B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by FeγRIIB1-BCR coligation

Journal of Immunology

Volumn 161, Issue 2, 1998, Pages 684-691

  Nakamura, Kazuhiro ^a   Cambier, John C ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN RECEPTOR; LYMPHOCYTE RECEPTOR; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; LIGATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; B-LYMPHOCYTES; CELL ADHESION MOLECULES; CYTOSOL; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE ACTIVATION; LYMPHOMA, B-CELL; MACROMOLECULAR SUBSTANCES; MICE; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, INSULIN; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, IGG; SHP1 PROTEIN TYROSINE PHOSPHATASE; SRC HOMOLOGY DOMAINS; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0032528493     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Adachi, M., E. H. Fischer, J. Ihle, K. Imai, F. Jirik, B. Neel, T. Pawson, S. H. Shen, M. Thomas, A. Ullrich, and Z. Zhao. 1996. Mammalian SH2-containing protein tyrosine phosphatases. Cell 85:15.
2. Tonks, N. K., and B. G. Neel. 1996. From form to function: signaling by protein tyrosine phosphatases. Cell 87:365.
3. Freeman, R. M., Jr., J. Plutzky, and B. G. Neel. 1992. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc. Natl. Acad. Sci. USA 89:11239.
4. Ahmad, S., D. Banville, Z. Zhao, E. H. Fischer, and S. H. Shen. 1993. A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Natl. Acad. Sci. USA 90:2197.
5. Feng, G. S., C. C. Hui, and T. Pawson. 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607.
6. Vogel, W., R. Lammers, J. Huang, and A. Ullrich. 1993. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259:1611.
7. Kazlauskas, A., G. S. Feng, T. Pawson, and M. Valius. 1993. The 64-kDa protein that associates with the platelet-derived growth factor receptor β subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc. Natl. Acad. Sci. USA 90:6939.
8. Kuhné, M. R., T. Pawson, G. E. Lienhard, and G. S. Feng. 1993. The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J. Biol. Chem. 268:11479.
9. Seely, B. L., D. R. Reichart, P. A. Staubs, B. H. Jhun, D. Hsu, H. Maegawa, K. L. Milarski, A. R. Saltiel, and J. M. Olefsky. 1995. Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. J. Biol. Chem. 270:19151.
10. Xiao, S., D. W. Rose, T. Sasaoka, H. Maegawa, T. R. Burke, Jr., P. P. Roller, S. E. Shoelson, and J. M. Olefsky. 1994. Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J. Biol. Chem. 269: 21244.
11. Yamauchi, K., K. L. Milarski, A. R. Saltiel, and J. E. Pessin. 1995. Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc. Natl. Acad. Sci. USA 92:664.
12. Rivard, N., F. R. McKenzie, J. M. Brondello, and J. Pouysségur. 1995. The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors. J. Biol. Chem. 270:11017.
13. Hausdorff, S. F., A. M. Bennett, B. G. Neel, and M. J. Birnbaum. 1995. Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation. J. Biol. Chem. 270:12965.
14. Bennett, A. M., S. F. Hausdorff, A. M. O'Reilly, R. M. Freeman, and B. G. Neel. 1996. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. Mol. Cell. Biol. 16:1189.
15. Roche, S., J. McGlade, M. Jones, G. D. Gish, T. Pawson, and S. A. Courtneidge. 1996. Requirement of phospholipase Cγ, the tyrosine phosphatase Syp and the adaptor proteins She and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways. EMBO J. 15:4940.
16. Saxton, T. M., M. Henkemeyer, S. Gasca, R. Shen, D. J. Rossi, F. Shalaby, G. S. Feng, and T. Pawson. 1997. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 16:2352.
17. Qu, C. K., Z. Q. Shi, R. Shen, F. Y. Tsai, S. H. Orkin, and G. S. Feng. 1997. A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol. Cell. Biol. 17:5499.
18. Li, W., R. Nishimura, A. Kashishian, A. G. Batzer, W. J. Kim, J. A. Cooper, and J. Schlessinger. 1994. A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell. Biol. 14:509.
19. Bennett, A. M., T. L. Tang, S. Sugimoto, C. T. Walsh, and B. G. Neel. 1994. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor β to Ras. Proc. Natl. Acad. Sci. USA 91:7335.
20. Vogel, W., and A. Ullrich. 1996. Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584. Cell Growth Differ. 7:1589.
21. Perkins, L. A., I. Larsen, and N. Perrimon. 1992. corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell 70:225.
22. Allard, J. D., H. C. Chang, R. Herbst, H. McNeill, and M. A. Simon. 1996. The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. Development 122:1137.
