L., Tugwell P., Campbell S. M., Abeles M., Clark P. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee [see Comments]. Arthritis Rheum. 33:1990;160-172.
36. Yunus M. B., Khan M. A., Rawlings K. K., Green J. R., Olson J. M. S. S. Genetic linkage analysis of multicase families with fibromyalgia syndrome. J. Rheumatol. 26:1999;408-412.