When protons attack: Microbial strategies of acid adaptation

Current Opinion in Microbiology

Volumn 2, Issue 2, 1999, Pages 170-174

  Foster, John W ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURVIVAL; ESCHERICHIA COLI; NONHUMAN; PH; PROTON TRANSPORT; REGULATOR GENE; REVIEW; SALMONELLA TYPHIMURIUM;

ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0033118208     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(99)80030-7     Document Type: Article

References (32)

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11. i at pH 5.9, all exhibited similar degrees of acid tolerance.
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19. s synthesis.
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23. o is neutral. There may be a novel mechanism controlling internal activity of urease.
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31. Muhlschlegel FA, Fonzi WA: PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression. Mol Cell Biol 1997, 17:5960-5967.
32. de Bernardis F, Muhlschlegel FA, Cassone A, Fonzi WA: The pH of the host niche controls gene expression in and virulence of Candida albicans. Infect Immun 1998, 66:3317-3325. This paper is notable for contributing to the link between pH and Candida morphogenesis as well as virulence. As homologous genes expressed in alkaline (PHR1) versus acid (PHR2) environments, PHR1 mutants do not form normal yeast or hyphal morphology at alkaline pH while PHR2 mutants have defective morphology at acidic pH. The reason for the differential expression of these two similar genes is not apparent. Although they are structurally similar and cause similar morphological defects when absent, it should be noted that the function of these proteins is not known.