23. Milarski, K. L., and A. R. Saltiel. 1994. Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J. Biol. Chem. 269:21239.
24. Yamauchi, K., V. Ribon, A. R. Saltiel, and J. E. Pessin. 1995. Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin. J. Biol. Chem. 270:17716.
25. Noguchi, T., T. Matozaki, Y. Fujioka, T. Yamao, M. Tsuda, T. Takada, and M. Kasuga. 1996. Characterization of a 115-kDa protein that binds to SH-PTP2. a protein-tyrosine phosphatase with Src homology 2 domains, in Chinese hamster ovary cells. J. Biol Chem. 271:27652.
26. Yamauchi, K., and J. E. Pessin. 1995. Epidermal growth factor-induced association of the SHPTP2 protein tyrosine phosphatase with a 115-kDa phosphotyrosine protein. J. Biol. Chem. 270:14871.
27. Fujioka, Y., T. Matozaki, T. Noguchi, A. Iwamatsu, T. Yamao, N. Takahashi, M. Tsuda, T. Takada, and M. Kasuga. 1996. A novel membrane glycoprotein. SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16:6887.
28. Kharitonenkov, A., Z. Chen, I. Sures, H. Wang, J. Schilling, and A. Ullrich. 1997. A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386:181.
29. Herbst, R., P. M. Carroll, J. D. Allard, J. Schilling, T. Raabe, and M. A. Simon. 1996. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell 85:899.
30. Raabe, T., J. Riesgo-Escovar, X. Liu, B. B. Sausenwein, P. Deak, P. Maröy, and E. Hafen. 1996. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between Sevenless and Ras1 in Drosophila. Cell 85:911.
31. Ali, S., Z. Chen, J. J. Lebrun, W. Vogel, A. Kharitonenkov, P. A. Kelly, and A. Ullrich. 1996. PTP1D is a positive regulator of the prolactin signal leading to β-cascin promoter activation. EMBO J. 15:135.
32. Fuhrer, D. K., G. S. Feng, and Y. C. Yang. 1995. Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes. J. Biol. Chem. 270:24826.
33. Yin, T., R. Shen, G. S. Feng, and Y. C. Yang. 1997. Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. J. Biol. Chem. 272:1032.
34. Tauchi, T., G. S. Feng, M. S. Marshall, R. Shen, C. Mantel, T. Pawson, and H. E. Broxmeyer. 1994. The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J. Biol. Chem. 269:25206.
35. Welham, M. J., U. Dechert, K. B. Leslie, F. Jirik, and J. W. Schrader. 1994. Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3′-kinase. J. Biol. Chem. 269:23764.
36. Tauchi, T., G. S. Feng, R. Shen, M. Hoatlin, G. C. Bagby, Jr., D. Kabat, L. Lu, and H. E. Broxmeyer. 1995. Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J. Biol. Chem. 270:5631.
37. Liu, L., J. E. Damen, M. D. Ware, and G. Krystal. 1997. Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2. J. Biol. Chem. 272: 10998.
38. Carlberg, K., and L. R. Rohrschneider. 1997. Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and phosphatidylinositol 3′-kinase in myeloid cells. J. Biol. Chem. 272:15943.
39. Gu, H., J. D. Griffin, and B. G. Neel. 1997. Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells. J. Biol. Chem. 272:16421.
40. Chan, P. L., and N. R. Sinclair. 1971. Regulation of the immune response. V. An analysis of the function of the Fc portion of antibody in suppression of an immune response with respect to interaction with components of the lymphoid system. Immunology 21:967.
41. Phillips, N. E., and D. C. Parker. 1983. Fc-dependent inhibition of mouse B cell activation by whole anti-μ antibodies. J. Immunol. 130:602.
42. Fridman, W. H., C. Bonnerot, M. Daeron, S. Amigorena, J. L. Teillaud, and C. Sautes. 1992. Structural bases of Fcγ receptor functions. Immunol. Rev. 125: 49.
43. Muta, T., T. Kurosaki, Z. Misulovin, M. Sanchez, M. C. Nussenzweig, and J. V. Ravetch. 1994. A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling. Nature 368:70.
44. D'Ambrosio, D., K. L. Hippen, S. A. Minskoff, I. Mellman, G. Pani, K. A. Siminovitch, and J. C. Cambier. 1995. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by FcγRIIB1. Science 268:293.
45. Olcese, L., P. Lang, F. Vély, A. Cambiaggi, D. Marguet, M. Bléry, K. L. Hippen, R. Biassoni, A. Moretta, L. Moretta, J. C. Cambier, and E. Vivier. 1996. Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J. Immunol. 156:4531.
