Basic mechanisms of epilepsy: Targets for therapeutic intervention

Epilepsia

Volumn 38, Issue SUPPL. 9, 1997, Pages

  Dichter, Marc A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Department of Neurology ^*  (United States)

Author keywords

Adenosine; Anticonvulsants; Calcium currents; Drug development; GABA; Interictal discharges; NMDA; Partial seizures; Primary generalized seizures

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTICONVULSIVE AGENT; N METHYL DEXTRO ASPARTIC ACID; PHENYTOIN;

BRAIN PROTECTION; CALCIUM CURRENT; CONFERENCE PAPER; DRUG MECHANISM; EPILEPSY; EPILEPTOGENESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; PRIORITY JOURNAL; RECEPTOR BINDING; SPIKE WAVE;

EID: 0030711507     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1997.tb05200.x     Document Type: Conference Paper

References (28)

1. Dichter M, Ayala GF. Cellular mechanisms of epilepsy: a status report. Science 1987;237:157-64.
2. Dichter M, Spencer W. Penicillin induced interictal discharges from cat hippocampus. II. Mechanisms underlying origin and restriction. J Neurophysiol 1969;32:663-87.
3. Yaari Y, Jensen M. Nonsynaptic mechanisms and interictal-ictal transitions in the mammalian hippocampus. In: Dichter M, ed. Mechanisms of epileptogenesis: the transition to seizure. New York: Plenum Press, 1988:183-98.
4. Dichter M. Modulation of inhibition and the transition to seizures. In: Dichter M, ed. Mechanisms of epileptogenesis: the transition to seizure. New York: Plenum Press, 1988:169-81.
5. B receptor feed-back on GABA release. J Physiol 1989;412:513-41.
6. Zucker R. Short-term synaptic plasticity. In: Cowan M, Shooter E, Stevens C, Thompson R, eds. Annual review of neuroscience. 12th ed. Palo Alto, CA: Annual Reviews, 1989:13-32.
7. Mumford J, Lewis P. Vigabatrin. In: Pisani F, Perucca E, Avanzini G, Richens A, eds. New antiepileptic drugs. Amsterdam: Elsevier, 1991:161-8.
8. Pierce MW, Suzdak PD, Gustavson LE, Mengel HB, McKelvy JF, Mant T. Tiagabine. Epilepsy Res Suppl 1991;3:157-60.
9. Macdonald R, Kelly K. Antiepileptic drug mechanisms of action. Epilepsia 1993;34(suppl 5):S1-8.
10. Twyman R, Rogers C, Macdonald R. Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital. Ann Neurol 1989;25:213-20.
11. Meldrum B. GABA-agonists as anti-epileptic agents. Adv Biochem Psychopharmacol 1981;26:207-17.
12. Yaari Y, Konnerth A, Heinemann U. Nonsynaptic epileptogenesis at the mammalian hippocampus in vitro. II. Role of extracellular potassium. J Neurophysiol 1986;56:424-38.
13. Dichter M, Herman C, Selzer M. Silent cells during interictal discharges and seizures in hippocampal penicillin foci. Evidence for the role of extracellular K in the transition from interictal state to seizures. Brain Res 1972;48:173-83.
14. Yaari Y, Konnerth A. Epileptogenesis in low extracellular calcium. Exp Brain Res 1986;14:353-65.
15. Dragunow M. Adenosine and epileptic seizures. In: Phillis J, ed. Adenosine and adenine nucleotides as regulators of cellular function. Boca Raton, FL: CRC Press, 1991:367-79.
16. Frosch M, Lipton S, Dichter M. Desensitization of GABA-activated currents and channels in cultured cortical neurons. J Neurosci 1992;12:3042-53.
17. Oh DJ, Dichter M. Desensitization of GABA induced currents in cultured rat hippocampal neurons. Neuroscience 1992;49:571-6.
18. Steriade M, McCormick D, Sejnowski T. Thalamocortical oscillations in the sleeping and aroused brain. Science 1993;262:679-85.
19. Coulter DA, Huguenard JR, Prince DA. Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current. J Physiol (Lond) 1989;414:587-604.
20. 2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell 1997;88:385-92.
21. Coulter DA, Huguenard JR, Prince DA. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol 1989;25:582-93.
22. Coulter DA, Huguenard IR, Prince DA. Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade. Br J Pharmacol 1990;100:807-13.
23. Coulter DA, Huguenard JR, Prince DA. Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. Br J Pharmacol 1990;100:800-6.
24. B receptor activation in absence seizures of lethargic (lh/lh) mice. Science 1992;257:398-401.
25. Hosford DA, Wang Y. Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin, and topiramate against human absence seizures. Epilepsia 1997;38:408-14.
26. Temkin N, Dikmen S, Winn HR. Clinical trials for seizure prevention. In: French J, Leppik I, Dichter M, eds. Antiepileptic drug treatment. Philadelphia: Lippincott-Raven Press, 1997:179-88. [Advances in neurology, vol. 76.]
27. Temkin N, Dikmen S, Winn HR. Clinical trials for seizure prevention. In: French J, Leppik I, Dichter M, eds. Antiepileptic drug treatment. Philadelphia: Lippincott-Raven Press, 1997:179-88. [Advances in neurology, vol. 76.]
28. Goldstein LB. Common drugs may influence motor recovery after stroke. Neurology 1995;45:865-71.