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Volumn 16, Issue 1-2, 1997, Pages 67-79

Molecular genetics of colon cancer

Author keywords

colon cancer; evolution; genesis

Indexed keywords

COLON CANCER; HUMAN; MOLECULAR GENETICS; PRIORITY JOURNAL; REVIEW;

EID: 0030906347     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005744323215     Document Type: Review
Times cited : (44)

References (119)
  • 2
    • 0003567592 scopus 로고
    • England and Wales. London: HMSO
    • HMSO. Mortality Statistics. Cause. England and Wales. London: HMSO, 1992
    • (1992) Mortality Statistics. Cause
  • 3
    • 0029113846 scopus 로고
    • Management and survival of patients with adenocarcinoma of the colon and rectum: A national survey of the Commission on Cancer
    • Beart RW, Steele GJ, Menck HR et al.: Management and survival of patients with adenocarcinoma of the colon and rectum: a national survey of the Commission on Cancer. J Amer Coll Surg 181: 225-236, 1995
    • (1995) J Amer Coll Surg , vol.181 , pp. 225-236
    • Beart, R.W.1    Steele, G.J.2    Menck, H.R.3
  • 4
    • 0000352810 scopus 로고
    • The spread of cancer and its effect on prognosis
    • Dukes CE, Bussey HJR: The spread of cancer and its effect on prognosis. Cancer 12: 309-320, 1958
    • (1958) Cancer , vol.12 , pp. 309-320
    • Dukes, C.E.1    Bussey, H.J.R.2
  • 5
    • 0023213901 scopus 로고
    • A new prognostic classification of rectal cancer
    • Jass JR, Love SB, Northover JMA: A new prognostic classification of rectal cancer. Lancet ii: 1303-1306, 1987
    • (1987) Lancet , vol.2 , pp. 1303-1306
    • Jass, J.R.1    Love, S.B.2    Northover, J.M.A.3
  • 7
    • 0026630266 scopus 로고
    • APC mutations occur early during colorectal tumorigenesis
    • Powell SM, Zilz N, Beazer-Barclay Y et al.: APC mutations occur early during colorectal tumorigenesis. Nature 359: 235-237, 1992
    • (1992) Nature , vol.359 , pp. 235-237
    • Powell, S.M.1    Zilz, N.2    Beazer-Barclay, Y.3
  • 8
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden J, Thliveris A, Samowitz W et al.: Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66: 589-600, 1991
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1    Thliveris, A.2    Samowitz, W.3
  • 9
    • 0025817880 scopus 로고
    • Identification of FAP locus genes from chromosome 5q21
    • Kinzler KW, Nilbert MC, Su LK et al.: Identification of FAP locus genes from chromosome 5q21. Science 253:661-665, 1991
    • (1991) Science , vol.253 , pp. 661-665
    • Kinzler, K.W.1    Nilbert, M.C.2    Su, L.K.3
  • 10
    • 0026894053 scopus 로고
    • Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
    • Miyoshi Y, Nagase H, Ando H et al.: Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1: 229-233, 1992
    • (1992) Hum Mol Genet , vol.1 , pp. 229-233
    • Miyoshi, Y.1    Nagase, H.2    Ando, H.3
  • 11
    • 0023278941 scopus 로고
    • Chromosome 5 allele loss in human colorectal carcinomas
    • Solomon E, Voss R, Hall V et al.: Chromosome 5 allele loss in human colorectal carcinomas. Nature 328: 616-619, 1987
    • (1987) Nature , vol.328 , pp. 616-619
    • Solomon, E.1    Voss, R.2    Hall, V.3
  • 12
    • 0028291928 scopus 로고
    • Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumours
    • Miyaki M, Konishi M, Kikuchi-Yanoshita R et al.: Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumours. Cancer Res 54: 3011-3020, 1994
    • (1994) Cancer Res , vol.54 , pp. 3011-3020
    • Miyaki, M.1    Konishi, M.2    Kikuchi-Yanoshita, R.3
  • 13
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1990
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 14
    • 0023223410 scopus 로고
    • Localization of the gene familial adenomatous polyposis on chromosome 5
    • Bodmer WF, Bailey CJ, Bodmer J et al.: Localization of the gene familial adenomatous polyposis on chromosome 5. Nature 328: 614-616, 1987
    • (1987) Nature , vol.328 , pp. 614-616
    • Bodmer, W.F.1    Bailey, C.J.2    Bodmer, J.3
  • 15
    • 0027096262 scopus 로고
    • Dietary intake of fiber and decreased risk of cancers of the colon and rectum; evidence from the combined analysis of 13 case-control studies
    • Howe GR, Benito E, Castelleto R et al.: Dietary intake of fiber and decreased risk of cancers of the colon and rectum; evidence from the combined analysis of 13 case-control studies. J Natl Cancer Inst 84(24): 1887-1896, 1992
    • (1992) J Natl Cancer Inst , vol.84 , Issue.24 , pp. 1887-1896
    • Howe, G.R.1    Benito, E.2    Castelleto, R.3
  • 16
    • 0027361020 scopus 로고
    • Dinier formation by an N-terminal coiled coil in the APC protein
