Structural model of the outer vestibule and selectivity filter of the Shaker voltage-gated K+ channel

Neuropharmacology

Volumn 35, Issue 7, 1996, Pages 761-773

  Durell, S R ^a   Guy, H R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Ion pores; Molecular models; Potassium channels; Protein structure; Scorpion toxins

Indexed keywords

AGITOXIN; CHARYBDOTOXIN; POTASSIUM CHANNEL; SCORPION VENOM; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; ION CONDUCTANCE; MODEL; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN STRUCTURE;

EID: 0029977966     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(96)00097-4     Document Type: Article

References (55)

1. Aiyar J., Ngyen A.N., Chandy K.G., Grissmer S. The P-region and S6 of Kv3.1 contribute to the formation of the ion-conduction pathway. Biophys. J. 67:1994;2261.
2. + channel revealed by the NMR-derived structures of scorpion toxins. Neuron. 15:1995;1169-1181.
3. Akabas M.H., Stauffer D.A., Xu M., Karlin A. Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science. 258:1992;307-310.
4. Bogusz S., Boxer A., Busath D.D. An SS1-SS2 β-barrel structure for the voltage-activated potassium channel. Prot. Engng. 5:1992;285-293.
5. Bontems F., Gilquin G., Roumestand C., Menez A., Toma F. Analysis of side-chain organization on a refined model of charybdotoxin: structural and functional implications. Biochemistry. 31:1992;7756-7764.
6. Bradley J.C., Richards W.G. Potassium channels: a computer prediction of structure and selectivity. Prot. Engng. 7:1993;859-862.
7. Chahine M., George A.L., Zhou M., Ji S., Sun W., Barchi R.L., Horn R. Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation. Neuron. 12:1994;281-294.
8. Choi K.L., Mossman C., Aubie J., Yellen G. The internal quaternary ammonium receptor site of Shaker potassium channels. Neuron. 10:1993;533-541.
9. Chou P.Y., Fasman G.D. Empirical predictions of protein conformation. Ann. Rev. Biochem. 47:1978;251-276.
10. + pore. Biophys. J. 65:1993;1235-1242.
11. Dougherty D.A., Stuffer D.A. Acetylcholine binding by a synthetic receptor: implications for biological recognition. Science. 250:1990;1558-1560.
12. Durell S.R., Guy H.R. Atomic scale structure and functional models of voltage-gated potassium channels. Biophys. J. 62:1992;238-250.
13. Feher V.A., Baldwin E.P., Dahlquist F.W. Access of ligands to cavities within the core of a protein is rapid. Nature Struct. Biol. 3:1996;516-521.
14. Garnier J., Osguthorpe D.J., Robson B. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J. Mol. Biol. 120:1978;97-120.
15. + channel: peptide and channel residues mediating molecular recognition. Neuron. 12:1994;1377-1388.
16. Gross A., MacKinnon R. Agitoxin footprinting the Shaker potassium channel pore. Neuron. 16:1996;399-406.
17. Guy H.R. (1990) Models of voltage- and transmitter-activated channels based on their amino acid sequences. In Monovalent Cations in Biological Systems (Pasternak C.A., Ed.), pp. 31-58. CRC Press, Boca Raton, FL.
18. Guy H.R. and Durell S.R. (1994) Using homology in modeling the structure of voltage-gated ion channels. In Molecular Evolution of Physiological Processes (Fambrough D., Ed.), pp. 197-212. The Rockefeller University Press, New York.
19. + channels. In Ion Channels and Genetic Diseases (Dawson D., Ed.), pp. 1-16. The Rockefeller University Press, New York.
20. Harper E.T., Rose G.D. Helix stop signals in proteins and peptides: the capping box. Biochemistry. 32:1993;7605-7609.
21. + channels. Science. 251:1991;942-944.
22. Heginbotham L., MacKinnon R. The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron. 8:1992;483-491.
23. + channel signature sequence. Biophys. J. 66:1994;1061-1067.
24. + channel pore through mutant cycles with a peptide inhibitor. Science. 268:1995;307-310.
25. Hol W.G.J., Halie L.M., Sander C. Dipoles of the α-helix and β-sheet: their role in protein folding. Nature (Lond.). 294:1981;532-536.
26. + channel examined through cysteine mutagenesis and chemical modification. Biophys. J. 70:1996;A122.
27. + conductance switch. Biophys. J. 62:1992;136-144.
28. Krezel A.M., Kasibhatla C., Hidalgo P., MacKinnon R., Wagner G. Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry. Prot. Sci. 4:1995;1478-1489.
29. Kumpf R.A., Dougherty D.A. A mechanism for ion selectivity in potassium channels: computational studies of the cation-π interactions. Science. 261:1993;1708-1710.
30. + channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis. Biophys. J. 68:1995;900-905.
31. + channel S4. Neuron. 16:1996;387-397.
32. + channel during gating. Neuron. 16:1996;859-867.
33. Lü Q., Miller C. Silver as a probe of pore-forming residues in a potassium channel. Science. 268:1995;304-307.
34. Lopez G.A., Jan Y.N., Jan L.Y. Evidence that the S6 segment of the Shaker voltage-gated channel comprises part of the pore. Nature. 367:1994;179-182.
35. + channels. Science. 250:1990;276-279.
36. Miller C. Potassium selectivity in proteins: oxygen cage or π in the face. Science. 261:1993;1692-1693.
37. + channel. Neuron. 16:1996;123-130.
38. + channel. J. Gen. Physiol. 92:1988;569-586.
39. Noda M., Ikeda T., Kayano T., Suzuki H., Takeshima H., Takahashi T., Kuno M., Numa S. Existence of distinct sodium channel messenger RNAs in rat brain. Nature. 320:1986;188-192.
40. Overington J., Donnelly D., Johnson M.S., Sali A., Blundell T.L. Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds. Prot. Sci. 1:1992;216-226.
41. + channel. Neuron. 9:1992;307-313.
42. Pascual J.M., Shieh C.C., Kirsch G.E., Brown A.M. Multiple residues specify external tetraethylammonium blockade in voltage-gated potassium channels. Biophys. J. 69:1995;428-434.
43. + pore structure revealed by reporter cysteines at inner and outer surfaces. Neuron. 14:1995;1055-1063.
44. + channel. Biochemistry. 32:1993;7879.
45. + channel selectivity filter by mutant cycle-based structure analysis. Neuron. 16:1996;131-139.
46. + channel. Biophys. J. 70:1996;A319.
47. Schreiber G., Fersht A.R. Energetics of protein-protein interactions: analysis of the Barnase-Barstar interface by single mutations and double mutant cycles. J. Mol. Biol. 248:1995;478-486.
48. + channels. Biophys. J. 67:1994;2316-2325.
49. Soman K.V., McCammon J.A., Brown A.M. Secondary structure prediction of the H5 pore of potassium channels. Prot. Engng. 8:1995;397-401.
50. + channels can simultaneously be occupied by at least three ions. Biophys. J. 68:1995;A129.
51. Sun Z.-P., Akabas M.H., Gouling E.H., Karlin A., Siegelbaum S.A. Exposure of residues in the cyclic nucleotide-gated channel pore: P region structure and function in gating. Neuron. 16:1996;141-149.
52. Tempel B.L., Papazian D.M., Schwarz T.L., Jan Y.N., Jan L.Y. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science. 237:1987;770-775.
53. Yang N., George A.L. Jr., Horn R. Molecular basis of charge movement in voltage-gated sodium channels. Neuron. 16:1996;113-122.
54. + channel. Science. 251:1991;939-942.
55. + channel by mutation of the H5 region. Nature. 349:1991;700-704.