Regulation of rDNA transcription during endothelin-1-induced hypertrophy of neonatal cardiomyocytes: Hyperphosphorylation of upstream binding factor, an rDNA transcription factor

Circulation Research

Volumn 78, Issue 3, 1996, Pages 354-361

  Luyken, Joachim ^a   Hannan, Ross D ^a   Cheung, Joseph Y ^a   Rothblum, Lawrence I ^a,b  

^a WEIS CENTER FOR RESEARCH   (United States)

^b GEISINGER MEDICAL CENTER   (United States)

Author keywords

cardiomyocyte hypertrophy; endothelin 1; phorbol 12 myristate 13 acetate; rDNA; upstream binding factor

Indexed keywords

DNA DIRECTED RNA POLYMERASE; ENDOTHELIN 1; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATE; PHOSPHOAMINO ACID; RIBOSOME DNA; RIBOSOME RNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEART HYPERTROPHY; IMMUNOBLOTTING; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RNA SYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0030023510     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.78.3.354     Document Type: Article

References (41)

1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayasi M, Mitsui Y, Yasaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-415.
2. Sokolovsky M. Endothelins and sarafotoxins and transmembrane signaling. Trends Biochem Sci. 1991;16:261-264.
3. Irons CE, Murray SF, Glembotsky CC. Identification of the receptor subtype responsible for endothelin-mediated protein kinase C activation and atrial natriuretic factor secretion from atrial myocytes. J Biol Chem. 1993;268:23417-23421.
4. Hirata Y, Fukuda Y, Yoshimi H, Emori T, Shichiri M, Marumo F. Specific receptor for endothelin in cultured rat cardiocytes. Biochem Biophys Res Commun. 1989;160:1438-1444.
5. Hemsen A, Franco-Cereceda A, Matran R, Rudehill A, Lundberg JM. Occurrence, specific binding sites and functional effects of endothelin in human cardiopulmonary tissue. Eur J Pharmacol. 1990;191:319-328.
6. Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotsky CC, Brown JH, Chien KR. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes: a paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 1990;265:20555-20562.
7. Ito H, Hirata Y, Hiroe M, Tsujino M, Adachi S, Takamoto T, Nitta M, Taniguchi K, Marumo F. Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes. Circ Res. 1991;69:209-215.
8. Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, Nogami A, Marumo F, Hiroe M. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest. 1993;92:398-403.
9. Allo SN, McDermott PJ, Carl LL, Morgan HE. Phorbol ester stimulation of protein kinase C activity and ribosomal DNA transcription: role in hypertrophic growth of cultured cardiomyocytes. J Biol Chem. 1991;266:22003-22009.
10. Allo S, Carl LL, Morgan HE. Acceleration of growth of cultured cardiomyocytes and translocation of protein kinase C. Am J Physiol. 1992;263:C319-C325.
11. Ito H, Hiroe M, Hirata Y, Fujisaki H, Adachi S, Akimoto H, Ohta Y, Marumo F. Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload. Circulation. 1994;89:2198-2203.
12. Bogoyevitch MA, Glennon PE, Anderson MB, Clerk A, Lazon A, Marshall CJ, Parker PJ, Sugden PH. Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. J Biol Chem. 1994;269: 1110-1119.
13. Bogoyevitch MA, Glennon PE, Sugden PH. Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes. FEBS Lett. 1993;317:271-275.
14. Clerk A, Bogoyevitch MA, Andersson MB, Sugden PH. Differential activation of protein kinase C isoforms by endothelin-land phenylephrine and subsequent stimulation of p42 and p44 mitogenactivated protein kinases in ventricular myocytes cultured from neonatal rat hearts. J Biol Chem. 1994;269:32848-32857.
15. 2+-dependent signaling. Circ Res. 1995;76:1-15.
16. Morgan HE, Chua BHL, Russo L. The Heart and Cardiovascular System. Fozzard H, Haber E, Jennings R, Katz A, Morgan H, eds. New York, NY: Raven Press Publishers; 1992:1505-1524.
17. McDermott PJ, Morgan HE. Contraction modulates the capacity for protein synthesis during growth of neonatal heart cells in culture. Circ Res. 1989;64:542-553.
18. McDermott PJ, Rothblum LI, Smith SD, Morgan HE. Accelerated rates of ribosomal RNA synthesis during growth of contracting heart cells in culture. J Biol Chem. 1989;264:220-227.
