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Volumn 9, Issue 4, 1997, Pages 498-503

Immunobiology of Helicobacter pylori infection

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; BACTERIAL IMMUNITY; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HELPER CELL; IMMUNOBIOLOGY; INCUBATION TIME; INFLAMMATION; NONHUMAN; REVIEW;

EID: 0030827244     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(97)80101-X     Document Type: Article
Times cited : (71)

References (52)
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    • Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets
    • This paper describes the eradication of a natural infection of H. mustelae in ferrets using a subunit vaccine composed of recombinant H. pylori urease plus cholera toxin.
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    • Cuenca, R.1    Blanchard, T.G.2    Czinn, S.J.3    Nedrud, J.G.4    Monath, T.P.5    Lee, C.K.6    Redline, R.W.7
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    • Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis
    • of outstanding interest
    • Lee CK, Weltzin R, Thomas WD, Kleanthous H, Ermak TH, Soman G, Hill JE, Ackerman SK, Monath TP. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. J Infect Dis. 172:1995;161-172. of outstanding interest.
    • (1995) J Infect Dis , vol.172 , pp. 161-172
    • Lee, C.K.1    Weltzin, R.2    Thomas, W.D.3    Kleanthous, H.4    Ermak, T.H.5    Soman, G.6    Hill, J.E.7    Ackerman, S.K.8    Monath, T.P.9
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    • Helicobacter pylori infections in IgA deficiency: Lack of role for the secretory immune system
    • This paper describes the lack of increase in incidence and severity of H. pylori infection in humans carrying IgA deficiency, which is one of the most common innate immunodeficiency conditions in man.
    • Bogstedt AK, Nava S, Wadstrom T, Hammarstrom L. Helicobacter pylori infections in IgA deficiency: lack of role for the secretory immune system. Clin Exp Immunol. 105:1996;202-204 This paper describes the lack of increase in incidence and severity of H. pylori infection in humans carrying IgA deficiency, which is one of the most common innate immunodeficiency conditions in man.
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    • Bogstedt, A.K.1    Nava, S.2    Wadstrom, T.3    Hammarstrom, L.4
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    • Orally immunized IgA-deficient mice are protected against H. felis infection [abstract]
    • of outstanding interest. So far only an abstract, but a paper to look for. It describes the lack of the role of the secretory IgA system in the protective effector mechanism elicited by mucosal vaccination against Helicobacter infection.
    • Nedrud T, Blanchard S, Czinn GR, Harriman GR. Orally immunized IgA-deficient mice are protected against H. felis infection [abstract]. of outstanding interest Gut. 39:1996;A45 So far only an abstract, but a paper to look for. It describes the lack of the role of the secretory IgA system in the protective effector mechanism elicited by mucosal vaccination against Helicobacter infection.
    • (1996) Gut , vol.39 , pp. 45
    • Nedrud, T.1    Blanchard, S.2    Czinn, G.R.3    Harriman, G.R.4
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    • Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori
    • of outstanding interest. This review describes the current knowledge on the molecular basis of evolution of virulence in H. pylori Type I virulent strains through the inheritance of DNA insertions that contain genes associated with disease.
    • Covacci A, Falkow S, Berg DE, Rappuoli R. Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori. of outstanding interest Trends Microbiol. 5:1997;205-208 This review describes the current knowledge on the molecular basis of evolution of virulence in H. pylori Type I virulent strains through the inheritance of DNA insertions that contain genes associated with disease.
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    • Covacci, A.1    Falkow, S.2    Berg, D.E.3    Rappuoli, R.4
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    • Safety of oral immunisation with recombinant urease in patients with Helicobacter pylori infection
    • of special interest. The first official report of a subunit vaccine Phase I trial performed last year with purified recombinant enzymatically inactive urease. 12 nonsymptomatic H. pylori infected volunteers were randomized to receive, orally, either 60mg of urease or a placebo once weekly for 4 weeks. Urease was well tolerated and no major adverse reactions occurred. Mean gastritis score assessed on bioptic specimens was not altered by treatment and only minor erosions were observed in three volunteers receiveing urease and in one receiving the placebo. As expected, however, as no mucosal adjuvant was used in this trial, all volunteers remained infected.
    • Kreiss C, Buclin T, Cosma M, Corthesy-Theulaz I, Michetti P. Safety of oral immunisation with recombinant urease in patients with Helicobacter pylori infection. of special interest Lancet. 347:1996;1630-1631 The first official report of a subunit vaccine Phase I trial performed last year with purified recombinant enzymatically inactive urease. 12 nonsymptomatic H. pylori infected volunteers were randomized to receive, orally, either 60mg of urease or a placebo once weekly for 4 weeks. Urease was well tolerated and no major adverse reactions occurred. Mean gastritis score assessed on bioptic specimens was not altered by treatment and only minor erosions were observed in three volunteers receiveing urease and in one receiving the placebo. As expected, however, as no mucosal adjuvant was used in this trial, all volunteers remained infected.
    • (1996) Lancet , vol.347 , pp. 1630-1631
    • Kreiss, C.1    Buclin, T.2    Cosma, M.3    Corthesy-Theulaz, I.4    Michetti, P.5


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