IκB-mediated inhibition of virus-induced beta interferon transcription

Journal of Virology

Volumn 73, Issue 4, 1999, Pages 2694-2702

  Algarté, Michèle ^a,b   Nguyen, Hannah ^a,b   Heylbroeck, Christophe ^a,b   Lin, Rongtuan ^a,b   Hiscott, John ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CHLORAMPHENICOL ACETYLTRANSFERASE; DOXYCYCLINE; TETRACYCLINE; DNA BINDING PROTEIN; I KAPPA B; MESSENGER RNA;

ARTICLE; DNA BINDING; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; GENE ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTERFERON PRODUCTION; NONHUMAN; PARAINFLUENZA VIRUS 1; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; VIRUS INFECTION; AMINO ACID SEQUENCE; BIOSYNTHESIS; CELL LINE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; MOLECULAR GENETICS; PARAMYXOVIRUS; RNA VIRUS INFECTION;

AMINO ACID SEQUENCE; CELL LINE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; HUMANS; I-KAPPA B PROTEINS; INTERFERON-BETA; MOLECULAR SEQUENCE DATA; RESPIROVIRUS; RESPIROVIRUS INFECTIONS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0032587325     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.4.2694-2702.1999     Document Type: Article

References (55)

1. Baldi, L., K. Brown, G. Franzoso, and U. Siebenlist. 1996 Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of IκBα. J. Biol. Chem. 271:376-379.
2. Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-681.
3. Beauparlant, P., and J. Hiscott. 1996. Biological and biochemical inhibitors of the NF-κB/Rel proteins and cytokine synthesis. Cytokine Growth Factor Rev. 7:175-190.
4. Beauparlant, P., H. Kwon, M. Clarke, R. Lin, N. Sonenberg, M. Wainberg, and J. Hiscott. 1996. Transdominant mutants of IκBα block Tat-TNF synergistic activation of HIV-1 expression and virus multiplication. J. Virol. 70:5777-5785.
5. Beauparlant, P., R. Lin, and J. Hiscott. 1996. The role of the C-terminal domain of IκBα in protein degradation and stability. J. Biol. Chem. 271: 10690-10696.
6. Brockman, J. A., D. C. Scherer, T. A. McKinsey, S. M. Hall, X. Qi, W. Y. Lee, and D. W. Ballard. 1995. Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation. Mol. Cell. Biol. 15:2809-2818.
7. Brown, K., G. Franzoso, L. Baldi, L. Carlson, L. Mills, Y.-C. Lin, S. Gerstberger, and U. Siebenlist. 1997. The signal response of IκBα is regulated by transferable N- and C-terminal domains. Mol. Cell. Biol. 17:3021-3027.
8. Brown, K., S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist. 1995. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485-1488.
9. Chen, Z., J. Hagler, V. J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev. 9:1586-1597.
10. Chu, Z.-L., J. Didonato, J. Hawiger, and D. W. Ballard. 1998. The Tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IκB kinases containing IKKα and IKKβ. J. Biol. Chem. 273:15891-15894.
11. Cohen, L., W. J. Henzel, and P. A. Baeuerle. 1998. IKAP is a scaffold protein of the IκB kinase complex. Nature 395:292-296.
12. DeLuca, C., H. J. Kwon, N. Pelletier, M. A. Wainberg, and J. Hiscott. 1998. NF-κB protects HIV-1 infected myeloid cells from apoptosis. Virology 244: 27-38.
13. DiDonato, J. A., M. Havakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548-554.
14. Eckner, R. 1996. p300 and CBP as transcriptional regulators and targets of oncogenic events. J. Biol. Chem. 377:685-688.
15. Escalante, C. R., J. Vie, D. Thanos, and A. K. Aggarwal. 1998. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Nature 391:103-106.
