Role of nitric oxide in ventricular dysfunction

Journal of Cardiac Failure

Volumn 4, Issue 3, 1998, Pages 249-260

  Arstall, M A ^a   Kelly, R A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

CARDIOVASCULAR AUTOREGULATION; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; HEART TRANSPLANTATION; HUMAN; IMMUNOREGULATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

EID: 0031685367     PISSN: 10719164     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1071-9164(98)80016-X     Document Type: Review

References (131)

1. Moncada S Higgs A Furchgott R International Union of Pharmacology Nomenclature in Nitric Oxide Research Pharmacol Rev 49 1997 137 142
2. Shah AM Paracrine modulation of heart cell function by endothelial cells Cardiovasc Res 31 1996 847 867
3. Bartunek J Shah AM Vanderheyden M Paulus WJ Dobutamine enhances cardiodepressant effects of receptor-mediated coronary endothelial stimulation Circulation 95 1997 90 96
4. Sadoff JD Scholz PM Weiss HR Endogenous basal nitric oxide production does not control myocardial oxygen consumption or function Proc Soc Exp Biol Med 211 1996 332 338
5. Zhang X Xie YW Nasjletti A Xu X Wolin MS Hintze TH ACE inhibitors promote nitric oxide accumulation to modulate myocardial oxygen consumption Circulation 95 1997 176 182
6. Laursen JB Harrison DG Modulation of myocardial oxygen consumption through ACE inhibitors: NO effect? Circulation 95 1997 14 16
7. Schulz R Dodge KL Lopaschuk GD Clanachan AS Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency Am J Physiol 272 1997 H1212 H1219
8. Gardner PR Costantino G Szabo C Salzman AL Nitric oxide sensitivity of the aconitases J Biol Chem 272 1997 25071 25076
9. Poderoso JJ Peralta JG Lisdero CL Carreras MC Radisic M Schopfer F Cadenas E Boveris A Nitric oxide regulates oxygen uptake and hydrogen peroxide release by the isolated beating rat heart Am J Physiol 274 1998 C112 C119
10. Kelly RA Balligand JL Smith TW Nitric oxide and cardiac function Circ Res 79 1996 363 380
11. Kelly RA Han X Nitrovasodilators have (small) direct effects on cardiac contractility: is this important? Circulation 96 1997 2493 2495
12. Winegrad S Endothelial cell regulation of contractility of the heart Annu Rev Physiol 59 1997 505 525
13. Feron O Belhassen L Kobzik L Smith TW Kelly RA Michel T Endothelial nitric oxide synthase targeting to caveolae: specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells J Biol Chem 271 1996 22810 22814
14. Michel T Feron O Nitric oxide synthases: which, where, how, and why? J Clin Invest 100 1997 2146 2152
15. Parton RG Way M Zorzi N Stang E Caveolin-3 associates with developing T-tubules during muscle differentiation J Cell Biol 136 1997 137 154
16. Elvan A Rubart M Zipes DP NO modulates autonomic effects on sinus discharge rate and AV nodal conduction in open-chest dogs Am J Physiol 272 1997 H263 H271
17. Shimoni Y Han X Severson D Giles WR Mediation by nitric oxide of the indirect effects of adenosine on calcium current in rabbit heart pacemaker cells Br J Pharmacol 119 1996 1463 1469
18. Martynyuk ARE Kane KA Cobbe SM Rankin AC Nitric oxide mediates the anti-adrenergic effect of adenosine on calcium current in isolated rabbit atrioventricular nodal cells Pflugers Arch Eur J Physiol 431 1996 452 457
19. Feron O Smith TW Michel T Kelly RA Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes J Biol Chem 272 1997 17744 17748
20. Ca-L is absent in mice with targeted disruption of endothelial nitric oxide synthase (eNOS) Proc Natl Acad Sci USA 95 1998 6510 6515
21. Hare MJ Kim B Flavahan NA Ricker KM Peng X Colman L Weiss RG Kass DA Pertussis toxin-sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart J Clin Invest 101 1998 1424 1431
22. Campbell DL Stamler JS Strauss HC Redox modulation of l -type calcium channels in ferret ventricular myocytes: dual mechanism regulation by nitric oxide and S-nitrosothiols J Gen Physiol 108 1996 277 293
