Highly significant role of Helicobacter pylori urease in phagocytosis and production of oxygen metabolites by human granulocytes

Journal of Infectious Diseases

Volumn 177, Issue 3, 1998, Pages 803-806

  Makristathis, Athanasios ^a   Rokita, Elmar ^b   Labigne, Agnès ^b   Willinger, Birgit ^b   Rotter, Manfred L ^b   Hirschi, Alexander M ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CYTOTOXIN; REACTIVE OXYGEN METABOLITE; UREASE;

AMMONIA FORMATION; ARTICLE; FLOW CYTOMETRY; GRANULOCYTE; HELICOBACTER; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; PHAGOCYTOSIS; PRIORITY JOURNAL; RESPIRATORY BURST;

EID: 0031887519     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/517814     Document Type: Article

References (10)

1. Hopkins RJ, Morris JG. Helicobacter pylori; the missing link in perspective. Am J Med 1994;97:265-77.
2. Marshall BJ, Barrett LJ, Prakash C, McCallum RW, Guerrant RL. Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid. Gastrocnterology 1990;99:697-702.
3. Eaton KA, Krakowka S. Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacterpylori. Infect Immun 1994; 62:3604-7.
4. Xiang Z, Censini S, Bayerli PF, et al. Analysis of expression of cagA and vacA virulence factors in 43 strains of Helicobacter pylori reveals that the clinical isolates can be divided into two major types and that cagA is not necessary for expression of the vacuolating toxin. Infect Immun 1995;63:94-8.
5. Ferrero RL, Cussac V, Courcoux P, Labigne A. Construction of isogenic urease-negative mutants of Helicobacter pylori by allelic exchange. J Bacteriol 1992;174:4212-7.
6. Schmitt W, Haas R. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Molec Microbiol 1994;12:307-19.
7. Zigmond SH, Hirsch JG. Effect of cytochalasin B on PMN locomotion, phagocytosis and glycolysis. Exp Cell Res 1972;73:383-93.
8. Rome G, Emmendörffer A, Oscr A, Roesler J, Valet G. Flow cytometric measurement of the respiratory burst activity of phagocytes using dihydrorhodamine 123. J Immununol Methods 1991;138:133-5.
9. DeChatelet LR, Long GD, Shirley PS,'et al. Mechanism of the luminoldependent chemiluminescence of human neutrophils. J Immunol 1982; 129:1589-93.
10. Raybourne RB, Bunning VK. Bacterium-host cell interactions at the cellular level: fluorescent labeling of bacteria and analysis of short-term bacterium-phagocyte interaction by flow cytometry. Infect Immun 1994;62:665-72.