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Volumn 17, Issue 10, 1997, Pages 6049-6056

HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; LEUCINE; MESSENGER RNA; MONOCLONAL ANTIBODY; NUCLEAR PROTEIN; POLYCLONAL ANTIBODY; RETINOBLASTOMA PROTEIN;

EID: 0030864009     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.10.6049     Document Type: Article
Times cited : (119)

References (48)
  • 1
    • 0020148927 scopus 로고
    • Nuclear location of the putative transforming protein of avian myelocytomatosis virus
    • Abrams, H. D., R. Rohrscheider, and N. Eisenman. 1982. Nuclear location of the putative transforming protein of avian myelocytomatosis virus. Cell 29: 427-439.
    • (1982) Cell , vol.29 , pp. 427-439
    • Abrams, H.D.1    Rohrscheider, R.2    Eisenman, N.3
  • 2
    • 0030602813 scopus 로고    scopus 로고
    • SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    • Bai, C., M. Sen, K. Hofmann, L. Ma, M. Goebl, J. W. Harper, and S. J. Elledge. 1996. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86:263-274.
    • (1996) Cell , vol.86 , pp. 263-274
    • Bai, C.1    Sen, M.2    Hofmann, K.3    Ma, L.4    Goebl, M.5    Harper, J.W.6    Elledge, S.J.7
  • 3
    • 0025092724 scopus 로고
    • Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement at mitosis
    • Bernat, R. L., G. G. Borisy, N. F. Rothfield, and W. C. Earnshaw. 1990. Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement at mitosis. J. Cell. Biol. 111:1519-1533.
    • (1990) J. Cell. Biol. , vol.111 , pp. 1519-1533
    • Bernat, R.L.1    Borisy, G.G.2    Rothfield, N.F.3    Earnshaw, W.C.4
  • 4
    • 0024429019 scopus 로고
    • Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
    • Chen, P.-L., P. Scully, J.-Y. Shew, J. Y. J. Wang, and W.-H. Lee. 1989. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58:1193-1198.
    • (1989) Cell , vol.58 , pp. 1193-1198
    • Chen, P.-L.1    Scully, P.2    Shew, J.-Y.3    Wang, J.Y.J.4    Lee, W.-H.5
  • 5
    • 0028888634 scopus 로고
    • Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner
    • Chen, P.-L., Y.-C. Ueng, T. Durfee, K.-C. Chen, T. Yang-Feng, and W.-H. Lee. 1995. Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner. Cell Growth Differ. 6:199-210.
    • (1995) Cell Growth Differ. , vol.6 , pp. 199-210
    • Chen, P.-L.1    Ueng, Y.-C.2    Durfee, T.3    Chen, K.-C.4    Yang-Feng, T.5    Lee, W.-H.6
  • 6
    • 0030031409 scopus 로고    scopus 로고
    • Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
    • Chen, P.-L., D. J. Riley, S. Chen-Kiang, and W.-H. Lee. 1996. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 93:465-469.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 465-469
    • Chen, P.-L.1    Riley, D.J.2    Chen-Kiang, S.3    Lee, W.-H.4
  • 7
    • 0029830342 scopus 로고    scopus 로고
    • Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
    • Chen, P.-L., D. J. Riley, Y. Chen, and W.-H. Lee. 1996. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10:2794-2804.
    • (1996) Genes Dev. , vol.10 , pp. 2794-2804
    • Chen, P.-L.1    Riley, D.J.2    Chen, Y.3    Lee, W.-H.4
  • 8
    • 0029987651 scopus 로고    scopus 로고
    • BRCA1 is a 220-kDa nuclear phosphoprotein that is phosphorylated in a cell cycle-dependent manner
    • Chen, Y., A. A. Farmer, C.-F. Chen, D. C. Jones, P.-L. Chen, and W.-H. Lee. 1996. BRCA1 is a 220-kDa nuclear phosphoprotein that is phosphorylated in a cell cycle-dependent manner. Cancer Res. 56:3168-3172.