46. Ono, M., S. Holland, P. Tempst, and J. V. Ravetch. 1996. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. Nature 383:263.
47. D'Ambrosio, D., D. C. Fong, and J. C. Cambier. 1996. The SHIP phosphatase becomes associated with FcγRIIB1 and is tyrosine phosphorylaled during 'negative' signaling. Immunol. Lett. 54:77.
48. Fong, D. C., O. Malbec, M. Arock, J. C. Cambier, W. H. Fridman, and M. Daeron. 1996. Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated FcγRIIB during negative regulation of IgE-dependent mouse mast cell activation. Immunol. Lett. 54:83.
49. Pani, G., M. Kozlowski, J. C. Cambier, G. B. Mills, and K. A. Siminovitch. 1995. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J. Exp. Med. 181:2077.
50. Ono, M., H. Okada, S. Bolland, S. Yanagi, T. Kurosaki, and J. V. Ravetch. 1997. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell 90:293.
51. Chacko, G. W., S. Tridandapani, J. E. Damen, L. Liu. G. Krystal, and K. M. Coggeshall. 1996. Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J. Immunol. 157:2234.
52. Kiener, P. A., M. N. Lioubin, L. R. Rohrschneider, J. A. Ledbetter, S. G. Nadler, and M. L. Diegel. 1997. Co-ligation of the antigen and Fc receptors gives rise to the selective modulation of intracellular signaling in B cells: regulation of the association of phosphatidylinositol 3-kinase and inositol 5′-phosphatase with the antigen receptor complex. J. Biol. Chem. 272:3838.
53. Tridandapani, S., G. W. Chacko, J. R. Van Brocklyn, and K. M. Coggeshall. 1997. Negative signaling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions. J. Immunol. 158:1125.
54. Tridandapani, S., T. Kelley, M. Pradhan, D. Cooney, L. B. Justement, and K. M. Coggeshall. 1997. Recruitment and phosphorylation of SH2-containing inositol phosphatase and She to the B-cell Fcγ immunoreceptor tyrosine-based inhibition motif peptide motif. Mol. Cell. Biol. 17:4305.
55. Kim, K. J., C. Kanellopoulos-Langevin, R. M. Merwin, D. H. Sachs, and R. Asofsky. 1979. Establishment and characterization of BALB/c lymphoma lines with B cell properties. J. Immunol. 122:549.
56. Jones, B., J. P. Tite, and C. A. Janeway, Jr. 1986. Different phenotypic variants of the mouse B cell tumor A20/2J are selected by antigen- and mitogen-triggered cytotoxicity of L3T4-positive, I-A-restricted T cell clones. J. Immunol. 136:348.
57. 2+ mobilizing signals when expressed on differentiated B lineage cells. J. Immunol. 144:3272.
58. 2+ mobilization and protein kinase C translocation. Proc. Natl. Acad. Sci. USA 85:6493.
59. Bazenet, C. E., J. A. Gelderloos, and A. Kazlauskas. 1996. Phosphorylation of tyrosine 720 in the platelet-derived growth factor α receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation. Mol. Cell Biol. 16:6926.
60. Boulton, T. G., N. Stahl, and G. D. Yancopoulos. 1994. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem. 269:11648.
61. David, M., G. Zhou, R. Pine, J. E. Dixon, and A. C. Larner. 1996. The SH2 domain-containing tyrosine phosphatase PTP1D is required for interferon α/β-induced gene expression. J. Biol. Chem. 271:15862.
62. Sarkar, S., K. Schlottmann, D. Cooney, and K. M. Coggeshall. 1996. Negative signaling via FcγRIIB1 in B cells blocks phospholipase Cγ2 tyrosine phosphorylation but not Syk or Lyn activation. J. Biol. Chem. 271:20182.
63. 2+ mobilization is integrated by CD19 dephosphorylation. Immunity 7:49.
64. Pluskey, S., T. J. Wandless, C. T. Walsh, and S. E. Shoelson. 1995. Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. J. Biol. Chem. 270:2897.
65. Frearson, J. A., T. Yi, and D. R. Alexander. 1996. A tyrosine-phosphorylated 110-120-kDa protein associates with the C-terminal SH2 domain of phosphotyrosine phosphatase-1D in T cell receptor-stimulated T cells. Eur. J. Immunol. 26:1539.
66. Holgado-Madruga, M., D. R. Emlet, D. K. Moscatello, A. K. Godwin, and A. J. Wong. 1996. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379:560.