Sequence-specific 1H, 13C and 15N assignment of the TMP-resistant dihydrofolate reductase mutant DHFR(F98Y) in the ternary complex with TMP and NADPH

Journal of Biomolecular NMR

Volumn 9, Issue 4, 1997, Pages 445-446

  Altmann, Serge ^a,b   Labhardt, Alexander M ^a   Senn, Hans ^a   Wüthrich, Kurt ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

Antibiotics resistance; Dihydrofolate reductase; Drug design; NMR assignments

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; ARTICLE; CHEMISTRY; DRUG EFFECT; GENETICS; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS;

FOLIC ACID ANTAGONISTS; MAGNETIC RESONANCE SPECTROSCOPY; MUTATION; NADP; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM; TRIMETHOPRIM RESISTANCE;

EID: 0031159426     PISSN: 09252738     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018315131994     Document Type: Article

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