    • (1996) Cancer Res. , vol.56 , pp. 3168-3172
    • Chen, Y.1    Farmer, A.A.2    Chen, C.-F.3    Jones, D.C.4    Chen, P.-L.5    Lee, W.-H.6
  • 9
    • 85036485258 scopus 로고    scopus 로고
    • HEC binds to the seventh regulatory subunit of 265 proteasome and modulates the degradation of mitotic cyclins
    • in press
    • Chen, Y., Z. D. Sharp, and W.-H. Lee. HEC binds to the seventh regulatory subunit of 265 proteasome and modulates the degradation of mitotic cyclins. J. Biol. Chem., in press.
    • J. Biol. Chem.
    • Chen, Y.1    Sharp, Z.D.2    Lee, W.-H.3
  • 10
    • 0027397548 scopus 로고
    • NuMA is required for the proper completion in mitosis
    • Compton, D. A., and D. W. Cleveland. 1993. NuMA is required for the proper completion in mitosis. J. Cell Biol. 120:947-957.
    • (1993) J. Cell Biol. , vol.120 , pp. 947-957
    • Compton, D.A.1    Cleveland, D.W.2
  • 11
    • 0028828193 scopus 로고
    • The self-destructive personality of a cell cycle in transition
    • Deshaies, R. J. 1995. The self-destructive personality of a cell cycle in transition. Curr. Opin. Cell Biol. 7:781-789.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 781-789
    • Deshaies, R.J.1
  • 12
    • 0024394856 scopus 로고
    • The bimG gene of Aspergillus nidulans, which is required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1
    • Doonan, H. J., and N. R. Morris. 1989. The bimG gene of Aspergillus nidulans, which is required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1. Cell 57:987-996.
    • (1989) Cell , vol.57 , pp. 987-996
    • Doonan, H.J.1    Morris, N.R.2
  • 13
    • 0027251721 scopus 로고
    • The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit
    • Durfee, T., K. Becherer, P.-L. Chen, S.-H. Yeh, Y. Yang, W.-H. Lee, and S. J. Elledge. 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7:555-569.
    • (1993) Genes Dev. , vol.7 , pp. 555-569
    • Durfee, T.1    Becherer, K.2    Chen, P.-L.3    Yeh, S.-H.4    Yang, Y.5    Lee, W.-H.6    Elledge, S.J.7
  • 14
    • 0028114564 scopus 로고
    • The amino terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that localizes to RNA processing centers
    • Durfee, T., M. A. Mancini, D. Jones, S. J. Elledge, and W.-H. Lee. 1994. The amino terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that localizes to RNA processing centers. J. Cell Biol. 127:609-622.
    • (1994) J. Cell Biol. , vol.127 , pp. 609-622
    • Durfee, T.1    Mancini, M.A.2    Jones, D.3    Elledge, S.J.4    Lee, W.-H.5
  • 15
    • 0028877327 scopus 로고
    • NuMA is required for the organization of microtubules into aster-like mitotic arrays
    • Gaglio, T., A. Seredi, and D. A. Compton. 1995. NuMA is required for the organization of microtubules into aster-like mitotic arrays. J. Cell Biol. 131: 693-708.
    • (1995) J. Cell Biol. , vol.131 , pp. 693-708
    • Gaglio, T.1    Seredi, A.2    Compton, D.A.3
  • 16
    • 0027444947 scopus 로고
    • S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase
    • Ghislain, M., A. Udvardy, and C. Mann. 1993. S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase. Nature 366:358-361.
    • (1993) Nature , vol.366 , pp. 358-361
    • Ghislain, M.1    Udvardy, A.2    Mann, C.3
  • 17
    • 0026089183 scopus 로고
    • Cyclin is degraded by the ubiquitin pathway
    • Glotzer, M., A. W. Murray, and M. W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349:132-138.
