The application of combinatorial and parallel diversity libraries to the discovery of antiinflammatory agents

Current Pharmaceutical Design

Volumn 3, Issue 5, 1997, Pages 503-513

  Campbell, David A ^a  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; ANTIINFLAMMATORY AGENT; BRADYKININ ANTAGONIST; CINALUKAST; CP 2458; CYCLOOXYGENASE 2; HYDROXAMIC ACID DERIVATIVE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; LEUKOTRIENE RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MATRIX METALLOPROTEINASE INHIBITOR; POLYSACCHARIDE; PROSTAGLANDIN; PROSTANOID RECEPTOR; PROTEINASE INHIBITOR; SAREDUTANT; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; TACHYKININ RECEPTOR; THROMBOXANE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; BINDING AFFINITY; DRUG ACTIVITY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG SCREENING; INFLAMMATION; LIBRARY; NEUROGENIC INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0030700304     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (46)

1. Ellman, J. A Chem. Rev. 1996, 96, 555-600
2. Gordon, E. M., Barrett, R. W ; Dower, W J.; Fodor, S P. A.; Gallop, M. A. J Med. Chem. 1994, 37, 1233-1251.
3. Hermkens, P. H. H.; Ottenheijm, H. C. J.; Rees, D. Tetrahedron 1997, 53, 5643-5678.
4. Hermkens, P. H. H.; Ottenheijm, H. C. J.; Rees, D. Tetrahedron 1996, 52, 4257-4554.
5. Yanofsky, S. D.; Baldwin, D. N.; Butler, J. H.; Holden, F. R.; Jacobs, J. W.; Balasubramanian, P.; Chinn, J. P.; Cwirla, S. E.; Peters-Bhatt, E.; Whitehorn, E. A.; Tate, E. H.; Akeson, A ; Bowlin, T. L ; Dower, W J ; Barrett, R. W. Proc. Natl. Acad. Sci. USA 1996, 93, 7381-7386.
6. Smith, G. P.; Petrenko, V. A. Chem Rev 1997, 97, 391-410.
7. Clackson, T.; Wells, J. A. Science 1995, 267, 383-386.
8. Thornberry, N. A.; Bull, H. G.; Calaycay, J. R.; Chapman, K. T.; Howard, A. D.; Kostura, M. J.; Miller, D. K.; Molineaux, S. M.; Weidner, J. R.; Aunins, J.; Elliston, K. O.; Ayala, J. M.; Casano, F. J , Chin, J , Ding. G. J.; Egger, L. A.; Gaffney, E. P ; Limjuco, G.; Palyha, O. C.; Raju, S. M.; Rolando, A. M.; Salley, J. P.; Yamin, T. T., Lee, T. D., Shively, J. E.; MacCross, M.; Mumford, R. A.; Schmidt, J A.; Tocci, M J. Nature 1992, 356, 768-774.
9. Cerretti, D P.; Kozlosky, C. J.; Mosley, B.; Nelson, N.; Van Ness, K.; Greenstreet, T. A.; March, C. J.; Kronheim, S. R., Druck, T.; Cannizzaro, L. A.; Huebner, K.; Black, R. A Science, 1992, 256, 97-100
10. Kuida, K.; Lippke, J. A.; Ku, G.; Harding, M. W.; Livingston, D. J ; Su, M. S.; Flavell, R A.; Science 1995, 267, 2000-2003.
11. Li, P.; Allen, H., Banerjee, S., Franklin, S.; Herzog, L.; Johnston, C.; McDowell, J , Paskind, M.; Rodman, L.; Salfeld, J.; Towne, E.; Tracey, D.; Wardwell, S.; Wei, F ; Wong, W.; Kamen, R.; Seshadri, T Cell, 1995, 80, 401-411.
12. Ghayur, T.; Banerjee, S.; Hugunin, M.; Butler, D.; Herzog, L.; Carter, A ; Quintal, L.; Sekut, L.; Talanian, R.; Paskind, M.; Wong, W ; Kamen, R.; Tracey, D ; Allen, H. Nature, 1997, 386, 619-623.
13. Smith, N. M.; Shi, L ; Navre, M. J. Biol. Chem. 1995, 270, 6440-6449.
14. Mathews, D J.; Wells, J. A. Science 1993, 260, 1113-1117.
15. Singh, J , Allen, M. P.; Ator, M. A.; Gainor, J. A ; Whipple, D. A.; Solowiej, J. E.; Treasurywala, A. M ; Morgan, B. A.; Gordon, T D : Upson, D A. J. Med. Chem. 1995, 38, 217-219.
16. Pinilla, C.; Appel, J. R.; Blanc, P.; Houghten, R. A. Biotechinques 1992, 13, 901-905.
17. Rano, T A.; Timkey, T.; Peterson, E. P.; Rotonda, J., Nicholson, D. W ; Becker, J. W.; Chapman, K. T.; Thornberry, N. A Chemistry & Biology 1997, 4, 149-155.
18. Maehr, H ; Yang, R. Bioorg. Med. Chem. Lett. 1997, 5, 493-496.