    • Joslyn G, Richardson DS, White R, Alber T: Dinier formation by an N-terminal coiled coil in the APC protein. Proc Natl Acad Sci USA 90: 11109-11113, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11109-11113
    • Joslyn, G.1    Richardson, D.S.2    White, R.3    Alber, T.4
  • 17
    • 0028801360 scopus 로고
    • The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase
    • Baeg GH, Matsumine A, Kuroda T et al.: The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J 14: 5618-5625, 1995
    • (1995) EMBO J , vol.14 , pp. 5618-5625
    • Baeg, G.H.1    Matsumine, A.2    Kuroda, T.3
  • 18
    • 0027756014 scopus 로고
    • Association of the APC tumor suppressor protein with catenins
    • Su LK, Vogelstein B, Kinzler KW: Association of the APC tumor suppressor protein with catenins. Science 262:1734-1737, 1993
    • (1993) Science , vol.262 , pp. 1734-1737
    • Su, L.K.1    Vogelstein, B.2    Kinzler, K.W.3
  • 19
    • 0027738023 scopus 로고
    • Assocation of the APC gene product with beta-catenin
    • Rubinfeld B, Souza B, Albert I et al.: Assocation of the APC gene product with beta-catenin. Science 262: 1731-1734, 1993
    • (1993) Science , vol.262 , pp. 1731-1734
    • Rubinfeld, B.1    Souza, B.2    Albert, I.3
  • 20
    • 0028033603 scopus 로고
    • Loss of apc protein expressed by human colonie epithelial-cells and the appearance of a specific low-molecular-weight form is associated with apoptosis in vitro
    • Browne S, Williams A, Hague A, Butt A et al.: Loss of apc protein expressed by human colonie epithelial-cells and the appearance of a specific low-molecular-weight form is associated with apoptosis in vitro. Int J Cancer 59: 56-64, 1994
    • (1994) Int J Cancer , vol.59 , pp. 56-64
    • Browne, S.1    Williams, A.2    Hague, A.3    Butt, A.4
  • 21
    • 0028409177 scopus 로고
    • The tumour suppressor APC product is associated with cell adhesion
    • Burchill SA: The tumour suppressor APC product is associated with cell adhesion. Bioassays 16: 225-227, 1994
    • (1994) Bioassays , vol.16 , pp. 225-227
    • Burchill, S.A.1
  • 22
    • 0027930066 scopus 로고
    • The APC gene product associates with microtubules in vivo and promotes their assembly in vitro
    • Munemitsu S, Souza B, Miller O et al.: The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. Cancer Res 54: 3676-3681, 1994
    • (1994) Cancer Res , vol.54 , pp. 3676-3681
    • Munemitsu, S.1    Souza, B.2    Miller, O.3
  • 23
    • 0027724691 scopus 로고
    • Alleles of the APC gene: An attenuated form of familial polyposis
    • Spirio L, Olschwang S, Groden J et al.: Alleles of the APC gene: an attenuated form of familial polyposis. Cell 75: 951-957, 1993
    • (1993) Cell , vol.75 , pp. 951-957
    • Spirio, L.1    Olschwang, S.2    Groden, J.3
  • 24
    • 0029897836 scopus 로고    scopus 로고
    • Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein
    • Friedl W, Meuschel S, Caspari R et al.: Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein. Hum Genet 97: 579-584, 1996
    • (1996) Hum Genet , vol.97 , pp. 579-584
    • Friedl, W.1    Meuschel, S.2    Caspari, R.3
  • 25
    • 0029100951 scopus 로고
    • Alternatively spliced adenomatous polyposis coli (APC) gene transcripts that delete exons mutated in attenuated APC
    • Samowitz WS, Thliveris A, Spirio LN, White R: Alternatively spliced adenomatous polyposis coli (APC) gene transcripts that delete exons mutated in attenuated APC. Oncogene 55: 3732-3734, 1995
    • (1995) Oncogene , vol.55 , pp. 3732-3734
    • Samowitz, W.S.1    Thliveris, A.2    Spirio, L.N.3    White, R.4
  • 26
    • 0029938751 scopus 로고    scopus 로고
    • Polyclonal origin of colonie adenomas in an XO/XY patient with FAP
    • Novelli MR, Williamson JA, Tomlinson IPM et al.: Polyclonal origin of colonie adenomas in an XO/XY patient with FAP. Science 272: 1187-1190, 1996
    • (1996) Science , vol.272 , pp. 1187-1190
    • Novelli, M.R.1    Williamson, J.A.2    Tomlinson, I.P.M.3
  • 27
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su LK, Kinzler KW, Vogelstein BV et al.: Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256: 668-670, 1992
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.K.1    Kinzler, K.W.2    Vogelstein, B.V.3
  • 28
    • 0029143510 scopus 로고
    • ApcMin: A mouse model for intestinal and mammary tumorigenesis
    • Moser AR, Luongo C, Gould KA et al.: ApcMin: a mouse model for intestinal and mammary tumorigenesis. Eur J Cancer 31A: 1061-1064, 1995
    • (1995) Eur J Cancer , vol.31 A , pp. 1061-1064
    • Moser, A.R.1    Luongo, C.2    Gould, K.A.3
  • 29
    • 0028998255 scopus 로고
    • The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia
    • MacPhee M, Chepenik KP, Liddell RA et al.: The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. Cell 81: 957-966, 1995
    • (1995) Cell , vol.81 , pp. 957-966
    • MacPhee, M.1    Chepenik, K.P.2    Liddell, R.A.3
  • 30
    • 0029988204 scopus 로고    scopus 로고
    • A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36
    • Tomlinson IPM, Neale K, Talbot IC et al.: A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36. J Med Genet 33: 268-273, 1996
    • (1996) J Med Genet , vol.33 , pp. 268-273
    • Tomlinson, I.P.M.1    Neale, K.2    Talbot, I.C.3
  • 31
    • 0028828611 scopus 로고
    • Absence of secretory phospholipase A2 gene alterations in human colorectal cancer
    • Riggins GJ, Markowitz S, Wilson JK et al.: Absence of secretory phospholipase A2 gene alterations in human colorectal cancer. Cancer Res 55(22): 5184-5186, 1995
    • (1995) Cancer Res , vol.55 , Issue.22 , pp. 5184-5186
    • Riggins, G.J.1    Markowitz, S.2    Wilson, J.K.3
  • 32
    • 0027145633 scopus 로고
    • Mutations of a mutS homolog in heriditary nonpolyposis colorectal cancer
    • Leach FS, Nicolaides NC, Papadopoulos N et al.: Mutations of a mutS homolog in heriditary nonpolyposis colorectal cancer. Cell 75: 1215-1225, 1993
    • (1993) Cell , vol.75 , pp. 1215-1225
    • Leach, F.S.1    Nicolaides, N.C.2    Papadopoulos, N.3
  • 33
    • 0027485551 scopus 로고
    • Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer
    • Lindblom A, Tannergard P, Werelius B, Nordenskjold M: Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer. Nat Genet 5: 279-282, 1993
    • (1993) Nat Genet , vol.5 , pp. 279-282
    • Lindblom, A.1    Tannergard, P.2    Werelius, B.3    Nordenskjold, M.4
  • 34
    • 0027742295 scopus 로고
    • The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
    • Fishel R, Lescoe MK, Rao MR et al.: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75: 1027-1038, 1993
    • (1993) Cell , vol.75 , pp. 1027-1038
    • Fishel, R.1    Lescoe, M.K.2    Rao, M.R.3
  • 35
    • 0027158031 scopus 로고
    • Cues to the pathogenesis of familial colorectal cancer
    • Aaltonen LA, Peltomaki P, Leach FS et al.: Cues to the pathogenesis of familial colorectal cancer. Science 260: 812-816, 1993
    • (1993) Science , vol.260 , pp. 812-816
    • Aaltonen, L.A.1    Peltomaki, P.2    Leach, F.S.3
  • 37
    • 0028859671 scopus 로고
    • Mismatch repair gene defects in sporadic colorectal cancers with microsatellile instability
    • Liu B, Nicolaides NC, Markowitz S et al.: Mismatch repair gene defects in sporadic colorectal cancers with microsatellile instability. Nat Genet 9: 48-55, 1995
    • (1995) Nat Genet , vol.9 , pp. 48-55
    • Liu, B.1    Nicolaides, N.C.2    Markowitz, S.3
  • 38
    • 0027967342 scopus 로고
    • Clinicopathological characteristics of colorectal carcinoma complicating ulcerative colitis
    • Connell WR, Talbot IC, Harpaz, N et al.: Clinicopathological characteristics of colorectal carcinoma complicating ulcerative colitis. Gut 35(10): 1419-1423, 1994
    • (1994) Gut , vol.35 , Issue.10 , pp. 1419-1423
    • Connell, W.R.1    Talbot, I.C.2    Harpaz, N.3
  • 39
    • 0029936242 scopus 로고    scopus 로고
    • Genetic pathways in colorectal cancer
    • Ilyas M, Tomlinson IPM: Genetic pathways in colorectal cancer. Histopathol 28: 389-399, 1996
    • (1996) Histopathol , vol.28 , pp. 389-399
    • Ilyas, M.1    Tomlinson, I.P.M.2
  • 40
    • 0028921585 scopus 로고
    • Common occurrence of APC and K-ras mutation in the spectrum of colitis-associated neoplasias
    • Redston M, Papadipoulos N, Caldas C et al.: Common occurrence of APC and K-ras mutation in the spectrum of colitis-associated neoplasias. Gastroenterol 108: 383-392, 1995
    • (1995) Gastroenterol , vol.108 , pp. 383-392
    • Redston, M.1    Papadipoulos, N.2    Caldas, C.3
  • 41
    • 0028979727 scopus 로고
    • Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms
    • Tarmin L, Yin J, Harpaz N et al.: Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms. Cancer Res 55: 2035-2038, 1995
    • (1995) Cancer Res , vol.55 , pp. 2035-2038
    • Tarmin, L.1    Yin, J.2    Harpaz, N.3
  • 42
    • 0025766540 scopus 로고
    • Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis
    • Burmer GC, Crispin DA, Kolli VR et al.: Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis. Cancer Commun 3: 167-172, 1991
    • (1991) Cancer Commun , vol.3 , pp. 167-172
    • Burmer, G.C.1    Crispin, D.A.2    Kolli, V.R.3
  • 43
    • 0028122352 scopus 로고
    • Mutations in the p53 gene: An early marker of neoplastic progression in ulcerative colitis
    • Brentnall TA, Crispin DA, Rabinovitch PS et al.: Mutations in the p53 gene: An early marker of neoplastic progression in ulcerative colitis. Gastroenterol 107: 369-378, 1994