    • (1991) Nature , vol.349 , pp. 132-138
    • Glotzer, M.1    Murray, A.W.2    Kirschner, M.W.3
  • 18
    • 0025922586 scopus 로고
    • The TPR snap helix: A novel protein repeat motif from mitosis to transcription
    • Goebl, M., and M. Yanagida. 1991. The TPR snap helix: a novel protein repeat motif from mitosis to transcription. Trends Biochem. Sci. 16:173-177.
    • (1991) Trends Biochem. Sci. , vol.16 , pp. 173-177
    • Goebl, M.1    Yanagida, M.2
  • 19
    • 0026058874 scopus 로고
    • The retinoblastoma gene product regulates progression through G1 phase of the cell cycle
    • Goodrich, D. W., N. P. Wang, Y.-W. Qian, E. Y.-H. P. Lee, and W.-H. Lee. 1991. The retinoblastoma gene product regulates progression through G1 phase of the cell cycle. Cell 67:293-302.
    • (1991) Cell , vol.67 , pp. 293-302
    • Goodrich, D.W.1    Wang, N.P.2    Qian, Y.-W.3    Lee, E.Y.-H.P.4    Lee, W.-H.5
  • 20
    • 0003448569 scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
    • Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual, p. 139-243. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
    • (1988) Antibodies: A Laboratory Manual , pp. 139-243
    • Harlow, E.1    Lane, D.2
  • 21
  • 22
    • 0026452949 scopus 로고
    • Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
    • Hartwell, L. 1992. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 71:543-546.
    • (1992) Cell , vol.71 , pp. 543-546
    • Hartwell, L.1
  • 23
    • 0029175719 scopus 로고
    • Nuclear matrix proteins as structural and functional components of the mitotic apparatus
    • He, D., C. Zeng, and B. R. Brinkley. 1995. Nuclear matrix proteins as structural and functional components of the mitotic apparatus. Int. Rev. Cytol. 162B:1-74.
    • (1995) Int. Rev. Cytol. , vol.162 B , pp. 1-74
    • He, D.1    Zeng, C.2    Brinkley, B.R.3
  • 24
    • 0023919168 scopus 로고
    • A temperature-sensitive mutation of Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase
    • Hirano, T., Y. Niraoka, and M. Yanagida. 1988. A temperature-sensitive mutation of Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase. J. Cell Biol. 106:1171-1183.
    • (1988) J. Cell Biol. , vol.106 , pp. 1171-1183
    • Hirano, T.1    Niraoka, Y.2    Yanagida, M.3
  • 25
    • 0027319328 scopus 로고
    • Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor
    • Holloway, S. L., M. Glotzer, R. W. King, and A. W. Murray. 1993. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73:1393-1402.
    • (1993) Cell , vol.73 , pp. 1393-1402
    • Holloway, S.L.1    Glotzer, M.2    King, R.W.3    Murray, A.W.4
  • 26
    • 0029033504 scopus 로고
    • Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast
    • Irniger, S., S. Piatti, C. Michaelis, and K. Nasmyth. 1995. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81:269-277.
    • (1995) Cell , vol.81 , pp. 269-277
    • Irniger, S.1    Piatti, S.2    Michaelis, C.3    Nasmyth, K.4
  • 27
    • 0027360552 scopus 로고
    • Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
    • Jordan, M. A., R. J. Toso, D. Thrower, and L. Wilson. 1993. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc. Natl. Acad. Sci. USA 90:9552-9556.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9552-9556
    • Jordan, M.A.1    Toso, R.J.2    Thrower, D.3    Wilson, L.4
  • 28
    • 0026643589 scopus 로고
    • Effects of vinblastine, podophyllotoxin and nocodazole on mitosis spindles. Implications for the role of microtubule dynamics in mitosis
    • Jordan, M. A., D. Thrower, and L. Wilson. 1992. Effects of vinblastine, podophyllotoxin and nocodazole on mitosis spindles. Implications for the role of microtubule dynamics in mitosis. J. Cell Sci. 102:401-416.