23. Mohr S Stamler JS Brune B Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment J Biol Chem 271 1996 4209 4214
24. Degerman E Belfrage P Manganiello VC Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3) J Biol Chem 272 1997 6823 6826
25. Belhassen L Kelly RA Smith TW Balligand JL Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart: regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes J Clin Invest 97 1996 1908 1915
26. Belhassen L Feron O Kaye DM Michel T Kelly RA Regulation by cAMP of post-translational processing and subcellular targeting of endothelial nitric-oxide synthase (type 3) in cardiac myocytes J Biol Chem 272 1997 11198 11204
27. Kobzik L Stringer B Balligand JL Reid MB Stamler JS Endothelial type nitric oxide synthase in skeletal muscle fibers: mitochondrial relationships Biochem Biophys Res Commun 211 1995 375 381
28. Xie YW Shen W Zhao G Xu X Wolin MS Hintze TH Role of endothelium-derived nitric oxide in the modulation of canine myocardial mitochondrial respiration in vitro: implications for the development of heart failure Circ Res 79 1996 381 387
29. Mohr S Stamler JS Brune B Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents FEBS Lett 348 1994 223 227
30. Gross WL Bak MI Ingwall JS Arstall MA Smith TW Balligand JL Kelly RA Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve Proc Natl Acad Sci USA 93 1996 5604 5609
31. Arstall MA Bailey C Gross WL Bak MI Balligand JL Kelly RA Reversible S-nitrosation of creatine kinase by nitric oxide in adult rat ventricular myocytes J Mol Cell Cardiol 30 1998 979 988
32. Xie QW Cho HJ Calaycay J Mumford RA Swiderek KM Lee TD Ding A Troso T Nathan C Cloning and characterization of inducible nitric oxide synthase from mouse macrophages Science 256 1992 225 228
33. Lowenstein CJ Glatt CS Bredt DS Snyder SH Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme Proc Natl Acad Sci USA 89 1992 6711 6715
34. 2+-independent nitric oxide synthase in the myocardium Br J Pharmacol 105 1992 575 580
35. Roberts AB Vodovotz Y Roche NS Sporn MB Nathan CF Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes Mol Endocrinol 6 1992 1921 1930
36. Roberts AB Roche NS Winokur TS Burmester JK Sporn MB Role of transforming growth factor-beta in maintenance of function of cultured neonatal cardiac myocytes: autocrine action and reversal of damaging effects of interleukin-1 J Clin Invest 90 1992 2056 2062
37. Balligand JL Ungureanu D Kelly RA Kobzik L Pimental D Michel T Smith TW Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium J Clin Invest 91 1993 2314 2319
38. Balligand JL Ungureanu-Longrois D Simmons WW Pimental Malinski TA Kapturczak M Taha Z Lowenstein CJ Davidoff AJ Kelly RA Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro J Biol Chem 269 1994 27580 27588
39. Brady AJ Poole-Wilson PA Harding SE Warren JB Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia Am J Physiol 263 1992 H1963 H1966
40. 2+]i and cell contraction in cultured chick ventricular myocytes Circ Res 75 1994 285 295
41. Tsujino M Hirata Y Imai T Kanno K Eguchi S Ito H Marumo F Induction of nitric oxide synthase gene by interleukin-1 beta in cultured rat cardiocytes Circulation 90 1994 375 383
42. Ungureanu-Longrois D Balligand JL Simmons WW Okada I Kobzik L Lowenstein CJ Kunkel SL Michel T Kelly RA Smith TW Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists Circ Res 77 1995 494 502
43. Balligand JL Ungureanu-Longrois D Simmons WW Kobzik L Lowenstein CJ Lamas S Kelly RA Smith TW Michel T Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma Am J Physiol 268 1995 H1293 H1303
44. Russell ME Wallace AF Wyner LR Newell JB Karnovsky MJ Upregulation and modulation of inducible nitric oxide synthase in rat cardiac allografts with chronic rejection and transplant arteriosclerosis Circulation 92 1995 457 464
45. Worrall NK Lazenby WD Misko TP Lin TS Rodi CP Manning PT Tilton RG Williamson JR Ferguson TB Jr Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase J Exp Med 181 1995 63 70