    • (1994) Gastroenterol , vol.107 , pp. 369-378
    • Brentnall, T.A.1    Crispin, D.A.2    Rabinovitch, P.S.3
  • 45
    • 0031048855 scopus 로고    scopus 로고
    • Clinical and molecular features of the Hereditary Mixed Polyposis Syndrome
    • in press
    • Whitelaw SC, Murday VA, Tomlinson IPM et al.: Clinical and molecular features of the Hereditary Mixed Polyposis Syndrome. Gastroenterol 1997, in press
    • (1997) Gastroenterol
    • Whitelaw, S.C.1    Murday, V.A.2    Tomlinson, I.P.M.3
  • 46
    • 0031012344 scopus 로고    scopus 로고
    • Localisation of a susceptibility focus for Peutz-Jeghers syndrome using comparative genomic hybridisation and targeted linkage analysis
    • Hemminki A, Tomlinson IPM, Markie D et al.: Localisation of a susceptibility focus for Peutz-Jeghers syndrome using comparative genomic hybridisation and targeted linkage analysis. Nat Genet 15: 87-90, 1997
    • (1997) Nat Genet , vol.15 , pp. 87-90
    • Hemminki, A.1    Tomlinson, I.P.M.2    Markie, D.3
  • 47
    • 4244061773 scopus 로고    scopus 로고
    • Identification of a juvenile polyposis tumor-suppressor gene locus (JP1) and demonstration of its deletion in subepithelial cells
    • Jacoby RF, Schlack S, Cole CE, Marshall DJ, Kuhlman G et al.: Identification of a juvenile polyposis tumor-suppressor gene locus (JP1) and demonstration of its deletion in subepithelial cells. Gastroenterol 110: A535, 1996
    • (1996) Gastroenterol , vol.110
    • Jacoby, R.F.1    Schlack, S.2    Cole, C.E.3    Marshall, D.J.4    Kuhlman, G.5
  • 48
    • 19144370572 scopus 로고    scopus 로고
    • Genetic mapping of the Hereditary Mixed Polyposis Syndrome to chromosome 6q
    • Thomas HJW, Whitelaw SC, Cottrell SE et al.: Genetic mapping of the Hereditary Mixed Polyposis Syndrome to chromosome 6q. Amer J Hum Genet 58: 770-776, 1996
    • (1996) Amer J Hum Genet , vol.58 , pp. 770-776
    • Thomas, H.J.W.1    Whitelaw, S.C.2    Cottrell, S.E.3
  • 49
    • 0030140025 scopus 로고    scopus 로고
    • Localization of the gene for Cowden disease to chromosome 10q22-23
    • Nelen MR, Padberg GW, Peeters EAJ et al.: Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet 13: 114-116, 1996
    • (1996) Nat Genet , vol.13 , pp. 114-116
    • Nelen, M.R.1    Padberg, G.W.2    Peeters, E.A.J.3
  • 50
    • 0017167185 scopus 로고
    • The clonal evaluation of tumor cell populations
    • Nowell PC: The clonal evaluation of tumor cell populations. Science 194: 23-28, 1976
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 51
    • 0344925835 scopus 로고
    • Evolutionary theory and cancer
    • Tomlinson IPM: Evolutionary theory and cancer. Trends Ecol Evol 8: 107-110, 1993
    • (1993) Trends Ecol Evol , vol.8 , pp. 107-110
    • Tomlinson, I.P.M.1
  • 52
    • 0015293873 scopus 로고
    • Regression phenomenon in familial polyposis
    • Shepherd JA: Regression phenomenon in familial polyposis. Proc Roy Soc Med 65: 169, 1972
    • (1972) Proc Roy Soc Med , vol.65 , pp. 169
    • Shepherd, J.A.1
  • 53
    • 0028576836 scopus 로고
    • Sulindac and polyp regression
    • Giardello FM: Sulindac and polyp regression. Cancer Met Rev 13: 279-283, 1994
    • (1994) Cancer Met Rev , vol.13 , pp. 279-283
    • Giardello, F.M.1
  • 54
    • 0023898932 scopus 로고
    • The ras gene family and human carcinogenesis
    • Bos JL: The ras gene family and human carcinogenesis. Mutat Res 195: 255-271, 1988
    • (1988) Mutat Res , vol.195 , pp. 255-271
    • Bos, J.L.1
  • 55
    • 0028062973 scopus 로고
    • Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons
    • Smith AJ, Stern HS, Penner M et al.: Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons. Cancer Res 54: 5527-5530, 1994
    • (1994) Cancer Res , vol.54 , pp. 5527-5530
    • Smith, A.J.1    Stern, H.S.2    Penner, M.3
  • 56
    • 0025362458 scopus 로고
    • c-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma
    • Burmer GC, Levine DS, Kulander BG et al.: c-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma. Gastroenterol 99: 416-420, 1990
    • (1990) Gastroenterol , vol.99 , pp. 416-420
    • Burmer, G.C.1    Levine, D.S.2    Kulander, B.G.3
  • 57
    • 0028931739 scopus 로고
    • Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis
    • Minamoto T, Yamashita N, Ochiai A et al.: Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis. Cancer 75(6 Suppl): 1520-1526, 1995
    • (1995) Cancer , vol.75 , Issue.6 SUPPL. , pp. 1520-1526
    • Minamoto, T.1    Yamashita, N.2    Ochiai, A.3
  • 58
    • 0028931923 scopus 로고
    • Aberrant crypt foci and K-ras mutations: Earliest recognised players or innocent bystanders in colon carcinogenesis?
