Recent advances in basic obesity research

JAMA

Volumn 282, Issue 16, 1999, Pages 1504-1506

  Yanovski, Jack A ^a,c   Yanovski, Susan Z ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDORPHIN; ENKEPHALIN; INTERMEDIN; LEPTIN; MELANOCORTIN RECEPTOR; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; UNCOUPLING PROTEIN;

APPETITE; BODY FAT; BODY MASS; CALORIC INTAKE; ENERGY EXPENDITURE; GENE MUTATION; HERITABILITY; HUMAN; HYPOTHALAMUS; MEDICAL RESEARCH; MOUSE; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SHORT SURVEY; THERMOGENESIS;

EID: 0032696042     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.282.16.1504     Document Type: Short Survey

References (37)

1. Flegal KM, Carrol MD, Kuczmarski RJ, Johnson CL. Overweight and obesity in the United States. Int J Obes Relat Metab Disord. 1998;22:39-47.
2. Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL. Increasing prevalence of overweight among US adults. JAMA. 1994;272:205-211.
3. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. Obes Res. 1998;6(suppl):51S-209S.
4. Stunkard AJ, Harris JR, Pedersen NL, McClearn GE. The body-mass index of twins who have been reared apart. N Engl J Med. 1990;322:1483-1487.
5. Allison DB, Kaprio J, Korkeila M, Koskenvuo M, Neale MC, Hayakawa K. The heritability of body mass index among an international sample of monozygotic twins reared apart. Int J Obes Relat Metab Disord. 1996;20:501-506.
6. Rolls BJ, Hammer VA. Fat, carbohydrate, and the regulation of energy intake. Am J Clin Nutr. 1995;62 (suppl):1086S-1095S.
7. Hill JO. Physical activity, body weight and body fat distribution. In: Leon A, ed. Physical Activity and Cardiovascular Health: A National Consensus. Champaign, Ill: Human Kinetics; 1997:272.
8. World Health Organization, Division of Noncommunicable Disease, Programme of Nutrition Family and Reproductive Health; June 3-5, 1997; Geneva, Switzerland. Abstract 276.
9. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue [published correction appears in Nature. 1995; 374:479]. Nature. 1994;372:425-432.
10. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995;83:1263-1271.
11. Chua SC Jr, Chung WK, Wu-Peng XS, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 1996;271:994-996.
12. Coleman DL. Obesity and diabetes. Diabetologia. 1978;14:141-148.
13. Campfield LA, Smith FJ, Guisez Y, et al. Recombinant mouse OB protein. Science. 1995;269:546-549.
14. Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269:543-546.
15. Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540-543.
16. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997;387:900.
17. Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998;392:398-401.
18. Perusse L, Chagnon YC, Weisnagel J, Bouchard C. The human obesity gene map: the 1998 update. Obes Res. 1999;7:111-129.
19. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-295.
20. Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382:250-252.
21. Chehab FF, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science. 1997;275:88-90.
22. Greenberg AS, Heymsfield SB, Fujioka K, et al. Preliminary safety and efficacy of recombinant methionyl leptin (rL) administered by SC injection in lean and obese subjects. Diabetes. 1998;47(suppl):LB-16.
23. Considine RV, Caro JF. Pleiotropic cellular effects of leptin. Curr Opin Endocrinol Diabetes. 1999; 6:163-169.
24. Krude H, Biebermann H, Luck W, et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 1998;19:155-157.
25. Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997;88:131-141.
26. Vaisse C, Clement K, Guy-Grand B, et al. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 1998;20:113-114.
27. Yeo GS, Farooqi IS, Aminian S, et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 1998;20:111-112.
28. Bultman SJ, Michaud EJ, Woychik RP. Molecular characterization of the mouse agouti locus. Cell. 1992; 71:1195-1204.
29. Lu D, Willard D, Patel IR, et al. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature. 1994;371:799-802.
30. Ristow M, Muller-Wieland D, Pfeiffer A, Krone W, Kahn CR. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med. 1998;339:953-959.
31. Argyropoulos G, Brown AM, Willi SM, et al. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. J Clin Invest. 1998;102:1345-1351.
32. Levine JA, Eberhardt NL, Jensen MD. Role of non-exercise activity thermogenesis in resistance to fat gain in humans. Science. 1999;283:212-214.
33. Klem ML, Wing RR, McGuiṙe MT, Seagle HM, Hill JO. A descriptive study of individuals successful at long-term maintenance of substantial weight loss. Am J Clin Nutr. 1997;66:239-246.
34. Barlow SE, Dietz WH, for the Maternal and Child Health Bureau, et al. Obesity evaluation and treatment. Pediatrics. 1998;102:E29.
35. Sjostrom CD, Lissner L, Sjostrom L. Relationships between changes in body composition and changes in cardiovascular risk factors. Obes Res. 1997; 5:519-530.
36. Karlsson J, Sjostrom L, Sullivan M. Swedish obese subjects (SOS) - an intervention study of obesity. Int J Obes Relat Metab Disord. 1998;22:113-126.
37. Gastrointestinal surgery for severe obesity. Nutrition. 1996;12:397-404.