46. Yang X Chowdhury N Cai B Brett J Marboe C Sciacca RR Michler RE Cannon PJ Induction of myocardial nitric oxide synthase by cardiac allograft rejection J Clin Invest 94 1994 714 721
47. Malinski T Taha Z Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor Nature 358 1992 676 678
48. de Vera ME Shapiro RA Nussler AK Mudgett JS Simmons RL Morris SMJ Billiar TR Geller DA Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter Proc Natl Acad Sci USA 93 1996 1054 1059
49. Gao J Morrison DC Parmely TJ Russell SW Murphy WJ An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide J Biol Chem 272 1997 1226 1230
50. Kinugawa K Shimizu T Yao A Kohmoto O Serizawa T Takahashi T Transcriptional regulation of inducible nitric oxide synthase in cultured neonatal rat cardiac myocytes Circ Res 81 1997 911 921
51. Nunokawa Y Oikawa S Tanaka S Expression of human inducible nitric oxide synthase is regulated by both promoter and 3′-regions Biochem Biophys Res Commun 233 1997 523 526
52. Xie Q A novel lipopolysaccharide-response element contributes to induction of nitric oxide synthase J Biol Chem 272 1997 14867 14872
53. Alonso J Sanchez dM Monton M Casado S Lopez-Farre A Endothelial cytosolic proteins bind to the 3′ untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha Mol Cell Biol 17 1997 5719 5726
54. Singh K Balligand JL Fischer TA Smith TW Kelly RA Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells: role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and STAT1 alpha J Biol Chem 271 1996 1111 1117
55. Da Silva J Pierrat B Mary JL Lesslauer W Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes J Biol Chem 272 1997 28373 28380
56. Miller BW Baier LD Morrison AR Overexpression of protein kinase C-zeta isoform increases cyclooxygenase-2 and inducible nitric oxide synthase Am J Physiol 273 1997 C130 C136
57. Ikeda U Maeda Y Kawahara Y Yokoyama M Shimada K Angiotensin II augments cytokine-stimulated nitric oxide synthesis in rat cardiac myocytes Circulation 92 1995 2683 2689
58. Ikeda U Murakami Y Kanbe T Shimada K Alpha-adrenergic stimulation enhances inducible nitric oxide synthase expression in rat cardiac myocytes J Mol Cell Cardiol 28 1996 1539 1545
59. Oddis CV Simmons RL Hattler BG Finkel MS cAMP enhances inducible nitric oxide synthase mRNA stability in cardiac myocytes Am J Physiol 269 1995 H2044 H2050
60. Ikeda U Yamamoto K Ichida M Ohkawa F Murata M Iimura O Kusano E Asano Y Shimada K Cyclic AMP augments cytokine-stimulated nitric oxide synthesis in rat cardiac myocytes J Mol Cell Cardiol 28 1996 789 795
61. Kasai K Hattori Y Banba N Hattori S Motohashi S Shimoda S Nakanishi N Gross SS Induction of tetrahy-drobiopterin synthesis in rat cardiac myocytes: impact on cytokine-induced NO generation Am J Physiol 273 1997 H665 H672
62. Oddis CV Finkel MS NF-kappa B and GTP cyclohydrolase regulate cytokine-induced nitric oxide production by cardiac myocytes Am J Physiol 270 1996 H1864 H1868
63. Simmons WW Ungureanu-Longrois D Smith GK Smith TW Kelly RA Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and l -arginine transport J Biol Chem 271 1996 23928 23937
64. Hattori Y Nakanishi N Kasai K Role of nuclear factor kappa B in cytokine-induced nitric oxide and tetrahydrobiopterin synthesis in rat neonatal cardiac myocytes J Mol Cell Cardiol 29 1997 1585 1592
65. Simmons WW Closs EI Cunningham JM Smith TW Kelly RA Cytokines and insulin induce cationic amino acid transporter (CAT) expression in cardiac myocytes: regulation of l -arginine transport and no production by CAT-1, CAT-2A, and CAT-2B J Biol Chem 271 1996 11694 11702
66. Kinugawa KI Kohmoto O Yao A Serizawa T Takahashi T Cardiac inducible nitric oxide synthase negatively modulates myocardial function in cultured rat myocytes Am J Physiol 272 1997 H35 H47
67. Pinsky DJ Cai B Yang X Rodriguez C Sciacca RR Cannon PJ The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta J Clin Invest 95 1995 677 685