    • Pretlow TP: Aberrant crypt foci and K-ras mutations: earliest recognised players or innocent bystanders in colon carcinogenesis? Gastroenterol 108: 600-603, 1995
    • (1995) Gastroenterol , vol.108 , pp. 600-603
    • Pretlow, T.P.1
  • 59
    • 0029003648 scopus 로고
    • Role of aberrant crypt foci in understanding the pathogenesis of colon cancer
    • Bird RP: Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 93: 55-71, 1995
    • (1995) Cancer Lett , vol.93 , pp. 55-71
    • Bird, R.P.1
  • 60
    • 0028321495 scopus 로고
    • Allelic loss of chromosome 18q and prognosis in colorectal cancer
    • Jen J, Kim H, Piantadosi S et al.: Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 331: 213-221, 1994
    • (1994) N Engl J Med , vol.331 , pp. 213-221
    • Jen, J.1    Kim, H.2    Piantadosi, S.3
  • 61
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal tumour development
    • Vogelstein BV, Fearon ER, Hamilton SR et al.: Genetic alterations during colorectal tumour development. N Engl J Med 319: 525-532, 1988
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.V.1    Fearon, E.R.2    Hamilton, S.R.3
  • 62
    • 0029919109 scopus 로고    scopus 로고
    • Hereditary cancer: Two hits revisited
    • Knudson AG: Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol 122: 135-140, 1996
    • (1996) J Cancer Res Clin Oncol , vol.122 , pp. 135-140
    • Knudson, A.G.1
  • 63
    • 0025909734 scopus 로고
    • Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers
    • Kinzler KW, Nilbert MC, Vogelstein B et al.: Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 251: 1366-1370, 1991
    • (1991) Science , vol.251 , pp. 1366-1370
    • Kinzler, K.W.1    Nilbert, M.C.2    Vogelstein, B.3
  • 64
    • 0028219675 scopus 로고
    • Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer
    • Curtis LJ, Bubb VJ, Gledhill S, Morris RG, Bird CC, Wyllie AH: Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. Hum Mol Genet 3: 443-446, 1994
    • (1994) Hum Mol Genet , vol.3 , pp. 443-446
    • Curtis, L.J.1    Bubb, V.J.2    Gledhill, S.3    Morris, R.G.4    Bird, C.C.5    Wyllie, A.H.6
  • 66
    • 15844390729 scopus 로고    scopus 로고
    • Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers
    • Thiagalingam S, Lengaver C, Leach FS et al.: Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 13: 343-346, 1996
    • (1996) Nat Genet , vol.13 , pp. 343-346
    • Thiagalingam, S.1    Lengaver, C.2    Leach, F.S.3
  • 67
    • 0025634118 scopus 로고
    • p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
    • Baker SJ, Preisinger AC, Jessup JM et al.: p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 50: 7712-7722, 1990
    • (1990) Cancer Res , vol.50 , pp. 7712-7722
    • Baker, S.J.1    Preisinger, A.C.2    Jessup, J.M.3
  • 68
    • 0026664077 scopus 로고
    • Expression of p53 and allelic loss in colorectal carcinoma
    • Cunningham J, Lust JA, Schaid DJ et al.: Expression of p53 and allelic loss in colorectal carcinoma. Cancer Res 52: 1974-1980, 1992
    • (1992) Cancer Res , vol.52 , pp. 1974-1980
    • Cunningham, J.1    Lust, J.A.2    Schaid, D.J.3
  • 69
    • 0026555153 scopus 로고
    • Immunohistochemical study of p53 expression in microwave-fixed, paraffin-embedded sections of colorectal carcinoma and adenoma
    • Kawasaki Y, Monden T, Morimoto H et al.: Immunohistochemical study of p53 expression in microwave-fixed, paraffin-embedded sections of colorectal carcinoma and adenoma. Am J Pathol 97: 244-249, 1992
    • (1992) Am J Pathol , vol.97 , pp. 244-249
    • Kawasaki, Y.1    Monden, T.2    Morimoto, H.3
  • 70
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane DP: Cancer. p53, guardian of the genome. Nature 358: 15-16, 1992
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 72
    • 0027155978 scopus 로고
    • Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer
    • Carder P, Wyllie AH, Purdie CA et al.: Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer. Oncogene 8: 1397-1401, 1993
    • (1993) Oncogene , vol.8 , pp. 1397-1401
    • Carder, P.1    Wyllie, A.H.2    Purdie, C.A.3
  • 73
    • 0028873269 scopus 로고
    • Somatic spectrum of cancer-associated single basepair substitutions in the TP53 gene is determined mainly by endogenous mechanisms of mutations and by selection
    • Krawczak M, Smith SB, Schmidtke J et al.: Somatic spectrum of cancer-associated single basepair substitutions in the TP53 gene is determined mainly by endogenous mechanisms of mutations and by selection. Hum Mutat 5: 48-57, 1995
    • (1995) Hum Mutat , vol.5 , pp. 48-57
    • Krawczak, M.1    Smith, S.B.2    Schmidtke, J.3
  • 74
    • 13344279424 scopus 로고    scopus 로고
    • The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
    • Ohta M, Inoue H, Cotticelli MG et al.: The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 84: 587-597, 1996
    • (1996) Cell , vol.84 , pp. 587-597
    • Ohta, M.1    Inoue, H.2    Cotticelli, M.G.3
  • 75
    • 0028033270 scopus 로고
    • Mutations and altered expression of p16INK4 in human cancer
    • Okamoto A, Demetrick DJ, Spillare EA et al.: Mutations and altered expression of p16INK4 in human cancer. Proc Natl Acad Sci USA 91: 11045-11049, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11045-11049
    • Okamoto, A.1    Demetrick, D.J.2    Spillare, E.A.3
  • 76
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L et al.: Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55: 4525-4530, 1995
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3
  • 77
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzalez ZM, Bender CM, Yang AS et al.: Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55: 4531-4535, 1995
