Explanation by a putative triester-like mechanism for the thio effects and Mn2+ rescues in reactions catalyzed by a hammerhead ribozyme

FEBS Letters

Volumn 431, Issue 2, 1998, Pages 154-160

  Zhou, De Min ^a,b,c   He, Qiu Chen ^a,b,c   Zhou, Jing Min ^a,b,c   Taira, Kazunari ^a,b,c  

^a NATL INST FOR ADV INTERDISC RES   (Japan)

^b NATL INST BIOSCI HUM TECHNOL   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Double metal ion mechanism; Hammerhead ribozyme; Metalloenzyme; Thio effect; Triester like mechanism

Indexed keywords

METAL ION; RIBOZYME;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

CATALYSIS; ESTERS; MAGNESIUM; MANGANESE; RNA, CATALYTIC; SUBSTRATE SPECIFICITY;

EID: 0032541089     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)00734-0     Document Type: Article

References (54)

1. Bassi, G.S., Mollegaard, N.E., Murchie, A.I.H., von Kitzing, E. and Lilley, D.M.J. (1995) Nature Struct. Biol. 2, 45-55.
2. Bassi, G.S., Murchie, A.I.H., Walter, F., Clegg, R.M. and Lilley, D.M.J. (1997) EMBO J. 2, 756-768.
3. Orita, M., Vinayak, R., Andrus, A., Warashina, M., Chiba, A., Kaniwa, H., Nishikawa, F., Nishikawa, S. and Taira, K. (1996) J. Biol. Chem. 271, 9447-9454.
4. Dahm, S.C. and Uhlenbeck, O.C. (1991) Biochemistry 30, 9464-9469.
5. Dahm, S.C., Derrick, W.B. and Uhlenbeck, O.C. (1993) Biochemistry 32, 13040-13045.
6. Uebayasi, M., Uchimaru, T., Kokuma, T., Sawata, S., Shimayama, T. and Taira, K. (1994) J. Org. Chem. 59, 7414-7420.
7. Steitz, T.A. and Steitz, J.A. (1993) Proc. Natl. Acad. Sci. USA 90, 6498-6502.
8. Sawata, S., Komiyama, M. and Taira, K. (1995) J. Am. Chem. Soc. 117, 2357-2358.
9. Pontius, B.W., Lott, W.B. and von Hippel, P.H. (1997) Proc. Natl. Acad. Sci. USA 94, 2290-2294.
10. Zhou, D.-M., Zhang, L.-H. and Taira, K. (1997) Proc. Natl. Acad. Sci. USA 94, 14343-14348.
11. Lott, W.B., Pontius, B.W. and von Hippel, P.H. (1998) Proc. Natl. Acad. Sci. USA 95, 542-547.
12. Pyle, A.M. (1993) Science 261, 709-714.
13. Eckstein, F. and Lilley, D.M.J. (1996) Catalytic RNA, Nucleic Acids and Molecular Biology, Vol. 10, Springer-Verlag, Berlin.
14. Birikh, K.R., Heaton, P.A. and Eckstein, F. (1997) Eur. J. Biochem. 245, 1-16.
15. Zhou, D.-M. and Taira, K. (1998) Chem. Rev. 98, 991-1026.
16. Peracchi, A., Beigelman, L., Scott, E.C., Uhlenbeck, O.C. and Herschlag, D. (1997) J. Biol. Chem. 272, 26822-26826.
17. Feig, A.L., Scott, W.G. and Uhlenbeck, O.C. (1998) Science 279, 81-84.
18. Scott, W.G., Finch, J.T. and Klug, A. (1995) Cell 81, 991-1002.
19. Scott, W.G. and Klug, A. (1996) Trends Biochem. Sci. 21, 220-224.
20. Scott, W.G., Murray, J.B., Arnold, J.R.P., Stoddard, B.L. and Klug, A. (1996) Science 274, 2065-2069.
21. Koizumi, M. and Ohtsuka, E. (1991) Biochemistry 30, 5145-5150.