68. Kajstura J Zhang X Liu Y Szoke E Cheng W Olivetti G Hintze TH Anversa P The cellular basis of pacing-induced dilated cardiomyopathy: myocyte cell loss and myocyte cellular reactive hypertrophy Circulation 92 1995 2306 2317
69. Liu Y Cigola E Cheng W Kajstura J Olivetti G Hintze TH Anversa P Myocyte nuclear mitotic division and programmed myocyte cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs Lab Invest 73 1995 771 787
70. Olivetti G Abbi R Quaini F Kajstura J Cheng W Nitahara JA Quaini E Di Loreto C Beltrami CA Krajewski S Reed JC Anversa P Apoptosis in the failing human heart N Engl J Med 336 1997 1131 1141
71. Shioi T Matsumori A Sasayama S Persistent expression of cytokine in the chronic stage of viral myocarditis in mice Circulation 94 1996 2930 2937
72. Mikami S Kawashima S Kanazawa K Hirata K Hotta H Hayashi Y Itoh H Yokoyama M Low-dose N omeganitro- L -arginine methyl ester treatment improves survival rate and decreases myocardial injury in a murine model of viral myocarditis induced by coxsackievirus B3 Circ Res 81 1997 504 511
73. Lowenstein CJ Hill SL Lafond-Walker A Wu J Allen G Landavere M Rose NR Herskowitz A Nitric oxide inhibits viral replication in murine myocarditis J Clin Invest 97 1996 1837 1843
74. Hiraoka Y Kishimoto C Takada H Nakamura M Kurokawa Ochiai H Shiraki K Nitric oxide and murine coxsackievirus B3 myocarditis: aggravation of myocarditis by inhibition of nitric oxide synthase J Am Coll Cardiol 28 1996 1610 1615
75. Ishiyama S Hiroe M Nishikawa T Abe S Shimojo T Ito H Ozasa S Yamakawa K Matsuzaki M Mohammed MU Nakazawa H Kasajima T Marumo F Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats Circulation 95 1997 489 496
76. Hirono S Islam MO Nakazawa M Yoshida Y Kodama M Shibata A Izumi T Imai S Expression of inducible nitric oxide synthase in rat experimental autoimmune myocarditis with special reference to changes in cardiac hemodynamics Circ Res 80 1997 11 20
77. Bachmaier K Neu N Pummerer C Duncan GS Mak TW Matsuyama T Penninger JM iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1 Circulation 96 1997 585 591
78. Lefer AM Rovetto MJ Influence of a myocardial depressant factor on physiologic properties of cardiac muscle Proc Soc Exp Biol Med 134 1970 269 273
79. Parrillo JE Pathogenetic mechanisms of septic shock N Engl J Med 328 1993 1471 1477
80. Abbas AK Lichtman AH Pober JS Cellular and molecular immunology 3rd ed 1997 W.B. Saunders Baltimore
81. Lange LG Schreiner GF Immune mechanisms of cardiac disease N Engl J Med 330 1994 1129 1135
82. Ungureanu-Longrois D Balligand JL Okada I Simmons WW Kobzik L Lowenstein CJ Kunkel SL Michel T Kelly RA Smith TW Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture Circ Res 77 1995 486 493
83. Levine B Kalman J Mayer L Fillit HM Packer M Elevated circulating levels of tumor necrosis factor in severe chronic heart failure N Engl J Med 323 1990 236 241
84. McMurray J Abdullah I Dargie HJ Shapiro D Increased concentrations of tumour necrosis factor in “cachectic” patients with severe chronic heart failure Br Heart J 66 1991 356 358
85. Matsumori A Yamada T Suzuki H Matoba Y Sasayama S Increased circulating cytokines in patients with myocarditis and cardiomyopathy Br Heart J 72 1994 561 566
86. Dutka DP Elborn JS Delamere F Shale DJ Morris GK Tumour necrosis factor alpha in severe congestive cardiac failure Br Heart J 70 1993 141 143
87. Katz SD Rao R Berman JW Schwarz M Demopoulos L Bijou R LeJemtel TH Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure: relation to nitric oxide-dependent vasodilation in the forearm circulation Circulation 90 1994 12 16
88. Torre-Amione G Kapadia S Lee J Bies RD Lebovitz R Mann DL Expression and functional significance of tumor necrosis factor receptors in human myocardium Circulation 92 1995 1487 1493