    • (1995) Cancer Res , vol.55 , pp. 4531-4535
    • Gonzalez, Z.M.1    Bender, C.M.2    Yang, A.S.3
  • 78
    • 0025221248 scopus 로고
    • Human colorectal cancer: High frequency of deletions at chromosome 1p35
    • Leister I, Weith A, Bruderlein S et al.: Human colorectal cancer: high frequency of deletions at chromosome 1p35. Cancer Res 50: 7232-7225, 1990
    • (1990) Cancer Res , vol.50 , pp. 7232-17225
    • Leister, I.1    Weith, A.2    Bruderlein, S.3
  • 79
    • 0028788862 scopus 로고
    • Deletion mapping defines different regions in 1p34.2-pter that may harbor genetic information related to human colorectal cancer
    • Praml C, Finke LH, Herfarth C et al.: Deletion mapping defines different regions in 1p34.2-pter that may harbor genetic information related to human colorectal cancer. Oncogene 11(7): 1357-1362, 1995
    • (1995) Oncogene , vol.11 , Issue.7 , pp. 1357-1362
    • Praml, C.1    Finke, L.H.2    Herfarth, C.3
  • 80
    • 0026464969 scopus 로고
    • A study of chromosome-6 allele loss in human colorectal carcinomas
    • Wildrick D, Alfaro S, Gope R, Boman B: A study of chromosome-6 allele loss in human colorectal carcinomas. Anticancer Res 12: 1717-1719, 1992
    • (1992) Anticancer Res , vol.12 , pp. 1717-1719
    • Wildrick, D.1    Alfaro, S.2    Gope, R.3    Boman, B.4
  • 81
    • 0027406542 scopus 로고
    • Evidence for the presence of two tumor suppressor genes on chromosome 8p for colorectal carcinoma
    • Fujiwara Y, Emi M, Ohata H et al.: Evidence for the presence of two tumor suppressor genes on chromosome 8p for colorectal carcinoma. Cancer Res 53: 1172-1174, 1993
    • (1993) Cancer Res , vol.53 , pp. 1172-1174
    • Fujiwara, Y.1    Emi, M.2    Ohata, H.3
  • 82
    • 0027256533 scopus 로고
    • Deletion mapping in colorectal cancer of a putative tumour suppressor gene in 8p22-p21.3
    • Cunningham C, Dunlop MG, Wyllie AH, Bird CC: Deletion mapping in colorectal cancer of a putative tumour suppressor gene in 8p22-p21.3. Oncogene 8: 1391-1396, 1993
    • (1993) Oncogene , vol.8 , pp. 1391-1396
    • Cunningham, C.1    Dunlop, M.G.2    Wyllie, A.H.3    Bird, C.C.4
  • 83
    • 0027419340 scopus 로고
    • Frequent loss of heterozygosity on chromosome-14 occurs in advanced colorectal carcinomas
    • Young J, Leggett B, Ward M et al.: Frequent loss of heterozygosity on chromosome-14 occurs in advanced colorectal carcinomas. Oncogene 8: 671-675, 1993
    • (1993) Oncogene , vol.8 , pp. 671-675
    • Young, J.1    Leggett, B.2    Ward, M.3
  • 84
    • 0028936598 scopus 로고
    • Frequent loss of heterozygosity at telomeric loci on 22q in sporadic colorectal cancers
    • Yana I, Kurahashi H, Nakamori S et al.: Frequent loss of heterozygosity at telomeric loci on 22q in sporadic colorectal cancers. Int J Cancer 60: 174-177, 1995
    • (1995) Int J Cancer , vol.60 , pp. 174-177
    • Yana, I.1    Kurahashi, H.2    Nakamori, S.3
  • 85
    • 0027943920 scopus 로고
    • Comparative genomic hybridisation: An overview
    • Houldsworth J, Chaganti RS: Comparative genomic hybridisation: an overview. Am J Pathol 145: 1253-1260, 1994
    • (1994) Am J Pathol , vol.145 , pp. 1253-1260
    • Houldsworth, J.1    Chaganti, R.S.2
  • 86
    • 2942569549 scopus 로고    scopus 로고
    • Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients
    • Liu B, Parsons R, Papadopoulos N et al.: Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med 2: 169-174, 1996
    • (1996) Nat Med , vol.2 , pp. 169-174
    • Liu, B.1    Parsons, R.2    Papadopoulos, N.3
  • 87
    • 0028276666 scopus 로고
    • Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
    • Kim H, Jen J, Vogelstein B, Hamilton SR: Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 145: 148-156, 1994
    • (1994) Am J Pathol , vol.145 , pp. 148-156
    • Kim, H.1    Jen, J.2    Vogelstein, B.3    Hamilton, S.R.4
  • 88
    • 0027452417 scopus 로고
    • Genomic instability occurs in colorectal carcinomas but not in adenomas
    • Young J, Leggett B, Gustafson C et al.: Genomic instability occurs in colorectal carcinomas but not in adenomas. Hum Mutat 2: 351-354, 1993
    • (1993) Hum Mutat , vol.2 , pp. 351-354
    • Young, J.1    Leggett, B.2    Gustafson, C.3
  • 89
    • 0029842358 scopus 로고    scopus 로고
    • Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability
    • Ilyas M, Tomlinson IPM, Novelli MR et al.: Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability. J Pathol 179:370-375, 1996
    • (1996) J Pathol , vol.179 , pp. 370-375
    • Ilyas, M.1    Tomlinson, I.P.M.2    Novelli, M.R.3
  • 90
    • 0028803770 scopus 로고
    • Failure of programmed cell death and differentiation as causes of tumors: Some simple mathematical models
    • Tomlinson IPM, Bodmer WF: Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models. Proc Natl Acad Sci USA 92: 11130-11134, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11130-11134
    • Tomlinson, I.P.M.1    Bodmer, W.F.2
  • 91
    • 8244236925 scopus 로고    scopus 로고
    • Models of non-autonomous interactions of tumour cells
    • in press
    • Tomlinson IPM, Bodmer WF: Models of non-autonomous interactions of tumour cells. Brit J Cancer 1997, in press
    • (1997) Brit J Cancer
    • Tomlinson, I.P.M.1    Bodmer, W.F.2
  • 92
    • 0028080215 scopus 로고
    • Cytokine networks in solid human tumors: Regulation of angiogenesis
    • Leek RD, Harris AL, Lewis CE: Cytokine networks in solid human tumors: regulation of angiogenesis. J Leukoc Biol 56: 423-435, 1994
    • (1994) J Leukoc Biol , vol.56 , pp. 423-435
    • Leek, R.D.1    Harris, A.L.2    Lewis, C.E.3
  • 93
    • 0027427241 scopus 로고