    • (1992) J. Cell Sci. , vol.102 , pp. 401-416
    • Jordan, M.A.1    Thrower, D.2    Wilson, L.3
  • 29
    • 0027466863 scopus 로고
    • Microinjection of a monoclonal antibody against SPN antigen, now identified by peptide sequences as the NuMa protein, induces micronuclei in PtK2 cells
    • Kallajoki, M., J. Harborth, K. Weber, and M. Osborn. 1993. Microinjection of a monoclonal antibody against SPN antigen, now identified by peptide sequences as the NuMA protein, induces micronuclei in PtK2 cells. J. Cell Sci. 104:139-150.
    • (1993) J. Cell Sci. , vol.104 , pp. 139-150
    • Kallajoki, M.1    Harborth, J.2    Weber, K.3    Osborn, M.4
  • 30
    • 0029004815 scopus 로고
    • A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
    • King, R. W., J. M. Peters, S. Tugenreich, M. Rolfe, P. Heiter, and M. W. Kirschner. 1995. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81:279-288.
    • (1995) Cell , vol.81 , pp. 279-288
    • King, R.W.1    Peters, J.M.2    Tugenreich, S.3    Rolfe, M.4    Heiter, P.5    Kirschner, M.W.6
  • 32
    • 0024294395 scopus 로고
    • Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase
    • Osmani, S. A., R. T. Pu, and N. R. Morris. 1988. Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase. Cell 53:237-244.
    • (1988) Cell , vol.53 , pp. 237-244
    • Osmani, S.A.1    Pu, R.T.2    Morris, N.R.3
  • 34
    • 0028170806 scopus 로고
    • The retinoblastoma protein: More than a tumor suppressor
    • Riley, D. J., E. Y.-H. P. Lee, and W.-H. Lee. 1994. The retinoblastoma protein: more than a tumor suppressor. Annu. Rev. Cell. Biol. 10:1-29.
    • (1994) Annu. Rev. Cell. Biol. , vol.10 , pp. 1-29
    • Riley, D.J.1    Lee, E.Y.-H.P.2    Lee, W.-H.3
  • 35
    • 0028080293 scopus 로고
    • Bypassing anaphase by fission yeast cut9 mutation: Requirement of cut9+ to initiate anaphase
    • Samejima, I., and M. Yanagida. 1994. Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase. J. Cell Biol. 127:1655-1670.
    • (1994) J. Cell Biol. , vol.127 , pp. 1655-1670
    • Samejima, I.1    Yanagida, M.2
  • 36
    • 0026484975 scopus 로고
    • Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: Identification of a gene with properties of the transcription factor E2F
    • Shan, B., X. Zhu, P.-L. Chen, T. Durfee, Y. Yan, D. Sharp, and W.-H. Lee. 1992. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12:5620-5631.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5620-5631
    • Shan, B.1    Zhu, X.2    Chen, P.-L.3    Durfee, T.4    Yan, Y.5    Sharp, D.6    Lee, W.-H.7
  • 37
    • 0025499908 scopus 로고
    • Microinjected centromere/kinetochore antibodies interfere with chromosome movement in meiosis and mitotic mouse oocytes
    • Simerly, C., R. Balczon, B. R. Brinkley, and G. Schatten. 1990. Microinjected centromere/kinetochore antibodies interfere with chromosome movement in meiosis and mitotic mouse oocytes. J. Cell Biol. 111:1491-1504.
    • (1990) J. Cell Biol. , vol.111 , pp. 1491-1504
    • Simerly, C.1    Balczon, R.2    Brinkley, B.R.3    Schatten, G.4
  • 38
    • 0026341646 scopus 로고
    • Chromosome aberrations and cancer
    • Solomon, E., J. Borrow, and A. D. Goddard. 1991. Chromosome aberrations and cancer. Science 254:1153-1160.