89. Ferrari R Bachetti T Confortini R Opasich C Febo O Corti A Cassani G Visioli O Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure Circulation 92 1995 1479 1486
90. Torre-Amione G Kapadia S Lee J Durand JB Bies RD Young JB Mann DL Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart Circulation 93 1996 704 711
91. Nozaki N Yamaguchi S Shirakabe M Nakamura H Tomoike: Soluble tumor necrosis factor receptors are elevated in relation to severity of congestive heart failure Jpn Circ J 61 1997 657 664
92. Mohler ER Sorensen LC Ghali JK Schocken DD Willis PW Bowers JA Cropp AB Pressler ML Role of cytokines in the mechanism of action of amlodipine: the PRAISE Heart Failure Trial J Am Coll Cardiol 30 1997 35 41
93. Deng MC Erren M Lütgen A Zimmerman P Brisse B Schmitz W Assmann G Breithardt G Scheld HH Interleukin-6 correlates with hemodynamic impairment during dobutamine administration in chronic heart failure Int J Cardiol 57 1996 129 134
94. Steele IC Nugent A-M Maguire S Hoper M Campbell G Halliday MI Nicholls DP Cytokine profile in chronic cardiac failure Eur J Clin Invest 26 1996 1018 1022
95. Zhao SP Zeng LH Elevated plasma levels of tumor necrosis factor in chronic heart failure with cachexia Int J Cardiol 58 1997 257 261
96. Aukrust P Ueland T Aass H Muller F Andreassen AK Nordoy I Aas H Kjekshus J Simonsen S Froland SS Gullestad L Elevated circulating levels of C-C chemokines in patients with congestive heart failure Circulation 97 1998 1136 1143
97. Eriksson SV Kjekhus J Eneroth P Edberg K Neopterin, tumor necrosis factor, C-reactive protein and prostoglandin E2 in patients with severe congestive heart failure with enalapril Circulation 96 1997 I 322
98. Gewurz H Zhang XH Lint TF Structure and function of the pentraxins Curr Opin Immunol 7 1995 54 64
99. de Belder AJ Radomski MW Why HJ Richardson PJ Martin JF Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvular heart disease Br Heart J 74 1995 426 430
100. de Belder AJ Radomski MW Why HJ Richardson PJ Bucknall CA Salas E Martin JF Moncada S Nitric oxide synthase activities in human myocardium Lancet 341 1993 84 85
101. Haywood GA Tsao PS von der Leyen HE Mann MJ Keeling PJ Trindade PT Lewis NP Byrne CD Rickenbacher PR Bishopric NH Cooke JP McKenna WJ Fowler MB Expression of inducible nitric oxide synthase in human heart failure Circulation 93 1996 1087 1094
102. Lewis NP Tsao PS Rickenbacher PR Xue C Johns RA Haywood GA von der Leyen H Trindade PT Cooke JP Hunt SA Billingham ME Valantine HA Fowler MB Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle Circulation 93 1996 720 729
103. Habib FM Springall DR Davies GJ Oakley CM Yacoub MH Polak JM Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy Lancet 347 1996 1151 1155
104. Satoh M Nakamura M Tamura G Makita S Segawa I Tashiro A Satodate R Hiramori K Inducible nitric oxide synthase and tumor necrosis factor-alpha in myocardium in human dilated cardiomyopathy J Am Coll Cardiol 29 1997 716 724
105. Winlaw DS Smythe GA Keogh AM Schyvens CG Spratt PM MacDonald PS Increased nitric oxide production in heart failure Lancet 344 1994 373 374
106. Winlaw DS Smythe GA Keogh AM Schyvens CG Spratt PM MacDonald PS Nitric oxide production and heart failure (letter) Lancet 345 1995 390 391
107. Hare JM Givertz MM Creager MA Colucci WS Increased sensitivity to nitric oxide synthase inhibition in patients with heart failure: potentiation of β -adrenergic inotropic responsiveness Circulation 97 1998 161 166
108. Fearon DT Seeking wisdom in innate immunity Nature 388 1997 323 324
109. Bendelac A Fearon DT Innate immunity: Innate pathways that control aquired immunity Curr Opin Immunol 9 1997 1 3
110. Medzhitov R Janeway CAJ Innate immunity: impact on the adaptive immune response Curr Opin Immunol 9 1997 4 9
111. Medzhitov R Janeway CA Jr Self-defense: the fruit fly style Proc Natl Acad Sci USA 95 1998 429 430
112. MacMicking JD North RJ LaCourse R Mudgett JS Shah SK Nathan CF Identification of nitric oxide synthase as a protective locus against tuberculosis Proc Natl Acad Sci USA 94 1997 5243 5248