    • Loss of human leukocyte antigen expression on colorectal tumor cell lines: Implications for anti-tumor immunity and immunotherapy
    • Browning MJ, Krausa P, Rowan A et al.: Loss of human leukocyte antigen expression on colorectal tumor cell lines: implications for anti-tumor immunity and immunotherapy. J Immunother 14: 163-168, 1993
    • (1993) J Immunother , vol.14 , pp. 163-168
    • Browning, M.J.1    Krausa, P.2    Rowan, A.3
  • 94
    • 0029126764 scopus 로고
    • MDR1/P-glycoprotein expression in colorectal cancer
    • Linn SC, Giaccone G: MDR1/P-glycoprotein expression in colorectal cancer. Eur J Cancer 31A: 1291-1294, 1995
    • (1995) Eur J Cancer , vol.31 A , pp. 1291-1294
    • Linn, S.C.1    Giaccone, G.2
  • 95
    • 0028967479 scopus 로고
    • In situ PCR: Protocols and applications
    • Nuovo GJ: In situ PCR: protocols and applications. PCR Methods Appl 4:S151-167, 1995
    • (1995) PCR Methods Appl , vol.4
    • Nuovo, G.J.1
  • 96
    • 0026658606 scopus 로고
    • Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells
    • Pignatelli M, Liu D, Nasim MM et al.: Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells. Br J Cancer 66: 629-634, 1992
    • (1992) Br J Cancer , vol.66 , pp. 629-634
    • Pignatelli, M.1    Liu, D.2    Nasim, M.M.3
  • 97
    • 0028060061 scopus 로고
    • Reduced E-cadherin expression correlates with increased invasiveness in colorectal carcinoma cell lines
    • Kinsella AR, Lepts GC, Hill CL, Jones M: Reduced E-cadherin expression correlates with increased invasiveness in colorectal carcinoma cell lines. Clin Exp Metastasis 12: 335-342, 1994
    • (1994) Clin Exp Metastasis , vol.12 , pp. 335-342
    • Kinsella, A.R.1    Lepts, G.C.2    Hill, C.L.3    Jones, M.4
  • 98
    • 0027745259 scopus 로고
    • E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study
    • Dorudi S, Sheffield JP, Poulsom R et al.: E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol 142: 981-986, 1993
    • (1993) Am J Pathol , vol.142 , pp. 981-986
    • Dorudi, S.1    Sheffield, J.P.2    Poulsom, R.3
  • 99
    • 0031008789 scopus 로고    scopus 로고
    • Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers
    • in press
    • Ilyas M, Tomlinson IPM, Hanby A et al.: Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers. Gut 1997, in press
    • (1997) Gut
    • Ilyas, M.1    Tomlinson, I.P.M.2    Hanby, A.3
  • 100
    • 0023778731 scopus 로고
    • Plasminogen activator profiles in neoplastic tissues of the human colon
    • De Bruin PAF, Griffioen G, Verspaget HW et al.: Plasminogen activator profiles in neoplastic tissues of the human colon. Cancer Res 48: 4520-4524, 1988
    • (1988) Cancer Res , vol.48 , pp. 4520-4524
    • De Bruin, P.A.F.1    Griffioen, G.2    Verspaget, H.W.3
  • 101
    • 0028838964 scopus 로고
    • Plasminogen activators and inhibitor type 1 in neoplastic colonie tissue from patients with familial adenomatous polyposis
    • Sier CFM, Vloedgraven HJM, Griffioen G et al.: Plasminogen activators and inhibitor type 1 in neoplastic colonie tissue from patients with familial adenomatous polyposis. Br J Cancer 71: 393-396, 1995
    • (1995) Br J Cancer , vol.71 , pp. 393-396
    • Sier, C.F.M.1    Vloedgraven, H.J.M.2    Griffioen, G.3
  • 102
    • 0029125910 scopus 로고
    • The potential roles of nm23 in cancer metastasis and cellular differentiation
    • MacDonald NJ, de la Rosa A, Steeg PS: The potential roles of nm23 in cancer metastasis and cellular differentiation. Eur J Cancer 31A: 1096-1100, 1995
    • (1995) Eur J Cancer , vol.31 A , pp. 1096-1100
    • MacDonald, N.J.1    De La Rosa, A.2    Steeg, P.S.3
  • 103
    • 0028973429 scopus 로고
    • Overexpression of nm23-H1 and nm23-H2 genes in colorectal carcinomas and loss of nm23-H1 expression in advanced tumour stages
    • Martinez JA, Prevot S, Nordlinger B et al.: Overexpression of nm23-H1 and nm23-H2 genes in colorectal carcinomas and loss of nm23-H1 expression in advanced tumour stages. Gut 37: 712-720, 1995
    • (1995) Gut , vol.37 , pp. 712-720
    • Martinez, J.A.1    Prevot, S.2    Nordlinger, B.3
  • 104
    • 0028232777 scopus 로고
    • Loss of heterozygosity of tumour suppressor gene loci in human colorectal carcinoma
    • Iacopetta B, DiGrandi S, Dix B, Haig C, Soong R, House A: Loss of heterozygosity of tumour suppressor gene loci in human colorectal carcinoma. Eur J Cancer 30A: 664-670, 1994
    • (1994) Eur J Cancer , vol.30 A , pp. 664-670
    • Iacopetta, B.1    DiGrandi, S.2    Dix, B.3    Haig, C.4    Soong, R.5    House, A.6
  • 105
    • 0027973944 scopus 로고
    • Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction
    • Cawkwell L, Lewis FA, Quirke P: Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. Br J Cancer 70: 813-818, 1994
    • (1994) Br J Cancer , vol.70 , pp. 813-818
    • Cawkwell, L.1    Lewis, F.A.2    Quirke, P.3
  • 106
    • 0028301964 scopus 로고
    • Prognostic-significance of the loss of heterozygosity of nm23-h1 and p53 genes in human colorectal carcinomas
    • Campo E, Miquel R, Jares P et al.: Prognostic-significance of the loss of heterozygosity of nm23-h1 and p53 genes in human colorectal carcinomas. Cancer 73: 2913-2921, 1994
    • (1994) Cancer , vol.73 , pp. 2913-2921
    • Campo, E.1    Miquel, R.2    Jares, P.3
  • 107
    • 0028670648 scopus 로고
    • Positive relationship between expression of CD44 and hepatic metastases in colorectal cancer
    • Ichikawa W: Positive relationship between expression of CD44 and hepatic metastases in colorectal cancer. Pathobiology 62: 172-179, 1994
    • (1994) Pathobiology , vol.62 , pp. 172-179
    • Ichikawa, W.1
  • 108
    • 0030063728 scopus 로고    scopus 로고
    • Are we any closer to genetic testing for common malignancies?