22. Slim, G. and Gait, M.J. (1991) Nucleic Acids Res. 19, 1183-1188.
23. Zhou, D.-M., Kumar, P.K.R., Zhang, L.H. and Taira, K. (1996) J. Am. Chem. Soc. 118, 8969-8970.
24. Santoro, S.W. and Joyce, G.F. (1997) Proc. Natl. Acad. Sci. USA 94, 4262-4266.
25. Warashina, M., Takagi, Y., Sawata, S., Zhou, D.-M., Kuwabara, T. and Taira, K. (1997) J. Org. Chem. 58, 3009-3017.
26. Shimayama, T., Nishikawa, S. and Taira, K. (1995) Biochemistry 34, 3649-3654.
27. Jaffe, E.K. and Cohn, M. (1979) J. Biol. Chem. 254, 10839-10845.
28. Pecoraro, V.L., Hermes, J.B. and Cleland, W.W. (1984) Biochemistry 23, 5262-5271.
29. Piccirilli, J.A., Vyle, J.S., Caruthers, M.H. and Cech, T.R. (1993) Nature 361, 85-88.
30. Weinstein, L.B., Earnshaw, D.J., Cosstic, R. and Cech, T.R. (1997) Nature 388, 805-808.
31. McSwiggen, J.A. and Cech, T.R. (1989) Science 244, 679-683.
32. Rajagopal, J., Doudna, J.A. and Szostak, J.W. (1989) Science 244, 692-694.
33. Warning, R.B. (1989) Nucleic Acids Res. 17, 10281-10293.
34. Michels, W.J. and Pyle, A.M. (1995) Biochemistry 34, 2965-2977.
35. Kuimelis, R.G. and Mclaughlin, L.W. (1998) Chem. Rev. (in press).
36. Pan, T., Long, D.V. and Uhlenbeck, O.C. (1993) in: The RNA World (Gesteland, R.F. and Atkins, J.F., Eds.), pp. 271-302, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
37. Kawahara, S., Wada, T. and Sekine, M. (1996) J. Am. Chem. Soc. 118, 9461-9468.
38. Perreault, D.M. and Anslyn, E.V. (1997) Angew. Chem. Int. Ed. Engl. 36, 432-450.
39. Anslyn, E. and Breslow, R. (1989) J. Am. Chem. Soc. 111, 4473-4482.
40. Breslow, R. and Huang, D.L. (1990) J. Am. Chem. Soc. 112, 9621-9623.
41. Breslow, R. and Xu, R. (1993) J. Am. Chem. Soc. 115, 10705-10713.
42. Breslow, R. (1993) Proc. Natl. Acad. Sci. USA 24, 319-324.
43. Menger, F.M. (1991) J. Org. Chem. 56, 6251-6252.
44. Haim, A. (1992) J. Am. Chem. Soc. 114, 8384-8388.
45. Breslow, R. and Xu, R. (1993) Proc. Natl. Acad. Sci. USA 90, 1201-1207.
46. Oivanen, M., Kuusela, S. and Lönnberg, H. (1998) Chem. Rev. (in press).
47. Florian, J. and Warshel, A. (1997) J. Am. Chem. Soc. 119, 5473-5474.
48. Frey, P.A. and Sammons, R.D. (1985) Science 228, 541-545.
49. Taira, K., Uebayasi, M., Maeda, H. and Furukawa, K. (1990) Protein Eng. 3, 691-701.
50. Taira, K., Uchimaru, T., Tanabe, K. and Nishikawa, S. (1991) Nucleic Acids Res. 19, 2747-2753.
51. Storer, J.W., Uchimaru, T., Tanabe, K., Uebayasi, M., Nishikawa, S. and Taira, K. (1991) J. Am. Chem. Soc. 113, 5216-5219.
52. Taira, K., Uchimaru, T., Storer, J.W., Yelimiena, A., Uebayasi, M. and Tanabe, K. (1993) J. Org. Chem. 58, 3009-3017.
53. Yelimiena, A., Uchimaru, T., Tanabe, K. and Taira, K. (1993) J. Am. Chem. Soc. 115, 3032-3033.
54. Murray, J.B., Terwey, D.P., Maloney, L., Karpeisky, A., Usman, N., Beigelman, L. and Scott, W.G. (1998) Cell 92, 665-673.