113. MacMicking JD Nathan C Hom G Chartrain N Fletcher DS Trumbauer M Stevens K Xie QW Sokol K Hutchinson N Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase (published erratum appears in Cell 1995; 81(7):1170) Cell 81 1995 641 650
114. Lancaster JR Jr Langrehr JM Bergonia HA Murase N Simmons RL Hoffman RA EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft J Biol Chem 267 1992 10994 10998
115. Winlaw DS Schyvens CG Smythe GA Du Z Rainer SP Keogh AM Mundy JA Lord RS Spratt PM MacDonald PS Urinary nitrate excretion is a noninvasive indicator of acute cardiac allograft rejection and nitric oxide production in the rat Transplantation 58 1994 1031 1036
116. Winlaw DS Schyvens CG Smythe GA Du ZY Rainer SP Lord RS Spratt PM MacDonald PS Selective inhibition of nitric oxide production during cardiac allograft rejection causes a small increase in graft survival Transplantation 60 1995 77 82
117. Kuo PC Alfrey EJ Krieger NR Abe KY Huie P Sibley RK Dafoe DC Differential localization of allograft nitric oxide synthesis: comparison of liver and heart transplantation in the rat model Immunology 87 1996 647 653
118. Worrall NK Chang K Suau GM Allison WS Misko TP Sullivan PM Tilton RG Williamson JR Ferguson TB Jr Inhibition of inducible nitric oxide synthase prevents myocardial and systemic vascular barrier dysfunction during early cardiac allograft rejection Circ Res 78 1996 769 779
119. Worrall NK Misko TP Sullivan PM Hui JJ Rodi CP Ferguson TB Jr Corticosteroids inhibit expression of inducible nitric oxide synthase during acute cardiac allograft rejection Transplantation 61 1996 324 328
120. Worrall NK Pyo RT Botney MD Misko TP Sullivan PM Alexander DG Lazenby WD Ferguson TB Inflammatory cell-derived NO modulates cardiac allograft contractile and electrophysiological function Am J Physiol 273 1997 H28 H37
121. Russell ME Hancock WW Akalin E Wallace AF Glysing-Jensen T Willett TA Sayegh MH Chronic cardiac rejection in the LEW to F344 rat model: blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis J Clin Invest 97 1996 833 838
122. Raisanen-Sokolowski A Glysing-Jensen T Mottram PL Russell ME Sustained anti-CD4/CD8 treatment blocks inflammatory activation and intimal thickening in mouse heart allografts Arterios Thromb Vasc Biol 17 1997 2115 2122
123. Koglin J Glysing-Jensen T Mudgett JS Russell ME Exacerbated transplant arteriosclerosis in iNOS-deficient mice: iNOS protects against immune-mediated intimal thickening Circulation 96 1997 I 171
124. Lafond-Walker A Chen CL Augustine S Wu TC Hruban RH Lowenstein CJ Inducible nitric oxide synthase expression in coronary arteries of transplanted human hearts with accelerated graft arteriosclerosis Am J Pathol 151 1997 919 925
125. Shears LL Kawaharada N Tzeng E Billiar TR Watkins SC Kovesdi I Lizonova A Pham SM Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis J Clin Invest 100 1997 2035 2042
126. Paulus WJ Kastner S Pujadas P Shah AM Drexler H Vanderheyden M Left ventricular contractile effects of inducible nitric oxide synthase in the human allograft Circulation 96 1997 3436 3442
127. Kubes P Granger DN Nitric oxide modulates microvascular permeability Am J Physiol 262 1992 H611 H615
128. Filep JG Delalandre A Beauchamp M Dual role for nitric oxide in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats Circ Res 81 1997 840 847
129. Reah G Bodenham AR Mallick A Daily EK Przybelski RJ Initial evaluation of diaspirin cross-linked hemoglobin (DCLHb) as a vasopressor in critically ill patients Crit Care Med 25 1997 1480 1488
130. Fischer SR Bone HG Powell WC McGuire R Traber LD Traber DL Pyridoxalated hemoglobin polyoxyethylene conjugate does not restore hypoxic pulmonary vasoconstriction in ovine sepsis Crit Care Med 25 1997 1551 1559
131. Heneka MT Loschmann PA Osswald H Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat J Clin Invest 99 1997 47 54