Local adenovirus-mediated CTLA4-immunoglobulin expression suppresses the immune responses to adenovirus vectors in the brain

Neuroscience

Volumn 95, Issue 1, 1999, Pages 217-226

  Ideguchi, M ^a   Kajiwara, K ^a   Yoshikawa, K ^a   Uchida, T ^a   Ito, H ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

galactosidase; Adenovirus vectors; Brain; CTLA4 Ig; Immune response; Immune suppression

Indexed keywords

ANTIBODY; BETA GALACTOSIDASE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN; NEUTRALIZING ANTIBODY; VIRUS VECTOR;

ADENOVIRUS; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BRAIN; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADENOVIRIDAE; ANIMALS; ANTIBODY FORMATION; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; BETA-GALACTOSIDASE; BRAIN; DRUG COMBINATIONS; GENETIC VECTORS; IMMUNITY, CELLULAR; IMMUNOCONJUGATES; IMMUNOGLOBULINS; MICE; MICE, INBRED C3H;

EID: 0032704286     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(99)00402-9     Document Type: Article

References (71)

1. Akli S., Caillaud C., Vigne E., Stratford-Perricaudet L.D., Poenaru L., Perracaudet M., Kahn A., Pachanski M.R. Transfer of foreign gene into the brain using adenovirus vectors. Nature Genet. 3:1993;224-228.
2. Ali M., Lemoine N.R., Ring C.J.A. The use of DNA viruses as vectors for gene therapy. Gene Ther. 1:1994;367-384.
3. Bajocchi G., Feldman S.H., Crystal R.G., Mastrangeli A. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nature Genet. 3:1993;229-234.
4. Barr D., Tubb J., Ferguson D., Scaria A., Lieber A., Wilson C., Perkins J., Kay M.A. Strain related variations in adenovirally mediated transgene expression in mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther. 2:1995;151-155.
5. Bout A., Imler J.-L., Schultz H., Perricaudet M., Zurcher C., Herbrink P., Valerio D., Pavirani A. In vivo adenovirus-mediated transfer of human CFTR cDNA to Rhesus monkey airway epithelium: efficacy, toxicity and safety. Gene Ther. 1:1994;385-394.
6. Byrnes A.P., MacLaren R.E., Charlton H.M. Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination. J. Neurosci. 16:1996;3045-3055.
7. Byrnes A.P., Rusby J.E., Wood M.J.A., Charlton H.M. Adenovirus gene transfer causes inflammation in the brain. Neuroscience. 66:1995;1015-1024.
8. Byrnes A.P., Wood M.J.A., Charlton H.M. Role of T cells in inflammation caused by adenovirus vectors in the brain. Gene Ther. 3:1996;644-651.
9. Cartmell T., Southgate T., Rees G.S., Castro M.G., Lowenstein P.R., Luheshi G.N. Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain. J. Neurosci. 19:1999;1517-1523.
10. Chiocca E.A., Choi B.B., Cai W., DeLuca N.A., Schaffer P.A., DiFiglia M., Breakefield X.O., Martuza R.L. Transfer and expression of the lac Z gene in rat brain neurons mediated by herpes simplex virus mutants. New Biol. 2:1990;739-746.
11. Couraud P.-O. Interactions between lymphocytes macrophages, and central nervous system cells. J. leukoc. Biol. 56:1994;407-415.
12. Croxford J.L., O'Neill J.K., Ali R.R., Browne K., Byrnes A.P., Dallman M.J., Wood M.J.A., Feldmann M., Baker D. Local gene therapy with CTLA4-immunoglobulin fusion protein in experimental allergic encephalomyelitis. Eur. J. Immunol. 28:1998;3904-3916.
13. Crystal R.G., Mcelvaney N.G., Rosenfeld M.A., Dhu C.S., Mastrangeli A., Hay J.G., Brody S.L., Jaffe H.A., Eissa N.T., Danel C. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nature Genet. 8:1994;42-51.
14. Dai Y., Schwartz E.M., Gu D., Zhang W.-W., Sarvetnick N., Verma I.M. Cellular and humoral immune responses to adenovirus vectors containing factor VIII gene: tolerization of factor VIII and vector antigens allows for long-term expression. Proc. natn. Acad. Sci. U.S.A. 92:1995;1401-1405.
15. Davidson B.L., Allen E.D., Kozarsky K.F., Wilson J.M., Roessler B.J. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nature Genet. 3:1993;219-223.
16. Davidson B.L., Doran S.E., Shewach D.S., Latta J.M., Hartman J.W., Roessler B.J. Expression of Escherichia coli beta-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transfer. Expl Neurol. 125:1994;258-267.
17. De Matteo R.P., Markmann J.F., Kozarsky K.F., Barker C.F., Raper S.E. Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion. Gene Ther. 3:1996;4-12.
18. Engelhardt J.F., Litzky L., Wilson J.M. Prolonged transgene expression in Cotton rat lung with recombinant adenoviruses in E2a. Hum. Gene Ther. 5:1994;1217-1229.
19. Engerhardt J.F., Ye X., Doranz B., Wilson J.M. Ablation of E2A in recombinant adenovirus improves transgene persistence and decreases inflammatory response in mouse liver. Proc. natn. Acad. Sci. U.S.A. 91:1994;6196-6200.