19. Maehr, H.; Yang, R. Tetrahedron Lett. 1996, 37, 5445-5448.
20. Look, G. C.; Schullek, J. R.; Holmes, C. P., Chinn, J. P ; Gordon, E. M ; Gallop, M. A. Bioorg. Med. Chem. Lett. 1996, 6, 707-712.
21. Walsh, D. A.; Uwaydah, I. M., U.S. Patent 5 061 720, 1991.
22. Holmes, C P.; Chinn, J. P.; Look, G. C.; Gordon, E. M.; Gallop, M. A. J. Org. Chem 1995, 60, 7328-7333.
23. Hirschmann, R.; Nicolaou, K. C.; Pietranico S.; Salvino, J , Leahy, E. M., Sprengler, P. A.; Furst, G ; Smith III, A. B.; Strader, C. D.; Cascieri, M. A.; Candelore, M. R.; Donaldson, C.; Vale, W.; Maechler, L. J. Am. Chem. Soc 1992, 114, 9217-9218.
24. Hirschmann, R.; Yao, W.; Cascieri, M. A. Strader, C. D.; Maechler, L.; Cichy-Knight, M. A ; Hynes, J.; van Rijn, R. D ; Sprengeler, P. A.; Smith III, A. B. J Med Chem. 1996, 39, 2441-2448.
25. Tjoeng, F.; Towery, D.; Bulock, J ; Whipple, D.; Fok, K.; Williams, M.; Zupec, M.; Adams, S. Int. J. Pept. Protein Res. 1990, 35, 141-146
26. Sclway, C. N.; Terrett, N. K. Bioorg. Med. Chem. 1996, 4, 645-654.
27. Emonds-Alt, X.; Vilain, P.; Goulaouic, P.; Protietto, V ; Van Broeck, D.; Naline, E.; Neliat, G.; Le Fur, G.; Brehere, J. C. Life Sci. 1992, 50, PL101-106.
28. Terrett, N. K.; Gardner, M.; Gordon, D. W.; Kobylecki, R. J ; Steele, J Tetrahedron 1995, 51, 8135-8173.
29. Gordon, D. W.; Steele, J. Bioorg. Med. Chem. Lett. 1995, 5, 47-50.
30. Koppel, G.; Dodds, C.; Houchins, B.; Hunden, D.; Johnson, D.; Owens, R., Chaney, M.; Usdin, T.; Hoffman, B., Brownstein, M. Chemistry and Biology 1995, 2, 483-487.
31. Fritz, J. E., Kaldor, S W.; PCT Int Appl., WO 97 00244 A1 970103.
32. Kaldor, S W.; Fritz, J. E., Tang, J.; McKinney, E. R. Bioorg. Med Chem. Lett. 1996, 6, 3041-3044.
33. Kaldor, S. W.; Siegel, M. G ; Fritz, J. E.; Dressman, B. A.; Hahn, P J. Tetrahedron Lett 1996, 37, 7193.
34. Arribas, J.; Goodly, L ; Vollmer, P.; Kishimoto, T. K.; Rose-John, S , Massague, J J. Biol Chem 1996, 271, 11376-11382.
35. Mullberg, J., Durie, F. H., Otten-Evans, C.; Alderson, M. R.; Rose-John, S ; Cosman, D.; Black, R. A.; Mohler, K. M. J Immunology 1995, 155, 5198-5205.
36. Preece, G.; Murphy, G.; Ager, A. J Biol. Chem. 1996, 271, 11634-11640.
37. Shuttleworth, S. Combinatorial Chemistry at Chiroscience: Design and implementation. Combinatorial Synthesis Symposium 2, University of Exeter, England July 22-25, 1996.
38. Foley, M A., Hassman, A S.; Drewry, D. H.; Greer, D. G.; Wagner, C. D.; Feldman, P. L.; Berman, J.; Bickett, D. M.; McGeehan, G. M.; Lambert, M. H.; Green, M Biorg. Med. Chem. Lett. 1996, 6, 1905-1910.
39. Rockwell, A.; Melden, M.; Copeland, R. A.; Hardman, K.; Decicco, C P.; DeGrado, W. F J. Am. Chem. Soc. 1996, 118, 10337-10338.
40. Floyd, C. D , Lewis, C. N.; Patel, S. R ; Whittaker, M. Tetrahedron Lett. 1996, 44, 8045-8048.
41. Gonnella, N C ; Bohacek, R.; Zhang, X.; Kolossvary, I.; Paris, C. G ; Melton, R.; Winter, C.; Hu, S. I.; Ganu, V. Proc. Natl. Acad. Sci. USA 1995, 92, 462-466.
42. Goodfellow, V. S.; Laudeman, C. P.; Gerrity, J. I.; Burkard, M.; Strobel, E.; Zuzack, J. S., McLeod, D A. Molecular Diversity 1996, 2, 97-102.
43. Seekamp, A., Till, G. O ; Mulligan, M. S.; Paulson, J C.; Anderson, D. C.; Miyasaka, M., Ward, P A. Am. J. Pathol. 1994, 144, 592-598
44. Buerke, M.; Weyrich, A. S.; Zheng, Z ; Gaeta, F. C. A.; Forrest, M. J.; Lefer, A. M. J. Clin. Invest. 1994, 93, 1140-1148.
45. Mulligan, M. S ; Watson, S R.; Fennie, C.; Ward, P. A J. Immunol. 1993, 151, 6410-6417.
46. Liang, R.; Yan, L ; Loebach, J.; Ge, M ; Uozumi, Y.; Sekanina, K ; Horan, N.; Gildersleeve, J.; Thompson, C ; Smith, A ; Biswas, K.; Still, W. C.; Kahne, D. Science 1996, 274, 1520-1522.