16. Falvo, J. V., D. Thanos, and T. Maniatis. 1995. Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y). Cell 83:1101-1111.
17. Garoufalis, E., I. Kwan, R. Lin, A. Mustafa, N. Pepin, A. Roulston, J. Lacoste, and J. Hiscott. 1994. Viral induction of the human interferon beta promoter: modulation of transcription by NF-κB/Rel proteins and interferon regulatory factors. J. Virol. 68:4707-4715.
18. Geleziunas, R., S. Ferrell, X. Lin, Y. Mu, E. Cunningham, M. Grant, Jr., M. Connelly, J. Hambor, K. Marcu. and W. Greene. 1998 Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase α (IKKα) and IKKβ cellular kinases. Mol. Cell. Biol. 18:5157-5165.
19. Hirano, F., M. Chung, H. Tanaka, N. Maruyama, I. Makino, D. Moore, and C. Scheidereit. 1998. Alternative splicing variants of IκBβ establish differential NF-κB signal responsiveness in human cells. Mol. Cell. Biol. 18:2596-2607.
20. Hiscott, J., H. Nguyen, and R. Lin. 1995. Molecular mechanisms of interferon beta gene induction. Sem. Virol. 6:161-173.
21. Horvai, A. E., L. Xu, E. Korzus, G. Brard, D. Kalafus, T. M. Mullen, D. W. Rose, M. G. Rosenfeld, and C. K. Glass. 1997. Nuclear integration of JAK/ STAT and RAS/AP-1 signalling by CBP and p300. Proc. Natl. Acad. Sci. USA 94:1074-1079.
22. Jaffray, E., K. M. Wood, and R. T. Hay. 1995. Domain organization of IκBα and trie sites of interaction with NF-κB p65. Mol. Cell. Biol. 15:2166-2172.
23. Kee, B. L., J. Arias, and M. R. Montminy. 1996. Adaptor-mediated recruitment of RNA polymcrase II to a signal-dependent activator. J. Biol. Chem. 271:2373-2375.
24. Kim, T. K., and T. Maniatis. 1998. The mechanism of transcriptional synergy of an in vitto assembled interferon-β enhanceosomr. Mol. Cell. 1:119-129.
25. Kwon, H., N. Pelletier, C. DeLuca, P. Genin, S. Cisternas, R. Lin, M. A. Wainberg, and J. Hiscott. 1998. Inducible expression of IκBα repressor mutants interferes with NF-κB activity and HIV-1 replication in Jurkat T cells. J. Biol. Chem. 273:7431-7440.
26. Lin, R., P. Beauparlant, C. Makris, S. Meloche, and J. Hiscott. 1996. Phosphorylation of IκBα in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol. Cell. Biol. 16:1401-1409.
27. Lin, R., C. Heylbroeck, P. M. Pitha, and J. Hiscott. 1998. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell. Biol. 18:2986-2996.
28. May, M. J., and S. Ghosh. 1998. Signal transduction through NF-κB. Immunol. Today 19:80-88.
29. Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. W. Li, D. B. Young, M. Barbosa, and M. Mann. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860-866.
30. Merika, M., A. J. Williams, G. Chen, T. Collins, and D. Thanos. 1998 Recruitment of CBP/p300 by the IFNβ enhanceosome is required for synergistic activation of transcription. Mol. Cell. 1:277-287.
31. Nemoto, S., J. Didonato, and A. Lin. 1998. Coordinate regulation of IκB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-κB inducing kinases. Mol. Cell. Biol. 18:7336-7343.
32. Pepin, N., A. Roulston, J. Lacoste, R. Lin, and J. Hiscott. 1994. Subcellular redistribution of HTLV-1-Tax protein by NF-κB/Rel transcription factors. Virology 204:706-716.
33. Phillips, R. J., and S. Ghosh. 1997. Regulation of IκBβ in WEHI 231 mature B cells. Mol. Cell. Biol. 17:4390-4396.
34. Rodriguez, M. S., I. Michalopoulos, F. Arenzana-Seisdedos, and R. T. Hay. 1995. Inducible degradation of IκBα in vitro and in vivo requires the acidic C-terminal domain of the protein. Mol. Cell. Biol. 15:2413-2419.