19. Hannan RD, Luyken J, Rothblum LI. Regulation of rDNA transcription factors during cardiomyocyte hypertrophy induced by adrenergic agents. J Biol Chem. 1995;270:8290-8297.
20. Moss T, Stefanovsky VY. Promotion and regulation of ribosomal transcription in eukaryotes by RNA polymerase I. Prog Nucleic Acid Res Mol Biol. 1995;50:25-66.
21. Paule M. Transcription: Mechanisms and Regulation. New York, NY: Raven Press Publishers; 1994.
22. Smith SD, Oriahi E, Lowe D, Yang-Yen HF, O'Mahony D, Rose K, Chen C, Rothblum LI. Characterization of factors that direct transcription of rat ribosomal DNA. Mol Cell Biol. 1990;10:3105-3116.
23. O'Mahony DJ, Smith SD, Xie WQ, Rothblum LI. Analysis of the phosphorylation, DNA-binding and dimerization properties of the RNA polymerase I transcription factors UBF1 and UBF2. Nucleic Acids Res. 1992;20:1301-1308.
24. O'Mahony DJ, Xie WQ, Smith SD, Singer HA, Rothblum LI. Differential phosphorylation and localization of the transcription factor UBF in vivo in response to serum deprivation: in vitro dephosphorylation of UBF reduces its transactivation properties. J Biol Chem. 1992;267;35-38.
25. Voit R, Schnapp A, Kuhn A, Rosenbauer H, Hirshmann P, Stunnenberg HG, Grummt I. The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation. EMBO J. 1992;11: 2211-2218.
26. Glibetic M, Taylor L, Larson D, Hannan R, Sells B, Rothblum L. The RNA polymerase I transcription factor UBF is the product of a primary response gene. J Biol Chem. 1995;270:4209-4212.
27. Hannan R, Luyken J, Rothblum LI. Regulation of ribosomal DNA transcription during contraction-induced hypertrophy of neonatal cardiomyocytes. J Biol Chem. In press.
28. McDermott PJ, Carl LL, Conner KJ, Allo SN. Transcriptional regulation of ribosomal RNA synthesis during growth of cardiac myocytes in culture. J Biol Chem. 1991;266:4409-4416.
29. Simpson PC, McGrath A, Savion S. Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines. Circ Res. 1982;51:787-801.
30. Cesarone CF, Bolognesi C, Santi L. Improved microfluorometric DNA determination in biological material using 33258 Hoechst. Anal Biochem. 1979;100:188-197.
31. Larson DE, Xie WO, Glibetic M, O'Mahony D, Sells BH, Rothblum LI. Coordinated decreases in rRNA gene transcription factors and rRNA synthesis during muscle cell differentiation. Proc Natl Acad Sci U S A. 1993;90:7933-7936.
32. Hannan RD, Stennard FA, West AK. Expression of c-fos and related genes in the rat heart in response to norepinephrine. J Mol Cell Biol. 1993;25:1137-1148.
33. Cavanaugh AH, Hempel WM, Taylor LJ, Rogalsky V, Todarov G, Rothblum LI. Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product. Nature. 1995;374:177-180.
34. Boyle J, van der Geer P, Hunter T. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thinlayer cellulose plates. Methods Enzymol. 1991;201:110-149.
35. Simpson PC, Kariya K, Karns LR, Long CS, Karliner JS. Adrenergic hormones and control of cardiac myocyte growth. Mol Cell Biochem. 1991;104:35-43.
36. Boulis NM, Davis M. Blockade of the spinal excitatory effect of cAMP on the startle reflex by intrathecal administration of the isoquinoline sulfonamide H-8: comparison to the protein kinase C inhibitor H-7. Brain Res. 1990;525:198-204.
37. Takahashi I, Kobayashi E, Nakano H, Murakata C, Saitoh H, Suzuki K, Tamaoki T. Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C. J Pharmacol Exp Ther. 1990;255: 1218-1221.
38. Toullec D, Pianetti P, Coster H, Bellergue P, Grand-Perret T, Ajakane M, Boissin P, Boursier E, Loriolle E. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem. 1991;266:15771-15781.
39. Wilkinson SE, Parker P, Nixon J. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1989;294:335-337.
40. Davis PD, Elliott LH, Harris W, Hill MK, Lawton G, Nixon JS, Wilkinson SE. Inhibitors of protein kinase C, 2: substituted bisindolylmaleimides with improved potency and selectivity. J Med Chem. 1992;35:994-1001.
41. Weinstein S, Gold M, DeFranco A. Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc Natl Acad Sci U S A. 1991;88:4148-4152.