Chronic ET(A) receptor blockade attenuates cardiac hypertrophy independently of blood pressure effects in renovascular hypertensive rats

Hypertension

Volumn 33, Issue 4, 1999, Pages 954-960

  Ehmke, Heimo ^a,c   Faulhaber, Jörg ^a   Münter, Klaus ^b   Kirchengast, Michael ^b   Wiesner, Rudolf J ^d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Knoll AG   (Germany)

^c Physiologisches Institut   (Germany)

^d NONE

Author keywords

Gene expression; Hypertension, renovascular; Remodeling; Renin angiotensin system

Indexed keywords

ANGIOTENSIN; ATRIAL NATRIURETIC FACTOR; DARUSENTAN; ENDOTHELIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; MESSENGER RNA; MYOSIN HEAVY CHAIN; ENDOTHELIN RECEPTOR; PHENYLPROPIONIC ACID DERIVATIVE; PYRIMIDINE DERIVATIVE; RENIN;

ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; FEMALE; HEART HYPERTROPHY; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART RATE; HEART VENTRICLE REMODELING; HEART WEIGHT; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENOVASCULAR HYPERTENSION; RNA ANALYSIS; SYSTOLIC BLOOD PRESSURE; ANIMAL; BLOOD; BLOOD PRESSURE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ATRIAL NATRIURETIC FACTOR; BLOOD PRESSURE; FEMALE; HEART RATE; HYPERTENSION, RENOVASCULAR; HYPERTROPHY, LEFT VENTRICULAR; MYOSIN HEAVY CHAINS; PHENYLPROPIONATES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; RENIN; RNA, MESSENGER;

EID: 0032588243     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.33.4.954     Document Type: Article

References (38)

1. Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, Nogami A, Marumo F, Hiroe M. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest. 1993;92:398-403.
2. Tamamori M, Ito H, Adachi S, Akimoto H, Marumo F, Hiroe M. Endothelin-3 induces hypertrophy of cardiomyocytes by the endogenous endothelin-1-mediated mechanism. J Clin Invest. 1996;97:366-372.
3. Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotski CC, Brown JH, Chien KR. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular hypertrophy. J Biol Chem. 1990;265:20555-20562.
4. Ito H, Hirata Y, Hiroe M, Tsujino M, Adachi S, Takamoto T, Nitta M, Taniguchi K, Marumo F. Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes. Circ Res. 1991;69:209-215.
5. Sadoshima J, Xu Y, Slayter HS, Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 1993;75:977-984.
6. Booz GW, Baker KM. Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension. 1996; 28:635-640.
7. Yamazaki T, Komuro I, Kudho S, Zou Y, Shiojima I, Hiroi Y, Mizuno T, Maemura K, Kurihara H, Aikawa R, Takano H, Yazaki Y. Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. J Biol Chem. 1996;271:3321-3328.
8. Mercadier JJ, Samuel JL, Michel JB, Zongazo MA, de la Bastie D, Lompre AM, Wisnewsky C, Rappaport L, Levy B, Schwartz K. Atrial natriuretic factor gene expression in rat ventricle during experimental hypertension. Am J Physiol. 1989;257:H979-H987.
9. Wiesner RJ, Ehmke H, Faulhaber J, Zak R, Rüegg JC. Dissociation of left ventricular hypertrophy, β-myosin heavy chain gene expression, and myosin isoform switch in rats after ascending aortic stenosis. Circulation. 1997;95:1253-1259.
10. Kim S, Ohta K, Hamaguchi A, Yukimura T, Miura K, Iwao H. Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats. Hypertension. 1995;25:1252-1259.
11. Sosic D, Nunez E, Frohlich ED, Prakash O. Angiotensin II increases left ventricular mass without affecting myosin isoform mRNAs. Hypertension. 1996;28:265-268.
12. Hilal-Dandan R, Merck DT, Lujan JP, Brunton LL. Coupling of the type A endothelin receptor to multiple responses in adult rat cardiac myocytes. Mol Pharmacol. 1994;45:1183-1190.
13. Sakai S, Miyauchi T, Sakurai T, Kasuya Y, Ihara M, Yamaguchi I, Goto K, Sugishita Y. Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Circulation. 1996;93:1214-1222.
14. Raschack M, Unger L, Riechers H, Klinge D. Receptor selectivity of endothelin antagonists and prevention of vasoconstriction and endothelin-induced sudden death. J Cardiovasc Pharmacol. 1995;26(suppl 3):S397-S399.
15. Riechers H, Albrecht HP, Amberg W, Baumann E, Bernard H, Böhm HJ, Klinge D, Kling A, Müller S, Raschack M, Unger L, Walker N, Wernet W. Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. J Med Chem. 1996;39:2123-2128.
16. Smith SH, Bishop SP. Selection criteria for drug-treated animals in two-kidney, one clip renal hypertension. Hypertension. 1986;8:700-705.
17. A-receptor blocker (LU 135252) in salt-loaded uninephrectomized stroke-prone spontaneously hypertensive rats. Hypertension. 1998;31:995-1001.
18. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
19. Schiaffino S, Samuel JL, Sassoon D, Lompre AM, Garner I, Marotte F, Buckingham M, Rappaport L, Schwartz K. Nonsynchronous accumulation of α-skeletal actin and β-myosin heavy chain mRNAs during early stages of pressure-overload-induced cardiac hypertrophy demonstrated by in situ hybridization. Circ Res. 1989;64:937-948.
20. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Press; 1989.
21. Schneider WC. Determination of nucleic acids in tissues by pentose analysis. Methods Enzymol. 1957;3:680-684.
22. Katholi RE. Renal nerves in the pathogenesis of hypertension in experimental animals and humans. Am J Physiol. 1983;245:F1-F14.
23. Kaddoura S, Firth JD, Boheler KR, Sugden PH, Poole-Wilson PA. Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo. Circulation. 1996;93:2068-2079.
24. Schlüter KD, Piper HM. Trophic effects of catecholamines and parathyroid hormone on adult ventricular cardiomyocytes. Am J Physiol. 1992;263:H1739-H1746.
25. Decker RS, Cook MG, Behnke-Barclay MM, Decker ML, Lesch M, Samarel AM. Catecholamines modulate protein turnover in cultured, quiescent rabbit cardiac myocytes. Am J Physiol. 1993;265:H329-H339.
26. Li JS, Knafo L, Turgeon A, Garcia R, Schiffrin EL. Effect of endothelin antagonism on blood pressure and vascular structure in renovascular hypertension. Am J Physiol. 1996;271:H88-H93.
27. A-receptor blockade in angiotensin II-induced hypertension. Hypertension. 1997;29(pt 2):435-441.
28. Rajagopalan S, Laursen JB, Borthayre A, Kurz S, Keiser J, Haleen S, Giaid A, Harrison DG. Role for endothelin-1 in angiotensin II-mediated hypertension. Hypertension. 1997;2(pt 1):29-34.
29. Schricker K, Scholz H, Hamann M, Clozel M, Krämer BK, Kurtz A. Role of endogenous endothelins in the renin system of normal and two-kidney, one clip rats. Hypertension. 1995;25:1025-1029.
30. Matsumura Y, Hisaki K, Ohyama T, Hayashi K, Morimoto S. Effects of endothelin on renal function and renin secretion in anesthetized rats. Eur J Pharmacol. 1989;166:577-580.
31. Rakugi H, Nakamura M, Saito H, Higaki J, Ogihara T. Endothelin inhibits renin release from isolated rat glomeruli. Biochem Biophys Res Commun. 1988;157:1164-1168.
32. Firth JD, Ratcliffe PJ. Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression. J Clin Invest. 1992;90:1023-1031.
33. A receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload. Circulation. 1994;89: 2198-2203.
34. Ichikawa K, Hidai C, Okuda C, Kimata S, Matsuoka R, Hosoda S, Quertermous T, Kawana M. Endogenous endothelin-1 mediates cardiac hypertrophy and switching of myosin heavy chain gene expression in rat ventricular myocardium. J Am Coll Cardiol. 1996;27:1286-1291.
35. Sadoshima J, Izumo S. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro: potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. Circ Res. 1995;77:1040-1052.
36. Thorburn J, McMahon M, Thorbum A. Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J Biol Chem. 1994;269:30580-30586.
37. Morgan HE, Baker KM. Cardiac hypertrophy: mechanical, neural, and endocrine dependence. Circulation. 1991;83:13-25.
38. Luyken J, Hannan RD, Cheung JY, Rothblum LI. Regulation of rDNA transcription during endothelin-1-induced hypertrophy of neonatal cardiomyocytes: hyperphosphorylation of upstream binding factor, an rDNA transcription factor. Circ Res. 1996;78:354-361.