35. Rothwarf, D. M., E. Zandi, G. Natoli, and M. Karin. 1998. IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 395:297-300.
36. Régnier, C., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and M. Rothe. 1997. Identification and characterization of an IκB kinase. Cell 90:373-383.
37. Scheidereit, C. 1998. Docking IκB kinases. Nature 395:225-226.
38. Scherer, D. C., J. A. Brockman, Z. Chen, T. Maniatis, and D. W. Ballard. 1995. Signal-induced degradation of IκBα requires site-specific ubiquitination. Proc. Natl. Acad, Sci. USA 92:11259-11263.
39. Schwarz, E., D. Antwerp, and I. Verma. 1996. Constitutive phosphorylation of IκBα by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IκBα. Mol. Cell. Biol. 16:3554-3559.
40. Suyang, H., R. Phillips, I. Douglas, and S. Ghosh. 1996. Role of unphosphorylated, newly synthesized IκBβ in persistent activation of NF-κB. Mol. Cell. Biol. 16:5444-5449.
41. Thanos, D., and T. Maniatis. 1995. Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome. Cell 83:1091-1100.
42. Thompson, J. E., R. J. Phillips, H. Erdjument-Bromage, P. Tempst, and S. Ghosh. 1995. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80:573-582.
43. Traenckner, E. B., H. L. Phal, T. Henkel, N. K. Schmidt, S. Wilk, and P. A. Baeuerle. 1995. Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NF-κB activation in response to diverse stimuli. EMBO J. 14:2876-2883.
44. Traenckner, E. B. M., H. L. Pahl, T. Henkel, K. N. Schmidt, S. Wilk, and P. A. Baeuerle. 1995. Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NF-κB activation in response to diverse stimuli. EMBO J. 14:2876-2883.
45. Tran, K., M. Merika, and D. Thanos. 1997. Distinct functional properties of IκBα and IκBβ. Mol. Cell. Biol. 17:5386-5399.
46. Uhlik, M., L. Good, G. Xiao, E. Harhaj, E. Zandi, M. Karin, and S.-C. Sun. 1998. NF-κB-inducing kinase and IκB kinase participate in human T-cell leukemia virus 1 Tax-mediated NF-κB activation. J. Biol. Chem. 273:21132-21136.
47. Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. V. Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735.
48. Vilcek, J., and G. Sen. 1996. Interferons and other cytokines, p. 375-399. In B. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology. Lippincott-Raven, New York, N.Y.
49. Wathelet, M. G., C. H. Lin, B. S. Parakh, L. V. Ronco, P. M. Howley, and T. Maniatis. 1998. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo. Mol. Cell. 1:507-518.
50. Weil, R., C. Laurent-Winter, and A. Israel. 1997. Regulation of IκBβ degradation. Similarities to and differences from IκBα. J. Biol. Chem. 272:9942-9949.
51. Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866-869.
52. Yamaoka, S., G. Courtois, C. Bessia, S. T. Whiteside, R. Weil, F. Agou, H. E. Kirk, R. J. Kay, and A. Israel. 1998. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93:1231-1240.
53. Yin, M.-J., L. B. Christerson, Y. Yamamoto, Y.-T. Kwak, S. Xu, F. Mercurio, M. Barbosa, M. H. Cobb, and R. B. Gaynor. 1998. HTLV-I Tax protein binds to MEKK1 to stimulate IκB kinase activity and NF-κB activation. Cell 93:875-884.
54. Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91:243-252.
55. Zhang, J. J., U. Vinkemeier, W. Gu, D. Chakravarti, C. M. Horvath, and J. E. Darnell. 1996. Two contact regions between STAT1 and CBP/p300 in interferon gamma signalling. Proc. Natl. Acad. Sci. USA 93:15092-15096.