    • Plummer SJ, Casey G: Are we any closer to genetic testing for common malignancies? Nat Med 2: 156-158, 1996
    • (1996) Nat Med , vol.2 , pp. 156-158
    • Plummer, S.J.1    Casey, G.2
  • 109
    • 0028885039 scopus 로고
    • Hereditary non-polyposis colorectal cancer and colonie adenomas: Aggressive adenomas?
    • Lynch HT, Smyrk T, Jass JR: Hereditary non-polyposis colorectal cancer and colonie adenomas: aggressive adenomas? Semin Surg Oncol 11: 406-410, 1995
    • (1995) Semin Surg Oncol , vol.11 , pp. 406-410
    • Lynch, H.T.1    Smyrk, T.2    Jass, J.R.3
  • 110
    • 0026593120 scopus 로고
    • Overview of screening and management of familial adenomatous polyposis
    • Rhodes M, Bradburn DM: Overview of screening and management of familial adenomatous polyposis. Gut 33: 125-131, 1992
    • (1992) Gut , vol.33 , pp. 125-131
    • Rhodes, M.1    Bradburn, D.M.2
  • 111
    • 0029915034 scopus 로고    scopus 로고
    • Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome)
    • Lynch HT, Smyrk T, Lynch JF: Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome). Int J Cancer 69: 38-43, 1996
    • (1996) Int J Cancer , vol.69 , pp. 38-43
    • Lynch, H.T.1    Smyrk, T.2    Lynch, J.F.3
  • 112
    • 0027248156 scopus 로고
    • Genetics, natural history, tumor spectrum, and pathology of hereditary non-polyposis colorectal cancer: An updated review
    • Lynch HT, Smyrk TC, Watson P et al.: Genetics, natural history, tumor spectrum, and pathology of hereditary non-polyposis colorectal cancer: an updated review. Gastroenterol 104: 1535-1549, 1993
    • (1993) Gastroenterol , vol.104 , pp. 1535-1549
    • Lynch, H.T.1    Smyrk, T.C.2    Watson, P.3
  • 113
    • 0029089040 scopus 로고
    • Colorectal adenomas in surgical specimens from subjects with hereditary non-polyposis colorectal cancer
    • Jass JR: Colorectal adenomas in surgical specimens from subjects with hereditary non-polyposis colorectal cancer. Histopathol 27: 263-267, 1995
    • (1995) Histopathol , vol.27 , pp. 263-267
    • Jass, J.R.1
  • 114
    • 0028141683 scopus 로고
    • Hereditary non-polyposis colon cancer - Morphologies, genes and mutations
    • Jass JR, Stewart SM, Stewart J, Lane MR: Hereditary non-polyposis colon cancer - morphologies, genes and mutations. Mutat Res 310: 125-133, 1994
    • (1994) Mutat Res , vol.310 , pp. 125-133
    • Jass, J.R.1    Stewart, S.M.2    Stewart, J.3    Lane, M.R.4
  • 115
    • 0028808828 scopus 로고
    • The effect of family size on estimates of the frequency of hereditary non-polyposis colorectal cancer
    • Percesepe A, Anti M, Roncucci L et al.:The effect of family size on estimates of the frequency of hereditary non-polyposis colorectal cancer. Br J Cancer 72: 1320-1323, 1995
    • (1995) Br J Cancer , vol.72 , pp. 1320-1323
    • Percesepe, A.1    Anti, M.2    Roncucci, L.3
  • 116
    • 0028799881 scopus 로고
    • Can molecular markers now be used for early diagnosis of malignancy?
    • Duffy MJ: Can molecular markers now be used for early diagnosis of malignancy? Clin Chem 41: 1419-1413, 1995
    • (1995) Clin Chem , vol.41 , pp. 1419-11413
    • Duffy, M.J.1
  • 117
    • 0027310175 scopus 로고
    • Detection and enumeration of circulating tumour cells in colorectal cancer
    • Leather AJ, Gallegos NC, Kocjan G et al.: Detection and enumeration of circulating tumour cells in colorectal cancer. Br J Surg 80: 777-780, 1993
    • (1993) Br J Surg , vol.80 , pp. 777-780
    • Leather, A.J.1    Gallegos, N.C.2    Kocjan, G.3
  • 118
    • 0027944206 scopus 로고
    • p53 status and the efficacy of cancer therapy in vivo
    • Lowe SW, Bodis S, McClatchey A et al.: p53 status and the efficacy of cancer therapy in vivo. Science 266: 807-810, 1994
    • (1994) Science , vol.266 , pp. 807-810
    • Lowe, S.W.1    Bodis, S.2    McClatchey, A.3
  • 119
    • 0028875761 scopus 로고
    • Expression of the APC gene after transfection into a colonie cancer cell line
    • Hargest R, Williamson R: Expression of the APC gene after transfection into a colonie cancer cell line. Gut 37: 826-829, 1995
    • (1995) Gut , vol.37 , pp. 826-829
    • Hargest, R.1    Williamson, R.2


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