    • (1991) Science , vol.254 , pp. 1153-1160
    • Solomon, E.1    Borrow, J.2    Goddard, A.D.3
  • 39
    • 0027759461 scopus 로고
    • SMC1: An essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family
    • Strunnikov, A. V., U. L. Larionov, and D. Koshland. 1993. SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family. J. Cell Biol. 123:1635-1648.
    • (1993) J. Cell Biol. , vol.123 , pp. 1635-1648
    • Strunnikov, A.V.1    Larionov, U.L.2    Koshland, D.3
  • 40
    • 0028942904 scopus 로고
    • SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation. defines a subgroup within the SMC family
    • Stunnikov, A. V., E. Hogan, and D. Koshland. 1995. SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation. defines a subgroup within the SMC family. Genes Dev 9:587-590.
    • (1995) Genes Dev , vol.9 , pp. 587-590
    • Stunnikov, A.V.1    Hogan, E.2    Koshland, D.3
  • 41
    • 0026681291 scopus 로고
    • Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4
    • Swaffield, J. C., J. F. Bromberg, and S. A. Johnston. 1992. Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4. Nature 357:698-670.
    • (1992) Nature , vol.357 , pp. 698-1670
    • Swaffield, J.C.1    Bromberg, J.F.2    Johnston, S.A.3
  • 42
    • 0029028237 scopus 로고
    • CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition
    • Tugenreich, S., J. Tomkiel, W. Earnshaw, and P. Heiter. 1995. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell 81:261-268.
    • (1995) Cell , vol.81 , pp. 261-268
    • Tugenreich, S.1    Tomkiel, J.2    Earnshaw, W.3    Heiter, P.4
  • 43
    • 0030604718 scopus 로고    scopus 로고
    • Kinesin-related proteins at mitotic spindle poles: Function and regulation
    • Walczak, C. Z., and T. J. Mitchison. 1996. Kinesin-related proteins at mitotic spindle poles: function and regulation. Cell 85:943-946.
    • (1996) Cell , vol.85 , pp. 943-946
    • Walczak, C.Z.1    Mitchison, T.J.2
  • 44
    • 0028881021 scopus 로고
    • Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae
    • Wang, Y., and D. J. Burke. 1995. Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 15:6838-6844.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6838-6844
    • Wang, Y.1    Burke, D.J.2
  • 45
    • 0016437925 scopus 로고
    • In vitro polymerization of microtubules into asters and spindles in homogenates of surf clam eggs
    • Weisenberg, R. C., and A. C. Rosenfeld. 1975. In vitro polymerization of microtubules into asters and spindles in homogenates of surf clam eggs. J. Cell Biol. 64:146-158.
    • (1975) J. Cell Biol. , vol.64 , pp. 146-158
    • Weisenberg, R.C.1    Rosenfeld, A.C.2
  • 46
    • 0029912971 scopus 로고    scopus 로고
    • Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast
    • Wells, W. A. E., and A. W. Murray. 1996. Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast. J. Cell Biol. 133:75-84.
    • (1996) J. Cell Biol. , vol.133 , pp. 75-84
    • Wells, W.A.E.1    Murray, A.W.2
  • 47
    • 0029317511 scopus 로고
    • Frontier questions about sister chromatid separation in anaphase
    • Yanagida, M. 1995. Frontier questions about sister chromatid separation in anaphase. Bioessays 17:519-526.
    • (1995) Bioessays , vol.17 , pp. 519-526
    • Yanagida, M.1
  • 48
    • 0029098787 scopus 로고
    • Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic phase progression
    • Shu, X., M. A. Mancini, K. H. Chang, C.-Y. Liu, C.-F. Chen, T. L. Yang-Feng, and W.-H. Lee. 1995. Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic phase progression. Mol. Cell. Biol. 15:5017-5029.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5017-5029
    • Shu, X.1    Mancini, M.A.2    Chang, K.H.3    Liu, C.-Y.4    Chen, C.-F.5    Yang-Feng, T.L.6    Lee, W.-H.7


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