20. Geddes B.J., Harding T.C., Hughes D.S., Byrnes A.P., Lightman S.L., Conde G., Uney J.B. Persistent transgene expression in the hypothalamus following stereotaxic delivery of a recombinant adenovirus: suppression of the immune response with cyclosporin. Endocrinology. 137:1996;5166-5169.
21. Geddes B.J., Harding T.C., Lightman S.L., Uney J.B. Long-term gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Nature Med. 3:1997;1402-1404.
22. Ginsberg H.S., Moldawer L.L., Sehgal P.B., Redington M., Kilian P.L., Chanock R.M., Prince G.A. A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc. natn. Acad. Sci. U.S.A. 88:1991;1651-1655.
23. Giordana M.T., Attanasio A., Cavalla P., Migheli A., Vigliani M.C., Schiffer D. Reactive cell proliferation and microglia following injury to the rat brain. Neuropath. appl. Neurobiol. 20:1994;163-174.
24. Graham F.L., Smiley L., Russel W.C., Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. gen. Virol. 36:1997;59-72.
25. Grubb B.R., Pickles R.J., Ye H., Yankaskas J.R., Vick R.N., Engerhardt J.F., Wilson J.M., Johnson L.G., Boucher R.C. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature. 371:1994;802-806.
26. Guérette B., Vilquin J.T., Gingras M., Gravel C., Wood K.J., Tremblay J.P. Prevention of immune reactions by first generation adenoviral vectors by monoclonal antibodies and CTLA4-Ig. Hum. Gene Ther. 7:1996;1455-1463.
27. Hermens W.T., Verhaagen J. Suppression of inflammation by dexamethasone prolongs adenoviral vector-mediated transgene expression in the facial nucleus of the rat. Brain Res. Bull. 47:1998;133-140.
28. Ikeda T., Hirata K., Tabuchi K., Tamura H., Tanaka S. Quantitative measurement of endotoxin in canine plasma using the new endotoxin-specific chromogenic test. Circulatory Shock. 23:1987;263-269.
29. Joly E., Oldstone M.B.A. Neuronal cells are deficient in loading peptides onto MHC class I molecules. Neuron. 8:1992;1185-1190.
30. Juillard V., Villefroy P., Godfrin D., Pavirani A., Venet A., Guillet J.-G. Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector. Eur. J. Immunol. 25:1995;3467-3473.
31. Kafri T., Morgan D., Krahl T., Sarvetnick N., Sherman L., Verma I. Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy. Proc. natn. Acad. Sci. U.S.A. 95:1998;11377-11382.
32. Kajiwara K., Byrnes A.P., Charlton H.M., Wood M.J.A., Wood K.J. Immune responses to adenoviral vectors during gene transfer in the brain. Hum. Gene Ther. 8:1997;253-265.
33. Kaplitt M.G., Leone P., Samulski R.J., Xiao X., Pfaff D.W., O'Malley K.L., During M.J. Long-term gene expression and phenotypic correction using adeno-associated virus in the mammalian brain. Nature Genet. 8:1994;148-154.
34. Kaplitt M.G., Pfaus J.G., Kleopoulos S.P., Hanlon B.A., Rabkin S.D., Pfaff D.W. Expression of a functional foreign gene in adult mammalian brain following in vivo transfer via a herpes simplex virus type 1 defective viral vector. Molec. cell. Neurosci. 2:1991;320-330.
35. Kay M.A., Holterman A.X., Meuse L., Gown A., Ochs H.D., Linsley P.S., Wilson C.B. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4-Ig administration. Nature Genet. 11:1995;191-197.
36. Kolls J.K., Lei D., Odom G., Nelson S., Summer W.R., Gerber M.A., Shellito J.E. Use of transient CD4 lymphocyte depletion to prolong transgene of E1-deleted adenovirus vectors. Hum. Gene Ther. 7:1996;489-497.
37. Le Gal La Salle G., Robert J.J., Berrard S., Ridoux V., Stratford-Perricaudet M., Mallet J. An adenovirus vector for gene transfer into neurons and glia in the brain. Science. 259:1993;988-990.
38. Linsley P.S., Brady W., Grosmaire L., Aruffo A., Damle N.K., Ledbetter J.A. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. exp. Med. 173:1991;721-730.
39. Linsley P.S., Brady W., Urnes M., Grosmaire L.S., Damle N.K., Ledbetter J.A. CTLA4 is a second receptor for the B cell activation antigen B7. J. exp. Med. 174:1991;561-569.
40. Linsley P.S., Clark E.A., Ledbetter J.A. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. natn. Acad. Sci. U.S.A. 87:1990;5031-5035.
41. Li Q., Kay M.A., Finegold M., Stratford-Perricaudet L.D., Woo S.L.C. Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum. Gene Ther. 4:1993;403-409.
42. Marrack P., Kppler J. The T cell receptor. Science. 238:1987;1073-1079.
43. Mastrangeli A., Harvey B.-G., Yao J., Wolff G., Kovesdi I., Crystal R.G., Flack-Pedersen E. "Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype. Hum. Gene Ther. 7:1996;79-87.
