Endothelin-1 Is Involved in Norepinephrine-Induced Ventricular Hypertrophy in Vivo Acute Effects of Bosentan, an Orally Active, Mixed Endothelin ETA and ETB Receptor Antagonist

Circulation

Volumn 93, Issue 11, 1996, Pages 2068-2079

  Kaddoura, Samer ^a,b   Firth, John D ^c   Boheler, Kenneth R ^a   Sugden, Peter H ^a   Poole Wilson, Philip A ^a,b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Bosentan; Endothelin; Hypertrophy; Norepinephrine; RNA

Indexed keywords

ALPHA ACTIN; ATRIAL NATRIURETIC FACTOR; BOSENTAN; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; MESSENGER RNA; MYOSIN HEAVY CHAIN; NORADRENALIN; PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; IMMUNOHISTOCHEMISTRY; MALE; NEWBORN; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACTINS; ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; ATRIAL NATRIURETIC FACTOR; BIOLOGICAL MARKERS; BODY WEIGHT; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; ENDOTHELINS; GENE EXPRESSION REGULATION; HYPERTROPHY, LEFT VENTRICULAR; MALE; MUSCLE PROTEINS; MYOCARDIUM; MYOSIN HEAVY CHAINS; NOREPINEPHRINE; ORGAN SIZE; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; RNA, ANTISENSE; RNA, MESSENGER; SULFONAMIDES;

EID: 0029886332     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.93.11.2068     Document Type: Article

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