Effect of endothelin antagonism on blood pressure and vascular structure in renovascular hypertensive rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 1 40-1, 1996, Pages

  Li, Jin S ^a   Knafo, Laurent ^a   Turgeon, André ^a   Garcia, Raúl ^a   Schiffrin, Ernesto L ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

bosentan; endothelin receptor antagonist; hypertension

Indexed keywords

BOSENTAN; ENDOTHELIN; ENDOTHELIN RECEPTOR ANTAGONIST; RENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE EXPRESSION; NONHUMAN; PATHOGENESIS; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENOVASCULAR HYPERTENSION;

EID: 33745399219     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.1.h88     Document Type: Article

References (22)

1. Baumbach, G. L., and D. D. Heistad. Remodeling of cerebral arterioles in chronic hypertension. Hypertension Dallas 13: 968-972, 1989.
2. Bobik, A., A. Grooms, J. A. Millar, A. Mitchell, and S. Grinpukel. Growth factor activity of endothelin on vascular smooth muscle. Am. J. Physiol. 258 (Cell Physiol. 27): C408-C415, 1990.
3. Cho, A., D. W. Courtman, and B. L. Langille. Apoptosis (programmed cell death) in arteries of the neonatal lamb. Circ. Res. 76: 168-175, 1995.
4. Day, R., R. Larivière, and E. L. Schiffrin. In situ hybridization shows increased endothelin-1 mRNA levels in endothelial cells of blood vessels of deoxycorticosteroae acetate-salt hypertensive rats. Am. J. Hypertens. 8: 294-300, 1995.
5. Deng, L. Y., and E. L. Schiffirin. Morphological and functional alterations of mesenteric small resistance arteries in early renal hypertension in the rat. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H1171-H1177, 1991.
6. Deng, L. Y., and E. L. Schiffrin. Effects of endothelin on resistance arteries of DOCA-salt hypertensive rats. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H1782-H1787, 1992.
7. Deng, L. Y., and E. L. Schiffrin. Effects of endothelin-1 and vasopressin on small arteries of spontaneously hypertensive rats. Am. J. Hypertens. 5: 817-822, 1992.
8. Langille, B. L., M. P. Bendeck, and F. W. Keeley. Adaptations of carotid arteries of young and mature rabbits to reduced carotid blood flow. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H931-H939, 1989.
9. Larivière, R., R. Day, and E. L. Schiffrin. Increased expression of endothelin-1 gene in blood vessels of deoxycorticosterone acetate-salt hypertensive rats. Hypertension Dallas 21: 916-920, 1993.
10. Larivière, R., L. Y. Deng, R. Day, P. Sventek, G. Thibault, and E. L. Schiffrin. Increased endothelin-1 gene expression in the endothelium of coronary arteries and in the endocardium of DOCA-salt hypertensive rats. J. Mol. Cell. Cardiol. 27: 2123-2131, 1995.
11. Larivière, R., P. Sventek, G. Thibault, and E. L. Schiffrin. Expression of endothelin-1 gene in blood vessels of adult spontaneously hypertensive rats. Life Sci. 56: 1889-1896, 1995.
12. Larivière, R., G. Thibault, and E. L. Schiffrin. Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats. Hypertension Dallas 21: 294-300, 1993.
13. Li, J.-S., R. Larivière, and E. L. Schiffrin. Effect of a non selective endothelin antagonist on vascular remodeling in DOCA-salt hypertensive rats. Hypertension Dallas 24: 183-188, 1994.
14. Li, J.-S., and E. L. Schiffrin. Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. Hypertension Dallas 25: 495-500, 1995.
15. Li, J.-S., and E. L. Schiffrin. Chronic endothelin receptor antagonist treatment of young spontaneously hypertensive rats. J. Hypertens. 13: 647-652, 1995.
16. Li, J.-S., W. Schürch, R. M. Touyz, and E. L. Schiffrin. Increased survival and reduced vascular hypertrophy and blood pressure in malignant DOCA-salt SHR treated with an endothelin receptor antagonist (Abstract). Hypertension Dallas 26: 576, 1995.
17. Schiffers, P. M. H., G. E. Fazzi, D. Van Ingen Schenau, and J. G. R. De Mey. Effects of candidate autocrine and paracrine mediators on growth responses in isolated rat arteries Arterioscler. Thromb. 14: 420-426, 1994.
18. Schiffrin, E. L. Endothelin, potential role in hypertension and vascular hypertrophy. Brief review. Hypertension Dallas 25: 1135-1143, 1995
19. Schiffrin, E. L., R. Larivière, J.-S. Li, P. Sventek, and R. M. Touyz. Deoxycorticosterone acetate plus salt induce overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats. Hypertension Dallas 25, Suppl. 2: 769-773, 1995.
20. Schiffrin, E. L., P. Sventek, J.-S. Li, A. Turgeon, and T. Reudelhuber. Antihypertensive effect of bosentan, a mixed ETA/ETB endothelin receptor antagonist, in DOCA-salt spontaneously hypertensive rats. Br. J. Pharmacol. 115: 1377-1381, 1995.
21. Sventek, P., J.-S. Li, K. Grove, C. F. Deschepper, and E. L. Schiffrin. Vascular structure and endothelin-1 gene expression in malignant hypertension induced by L-NAME in spontaneously hypertensive rats. Hypertension Dallas 27: 49-55, 1996.
22. Sventek, P., A. Turgeon, R. Garcia, and E. L. Schiffrin. Vascular and cardiac overexpression of endothelin-1 gene in 1-kidney, one clip Goldblatt hypertensive rats but only in the late phase of 2-kidney, 1 clip Goldblatt hvpertension. J. Hypertens. 14: 57-64, 1996.