44. Matyszak M.K., Perry V.H. Demyelination in the central nervous system following a delayed-type hypersensitivity response to bacillus Calmett-Guérin. Neuroscience. 64:1995;967-977.
45. McGrory W.J., Bautista D.S., Graham F.L. A simple technique for the rescue of early region I mutations into infections human adenovirus type 5. Virology. 163:1988;614-617.
46. Merrill J.E., Ignarro L.J., Sherman M.P., Melinek J., Lane T.E. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151:1993;2132-2141.
47. Momburg F., Koch N., Möller P., Moldenhauer G., Butcher G.W., Hammerling G.J. Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with IFN-gamma. J. Immunol. 136:1986;940-948.
48. Naldini L., Blomer U., Gallay P., Ory D., Mulligan R., Gage F.H., Verma I.M., Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 272:1996;263-267.
49. Obayashi T., Tamura H., Tanaka S., Ohki M., Takahashi S., Arai M., Masuda M., Kawai T. A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical applications. Clin. Chim. Acta. 149:1985;55-65.
50. Oral H.B., Larkin D.F.P., Fehervari Z., Byrnes A.P., Rankin A.M., Haskard D.O., Wood M.J.A., Dallman M.J., George A.J.T. Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea. Gene Ther. 4:1997;639-647.
51. Perry V.H., Anerson P.-B., Gordon S. Macrophages and inflammation in the central nervous system. Trends Neurosci. 16:1993;268-273.
52. Poller W., Schneider-Rasp S., Liebert U., Merklein F., Thalheimer P., Haack A., Schwaab R., Schmitt C., Brackmann H.-H. Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host. Gene Ther. 3:1996;521-530.
53. Prince G.A., Porter D.D., Jenson A.B., Horswood R.L., Chanock R.M., Ginsberg H.S. Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus). J. Virol. 67:1993;101-111.
54. Rabinowitz S.S., Gordon S. Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. J. exp. Med. 174:1991;827-836.
55. Sawchuk S.J., Boivin G.P., Duwel L.E., Ball W., Bove K., Trapnell B., Hirsch R. Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium. Hum. Gene Ther. 7:1996;499-506.
56. Schwartz R.H. A cell culture model for T lymphocyte clonal anergy. Science. 248:1990;1349-1356.
57. Selmaj K., Paine C.S., Farooq M., Norton W.T., Brosnan C.F. Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphocytoxin. J. Immunol. 147:1991;1522-1529.
58. Setoguchi Y., Ari H., Chu C.S., Crystal R.G. Intraperitoneal in vivo gene therapy to delivery a1-antitrypsin to the systemic circulation. Am. J. Respir. Cell molec. Biol. 10:1994;369-377.
59. Simon R.H., Engerhardt J.F., Yang Y., Zepeda M., Weber-Pendleton S., Grossman M., Wilson J.M. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study. Hum. Gene Ther. 4:1993;771-780.
60. Sloan D.J., Wood M.J., Charlton H.M. The immune response to intracerebral neural grafts. Trends Neurosci. 14:1991;341-346.
61. Smith T.A.G., White B.D., Gardner J.M., Kaleko M., McClelland A. Transient immunosupression permits successful repetitive intravenous administration of an adenovirus vector. Gene Ther. 3:1996;496-502.
62. Smith T.A., Mehaffey M.G., Kayda D.B., Saunders J.M., Yei S., Trapnell B.C., McClelland A., Kaleko M. Adenovirus mediated expression of therapeutic plasma levels of human factor VIII in mice. Nature Genet. 5:1993;397-402.
63. Springer T., Galfè G., Secher D.S., Milstein C. Monoclonal xenogenic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur. J. Immunol. 8:1978;539-551.
64. Stevendon P.G., Hawke S., Sloan D.J., Brangham R.M. The immunogenicity of intracerebral virus infection depends on anatomical site. J. Virol. 71:1997;145-151.
65. Wilson J.M., Engelhardt J.F., Grossman M., Simon R.H., Yang Y. Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial. Hum. Gene Ther. 5:1994;501-519.
66. Yang Y., Ertl H.C.J., Wilson J.M. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity. 1:1994;433-442.
67. Yang Y., Li Q., Ertl H.C.J., Wilson J.M. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:1995;2004-2015.
68. Yang Y., Nunes F.A., Berencsi K., Furth E.E., Gönczöl E., Wilson J.M. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene transfer. Proc. natn. Acad. Sci. U.S.A. 91:1994;4407-4411.
69. Yang Y., Nunes F.A., Berencsi K., Gönczöl E., Engelhardt J.F., Wilson J.M. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet. 7:1994;362-369.
70. Yang Y., Trinchieri G., Wilson J.M. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med. 1:1995;890-893.
71. Zubler R.H., Lowenthal J.W., Erard F., Hashimoto N., Devos R., Macdonald H.R. Activated B cell express receptor for, and proliferative in response to, pure interleukin 2. J. exp. Med. 160:1984;1170-1183.